The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017] See more...

Aliases for CCNB1 Gene

Aliases for CCNB1 Gene

  • Cyclin B1 2 3 5
  • G2/Mitotic-Specific Cyclin-B1 3 4
  • CCNB 3 4
  • G2/Mitotic-Specific Cyclin B1 2
  • CCNB1 5

External Ids for CCNB1 Gene

Previous HGNC Symbols for CCNB1 Gene

  • CCNB

Previous GeneCards Identifiers for CCNB1 Gene

  • GC05P068614
  • GC05P070028
  • GC05P068433
  • GC05P068478
  • GC05P068498
  • GC05P068462
  • GC05P065418

Summaries for CCNB1 Gene

Entrez Gene Summary for CCNB1 Gene

  • The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]

GeneCards Summary for CCNB1 Gene

CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Tongue Carcinoma and Adrenal Carcinoma. Among its related pathways are Cell cycle Cell cycle (generic schema) and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include protein kinase binding and patched binding. An important paralog of this gene is CCNB2.

UniProtKB/Swiss-Prot Summary for CCNB1 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Wiki entry for CCNB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNB1 Gene

Genomics for CCNB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNB1

Top Transcription factor binding sites by QIAGEN in the CCNB1 gene promoter:
  • Lhx3a
  • LHX3b
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • p300
  • p53
  • YY1

Genomic Locations for CCNB1 Gene

Latest Assembly
11,111 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
11,096 bases
Plus strand

(GRCh37/hg19 by Ensembl)
11,236 bases
Plus strand

Genomic View for CCNB1 Gene

Genes around CCNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB1 Gene

Proteins for CCNB1 Gene

  • Protein details for CCNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G2/mitotic-specific cyclin-B1
    Protein Accession:
    Secondary Accessions:
    • A8K066
    • Q5TZP9

    Protein attributes for CCNB1 Gene

    433 amino acids
    Molecular mass:
    48337 Da
    Quaternary structure:
    • Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187).

    Three dimensional structures from OCA and Proteopedia for CCNB1 Gene

    Alternative splice isoforms for CCNB1 Gene


neXtProt entry for CCNB1 Gene

Post-translational modifications for CCNB1 Gene

  • Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
  • Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
  • Ubiquitination at Lys190
  • Modification sites at PhosphoSitePlus

Antibodies for research

No data available for DME Specific Peptides for CCNB1 Gene

Domains & Families for CCNB1 Gene

Gene Families for CCNB1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CCNB1 Gene

Suggested Antigen Peptide Sequences for CCNB1 Gene

GenScript: Design optimal peptide antigens:
  • G2/mitotic-specific cyclin-B1 (CCNB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin AB subfamily.
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB1: view

Function for CCNB1 Gene

Molecular function for CCNB1 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
GENATLAS Biochemistry:
cyclin B1,complexing with CDC2 (M phase promoting factor (MPF) component),regulating G2/M transition (checkpoint) of the cell cycle,nucleocytoplasmic shuttling protein,accumulating in the cytoplasm through S and G2 phases and translocating to the nucleus during prophase

Gene Ontology (GO) - Molecular Function for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005113 patched binding IPI 11331587
GO:0005515 protein binding IPI 8756624
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IPI 12524548
GO:0044389 ubiquitin-like protein ligase binding IPI 15749827
genes like me logo Genes that share ontologies with CCNB1: view
genes like me logo Genes that share phenotypes with CCNB1: view

Animal Models for CCNB1 Gene

MGI Knock Outs for CCNB1:
  • Ccnb1 Ccnb1<tm1b(KOMP)Wtsi>
  • Ccnb1 Ccnb1<tm1Thnt>

miRNA for CCNB1 Gene

miRTarBase miRNAs that target CCNB1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNB1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNB1 Gene

Localization for CCNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNB1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNB1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 2
extracellular 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0000922 spindle pole IDA 18195732
GO:0000942 condensed nuclear chromosome outer kinetochore IDA 18195732
GO:0005634 nucleus IBA,IDA 11331587
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNB1: view

Pathways & Interactions for CCNB1 Gene

genes like me logo Genes that share pathways with CCNB1: view

Pathways by source for CCNB1 Gene

4 GeneGo (Thomson Reuters) pathways for CCNB1 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle_Chromosome condensation in prometaphase
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
10 Qiagen pathways for CCNB1 Gene
  • 14-3-3 and Cell Cycle Regulation
  • ATM Pathway
  • Breast Cancer Regulation by Stathmin1
  • Calpain Protease Regulates Cellular Mechanics
  • Cyclins and Cell Cycle Regulation
1 Cell Signaling Technology pathway for CCNB1 Gene
1 GeneTex pathway for CCNB1 Gene

SIGNOR curated interactions for CCNB1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle IEA --
GO:0001556 oocyte maturation IEA --
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with CCNB1: view

Drugs & Compounds for CCNB1 Gene

(63) Drugs for CCNB1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Temozolomide Approved, Investigational Pharma Alkylating Agents 945
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
Purvalanol A Experimental Pharma 0
(R)-DRF053 dihydrochloride Pharma cdk/CK1 inhibitor,potent and ATP-competitive, Dual CK1/cdk inhibitor 0
Aminopurvalanol A Pharma 0

