The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016] See more...

Aliases for CCNA2 Gene

Aliases for CCNA2 Gene

  • Cyclin A2 2 3 5
  • Cyclin-A2 3 4
  • Cyclin-A 3 4
  • CCN1 3 4
  • CCNA 3 4
  • Cyclin A 4
  • CCNA2 5

External Ids for CCNA2 Gene

Previous HGNC Symbols for CCNA2 Gene

  • CCNA
  • CCN1

Previous GeneCards Identifiers for CCNA2 Gene

  • GC04M123663
  • GC04M123018
  • GC04M123130
  • GC04M123197
  • GC04M123096
  • GC04M122957
  • GC04M122737
  • GC04M118464

Summaries for CCNA2 Gene

Entrez Gene Summary for CCNA2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]

GeneCards Summary for CCNA2 Gene

CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Retinoblastoma. Among its related pathways are Transcriptional misregulation in cancer and Cyclin A/B1 associated events during G2/M transition. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.

UniProtKB/Swiss-Prot Summary for CCNA2 Gene

  • Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

Gene Wiki entry for CCNA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNA2 Gene

Genomics for CCNA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J121821 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.8 832 3.8 SP1 CREB1 PRDM10 REST ZNF629 ZNF512 IKZF1 ZNF692 POLR2A RCOR2 CCNA2 EXOSC9 BBS7 KIAA1109 HSALNG0036825
GH04J121788 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 +31.6 31621 9.4 TEAD4 LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 ZNF24 MTA1 REST SMIM43 PP12613 CCNA2 BBS7 EXOSC9 piR-38583-012 lnc-TMEM155-2
GH04J121873 Enhancer 0.5 Ensembl 16 -49.9 -49867 0.4 PKNOX1 NR2F1 NR2F6 TCF12 TBX21 KDM1A TEAD4 CBFA2T3 CCNA2 EXOSC9 BBS7 ENSG00000261501 lnc-BBS7-1 TRPC3
GH04J122763 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 4.6 -941.0 -940983 3.8 GATAD2A ZNF512 RFX1 KDM1A JUND PKNOX1 KAT8 SP1 BRD9 DPF2 CETN4P FGF2 BBS12 NUDT6 SPATA5 CCNA2 RF00994-764 LOC727709
GH04J121879 Enhancer 0.3 Ensembl 10.9 -57.3 -57268 0.4 SPI1 CCNA2 ENSG00000261501 BBS7 lnc-BBS7-1 TRPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNA2

Top Transcription factor binding sites by QIAGEN in the CCNA2 gene promoter:
  • ATF-2
  • CREB
  • deltaCREB
  • Meis-1
  • Meis-1a
  • TBP
  • TFIID

Genomic Locations for CCNA2 Gene

Genomic Locations for CCNA2 Gene
chr4:121,816,444-121,823,933
(GRCh38/hg38)
Size:
7,490 bases
Orientation:
Minus strand
chr4:122,737,599-122,745,088
(GRCh37/hg19)
Size:
7,490 bases
Orientation:
Minus strand

Genomic View for CCNA2 Gene

Genes around CCNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNA2 Gene

Proteins for CCNA2 Gene

  • Protein details for CCNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20248-CCNA2_HUMAN
    Recommended name:
    Cyclin-A2
    Protein Accession:
    P20248
    Secondary Accessions:
    • A8K7B6
    • Q2M3U6
    • Q4W5P4
    • Q6LER8

    Protein attributes for CCNA2 Gene

    Size:
    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with INCA1 (PubMed:21540187).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL32.

    Three dimensional structures from OCA and Proteopedia for CCNA2 Gene

neXtProt entry for CCNA2 Gene

Post-translational modifications for CCNA2 Gene

  • Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
  • Ubiquitination at Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCNA2 Gene

Domains & Families for CCNA2 Gene

Gene Families for CCNA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNA2 Gene

Suggested Antigen Peptide Sequences for CCNA2 Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-A2 (CCNA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20248

UniProtKB/Swiss-Prot:

CCNA2_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA2: view

Function for CCNA2 Gene

Molecular function for CCNA2 Gene

UniProtKB/Swiss-Prot Function:
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
GENATLAS Biochemistry:
cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target gene,

Phenotypes From GWAS Catalog for CCNA2 Gene

Gene Ontology (GO) - Molecular Function for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0005515 protein binding IPI 7630397
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IDA 1312467
GO:0019901 protein kinase binding IEA,IPI 1312467
GO:0019904 protein domain specific binding IPI 15024385
genes like me logo Genes that share ontologies with CCNA2: view
genes like me logo Genes that share phenotypes with CCNA2: view

Animal Models for CCNA2 Gene

MGI Knock Outs for CCNA2:

Animal Model Products

CRISPR Products

miRNA for CCNA2 Gene

miRTarBase miRNAs that target CCNA2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNA2 Gene

Localization for CCNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA2 Gene

Nucleus. Cytoplasm. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269 PubMed:1312467, ECO:0000269 PubMed:17698606}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNA2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 3
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus IEA --
GO:0005634 nucleus IBA,IDA 1312467
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNA2: view

Pathways & Interactions for CCNA2 Gene

PathCards logo

SuperPathways for CCNA2 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
2 DNA Double-Strand Break Repair
3 Cell cycle Cell cycle (generic schema)
.38
.38
.01
4 AMP-activated Protein Kinase (AMPK) Signaling
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CCNA2: view

