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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cycli... See more...
Aliases for CCNE1 Gene
Aliases for CCNE1 Gene
External Ids for CCNE1 Gene
- HGNC: 1589
- Entrez Gene: 898
- Ensembl: ENSG00000105173
- OMIM: 123837
- UniProtKB: P24864
Previous HGNC Symbols for CCNE1 Gene
- CCNE
Previous GeneCards Identifiers for CCNE1 Gene
- GC19P030925
- GC19P030751
- GC19P034978
- GC19P034994
- GC19P030302
- GC19P026814
Summaries for CCNE1 Gene
-
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
-
Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.
GeneCards Summary for CCNE1 Gene
CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Bowenoid Papulosis and Facial Dermatosis. Among its related pathways are E2F transcription factor network and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCNE2.
UniProtKB/Swiss-Prot Summary for CCNE1 Gene
-
Essential for the control of the cell cycle at the G1/S (start) transition.
Additional gene information for CCNE1 Gene
- HGNC(1589)
- Entrez Gene(898)
- Ensembl(ENSG00000105173)
- OMIM(123837)
- UniProtKB(P24864)
- Open Targets Platform(ENSG00000105173)
- Monarch Initiative
- Search for CCNE1 at DataMed
- Search for CCNE1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNE1 Gene
Genomics for CCNE1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCNE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCNE1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNE1
- Top Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
Genomic Locations for CCNE1 Gene
Genomic Locations for CCNE1 Gene
- chr19:29,811,991-29,824,312
- (GRCh38/hg38)
- Size:
- 12,322 bases
- Orientation:
- Plus strand
- chr19:30,302,805-30,315,215
- (GRCh37/hg19)
- Size:
- 12,411 bases
- Orientation:
- Plus strand
Genomic View for CCNE1 Gene
Genes around CCNE1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q12 by HGNC
- 19q12 by Entrez Gene
- 19q12 by Ensembl
CCNE1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNE1 Gene
Proteins for CCNE1 Gene
-
Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24864-CCNE1_HUMAN
- Recommended name:
- G1/S-specific cyclin-E1
- Protein Accession:
- P24864
- A8K684
- Q14091
- Q8NFG1
- Q92501
- Q9UD21
Protein attributes for CCNE1 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 47077 Da
- Quaternary structure:
-
- Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).
- Miscellaneous:
-
- [Isoform E1S]: Lacks 49 residues within the cyclin box and cannot complex with CDK2.
Protein Expression for CCNE1 Gene
Post-translational modifications for CCNE1 Gene
- Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
- Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CCNE1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCNE1
- Novus Biologicals Antibodies for CCNE1
-
Abcam antibodies for CCNE1
- Invitrogen Antibodies for CCNE1 (AFLGC-CCNE1)
- antibodies-online: Show 4 available Cyclin E (CCN-E) Antibodies ranked by validation data
- Compare Top Cyclin E (CCN-E) Antibodies
-
Recommended
- 217 WB Antibodies (anti-human)
- 20 IHC Antibodies (anti-human)
- 16 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IF (cc) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 63 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 48 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCNE1
- Sino Biological Antibodies for CCNE1
Protein Products
-
OriGene Purified Proteins for CCNE1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNE1
- Origene Custom Protein Services for CCNE1
- Sino Biological Recombinant Proteins for CCNE1
- Sino Biological Cell Lysates for CCNE1
-
Abcam proteins for CCNE1
Assay Products
- RayBiotech Custom Human Cyclin E1 ELISA
- Novus Biologicals ELISA Kits for CCNE1
-
Boster Bio ELISA Kits for CCNE1
No data available for DME Specific Peptides for CCNE1 Gene
Domains & Families for CCNE1 Gene
Gene Families for CCNE1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for CCNE1 Gene
- InterPro:
- Blocks:
-
- Cyclin
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNE1 Gene
- GenScript: Design optimal peptide antigens:
-
- G1/S-specific cyclin-E1 (CCNE1_HUMAN)
- Cyclin E1 (F6KX26_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P24864- Family:
-
- Belongs to the cyclin family. Cyclin E subfamily.
Function for CCNE1 Gene
Molecular function for CCNE1 Gene
- UniProtKB/Swiss-Prot Function:
- Essential for the control of the cell cycle at the G1/S (start) transition.