(27) Additional Compounds for CCNB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(7) ApexBio Compounds for CCNB1 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive 1241675-76-2
Aminopurvalanol A 220792-57-4
Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas 3543-75-7
Nocodazole Tubulin production inhibitor,anti-neoplastic agent 31430-18-9
NSC 693868 40254-90-8
Purvalanol A 212844-53-6
Temozolomide 85622-93-1
genes like me logo Genes that share compounds with CCNB1: view

Drug products for research

Transcripts for CCNB1 Gene

mRNA/cDNA for CCNB1 Gene

17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNB1

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -

Relevant External Links for CCNB1 Gene

GeneLoc Exon Structure for

Expression for CCNB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNB1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for CCNB1 Gene

This gene is overexpressed in Breast (53.7) and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNB1

SOURCE GeneReport for Unigene cluster for CCNB1 Gene:


Evidence on tissue expression from TISSUES for CCNB1 Gene

  • Nervous system(4.5)
  • Skin(4.2)
  • Intestine(3.9)
  • Liver(3.8)
  • Lung(3.7)
  • Muscle(3.2)
  • Lymph node(2.9)
  • Pancreas(2.8)
  • Kidney(2.7)
  • Bone marrow(2.7)
  • Blood(2.6)
  • Eye(2.6)
  • Stomach(2.5)
  • Bone(2.5)
  • Thyroid gland(2.2)
  • Spleen(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CCNB1: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNB1 Gene

Orthologs for CCNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNB1 29 30
  • 99.92 (n)
(Canis familiaris)
Mammalia -- 30
  • 93 (a)
-- 30
  • 93 (a)
CCNB1 29
  • 90.9 (n)
-- 30
  • 87 (a)
(Bos Taurus)
Mammalia CCNB1 29 30
  • 89.77 (n)
(Rattus norvegicus)
Mammalia Ccnb1 29
  • 83.1 (n)
(Mus musculus)
Mammalia Ccnb1 29 16 30
  • 82.05 (n)
Ccnb1-ps 16
(Monodelphis domestica)
Mammalia CCNB1 30
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CCNB1 30
  • 80 (a)
(Anolis carolinensis)
Reptilia CCNB1 30
  • 71 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccnb1.2 29
  • 69.88 (n)
MGC76039 29
African clawed frog
(Xenopus laevis)
Amphibia ccnb1-prov 29
(Danio rerio)
Actinopterygii ccnb1 29 30
  • 65.82 (n)
ccnb1l 30
  • 43 (a)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7163 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004962 29
  • 52.13 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CycB 29 30 31
  • 51.92 (n)
(Caenorhabditis elegans)
Secernentea cyb-1 30 31
  • 34 (a)
cyb-2.1 30 31
  • 31 (a)
cyb-2.2 30 31
  • 29 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB3 29 30
  • 45.62 (n)
CLB4 30
  • 26 (a)
CLB1 30
  • 26 (a)
CLB2 30
  • 26 (a)
CLB6 30
  • 24 (a)
CLB5 30 32
  • 24 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYCB1;3 29
  • 48.75 (n)
(Oryza sativa)
Liliopsida Os.9246 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3299 30
  • 39 (a)
Species where no ortholog for CCNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCNB1 Gene

Gene Tree for CCNB1 (if available)
Gene Tree for CCNB1 (if available)
Evolutionary constrained regions (ECRs) for CCNB1: view image
Alliance of Genome Resources:
Additional Orthologs for CCNB1

Paralogs for CCNB1 Gene

(8) SIMAP similar genes for CCNB1 Gene using alignment to 5 proteins:

  • E9PC90_HUMAN
  • H0Y9U8_HUMAN
  • H0YA62_HUMAN
genes like me logo Genes that share paralogs with CCNB1: view

Variants for CCNB1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCNB1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCNB1 Gene

Variant ID Type Subtype PubMed ID
dgv358e215 CNV deletion 23714750
dgv5694n100 CNV gain 25217958
esv2671857 CNV deletion 23128226
nsv509066 CNV insertion 20534489

Variation tolerance for CCNB1 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNB1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNB1 Gene

Disorders for CCNB1 Gene

MalaCards: The human disease database

(30) MalaCards diseases for CCNB1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tongue carcinoma
  • tongue cancer
adrenal carcinoma
  • carcinoma of the adrenal gland
  • rb1
laryngeal squamous cell carcinoma
  • epidermoid carcinoma of the larynx
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search CCNB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNB1

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB1 Gene

Publications for CCNB1 Gene

  1. NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. (PMID: 16009132) Bassermann F … Duyster J (Cell 2005) 3 4 22
  2. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. (PMID: 12524548) Jackman M … Pines J (Nature cell biology 2003) 3 4 22
  3. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. (PMID: 12447691) Yuan J … Strebhardt K (Oncogene 2002) 3 4 22
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 40
  5. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. (PMID: 21540187) Bäumer N … Müller-Tidow C (The Journal of biological chemistry 2011) 3 4

Products for CCNB1 Gene

  • Addgene plasmids for CCNB1

Sources for CCNB1 Gene