Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCNA2 Gene

Aliases for CCNA2 Gene

  • Cyclin A2 2 3 5
  • Cyclin-A 3 4
  • CCN1 3 4
  • CCNA 3 4
  • Cyclin-A2 3
  • Cyclin A 4

External Ids for CCNA2 Gene

Previous HGNC Symbols for CCNA2 Gene

  • CCNA
  • CCN1

Previous GeneCards Identifiers for CCNA2 Gene

  • GC04M123663
  • GC04M123018
  • GC04M123130
  • GC04M123197
  • GC04M123096
  • GC04M122957
  • GC04M122737
  • GC04M118464

Summaries for CCNA2 Gene

Entrez Gene Summary for CCNA2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]

GeneCards Summary for CCNA2 Gene

CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Valproate Embryopathy. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.

UniProtKB/Swiss-Prot for CCNA2 Gene

  • Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

Gene Wiki entry for CCNA2 Gene

Additional gene information for CCNA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNA2 Gene

Genomics for CCNA2 Gene

GeneHancer (GH) Regulatory Elements for CCNA2 Gene

Promoters and enhancers for CCNA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I121821 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.8 763 3 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 CCNA2 EXOSC9 BBS7 ENSG00000237868
GH04I121788 Enhancer 1.2 ENCODE dbSUPER 11.5 +33.4 33364 3.3 PKNOX1 ATF1 ARNT IRF4 NCOA2 TCF12 ZNF766 GATA2 E2F8 FOS TMEM155 PP12613 CCNA2 BBS7 EXOSC9
GH04I121794 Enhancer 1.1 Ensembl ENCODE 11.5 +28.1 28142 2.5 PKNOX1 ATF1 FOXA2 ARNT ZFP64 NCOA2 TCF12 ZNF766 GATA2 ATF7 TMEM155 PP12613 CCNA2 BBS7 EXOSC9
GH04I122763 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -940.9 -940872 4 PKNOX1 FOXA2 ARNT DMAP1 IRF4 GTF3C2 TCF12 FOS ATF7 RUNX3 CETN4P FGF2 BBS12 NUDT6 SPATA5 CCNA2 LOC727709 RPL34P12
GH04I121869 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 -46.4 -46350 1.8 HDGF PKNOX1 ATF1 ARID4B BRCA1 ZNF48 YY1 ETS1 POLR2B ZNF143 BBS7 ENSG00000261501 CCNA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCNA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNA2 gene promoter:

Genomic Locations for CCNA2 Gene

Genomic Locations for CCNA2 Gene
chr4:121,816,444-121,823,933
(GRCh38/hg38)
Size:
7,490 bases
Orientation:
Minus strand
chr4:122,737,599-122,745,088
(GRCh37/hg19)

Genomic View for CCNA2 Gene

Genes around CCNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNA2 Gene

Proteins for CCNA2 Gene

  • Protein details for CCNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20248-CCNA2_HUMAN
    Recommended name:
    Cyclin-A2
    Protein Accession:
    P20248
    Secondary Accessions:
    • A8K7B6
    • Q2M3U6
    • Q4W5P4
    • Q6LER8

    Protein attributes for CCNA2 Gene

    Size:
    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460).
    • (Microbial infection) Interacts with human cytomegalovirus protein UL32.

    Three dimensional structures from OCA and Proteopedia for CCNA2 Gene

neXtProt entry for CCNA2 Gene

Post-translational modifications for CCNA2 Gene

  • Polyubiquitinated via Lys-11-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
  • Ubiquitination at posLast=5454

Other Protein References for CCNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNA2 (CCNA2)

No data available for DME Specific Peptides for CCNA2 Gene

Domains & Families for CCNA2 Gene

Gene Families for CCNA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNA2 Gene

Suggested Antigen Peptide Sequences for CCNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20248

UniProtKB/Swiss-Prot:

CCNA2_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA2: view

Function for CCNA2 Gene

Molecular function for CCNA2 Gene

GENATLAS Biochemistry:
cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot Function:
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

Gene Ontology (GO) - Molecular Function for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7630397
GO:0019901 protein kinase binding IPI 1312467
GO:0019904 protein domain specific binding IPI 15024385
GO:0097472 contributes_to cyclin-dependent protein kinase activity IDA 1312467
genes like me logo Genes that share ontologies with CCNA2: view
genes like me logo Genes that share phenotypes with CCNA2: view

Animal Models for CCNA2 Gene

MGI Knock Outs for CCNA2:

Animal Model Products

Clone Products

  • Addgene plasmids for CCNA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNA2 Gene

Localization for CCNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA2 Gene

Nucleus. Cytoplasm. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269 PubMed:1312467, ECO:0000269 PubMed:17698606}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNA2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus IEA --
GO:0005634 nucleus IDA 1312467
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNA2: view

Pathways & Interactions for CCNA2 Gene

SuperPathways for CCNA2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 DNA Double-Strand Break Repair
3 Cell cycle Cell cycle (generic schema)
.01
4 AMP-activated Protein Kinase (AMPK) Signaling
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CCNA2: view

SIGNOR curated interactions for CCNA2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 1312467
GO:0007049 cell cycle IEA --
GO:0007265 Ras protein signal transduction IEP 9054499
GO:0016032 viral process IEA --
GO:0016572 histone phosphorylation IDA 11746698
genes like me logo Genes that share ontologies with CCNA2: view

Drugs & Compounds for CCNA2 Gene

(113) Drugs for CCNA2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol Experimental Pharma Target 0
(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol Experimental Pharma Target 0
(2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE Experimental Pharma Target 0
[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine Experimental Pharma Target 0
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID Experimental Pharma Target 0

(42) Additional Compounds for CCNA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNA2: view

Transcripts for CCNA2 Gene

mRNA/cDNA for CCNA2 Gene

Unigene Clusters for CCNA2 Gene

Cyclin A2:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCNA2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA2 Gene

No ASD Table

Relevant External Links for CCNA2 Gene

GeneLoc Exon Structure for
CCNA2
ECgene alternative splicing isoforms for
CCNA2

Expression for CCNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNA2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCNA2 Gene:

CCNA2

SOURCE GeneReport for Unigene cluster for CCNA2 Gene:

Hs.58974

Evidence on tissue expression from TISSUES for CCNA2 Gene

  • Nervous system(4.6)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with CCNA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNA2 Gene

Orthologs for CCNA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNA2 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia CCNA2 33 34
  • 91.82 (n)
cow
(Bos Taurus)
Mammalia CCNA2 33 34
  • 90.62 (n)
rat
(Rattus norvegicus)
Mammalia Ccna2 33
  • 87.85 (n)
mouse
(Mus musculus)
Mammalia Ccna2 33 16 34
  • 86.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCNA2 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNA2 33 34
  • 68.21 (n)
lizard
(Anolis carolinensis)
Reptilia CCNA2 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccna2 33
  • 65.08 (n)
Str.6336 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397933 33
zebrafish
(Danio rerio)
Actinopterygii CCNA2 (2 of 2) 34
  • 71 (a)
OneToMany
ccna2 33 34
  • 65.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012413 33
  • 57.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycA 35 33 34
  • 52.83 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK507.6 35
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLN1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCA2;4 33
  • 47.65 (n)
rice
(Oryza sativa)
Liliopsida Os12g0502300 33
  • 51.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10122 34
  • 58 (a)
OneToMany
Species where no ortholog for CCNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNA2 Gene

ENSEMBL:
Gene Tree for CCNA2 (if available)
TreeFam:
Gene Tree for CCNA2 (if available)

Paralogs for CCNA2 Gene

Paralogs for CCNA2 Gene

(4) SIMAP similar genes for CCNA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCNA2: view

Variants for CCNA2 Gene

Sequence variations from dbSNP and Humsavar for CCNA2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1053813063 uncertain-significance, Bardet-Biedl syndrome 121,824,864(-) A/G upstream_transcript_variant
rs1507996 likely-benign, Bardet-Biedl syndrome 121,824,574(-) C/T upstream_transcript_variant
rs181687808 uncertain-significance, Bardet-Biedl syndrome 121,824,536(-) C/T upstream_transcript_variant
rs190252263 uncertain-significance, Bardet-Biedl syndrome 121,825,587(-) A/G upstream_transcript_variant
rs3217753 benign, Bardet-Biedl syndrome 121,825,170(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNA2 Gene

Variant ID Type Subtype PubMed ID
esv3602016 CNV gain 21293372
nsv997539 CNV gain 25217958

Variation tolerance for CCNA2 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNA2 Gene

Human Gene Mutation Database (HGMD)
CCNA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNA2 Gene

Disorders for CCNA2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CCNA2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
splenic diffuse red pulp small b-cell lymphoma
  • sdrpl
valproate embryopathy
  • valproate embryopathy, susceptibility to
thyroid lymphoma
testicular cancer
  • childhood neoplasm of the testis
myxofibrosarcoma
  • fibromyxosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CCNA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNA2 Gene

Publications for CCNA2 Gene

  1. Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. (PMID: 24101496) Bogdanow B … Wiebusch L (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
  2. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PMID: 21596315) Huang X … Dixit VM (Molecular cell 2011) 3 4 58
  3. The pure anti-androgen bicalutamide inhibits cyclin A expression both in androgen-dependent and -independent cell lines. (PMID: 20126974) Katayama H … Nishizawa Y (International journal of oncology 2010) 3 22 58
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for CCNA2 Gene

  • Addgene plasmids for CCNA2

Sources for CCNA2 Gene

Content
Loading form....