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Aliases for CCNB1 Gene

Aliases for CCNB1 Gene

  • Cyclin B1 2 3 5
  • CCNB 3 4
  • G2/Mitotic-Specific Cyclin-B1 3
  • G2/Mitotic-Specific Cyclin B1 2

External Ids for CCNB1 Gene

Previous HGNC Symbols for CCNB1 Gene

  • CCNB

Previous GeneCards Identifiers for CCNB1 Gene

  • GC05P068614
  • GC05P070028
  • GC05P068433
  • GC05P068478
  • GC05P068498
  • GC05P068462
  • GC05P065418

Summaries for CCNB1 Gene

Entrez Gene Summary for CCNB1 Gene

  • The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]

GeneCards Summary for CCNB1 Gene

CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Thyroid Lymphoma and Adrenal Carcinoma. Among its related pathways are Cyclin A/B1 associated events during G2/M transition and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein kinase binding and patched binding. An important paralog of this gene is CCNB2.

UniProtKB/Swiss-Prot for CCNB1 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Wiki entry for CCNB1 Gene

Additional gene information for CCNB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB1 Gene

Genomics for CCNB1 Gene

GeneHancer (GH) Regulatory Elements for CCNB1 Gene

Promoters and enhancers for CCNB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J069166 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 403 2.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CCNB1 CCDC125 GTF2H2C RAD17 PIR41528
GH05J069093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.8 -72.6 -72566 2.4 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 SLC30A5 GTF2H2C SNORA50D CCNB1 CENPH OCLN SMN2 ENSG00000248664
GH05J069188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.1 +22.7 22715 2.4 PKNOX1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B CENPH ENSG00000280187 PIR38105 PIR48224 PIR41528 PIR42195 CDK7 GTF2H2C CCDC125 SLC30A5
GH05J069233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +67.9 67906 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CDK7 CCDC125 SLC30A5 GTF2H2C ENSG00000198237 ENSG00000254701 CENPH CCNB1 SNORA50D SMN2
GH05J069042 Enhancer 1.1 Ensembl ENCODE 10.7 -123.9 -123861 1.4 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ELK1 ZNF143 MIER2 REST ENSG00000250237 CCNB1 LINC02198
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNB1 gene promoter:
  • p53
  • p300
  • LHX3b
  • Lhx3a
  • YY1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for CCNB1 Gene

Genomic Locations for CCNB1 Gene
11,236 bases
Plus strand
11,236 bases
Plus strand

Genomic View for CCNB1 Gene

Genes around CCNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB1 Gene

Proteins for CCNB1 Gene

  • Protein details for CCNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G2/mitotic-specific cyclin-B1
    Protein Accession:
    Secondary Accessions:
    • A8K066
    • Q5TZP9

    Protein attributes for CCNB1 Gene

    433 amino acids
    Molecular mass:
    48337 Da
    Quaternary structure:
    • Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566).

    Three dimensional structures from OCA and Proteopedia for CCNB1 Gene

    Alternative splice isoforms for CCNB1 Gene


neXtProt entry for CCNB1 Gene

Post-translational modifications for CCNB1 Gene

  • Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
  • Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
  • Ubiquitination at Lys190
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CCNB1 Gene

Domains & Families for CCNB1 Gene

Gene Families for CCNB1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CCNB1 Gene

Suggested Antigen Peptide Sequences for CCNB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin AB subfamily.
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB1: view

Function for CCNB1 Gene

Molecular function for CCNB1 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
GENATLAS Biochemistry:
cyclin B1,complexing with CDC2 (M phase promoting factor (MPF) component),regulating G2/M transition (checkpoint) of the cell cycle,nucleocytoplasmic shuttling protein,accumulating in the cytoplasm through S and G2 phases and translocating to the nucleus during prophase

Gene Ontology (GO) - Molecular Function for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0005113 patched binding IPI 11331587
GO:0005515 protein binding IPI 8756624
GO:0016301 kinase activity IEA --
GO:0019901 protein kinase binding IPI 12524548
genes like me logo Genes that share ontologies with CCNB1: view
genes like me logo Genes that share phenotypes with CCNB1: view

Animal Model Products

miRNA for CCNB1 Gene

miRTarBase miRNAs that target CCNB1

Clone Products

  • Addgene plasmids for CCNB1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNB1 Gene

Localization for CCNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNB1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNB1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 18195732
GO:0000942 condensed nuclear chromosome outer kinetochore IDA 18195732
GO:0005634 nucleus IDA,IEA 11331587
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 11331587
genes like me logo Genes that share ontologies with CCNB1: view

Pathways & Interactions for CCNB1 Gene

genes like me logo Genes that share pathways with CCNB1: view

SIGNOR curated interactions for CCNB1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle IEA --
GO:0001556 oocyte maturation IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001933 negative regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CCNB1: view