- GENATLAS Biochemistry:
- cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability
Phenotypes From GWAS Catalog for CCNE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | NAS | 15572661 |
| GO:0004672 | protein kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 8756624 |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IBA | 21873635 |
Phenotypes for CCNE1 Gene
- MGI mutant phenotypes for CCNE1:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for CCNE1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased G1 DNA content
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased NF-kappaB reporter expression
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased HPV18 LCR reporter activity
- Increased hepcidin::fluc mRNA expression
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability in ovarian lineage
- G0/1 arrest
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCNE1 - Select products 50% OFF >
- * CCNE1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCNE1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNE1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNE1
miRNA for CCNE1 Gene
- miRTarBase miRNAs that target CCNE1
-
- hsa-miR-15b-5p (MIRT000276)
- hsa-miR-503-5p (MIRT000646)
- hsa-miR-424-5p (MIRT000936)
- hsa-miR-16-5p (MIRT001226)
- hsa-miR-15a-5p (MIRT001228)
- hsa-miR-107 (MIRT004693)
- hsa-miR-185-5p (MIRT004698)
- hsa-miR-103a-3p (MIRT004762)
- hsa-miR-26b-5p (MIRT006308)
- hsa-miR-26a-5p (MIRT006309)
- hsa-miR-16-1-3p (MIRT006741)
- mmu-miR-16-5p (MIRT006940)
- hsa-miR-195-5p (MIRT007237)
- hsa-miR-215-5p (MIRT024440)
- hsa-miR-192-5p (MIRT026235)
- hsa-miR-151a-3p (MIRT035523)
- hsa-miR-342-5p (MIRT038211)
- hsa-miR-125b-5p (MIRT045919)
- hsa-miR-92a-3p (MIRT049367)
- hsa-miR-383-3p (MIRT081648)
- hsa-miR-497-5p (MIRT081649)
- hsa-miR-4524a-5p (MIRT081651)
- hsa-miR-4694-3p (MIRT081652)
- hsa-miR-4524b-5p (MIRT081653)
- hsa-miR-6838-5p (MIRT081654)
- hsa-miR-7-5p (MIRT438133)
- hsa-miR-4477a (MIRT558884)
- hsa-miR-524-5p (MIRT558885)
- hsa-miR-520d-5p (MIRT558886)
- hsa-miR-5191 (MIRT558887)
- hsa-miR-646 (MIRT558888)
- rno-miR-16-5p (MIRT731188)
- gga-miR-103-3p (MIRT732143)
- hsa-miR-25-5p (MIRT733155)
- hsa-miR-30c-2-3p (MIRT734118)
- mmu-miR-195a-5p (MIRT734584)
- mmu-miR-497a-5p (MIRT734585)
- hsa-miR-144-5p (MIRT735303)
- hsa-miR-892b (MIRT735503)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNE1
- Browse OriGene Inhibitory RNA Products For CCNE1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNE1
Clone Products
- Applied Biological Materials (abm): Clones for CCNE1 - Select products 50% OFF >
- * CCNE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226185
- MR226185
- MR226185L1
- MR226185L2
- MR226185L3
- MR226185L4
- RC204289
- RC204289L1
- RC204289L2
- RC204289L3
- RC204289L4
- RC213217
- RC213217L3
- RC213217L4
- RG204289
- RG213217
- RR201927
- RR201927L3
- RR201927L4
- MR226185L1V
- MR226185L2V
- MR226185L3V
- MR226185L4V
- RC204289L1V
- RC204289L2V
- RC204289L3V
- RC204289L4V
- RC213217L3V
- RC213217L4V
- RR201927L3V
- RR201927L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCNE1
- Addgene plasmids for CCNE1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNE1
Cell Line Products
-
Horizon Cell Lines for CCNE1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE1 Gene
Localization for CCNE1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IBA | 21873635 |
| GO:0005634 | nucleus | IEA,IDA | 16109376 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005813 | centrosome | IBA | 21873635 |
Pathways & Interactions for CCNE1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.78
|
|
| 2 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
G1-S Phase Transition
.67
|
Cell Cycle Control by BTG Proteins
.36
|
| 3 | Cell cycle Role of SCF complex in cell cycle regulation |
Cell cycle Regulation of G1/S transition (part 1)
.40
Cell cycle Role of SCF complex in cell cycle regulation
.40
|
Cell cycle ESR1 regulation of G1/S transition
.34
Immune response MIF-JAB1 signaling
.33
|
| 4 | DNA Damage Response | ||
| 5 | Chaperonin-mediated protein folding |
.94
|
|
Pathways by source for CCNE1 Gene
1 Sino Biological pathway for CCNE1 Gene
20 BioSystems pathways for CCNE1 Gene
31 Reactome pathways for CCNE1 Gene
17 KEGG pathways for CCNE1 Gene
10 GeneGo (Thomson Reuters) pathways for CCNE1 Gene
- Cell cycle Cell cycle (generic schema)
- Cell cycle ESR1 regulation of G1/S transition
- Cell cycle Regulation of G1/S transition (part 1)
- Cell cycle Regulation of G1/S transition (part 2)
- Cell cycle Role of SCF complex in cell cycle regulation
15 Qiagen pathways for CCNE1 Gene
- Breast Cancer Regulation by Stathmin1
- Calpain Protease Regulates Cellular Mechanics
- Cell Cycle Control by BTG Proteins
