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Aliases for CCNE1 Gene

Aliases for CCNE1 Gene

  • Cyclin E1 2 3 5
  • G1/S-Specific Cyclin-E1 3 4
  • CCNE 3 4
  • Cyclin Es 2
  • Cyclin Et 2
  • PCCNE1 3

External Ids for CCNE1 Gene

Previous HGNC Symbols for CCNE1 Gene

  • CCNE

Previous GeneCards Identifiers for CCNE1 Gene

  • GC19P030925
  • GC19P030751
  • GC19P034978
  • GC19P034994
  • GC19P030302
  • GC19P026814

Summaries for CCNE1 Gene

Entrez Gene Summary for CCNE1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

CIViC summary for CCNE1 Gene

  • Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.

GeneCards Summary for CCNE1 Gene

CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Chronic Endophthalmitis and Bowenoid Papulosis. Among its related pathways are Oocyte meiosis and Mitotic G1-G1/S phases. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCNE2.

UniProtKB/Swiss-Prot for CCNE1 Gene

  • Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Wiki entry for CCNE1 Gene

Additional gene information for CCNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE1 Gene

Genomics for CCNE1 Gene

GeneHancer (GH) Regulatory Elements for CCNE1 Gene

Promoters and enhancers for CCNE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J029810 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 622.2 +1.1 1140 5.5 HDGF SP1 ZFX MNT CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 POLR2A CCNE1 ENSG00000266910 ENSG00000267433 GC19P029609
GH19J029836 Enhancer 1 Ensembl ENCODE 30.1 +25.5 25503 2.4 SP1 NKRF ZNF121 JUND RELA CREM MLLT1 IKZF1 IKZF2 LARP7 CCNE1 ENSG00000267433 GC19P029609
GH19J029835 Enhancer 0.9 Ensembl ENCODE 30.8 +22.7 22703 2 CREM IKZF1 CREB1 CEBPG IKZF2 CTBP1 HES1 EED KLF4 PKNOX1 CCNE1 ENSG00000267433 GC19P029609
GH19J029804 Enhancer 1.1 Ensembl ENCODE 21.2 -6.0 -6019 3.6 SP1 CC2D1A ZNF148 CEBPG YY1 ZNF384 ZNF644 POLR2A RXRA RFX1 CCNE1 ENSG00000266910 C19orf12 GC19P029609
GH19J029874 Enhancer 1.1 ENCODE dbSUPER 16.6 +61.8 61781 0.2 ZFX CTCF ZNF121 ZNF174 KLF14 RAD21 GLIS2 ZNF221 ZBTB8A ZIC2 CCNE1 ENSG00000267433 GC19P029609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for CCNE1 Gene

Genomic Locations for CCNE1 Gene
chr19:29,811,898-29,824,312
(GRCh38/hg38)
Size:
12,415 bases
Orientation:
Plus strand
chr19:30,302,805-30,315,215
(GRCh37/hg19)
Size:
12,411 bases
Orientation:
Plus strand

Genomic View for CCNE1 Gene

Genes around CCNE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE1 Gene

Proteins for CCNE1 Gene

  • Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24864-CCNE1_HUMAN
    Recommended name:
    G1/S-specific cyclin-E1
    Protein Accession:
    P24864
    Secondary Accessions:
    • A8K684
    • Q14091
    • Q8NFG1
    • Q92501
    • Q9UD21

    Protein attributes for CCNE1 Gene

    Size:
    410 amino acids
    Molecular mass:
    47077 Da
    Quaternary structure:
    • Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).

    Three dimensional structures from OCA and Proteopedia for CCNE1 Gene

    Alternative splice isoforms for CCNE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNE1 Gene

Post-translational modifications for CCNE1 Gene

  • Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
  • Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CCNE1 Gene

Domains & Families for CCNE1 Gene

Gene Families for CCNE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNE1 Gene

Suggested Antigen Peptide Sequences for CCNE1 Gene

GenScript: Design optimal peptide antigens:
  • G1/S-specific cyclin-E1 (CCNE1_HUMAN)
  • Cyclin E1 (F6KX26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P24864

UniProtKB/Swiss-Prot:

CCNE1_HUMAN :
  • Belongs to the cyclin family. Cyclin E subfamily.
Family:
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE1: view

Function for CCNE1 Gene

Molecular function for CCNE1 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G1/S (start) transition.
GENATLAS Biochemistry:
cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability

Phenotypes From GWAS Catalog for CCNE1 Gene

Gene Ontology (GO) - Molecular Function for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0004672 contributes_to protein kinase activity IBA 21873635
GO:0005515 protein binding IPI 8756624
GO:0016301 kinase activity IEA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with CCNE1: view
genes like me logo Genes that share phenotypes with CCNE1: view

Animal Models for CCNE1 Gene

MGI Knock Outs for CCNE1:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCNE1 - Now 50% OFF >
  • * CCNE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCNE1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for CCNE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE1 Gene

Localization for CCNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNE1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IDA,IEA 16109376
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA 21873635
genes like me logo Genes that share ontologies with CCNE1: view