Pathways by source for CCNA2 Gene

10 GeneGo (Thomson Reuters) pathways for CCNA2 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Regulation of G1/S transition (part 2)
  • Cell cycle Transition and termination of DNA replication
9 Qiagen pathways for CCNA2 Gene
  • Breast Cancer Regulation by Stathmin1
  • Calpain Protease Regulates Cellular Mechanics
  • Cyclins and Cell Cycle Regulation
  • eNOS Signaling
  • Estrogen-mediated S-Phase Entry
1 Cell Signaling Technology pathway for CCNA2 Gene
1 GeneTex pathway for CCNA2 Gene

SIGNOR curated interactions for CCNA2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000086 G2/M transition of mitotic cell cycle IDA 1312467
GO:0006275 regulation of DNA replication IMP 17234884
GO:0007049 cell cycle IEA --
GO:0007265 Ras protein signal transduction IEP 9054499
genes like me logo Genes that share ontologies with CCNA2: view

Drugs & Compounds for CCNA2 Gene

(115) Drugs for CCNA2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol Experimental Pharma Target 0
(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol Experimental Pharma Target 0
(2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamide Experimental Pharma Target 0
[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine Experimental Pharma Target 0
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID Experimental Pharma Target 0

(40) Additional Compounds for CCNA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNA2: view

Transcripts for CCNA2 Gene

mRNA/cDNA for CCNA2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNA2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA2 Gene

No ASD Table

Relevant External Links for CCNA2 Gene

GeneLoc Exon Structure for
CCNA2

Expression for CCNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNA2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNA2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNA2

SOURCE GeneReport for Unigene cluster for CCNA2 Gene:

Hs.58974

Evidence on tissue expression from TISSUES for CCNA2 Gene

  • Nervous system(4.7)
  • Lymph node(3.4)
  • Intestine(3.1)
  • Lung(3)
  • Liver(2.9)
  • Skin(2.9)
  • Bone marrow(2.8)
  • Blood(2.7)
  • Kidney(2.6)
  • Muscle(2.5)
  • Heart(2.4)
  • Spleen(2.4)
  • Bone(2.3)
  • Stomach(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with CCNA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNA2 Gene

Orthologs for CCNA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNA2 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCNA2 30 31
  • 91.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNA2 30 31
  • 90.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccna2 30
  • 87.85 (n)
Mouse
(Mus musculus)
Mammalia Ccna2 30 17 31
  • 86.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
-- 31
  • 60 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNA2 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNA2 30 31
  • 68.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCNA2 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccna2 30
  • 65.08 (n)
Str.6336 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397933 30
Zebrafish
(Danio rerio)
Actinopterygii CCNA2 (2 of 2) 31
  • 71 (a)
OneToMany
ccna2 30 31
  • 65.03 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012413 30
  • 57.14 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CycA 30 31 32
  • 52.83 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ZK507.6 32
  • 37 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLN1 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYCA2;4 30
  • 47.65 (n)
Rice
(Oryza sativa)
Liliopsida Os12g0502300 30
  • 51.94 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10122 31
  • 58 (a)
OneToMany
Species where no ortholog for CCNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCNA2 Gene

ENSEMBL:
Gene Tree for CCNA2 (if available)
TreeFam:
Gene Tree for CCNA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNA2: view image

Paralogs for CCNA2 Gene

(4) SIMAP similar genes for CCNA2 Gene using alignment to 1 proteins:

  • CCNA2_HUMAN
genes like me logo Genes that share paralogs with CCNA2: view

Variants for CCNA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNA2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
743205 Benign: not provided 121,822,482(-) C/T SYNONYMOUS_VARIANT
767975 Benign: not provided 121,821,062(-) T/. NO_SEQUENCE_ALTERATION
778159 Benign: not provided 121,822,638(-) G/T SYNONYMOUS_VARIANT
787278 Benign: not provided 121,822,526(-) T/C MISSENSE_VARIANT
rs769242 - p.Ile163Val

Additional dbSNP identifiers (rs#s) for CCNA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNA2 Gene

Variant ID Type Subtype PubMed ID
esv3602016 CNV gain 21293372
nsv997539 CNV gain 25217958

Variation tolerance for CCNA2 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNA2 Gene

Human Gene Mutation Database (HGMD)
CCNA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNA2 Gene

Disorders for CCNA2 Gene

MalaCards: The human disease database

(43) MalaCards diseases for CCNA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
splenic diffuse red pulp small b-cell lymphoma
  • sdrpl
retinoblastoma
  • rb1
endometrial cancer
  • endometrial cancer, familial
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
melanotic neuroectodermal tumor
  • infantile melanotic neuroectodermal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CCNA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNA2 Gene

Publications for CCNA2 Gene

  1. Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. (PMID: 24101496) Bogdanow B … Wiebusch L (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4
  2. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. (PMID: 21540187) Bäumer N … Müller-Tidow C (The Journal of biological chemistry 2011) 3 4
  3. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PMID: 21596315) Huang X … Dixit VM (Molecular cell 2011) 3 4
  4. Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2. (PMID: 20193482) Li HP … Sun Y (Chinese medical journal 2010) 3 23
  5. The pure anti-androgen bicalutamide inhibits cyclin A expression both in androgen-dependent and -independent cell lines. (PMID: 20126974) Katayama H … Nishizawa Y (International journal of oncology 2010) 3 23

Products for CCNA2 Gene

  • Addgene plasmids for CCNA2

Sources for CCNA2 Gene