Aliases for CCN4 Gene
- Cellular Communication Network Factor 4 2 3 5
- WISP1 Overlapping Transcript 1 (Non-Protein Coding) 2 3
- WNT1-Inducible-Signaling Pathway Protein 1 3 4
- WNT1 Inducible Signaling Pathway Protein 1 2 3
- WISP1 3'UTR-Associated RNA 1 2 3
- CCN Family Member 4 3 4
- WNT1 Induced Secreted Protein 1 3
- Wnt-1-Induced Secreted Protein 4
External Ids for CCN4 Gene
Previous HGNC Symbols for CCN4 Gene
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
GeneCards Summary for CCN4 Gene
CCN4 (Cellular Communication Network Factor 4) is a Protein Coding gene. Diseases associated with CCN4 include Bladder Papillary Transitional Cell Neoplasm and Urinary Tract Papillary Transitional Cell Benign Neoplasm. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. An important paralog of this gene is CCN6.
UniProtKB/Swiss-Prot Summary for CCN4 Gene
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.