Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds ... See more...

Aliases for CCNB2 Gene

Aliases for CCNB2 Gene

  • Cyclin B2 2 3 5
  • G2/Mitotic-Specific Cyclin-B2 3 4
  • HsT17299 2 3
  • CCNB2 5

External Ids for CCNB2 Gene

Previous GeneCards Identifiers for CCNB2 Gene

  • GC15P054954
  • GC15P052444
  • GC15P056976
  • GC15P057113
  • GC15P057184
  • GC15P059397
  • GC15P036219

Summaries for CCNB2 Gene

Entrez Gene Summary for CCNB2 Gene

  • Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNB2 Gene

CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include Breast Cancer. Among its related pathways are ATM Pathway and Cell cycle_Spindle assembly and chromosome separation. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.

UniProtKB/Swiss-Prot Summary for CCNB2 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Wiki entry for CCNB2 Gene

Additional gene information for CCNB2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNB2 Gene

Genomics for CCNB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J059104 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 634 2.9 SP1 HNRNPL CREB1 ZNF629 ZNF512 IKZF1 POLR2A BACH1 FOS LARP7 CCNB2 piR-53583 RNF111 LDHAL6B
GH15J058568 Enhancer 0.8 Ensembl ENCODE 13.6 -536.7 -536725 1.2 MTA2 SOX6 MGA MTA3 CTBP1 RUNX3 GATAD2A EHMT2 NFIC ZNF592 CCNB2 SNORD3P1 LOC101928725 MINDY2 LIPC ADAM10 piR-31508-018 ENSG00000259250 ALDH1A2
GH15J060076 Enhancer 1 Ensembl ENCODE 4.8 +971.1 971075 4.8 PRDM10 ZNF629 ZNF692 ZIC2 ZSCAN4 ZNF600 ZNF341 ZNF561 ARNT ZBTB44 ICE2 BNIP2 RPS3AP6 CCNB2 MESTP2 ENSG00000259223 FOXB1 ANXA2
GH15J059168 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +64.9 64942 3.8 POLR2A FOXA1 ZIC2 CEBPA JUND CEBPB FOS FOSL2 SAP130 ZNF384 MIR2116 LDHAL6B RNF111 ADAM10 SLTM RF00017-1798 CCNB2 MYO1E
GH15J059138 Enhancer 0.9 ENCODE 0.3 +33.2 33231 0.2 CTCF ZBTB33 JUND ZNF143 ZNF24 MTA1 REST NR2C1 RAD21 HDAC1 SLTM RPS3AP6 PIGHP1 BNIP2 RNF111 MIR2116 ENSG00000259732 RF00017-1798 CCNB2 LDHAL6B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNB2

Top Transcription factor binding sites by QIAGEN in the CCNB2 gene promoter:
  • GATA-2
  • IRF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1
  • POU2F1a
  • Sox9

Genomic Locations for CCNB2 Gene

Genomic Locations for CCNB2 Gene
chr15:59,105,126-59,125,045
(GRCh38/hg38)
Size:
19,920 bases
Orientation:
Plus strand
chr15:59,397,277-59,417,244
(GRCh37/hg19)
Size:
19,968 bases
Orientation:
Plus strand

Genomic View for CCNB2 Gene

Genes around CCNB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB2 Gene

Proteins for CCNB2 Gene

  • Protein details for CCNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95067-CCNB2_HUMAN
    Recommended name:
    G2/mitotic-specific cyclin-B2
    Protein Accession:
    O95067
    Secondary Accessions:
    • B3KM93
    • Q6FI99

    Protein attributes for CCNB2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45282 Da
    Quaternary structure:
    • Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

neXtProt entry for CCNB2 Gene

Post-translational modifications for CCNB2 Gene

  • Ubiquitination at Lys328, Lys360, and Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNB2 Gene

Domains & Families for CCNB2 Gene

Gene Families for CCNB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CCNB2 Gene

InterPro:
Blocks:
  • Cyclin
ProtoNet:

Suggested Antigen Peptide Sequences for CCNB2 Gene

GenScript: Design optimal peptide antigens:
  • G2/mitotic-specific cyclin-B2 (CCNB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95067

UniProtKB/Swiss-Prot:

CCNB2_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB2: view

Function for CCNB2 Gene

Molecular function for CCNB2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Phenotypes From GWAS Catalog for CCNB2 Gene

Gene Ontology (GO) - Molecular Function for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0005515 protein binding IPI 15232106
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA --
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with CCNB2: view
genes like me logo Genes that share phenotypes with CCNB2: view

Animal Models for CCNB2 Gene

MGI Knock Outs for CCNB2:

Animal Model Products

CRISPR Products

miRNA for CCNB2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNB2 Gene

Localization for CCNB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNB2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 3
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IEA,IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA,IDA 21399614
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNB2 Gene

