This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-lik... See more...

Aliases for CCN5 Gene

Aliases for CCN5 Gene

  • Cellular Communication Network Factor 5 2 3 5
  • CTGF-L 2 3 4
  • CT58 2 3 4
  • Connective Tissue Growth Factor-Related Protein 58 3 4
  • Connective Tissue Growth Factor-Like Protein 3 4
  • WNT1 Inducible Signaling Pathway Protein 2 2 3
  • CCN Family Member 5 3 4
  • WISP-2 2 4
  • WISP2 3 4
  • WNT1-Inducible-Signaling Pathway Protein 2 4
  • CTGFL 4
  • CCN5 5

External Ids for CCN5 Gene

Previous HGNC Symbols for CCN5 Gene

  • WISP2

Summaries for CCN5 Gene

Entrez Gene Summary for CCN5 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCN5 Gene

CCN5 (Cellular Communication Network Factor 5) is a Protein Coding gene. Diseases associated with CCN5 include Wilms Tumor 5 and Bladder Papillary Transitional Cell Neoplasm. An important paralog of this gene is CCN2.

UniProtKB/Swiss-Prot Summary for CCN5 Gene

  • May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

Gene Wiki entry for CCN5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN5 Gene

Genomics for CCN5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCN5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCN5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN5

Genomic Locations for CCN5 Gene

Genomic Locations for CCN5 Gene
chr20:44,714,204-44,728,509
(GRCh38/hg38)
Size:
14,306 bases
Orientation:
Plus strand
chr20:43,343,485-43,357,150
(GRCh37/hg19)
Size:
13,666 bases
Orientation:
Plus strand

Genomic View for CCN5 Gene

Genes around CCN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCN5 Gene

Proteins for CCN5 Gene

  • Protein details for CCN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76076-CCN5_HUMAN
    Recommended name:
    CCN family member 5
    Protein Accession:
    O76076
    Secondary Accessions:
    • B2R9N4
    • E1P612
    • Q6PEG3

    Protein attributes for CCN5 Gene

    Size:
    250 amino acids
    Molecular mass:
    26825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCN5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCN5 Gene

Post-translational modifications for CCN5 Gene

No Post-translational modifications

Other Protein References for CCN5 Gene

No data available for DME Specific Peptides for CCN5 Gene

Domains & Families for CCN5 Gene

Gene Families for CCN5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCN5 Gene

InterPro:
Blocks:
  • Thrombospondin, type I
  • von Willebrand factor, type C
ProtoNet:

Suggested Antigen Peptide Sequences for CCN5 Gene

GenScript: Design optimal peptide antigens:
  • WNT1 inducible signaling pathway protein 2 (Q6PEG3_HUMAN)
  • Connective tissue growth factor-related protein 58 (WISP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76076

UniProtKB/Swiss-Prot:

CCN5_HUMAN :
  • Belongs to the CCN family.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CCN5: view

Function for CCN5 Gene

Molecular function for CCN5 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

Phenotypes From GWAS Catalog for CCN5 Gene

Gene Ontology (GO) - Molecular Function for CCN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA 21873635
GO:0005515 protein binding IEA --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA 21873635
genes like me logo Genes that share ontologies with CCN5: view
genes like me logo Genes that share phenotypes with CCN5: view

Animal Models for CCN5 Gene

MGI Knock Outs for CCN5:
  • Ccn5 Ccn5<tm1(KOMP)Vlcg>
  • Ccn5 Ccn5<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for CCN5

CRISPR Products

miRNA for CCN5 Gene

miRTarBase miRNAs that target CCN5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCN5 Gene

Localization for CCN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCN5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCN5 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CCN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 10358067
GO:0005634 nucleus IDA 20531984
GO:0031012 extracellular matrix IBA 21873635
genes like me logo Genes that share ontologies with CCN5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCN5 Gene

Pathways & Interactions for CCN5 Gene

PathCards logo

SuperPathways for CCN5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA 21873635
GO:0007165 signal transduction TAS,IBA 21873635
GO:0007267 cell-cell signaling TAS 9843955
GO:0060548 negative regulation of cell death IBA 21873635
genes like me logo Genes that share ontologies with CCN5: view

No data available for Pathways by source and SIGNOR curated interactions for CCN5 Gene

Drugs & Compounds for CCN5 Gene

(4) Drugs for CCN5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCN5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCN5: view

Transcripts for CCN5 Gene

mRNA/cDNA for CCN5 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN5

Alternative Splicing Database (ASD) splice patterns (SP) for CCN5 Gene

No ASD Table

Relevant External Links for CCN5 Gene

GeneLoc Exon Structure for
CCN5

Expression for CCN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN5

SOURCE GeneReport for Unigene cluster for CCN5 Gene:

Hs.592145

mRNA Expression by UniProt/SwissProt for CCN5 Gene:

O76076-CCN5_HUMAN
Tissue specificity: Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.

Evidence on tissue expression from TISSUES for CCN5 Gene

  • Muscle(4.5)
  • Lung(4.5)
  • Nervous system(4.3)
  • Heart(2.7)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with CCN5: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN5 Gene

Orthologs for CCN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCN5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WISP2 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WISP2 30 31
  • 88.13 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WISP2 30 31
  • 87.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wisp2 30 31
  • 80 (n)
OneToOne
Ccn5 17
Rat
(Rattus norvegicus)
Mammalia Wisp2 30
  • 78.4 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia WISP2 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WISP2 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WISP2 30 31
  • 68.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WISP2 31
  • 53 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii wisp2 31
  • 32 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for CCN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCN5 Gene

ENSEMBL:
Gene Tree for CCN5 (if available)
TreeFam:
Gene Tree for CCN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCN5: view image

Paralogs for CCN5 Gene

Paralogs for CCN5 Gene

genes like me logo Genes that share paralogs with CCN5: view

Variants for CCN5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN5 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
714900 Benign: not provided 44,720,109(+) C/T SYNONYMOUS_VARIANT
717864 Benign: not provided 44,724,965(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs33932543 - p.Arg59Gln

Additional dbSNP identifiers (rs#s) for CCN5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCN5 Gene

Variant ID Type Subtype PubMed ID
esv1001878 CNV gain 20482838
nsv1056102 CNV loss 25217958
nsv179790 CNV deletion 16902084
nsv458985 CNV gain 19166990
nsv586076 CNV gain 21841781

Variation tolerance for CCN5 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN5 Gene

Disorders for CCN5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CCN5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wilms tumor 5
  • nephroblastoma
bladder papillary transitional cell neoplasm
  • urinary bladder papillary urothelial neoplasm
urinary tract papillary transitional cell benign neoplasm
  • inverted papilloma of urinary tract
acth-independent macronodular adrenal hyperplasia
  • aimah1
bladder transitional cell papilloma
  • bladder papilloma
- elite association - COSMIC cancer census association via MalaCards
Search CCN5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CCN5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCN5 Gene

Publications for CCN5 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D … Levine AJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23
  2. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (PMID: 10358067) Kumar S … Lee JC (The Journal of biological chemistry 1999) 3 4 23
  3. Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. (PMID: 20372786) Davies SR … Jiang WG (International journal of oncology 2010) 3 23
  4. CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. (PMID: 18794149) Banerjee S … Banerjee SK (Cancer research 2008) 3 23
  5. Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. (PMID: 18559502) Dhar G … Banerjee SK (Cancer research 2008) 3 23

Products for CCN5 Gene

Sources for CCN5 Gene