The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and de... See more...

Aliases for CCNB3 Gene

Aliases for CCNB3 Gene

  • Cyclin B3 2 3 5
  • G2/Mitotic-Specific Cyclin-B3 3 4
  • CCNB3 5
  • CYCB3 4

External Ids for CCNB3 Gene

Previous GeneCards Identifiers for CCNB3 Gene

  • GC0XP048582
  • GC0XP048040
  • GC0XP048722
  • GC0XP048944
  • GC0XP049860
  • GC0XP049967
  • GC0XP047471

Summaries for CCNB3 Gene

Entrez Gene Summary for CCNB3 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CCNB3 Gene

CCNB3 (Cyclin B3) is a Protein Coding gene. Diseases associated with CCNB3 include Pregnancy Loss, Recurrent 1 and Bone Sarcoma. Among its related pathways are ATM Pathway and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB2.

UniProtKB/Swiss-Prot Summary for CCNB3 Gene

  • Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNB3 Gene

Genomics for CCNB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ050203 Promoter/Enhancer 1.1 Ensembl ENCODE 600.7 +2.0 1971 1.8 CTCF PRDM10 REST RAD21 ZNF740 TRIM22 ELF4 SOX6 MGA SP1 CCNB3 NONHSAG054477.2 lnc-AKAP4-1 DGKK
GH0XJ050201 Enhancer 0.7 Ensembl ENCODE 600.7 -0.3 -321 1.7 ZNF316 JUN MAFF JUND FOSL1 EP300 MAFK EMSY CCNB3 AKAP4 lnc-AKAP4-1
GH0XJ050430 Enhancer 0.9 Ensembl ENCODE 0.1 +228.5 228545 2.1 GATAD2A KDM1A RCOR2 RBFOX2 CEBPA SOX13 TCF7 FOXA2 TEAD1 KDM6A piR-57135-149 lnc-DGKK-1 DGKK CCNB3
GH0XJ050432 Enhancer 0.6 ENCODE 0.1 +230.5 230483 1.7 TEAD4 RBFOX2 SOX13 TCF7 DRAP1 SMAD4 CHD4 NFIL3 RARA KDM1A piR-57135-149 lnc-DGKK-1 DGKK CCNB3
GH0XJ050456 Enhancer 0.4 Ensembl 0.1 +254.6 254588 1.4 CTCF CEBPG ATF4 ATF3 DGKK lnc-DGKK-1 piR-57135-149 CCNB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNB3

Top Transcription factor binding sites by QIAGEN in the CCNB3 gene promoter:
  • Hlf
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • TGIF

Genomic Locations for CCNB3 Gene

Genomic Locations for CCNB3 Gene
chrX:50,202,713-50,351,914
(GRCh38/hg38)
Size:
149,202 bases
Orientation:
Plus strand
chrX:49,967,364-50,094,913
(GRCh37/hg19)
Size:
127,550 bases
Orientation:
Plus strand

Genomic View for CCNB3 Gene

Genes around CCNB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB3 Gene

Proteins for CCNB3 Gene

  • Protein details for CCNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWL7-CCNB3_HUMAN
    Recommended name:
    G2/mitotic-specific cyclin-B3
    Protein Accession:
    Q8WWL7
    Secondary Accessions:
    • B1AQI5
    • B1AQI6
    • Q96SB5
    • Q96SB6
    • Q96SB7
    • Q9NT38

    Protein attributes for CCNB3 Gene

    Size:
    1395 amino acids
    Molecular mass:
    157916 Da
    Quaternary structure:
    • Interacts with CDK2 kinase.

    Alternative splice isoforms for CCNB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNB3 Gene

Post-translational modifications for CCNB3 Gene

  • Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNB3 Gene

Domains & Families for CCNB3 Gene

Gene Families for CCNB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNB3 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
  • Cyclin
ProtoNet:

Suggested Antigen Peptide Sequences for CCNB3 Gene

GenScript: Design optimal peptide antigens:
  • G2/mitotic-specific cyclin-B3 (CCNB3_HUMAN)
  • Cyclin B3 (Q8WTR6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWL7

UniProtKB/Swiss-Prot:

CCNB3_HUMAN :
  • The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the cyclin family. Cyclin AB subfamily.
Domain:
  • The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB3: view

Function for CCNB3 Gene

Molecular function for CCNB3 Gene

UniProtKB/Swiss-Prot Function:
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.

Phenotypes From GWAS Catalog for CCNB3 Gene

Gene Ontology (GO) - Molecular Function for CCNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0005515 protein binding IPI 12185076
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA,IEA --
genes like me logo Genes that share ontologies with CCNB3: view
genes like me logo Genes that share phenotypes with CCNB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCNB3 Gene

Localization for CCNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNB3 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA 21873635
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CCNB3: view

Pathways & Interactions for CCNB3 Gene

PathCards logo

SuperPathways for CCNB3 Gene

SuperPathway Contained pathways
1 Cell cycle
2 GPCR Pathway
.59
.58
3 DNA Damage Response
4 Cellular senescence (KEGG)
5 FoxO signaling pathway
genes like me logo Genes that share pathways with CCNB3: view