Drugs & Compounds for CCNB1 Gene

(64) Drugs for CCNB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Temozolomide Approved, Investigational Pharma Alkylating Agents 758
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
Purvalanol A Experimental Pharma 0
(R)-DRF053 dihydrochloride Pharma cdk/CK1 inhibitor,potent and ATP-competitive, Dual CK1/cdk inhibitor 0
Aminopurvalanol A Pharma 0

(26) Additional Compounds for CCNB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNB1: view

Transcripts for CCNB1 Gene

mRNA/cDNA for CCNB1 Gene

Unigene Clusters for CCNB1 Gene

Cyclin B1:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCNB1

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -

Relevant External Links for CCNB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNB1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for CCNB1 Gene

This gene is overexpressed in Breast (53.7) and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNB1 Gene:


SOURCE GeneReport for Unigene cluster for CCNB1 Gene:


Evidence on tissue expression from TISSUES for CCNB1 Gene

  • Nervous system(4.4)
  • Skin(4)
  • Intestine(3.8)
  • Liver(3.6)
  • Lung(3.6)
  • Muscle(2.8)
  • Lymph node(2.4)
  • Bone marrow(2.2)
  • Pancreas(2.2)
  • Blood(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with CCNB1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNB1 Gene

Orthologs for CCNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNB1 34 33
  • 99.92 (n)
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
-- 34
  • 93 (a)
CCNB1 33
  • 90.9 (n)
-- 34
  • 87 (a)
(Bos Taurus)
Mammalia CCNB1 34 33
  • 89.77 (n)
(Rattus norvegicus)
Mammalia Ccnb1 33
  • 83.1 (n)
(Mus musculus)
Mammalia Ccnb1 34 33
  • 82.05 (n)
Ccnb1-ps 16
(Monodelphis domestica)
Mammalia CCNB1 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CCNB1 34
  • 80 (a)
(Anolis carolinensis)
Reptilia CCNB1 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnb1.2 33
  • 69.88 (n)
MGC76039 33
African clawed frog
(Xenopus laevis)
Amphibia ccnb1-prov 33
(Danio rerio)
Actinopterygii ccnb1 34 33 33
  • 65.82 (n)
ccnb1l 34
  • 43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7163 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004962 33
  • 52.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycB 34 35 33
  • 51.92 (n)
(Caenorhabditis elegans)
Secernentea cyb-1 34 35
  • 34 (a)
cyb-2.1 34 35
  • 31 (a)
cyb-2.2 34 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB3 34 33
  • 45.62 (n)
CLB4 34
  • 26 (a)
CLB1 34
  • 26 (a)
CLB2 34
  • 26 (a)
CLB5 36 34
  • 24 (a)
CLB6 34
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCB1;3 33
  • 48.75 (n)
(Oryza sativa)
Liliopsida Os.9246 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3299 34
  • 39 (a)
Species where no ortholog for CCNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNB1 Gene

Gene Tree for CCNB1 (if available)
Gene Tree for CCNB1 (if available)
Evolutionary constrained regions (ECRs) for CCNB1: view image

Paralogs for CCNB1 Gene

Paralogs for CCNB1 Gene

(8) SIMAP similar genes for CCNB1 Gene using alignment to 5 proteins:

  • E9PC90_HUMAN
  • H0Y9U8_HUMAN
  • H0YA62_HUMAN
genes like me logo Genes that share paralogs with CCNB1: view

Variants for CCNB1 Gene

Sequence variations from dbSNP and Humsavar for CCNB1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000074608 -- 69,177,084(+) C/G intron_variant
rs1000384479 -- 69,166,395(+) A/G upstream_transcript_variant
rs1000415781 -- 69,166,739(+) G/T upstream_transcript_variant
rs1000445690 -- 69,169,396(+) T/C intron_variant
rs1000478296 -- 69,169,082(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB1 Gene

Variant ID Type Subtype PubMed ID
dgv358e215 CNV deletion 23714750
dgv5694n100 CNV gain 25217958
esv2671857 CNV deletion 23128226
nsv509066 CNV insertion 20534489

Variation tolerance for CCNB1 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNB1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB1 Gene

Disorders for CCNB1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CCNB1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thyroid lymphoma
adrenal carcinoma
  • adrenocortical carcinoma
suppressor of tumorigenicity 3
  • st3
nasopharyngeal carcinoma
  • npca
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search CCNB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNB1

Genetic Association Database
Human Genome Epidemiology Navigator
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB1 Gene

Publications for CCNB1 Gene

  1. NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. (PMID: 16009132) Bassermann F … Duyster J (Cell 2005) 3 4 22 58
  2. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. (PMID: 12447691) Yuan J … Strebhardt K (Oncogene 2002) 3 4 22 58
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  4. Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain. (PMID: 20368335) Chou ST … Chen MS (The Journal of biological chemistry 2010) 3 22 58
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58

Products for CCNB1 Gene

  • Addgene plasmids for CCNB1

Sources for CCNB1 Gene