Pathways & Interactions for CCNE1 Gene

genes like me logo Genes that share pathways with CCNE1: view

SIGNOR curated interactions for CCNE1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000082 G1/S transition of mitotic cell cycle IEA,TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0000278 mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with CCNE1: view

Drugs & Compounds for CCNE1 Gene

(16) Drugs for CCNE1 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3185
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2309
Alisertib Investigational Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
Dinaciclib Investigational Pharma inhibitor, Biomarker CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors 0
Anti-Infective Agents Pharma 25773
genes like me logo Genes that share compounds with CCNE1: view

Transcripts for CCNE1 Gene

Unigene Clusters for CCNE1 Gene

Cyclin E1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCNE1 - Now 50% OFF >
  • * CCNE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCNE1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for CCNE1

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for CCNE1 Gene

GeneLoc Exon Structure for
CCNE1
ECgene alternative splicing isoforms for
CCNE1

Expression for CCNE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for CCNE1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNE1 Gene



Protein tissue co-expression partners for CCNE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNE1 Gene:

CCNE1

SOURCE GeneReport for Unigene cluster for CCNE1 Gene:

Hs.244723

mRNA Expression by UniProt/SwissProt for CCNE1 Gene:

P24864-CCNE1_HUMAN
Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Evidence on tissue expression from TISSUES for CCNE1 Gene

  • Liver(2.4)
  • Stomach(2.4)
  • Intestine(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CCNE1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE1 Gene

Orthologs for CCNE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNE1 35 34
  • 99.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCNE1 35 34
  • 88.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCNE1 35 34
  • 86.6 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccne1 34
  • 79.41 (n)
mouse
(Mus musculus)
Mammalia Ccne1 17 35 34
  • 79.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNE1 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNE1 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNE1 35 34
  • 74.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNE1 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne1 34
  • 66.16 (n)
zebrafish
(Danio rerio)
Actinopterygii ccne1 35 34
  • 63.68 (n)
OneToOne
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3561 34
fruit fly
(Drosophila melanogaster)
Insecta CycE 35 36 34
  • 52.43 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cye-1 35 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB6 35
  • 18 (a)
ManyToMany
CLB1 35
  • 17 (a)
ManyToMany
CLB2 35
  • 17 (a)
ManyToMany
CLB3 35
  • 17 (a)
ManyToMany
CLB5 35
  • 16 (a)
ManyToMany
CLB4 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Cin.14750 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14750 34
Species where no ortholog for CCNE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE1 Gene

ENSEMBL:
Gene Tree for CCNE1 (if available)
TreeFam:
Gene Tree for CCNE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNE1: view image

Paralogs for CCNE1 Gene

(2) SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:

  • CCNE1_HUMAN
  • C9J2U0_HUMAN
  • F6KX26_HUMAN
  • I3L1Q9_HUMAN
  • I3L413_HUMAN
  • V5W5X2_HUMAN
  • V5W643_HUMAN
genes like me logo Genes that share paralogs with CCNE1: view

Variants for CCNE1 Gene

Sequence variations from dbSNP and Humsavar for CCNE1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000345404 -- 29,811,839(+) G/A upstream_transcript_variant
rs1000514115 -- 29,824,675(+) G/A downstream_transcript_variant
rs1000522945 -- 29,818,351(+) GGGG/GG/GGGGG intron_variant
rs1000533643 -- 29,812,899(+) T/C intron_variant
rs1000621456 -- 29,824,626(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE1 Gene

Variant ID Type Subtype PubMed ID
dgv1035e212 CNV loss 25503493
esv274862 CNV loss 21479260
nsv1072344 CNV deletion 25765185
nsv1121975 CNV deletion 24896259
nsv1126519 CNV deletion 24896259
nsv1133066 OTHER inversion 24896259
nsv2456 CNV deletion 18451855
nsv828517 CNV gain 20364138
nsv828518 CNV loss 20364138
nsv833800 CNV loss 17160897

Variation tolerance for CCNE1 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNE1
Human Gene Mutation Database (HGMD)
CCNE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE1 Gene

Disorders for CCNE1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CCNE1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic endophthalmitis
bowenoid papulosis
  • bp
clear cell adenocarcinoma of the ovary
  • ovarian clear cell adenocarcinoma
phlyctenulosis
  • phlyctenular keratoconjunctivitis
facial dermatosis
  • facial dermatoses
- elite association - COSMIC cancer census association via MalaCards
Search CCNE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNE1 Gene

Publications for CCNE1 Gene

  1. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PMID: 19258477) Goode EL … Sellers TA (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 45 58
  2. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver KE … Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) Team (Carcinogenesis 2008) 3 23 45 58
  3. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H … Gayther SA (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 23 45 58
  4. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato EM … Pharoah PD (Breast cancer research : BCR 2008) 3 23 45 58
  5. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PMID: 17409409) Gayther SA … Ovarian Cancer Association Consortium (Cancer research 2007) 3 23 45 58

Products for CCNE1 Gene

Sources for CCNE1 Gene

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