Pathways & Interactions for CCNB2 Gene

genes like me logo Genes that share pathways with CCNB2: view

Pathways by source for CCNB2 Gene

4 GeneGo (Thomson Reuters) pathways for CCNB2 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle_Chromosome condensation in prometaphase
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
10 Qiagen pathways for CCNB2 Gene
  • 14-3-3 and Cell Cycle Regulation
  • ATM Pathway
  • Breast Cancer Regulation by Stathmin1
  • Calpain Protease Regulates Cellular Mechanics
  • Cyclins and Cell Cycle Regulation
1 GeneTex pathway for CCNB2 Gene

Gene Ontology (GO) - Biological Process for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001701 in utero embryonic development IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for SIGNOR curated interactions for CCNB2 Gene

Drugs & Compounds for CCNB2 Gene

(3) Drugs for CCNB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNB2: view

Transcripts for CCNB2 Gene

mRNA/cDNA for CCNB2 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNB2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2:
SP3:

Relevant External Links for CCNB2 Gene

GeneLoc Exon Structure for
CCNB2

Expression for CCNB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNB2 Gene

mRNA differential expression in normal tissues according to GTEx for CCNB2 Gene

This gene is overexpressed in Testis (x12.5).

Protein differential expression in normal tissues from HIPED for CCNB2 Gene

This gene is overexpressed in Testis (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNB2 Gene



Protein tissue co-expression partners for CCNB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNB2

SOURCE GeneReport for Unigene cluster for CCNB2 Gene:

Hs.194698

Evidence on tissue expression from TISSUES for CCNB2 Gene

  • Nervous system(4.7)
  • Blood(2.7)
  • Bone marrow(2.7)
  • Intestine(2.5)
  • Lymph node(2.4)
  • Skin(2.4)
  • Lung(2.3)
  • Liver(2.2)
  • Adrenal gland(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with CCNB2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNB2 Gene

Orthologs for CCNB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNB2 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
OneToMany
CCNB2 30
  • 90.85 (n)
-- 31
  • 83 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CCNB2 30 31
  • 87.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccnb2 30
  • 87.57 (n)
Mouse
(Mus musculus)
Mammalia Ccnb2 30 17 31
  • 86.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCNB2 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNB2 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNB2 30 31
  • 69.71 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccnb2 30
  • 63.73 (n)
Ccnb2 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397743 30
Zebrafish
(Danio rerio)
Actinopterygii ccnb2 30 31
  • 62.28 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4250 30
Fruit Fly
(Drosophila melanogaster)
Insecta CycB 31 32
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cyb-2.1 31 32
  • 30 (a)
ManyToMany
cyb-1 31 32
  • 30 (a)
ManyToMany
cyb-2.2 31 32
  • 29 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB2 30 31 33
  • 54.32 (n)
ManyToMany
CLB3 31
  • 27 (a)
ManyToMany
CLB1 31
  • 27 (a)
ManyToMany
CLB6 31
  • 23 (a)
ManyToMany
CLB4 31
  • 22 (a)
ManyToMany
CLB5 31
  • 22 (a)
ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15543g 30
  • 50.38 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAR099W 30
  • 48.39 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYCB2;4 30
  • 52.17 (n)
Soybean
(Glycine max)
eudicotyledons Gma.174 30
Rice
(Oryza sativa)
Liliopsida Os04g0563700 30
  • 49.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3299 31
  • 39 (a)
OneToMany
Species where no ortholog for CCNB2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCNB2 Gene

ENSEMBL:
Gene Tree for CCNB2 (if available)
TreeFam:
Gene Tree for CCNB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNB2: view image

Paralogs for CCNB2 Gene

(5) SIMAP similar genes for CCNB2 Gene using alignment to 2 proteins:

  • CCNB2_HUMAN
  • H0YMP3_HUMAN

Pseudogenes.org Pseudogenes for CCNB2 Gene

genes like me logo Genes that share paralogs with CCNB2: view

Variants for CCNB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNB2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
711953 Benign: not provided 59,114,475(+) T/C MISSENSE_VARIANT
750783 Likely Benign: not provided 59,114,461(+) T/G SYNONYMOUS_VARIANT
777248 Benign: not provided 59,107,670(+) G/A SYNONYMOUS_VARIANT
781291 Benign: not provided 59,124,864(+) T/C MISSENSE_VARIANT
rs16941036 - p.Met100Thr

Additional dbSNP identifiers (rs#s) for CCNB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNB2 Gene

Variant ID Type Subtype PubMed ID
esv3636638 CNV loss 21293372
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv833025 CNV gain 17160897

Variation tolerance for CCNB2 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB2 Gene

Disorders for CCNB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CCNB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCNB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB2 Gene

Publications for CCNB2 Gene

  1. [Molecular mechanism of radiosensitizing effect of paclitaxel]. (PMID: 19664331) Weng WW … Hong CJ (Ai zheng = Aizheng = Chinese journal of cancer 2009) 3 23
  2. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 41
  3. Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2. (PMID: 17533373) Bellanger S … Sobczak-Thépot J (Oncogene 2007) 3 23
  4. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. (PMID: 17289878) Park SH … Kim DG (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for CCNB2 Gene

  • Signalway ELISA kits for CCNB2

Sources for CCNB2 Gene