- Cyclins and Cell Cycle Regulation
- DNA Damage Induced 14-3-3Sigma Signaling
1 Cell Signaling Technology pathway for CCNE1 Gene
1 GeneTex pathway for CCNE1 Gene
Interacting Proteins for CCNE1 Gene
Selected Interacting proteins:
P24864-CCNE1_HUMAN
ENSP00000262643
for CCNE1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCNE1
SIGNOR curated interactions for CCNE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA,TAS | -- |
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000723 | telomere maintenance | IEA | -- |
Drugs & Compounds for CCNE1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 | ||
| Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2451 | ||
| Alisertib | Investigational | Pharma | inhibitor, Biomarker | Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors | 0 | |
| Dinaciclib | Investigational | Pharma | inhibitor, Biomarker | CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors | 0 | |
| Anti-Infective Agents | Pharma | 22229 |
Transcripts for CCNE1 Gene
mRNA/cDNA for CCNE1 Gene
- 5 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262643 1954 nts (view in UCSC)
- ENST00000575243 820 nts (view in UCSC)
- ENST00000444983 1680 nts (view in UCSC)
- ENST00000586912 415 nts (view in UCSC)
- ENST00000576532 1085 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCNE1 - Select products 50% OFF >
- * CCNE1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCNE1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNE1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNE1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNE1
- Browse OriGene Inhibitory RNA Products For CCNE1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNE1
Clone Products
- Applied Biological Materials (abm): Clones for CCNE1 - Select products 50% OFF >
- * CCNE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226185
- MR226185
- MR226185L1
- MR226185L2
- MR226185L3
- MR226185L4
- RC204289
- RC204289L1
- RC204289L2
- RC204289L3
- RC204289L4
- RC213217
- RC213217L3
- RC213217L4
- RG204289
- RG213217
- RR201927
- RR201927L3
- RR201927L4
- MR226185L1V
- MR226185L2V
- MR226185L3V
- MR226185L4V
- RC204289L1V
- RC204289L2V
- RC204289L3V
- RC204289L4V
- RC213217L3V
- RC213217L4V
- RR201927L3V
- RR201927L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCNE1
- Addgene plasmids for CCNE1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNE1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for CCNE1 Gene
- GeneLoc Exon Structure for
- CCNE1
Expression for CCNE1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene
This gene is overexpressed in Testis (x4.8).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNE1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNE1
SOURCE GeneReport for Unigene cluster for CCNE1 Gene:
Hs.244723mRNA Expression by UniProt/SwissProt for CCNE1 Gene:
P24864-CCNE1_HUMAN
Tissue specificity:
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Evidence on tissue expression from TISSUES for CCNE1 Gene
- Liver(3)
- Intestine(3)
- Stomach(2.9)
- Nervous system(2.9)
- Heart(2.8)
- Muscle(2.8)
- Kidney(2.6)
- Bone marrow(2.5)
- Skin(2.4)
- Lymph node(2.3)
- Blood(2.3)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for CCNE1
-
OriGene qPCR primer pairs and template standards for CCNE1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE1 Gene
Orthologs for CCNE1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCNE1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CCNE1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CCNE1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ccne1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ccne1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CCNE1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CCNE1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CCNE1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CCNE1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ccne1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ccne1 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3561 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CycE 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cye-1 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CLB6 31 |
|
ManyToMany | |
| CLB1 31 |
|
ManyToMany | |||
| CLB2 31 |
|
ManyToMany | |||
| CLB3 31 |
|
ManyToMany | |||
| CLB5 31 |
|
ManyToMany | |||
| CLB4 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14750 30 |
|
- Species where no ortholog for CCNE1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CCNE1 Gene
- ENSEMBL:
- Gene Tree for CCNE1 (if available)
- TreeFam:
- Gene Tree for CCNE1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCNE1: view image
Paralogs for CCNE1 Gene
Paralogs for CCNE1 Gene
