Aliases for CCNE1 Gene
External Ids for CCNE1 Gene
Previous HGNC Symbols for CCNE1 Gene
Previous GeneCards Identifiers for CCNE1 Gene
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.
GeneCards Summary for CCNE1 Gene
CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Chronic Endophthalmitis and Facial Dermatosis. Among its related pathways are Cellular Senescence (REACTOME) and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCNE2.
UniProtKB/Swiss-Prot Summary for CCNE1 Gene
Essential for the control of the cell cycle at the G1/S (start) transition.