External Ids for CCNB3 Gene
Previous GeneCards Identifiers for CCNB3 Gene
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for CCNB3 Gene
CCNB3 (Cyclin B3) is a Protein Coding gene. Diseases associated with CCNB3 include Small Cell Sarcoma and Ewing Sarcoma. Among its related pathways are FoxO signaling pathway and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB2.
UniProtKB/Swiss-Prot for CCNB3 Gene
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.