Pathways by source for CCNB3 Gene

4 GeneGo (Thomson Reuters) pathways for CCNB3 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle_Chromosome condensation in prometaphase
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
8 Qiagen pathways for CCNB3 Gene
  • 14-3-3 and Cell Cycle Regulation
  • ATM Pathway
  • Breast Cancer Regulation by Stathmin1
  • Calpain Protease Regulates Cellular Mechanics
  • Cyclins and Cell Cycle Regulation
1 GeneTex pathway for CCNB3 Gene

Gene Ontology (GO) - Biological Process for CCNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle IEA --
GO:0044772 mitotic cell cycle phase transition IBA 21873635
genes like me logo Genes that share ontologies with CCNB3: view

No data available for SIGNOR curated interactions for CCNB3 Gene

Drugs & Compounds for CCNB3 Gene

No Compound Related Data Available

Transcripts for CCNB3 Gene

mRNA/cDNA for CCNB3 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNB3

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:

Relevant External Links for CCNB3 Gene

GeneLoc Exon Structure for
CCNB3

Expression for CCNB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNB3 Gene

This gene is overexpressed in Testis (x16.7).

Protein differential expression in normal tissues from HIPED for CCNB3 Gene

This gene is overexpressed in Frontal cortex (36.2) and Pancreatic juice (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNB3 Gene



Protein tissue co-expression partners for CCNB3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNB3

SOURCE GeneReport for Unigene cluster for CCNB3 Gene:

Hs.130310

mRNA Expression by UniProt/SwissProt for CCNB3 Gene:

Q8WWL7-CCNB3_HUMAN
Tissue specificity: Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.

Evidence on tissue expression from TISSUES for CCNB3 Gene

  • Intestine(5)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with CCNB3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNB3 Gene

Orthologs for CCNB3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNB3 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia CCNB3 30 31
  • 71.11 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNB3 31
  • 64 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccnb3 30
  • 59.65 (n)
Mouse
(Mus musculus)
Mammalia Ccnb3 30 17 31
  • 58.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNB3 31
  • 54 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCNB3 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNB3 31
  • 55 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCNB3 31
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ccnb3-A-prov 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.10800 30
Zebrafish
(Danio rerio)
Actinopterygii ccnb3 31
  • 47 (a)
OneToOne
Dr.15486 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2747 30
Fruit Fly
(Drosophila melanogaster)
Insecta CycB3 31 32
  • 34 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cyb-3 31
  • 35 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB3 31
  • 25 (a)
ManyToMany
CLB6 31
  • 24 (a)
ManyToMany
CLB1 31
  • 23 (a)
ManyToMany
CLB2 31
  • 23 (a)
ManyToMany
CLB4 31
  • 22 (a)
ManyToMany
CLB5 31
  • 21 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8934 31
  • 38 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14019 30
Species where no ortholog for CCNB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCNB3 Gene

ENSEMBL:
Gene Tree for CCNB3 (if available)
TreeFam:
Gene Tree for CCNB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNB3: view image

Paralogs for CCNB3 Gene

(2) SIMAP similar genes for CCNB3 Gene using alignment to 2 proteins:

  • CCNB3_HUMAN
  • Q8WTR6_HUMAN

Pseudogenes.org Pseudogenes for CCNB3 Gene

genes like me logo Genes that share paralogs with CCNB3: view

Variants for CCNB3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNB3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
619178 Pathogenic: Recurrent abortion 50,346,749(+) T/A MISSENSE_VARIANT
709387 Benign: not provided 50,310,275(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
711172 Benign: not provided 50,308,934(+) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT
721550 Likely Benign: not provided 50,309,062(+) A/G MISSENSE_VARIANT,INTRON_VARIANT
727698 Benign: not provided 50,308,731(+) T/A MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CCNB3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNB3 Gene

Variant ID Type Subtype PubMed ID
nsv1125092 CNV duplication 24896259
nsv1152203 CNV duplication 26484159
nsv508771 CNV insertion 20534489

Variation tolerance for CCNB3 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNB3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB3 Gene

Disorders for CCNB3 Gene

MalaCards: The human disease database

(29) MalaCards diseases for CCNB3 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pregnancy loss, recurrent 1
  • pregnancy loss, recurrent, susceptibility to, 1
bone sarcoma
small cell sarcoma
  • sarcoma, small cell
kidney sarcoma
  • renal sarcoma
clear cell sarcoma
  • adult soft part clear cell sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CCNB3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CCNB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB3 Gene

Publications for CCNB3 Gene

  1. Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. (PMID: 12185076) Nguyen TB … Koff A (The Journal of biological chemistry 2002) 2 3 4 23
  2. Molecular cloning, gene localization, and structure of human cyclin B3. (PMID: 11846420) Lozano JC … Picard A (Biochemical and biophysical research communications 2002) 2 3 4 23
  3. Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins. (PMID: 8313904) Gallant P … Nigg EA (The EMBO journal 1994) 3 23
  4. An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study. (PMID: 30064235) Krskova L … Kodet R (Neoplasma 2018) 3
  5. Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion: Analysis of 11 Cases With a Reappraisal of the Utility of Immunohistochemistry for BCOR and CCNB3. (PMID: 28877060) Matsuyama A … Hisaoka M (The American journal of surgical pathology 2017) 3

Products for CCNB3 Gene

Sources for CCNB3 Gene