(2) SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:
- CCNE1_HUMAN
- C9J2U0_HUMAN
- F6KX26_HUMAN
- I3L1Q9_HUMAN
- I3L413_HUMAN
- V5W5X2_HUMAN
- V5W643_HUMAN
Variants for CCNE1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1035e212 | CNV | loss | 25503493 |
| esv274862 | CNV | loss | 21479260 |
| nsv1072344 | CNV | deletion | 25765185 |
| nsv1121975 | CNV | deletion | 24896259 |
| nsv1126519 | CNV | deletion | 24896259 |
| nsv1133066 | OTHER | inversion | 24896259 |
| nsv2456 | CNV | deletion | 18451855 |
| nsv828517 | CNV | gain | 20364138 |
| nsv828518 | CNV | loss | 20364138 |
| nsv833800 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.14;
23.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCNE1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNE1 Gene
Disorders for CCNE1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bowenoid papulosis |
|
|
| facial dermatosis |
|
|
| retinoblastoma |
|
|
| clear cell adenocarcinoma of the ovary |
|
|
| senile angioma |
|
|
Search CCNE1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCNE1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCNE1 Gene
Publications for CCNE1 Gene
- Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PMID: 19258477) Goode EL … Sellers TA (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
- Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H … Gayther SA (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 23 41
- Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato EM … Pharoah PD (Breast cancer research : BCR 2008) 3 23 41
- Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver KE … Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) Team (Carcinogenesis 2008) 3 23 41
- Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PMID: 17409409) Gayther SA … Ovarian Cancer Association Consortium (Cancer research 2007) 3 23 41
ExternalLinks
Products for CCNE1 Gene
- Custom Antibody ServicesOriGene Antibodies for CCNE1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCNE1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNE1
- Origene Custom Protein Services for CCNE1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNE1
- Browse OriGene Inhibitory RNA Products For CCNE1
- OriGene qPCR primer pairs for CCNE1
- OriGene qPCR primer pairs and template standards for CCNE1
- OriGene CRISPR knockouts for CCNE1
- MG226185
- MR226185
- MR226185L1
- MR226185L2
- MR226185L3
- MR226185L4
- RC204289
- RC204289L1
- RC204289L2
- RC204289L3
- RC204289L4
- RC213217
- RC213217L3
- RC213217L4
- RG204289
- RG213217
- RR201927
- RR201927L3
- RR201927L4
- MR226185L1V
- MR226185L2V
- MR226185L3V
- MR226185L4V
- RC204289L1V
- RC204289L2V
- RC204289L3V
- RC204289L4V
- RC213217L3V
- RC213217L4V
- RR201927L3V
- RR201927L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCNE1
- Sino Biological Human cDNA Clone for CCNE1
- Sino Biological Recombinant Proteins for CCNE1
- Sino Biological Cell Lysates for CCNE1
- Sino Biological Antibodies for CCNE1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCNE1
- Novus Biologicals proteins and lysates for CCNE1
- Novus Biologicals ELISA Kits for CCNE1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCNE1
- Abcam proteins for CCNE1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Invitrogen Antibodies for CCNE1 (AFLGC-CCNE1)
- VectorBuilder Custom and pre-made DNA vectors for CCNE1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCNE1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCNE1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCNE1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCNE1
- Addgene plasmids for CCNE1
- antibodies-online: Show 4 available Cyclin E (CCN-E) Antibodies ranked by validation data
- Compare Top Cyclin E (CCN-E) Antibodies
- Recommended
- 217 WB Antibodies (anti-human)
- 20 IHC Antibodies (anti-human)
- 16 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IF (cc) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 63 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 48 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 19 available Cyclin E (CCN-E) Elisa Kits ranked by validation data
- Compare Top Cyclin E (CCN-E) Elisa Kits
- antibodies-online: Show 16 available Cyclin E (CCN-E) Proteins ranked by validation data
- Compare Top Cyclin E (CCN-E) Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CCNE1
- Search Santa Cruz Biotechnology (SCBT) for CCNE1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCNE1
- Horizon Cell Lines for CCNE1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNE1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNE1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCNE1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNE1
Sources for CCNE1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB