The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin... See more...

Aliases for CCNA1 Gene

Aliases for CCNA1 Gene

  • Cyclin A1 2 3 5
  • Cyclin-A1 3 4
  • CT146 2 3
  • Testicular Tissue Protein Li 34 3
  • CCNA1 5

External Ids for CCNA1 Gene

Previous GeneCards Identifiers for CCNA1 Gene

  • GC13P034993
  • GC13P030993
  • GC13P035942
  • GC13P034804
  • GC13P035904
  • GC13P037005
  • GC13P017817

Summaries for CCNA1 Gene

Entrez Gene Summary for CCNA1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNA1 Gene

CCNA1 (Cyclin A1) is a Protein Coding gene. Diseases associated with CCNA1 include Myeloid Leukemia and Testicular Cancer. Among its related pathways are Cell cycle Cell cycle (generic schema) and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA2.

UniProtKB/Swiss-Prot Summary for CCNA1 Gene

  • May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Gene Wiki entry for CCNA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNA1 Gene

Genomics for CCNA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J036432 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.7 +1.4 1413 3 POLR2A ZIC2 ZNF341 SIN3A KLF9 SP2 BCL11B PRDM10 BHLHE40 ZBTB48 CCNA1 HSALNG0096383 lnc-CCNA1-1 NONHSAG013228.2 CCDC169 SPART-AS1 SERTM1
GH13J036858 Enhancer 0.8 Ensembl ENCODE 10.4 +427.2 427234 1.8 ZNF654 CEBPA REST CTCF RAD21 SMC3 ELF3 RXRB EGR2 MIXL1 SMAD9 LAMTOR3P1 RFXAP CCNA1 SERTM1 SUPT20H piR-35568-002 SMAD9-IT1
GH13J036450 Enhancer 0.4 Ensembl 18.8 +21.4 21413 2.6 SPI1 ZNF366 ZNF512 CCNA1 RFXAP piR-50443-099 lnc-CCNA1-1 SERTM1
GH13J036453 Enhancer 0.5 Ensembl 11.1 +24.2 24213 1.8 ZNF654 ZIC2 CTCF RAD21 ATF2 SMC3 CREB1 SCRT2 CCNA1 RFXAP piR-50443-099 lnc-CCNA1-1 SERTM1
GH13J036530 Enhancer 0.5 Ensembl 10.6 +102.0 102013 5.8 YY1 POLR2A JUND ATF2 EP300 CCNA1 SERTM1 SOHLH2 HSALNG0096388 RF00017-1267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNA1

Top Transcription factor binding sites by QIAGEN in the CCNA1 gene promoter:
  • IRF-7A
  • MyoD

Genomic Locations for CCNA1 Gene

Latest Assembly
chr13:36,430,488-36,442,870
(GRCh38/hg38)
Size:
12,383 bases
Orientation:
Plus strand

Previous Assembly
chr13:37,006,092-37,017,007
(GRCh37/hg19 by Entrez Gene)
Size:
10,916 bases
Orientation:
Plus strand

chr13:37,005,967-37,017,019
(GRCh37/hg19 by Ensembl)
Size:
11,053 bases
Orientation:
Plus strand

Genomic View for CCNA1 Gene

Genes around CCNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNA1 Gene

Proteins for CCNA1 Gene

  • Protein details for CCNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78396-CCNA1_HUMAN
    Recommended name:
    Cyclin-A1
    Protein Accession:
    P78396
    Secondary Accessions:
    • B7Z7E3
    • Q5T3V0
    • Q5U0G2
    • Q8IY91

    Protein attributes for CCNA1 Gene

    Size:
    465 amino acids
    Molecular mass:
    52358 Da
    Quaternary structure:
    • Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 (PubMed:15159402, PubMed:21540187). Interacts with KLHDC9 (PubMed:15159402).

    Alternative splice isoforms for CCNA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNA1 Gene

Post-translational modifications for CCNA1 Gene

  • Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNA1 Gene

Domains & Families for CCNA1 Gene

Gene Families for CCNA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNA1 Gene

Suggested Antigen Peptide Sequences for CCNA1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79291, highly similar to Cyclin-A1 (B7Z7E3_HUMAN)
  • Cyclin-A1 (CCNA1_HUMAN)
  • Cyclin A1 (F6KX25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78396

UniProtKB/Swiss-Prot:

CCNA1_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA1: view

Function for CCNA1 Gene

Molecular function for CCNA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
GENATLAS Biochemistry:
cyclin A1,complexing with CDK2,expressed in meiotic cell in the testis and brain and in several leukemic cell lines,regulator of cell-cycle

Phenotypes From GWAS Catalog for CCNA1 Gene

Gene Ontology (GO) - Molecular Function for CCNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8756624
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with CCNA1: view
genes like me logo Genes that share phenotypes with CCNA1: view

Animal Models for CCNA1 Gene

MGI Knock Outs for CCNA1:

miRNA for CCNA1 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNA1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNA1 Gene

Localization for CCNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNA1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS 9041194
genes like me logo Genes that share ontologies with CCNA1: view

Pathways & Interactions for CCNA1 Gene

PathCards logo

SuperPathways for CCNA1 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 DNA Double-Strand Break Repair
3 Cell cycle Cell cycle (generic schema)
.38
.38
.01
4 AMP-activated Protein Kinase (AMPK) Signaling
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CCNA1: view

Pathways by source for CCNA1 Gene

9 GeneGo (Thomson Reuters) pathways for CCNA1 Gene
  • Cell cycle Cell cycle (generic schema)
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Regulation of G1/S transition (part 2)
  • Cell cycle Transition and termination of DNA replication
9 Qiagen pathways for CCNA1 Gene
  • Breast Cancer Regulation by Stathmin1
  • Calpain Protease Regulates Cellular Mechanics
  • Cyclins and Cell Cycle Regulation
  • eNOS Signaling
  • Estrogen-mediated S-Phase Entry
1 GeneTex pathway for CCNA1 Gene

SIGNOR curated interactions for CCNA1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007141 male meiosis I TAS 9843212
GO:0007283 spermatogenesis TAS 9843212
genes like me logo Genes that share ontologies with CCNA1: view

Drugs & Compounds for CCNA1 Gene

(2) Additional Compounds for CCNA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNA1: view

Transcripts for CCNA1 Gene

mRNA/cDNA for CCNA1 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNA1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: - -
SP4: - -
SP5: - - - -

Relevant External Links for CCNA1 Gene

GeneLoc Exon Structure for
CCNA1

Expression for CCNA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNA1 Gene

This gene is overexpressed in Testis (x15.6) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for CCNA1 Gene

This gene is overexpressed in Heart (35.9) and Testis (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNA1 Gene



Protein tissue co-expression partners for CCNA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNA1

SOURCE GeneReport for Unigene cluster for CCNA1 Gene:

Hs.417050

mRNA Expression by UniProt/SwissProt for CCNA1 Gene:

P78396-CCNA1_HUMAN
Tissue specificity: Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Evidence on tissue expression from TISSUES for CCNA1 Gene

  • Nervous system(4.6)
  • Blood(4.4)
  • Lymph node(4.3)
  • Spleen(4.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CCNA1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNA1 Gene

Orthologs for CCNA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNA1 29 30
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCNA1 29 30
  • 88.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNA1 29 30
  • 86.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccna1 29
  • 83.53 (n)
Mouse
(Mus musculus)
Mammalia Ccna1 29 16 30
  • 83.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCNA1 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNA1 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNA1 29 30
  • 69.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCNA1 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccna1 29
  • 66.75 (n)
Str.4034 29
African clawed frog
(Xenopus laevis)
Amphibia LOC397885 29
Zebrafish
(Danio rerio)
Actinopterygii ccna1 29 30
  • 61.03 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2245 29
Fruit Fly
(Drosophila melanogaster)
Insecta CycA 30 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ZK507.6 31
  • 36 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYCA3;2 29
  • 53.16 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0607600 29
  • 51.75 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10122 30
  • 57 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5837 29
Species where no ortholog for CCNA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCNA1 Gene

ENSEMBL:
Gene Tree for CCNA1 (if available)
TreeFam:
Gene Tree for CCNA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNA1: view image
Alliance of Genome Resources:
Additional Orthologs for CCNA1

Paralogs for CCNA1 Gene

(1) SIMAP similar genes for CCNA1 Gene using alignment to 2 proteins:

  • CCNA1_HUMAN
  • F6KX25_HUMAN
genes like me logo Genes that share paralogs with CCNA1: view

Variants for CCNA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNA1 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs1317006880 Likely Benign: not provided 36,438,089(+) A/G
NM_003914.4(CCNA1):c.567A>G (p.Ser189=)
SYNONYMOUS
rs144283302 Likely Benign: not provided 36,438,778(+) T/C
NM_003914.4(CCNA1):c.804T>C (p.Ala268=)
SYNONYMOUS
rs146743791 Benign: not provided 36,441,177(+) G/A
NM_003914.4(CCNA1):c.1158G>A (p.Leu386=)
SYNONYMOUS
rs61729896 Benign: not provided 36,437,652(+) T/C
NM_003914.4(CCNA1):c.321T>C (p.Tyr107=)
SYNONYMOUS
rs61755283 Benign: not provided 36,438,694(+) G/A
NM_003914.4(CCNA1):c.720G>A (p.Thr240=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCNA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CCNA1 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNA1
Leiden Open Variation Database (LOVD)
CCNA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNA1 Gene

Disorders for CCNA1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CCNA1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukaemia myelogenous
testicular cancer
  • childhood neoplasm of the testis
leukemia
  • leukemias
acute promyelocytic leukemia
  • apl
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CCNA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNA1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNA1 Gene

Publications for CCNA1 Gene

  1. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. (PMID: 9041194) Yang R … Koeffler HP (Cancer research 1997) 2 3 4 22
  2. Mutations of the cyclin A1 gene are not a common cause of male infertility. (PMID: 19886767) Zhoucun A … Yang Y (Systems biology in reproductive medicine 2009) 3 22 40
  3. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (PMID: 10022926) Yang R … Koeffler HP (Molecular and cellular biology 1999) 3 4 22
  4. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. (PMID: 21540187) Bäumer N … Müller-Tidow C (The Journal of biological chemistry 2011) 3 4
  5. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PMID: 20457893) Hsia DA … Izumiya Y (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22

Products for CCNA1 Gene

Sources for CCNA1 Gene