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The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
CCN3 (Cellular Communication Network Factor 3) is a Protein Coding gene. Diseases associated with CCN3 include Wilms Tumor 5 and Rhabdomyosarcoma. Among its related pathways are Notch Signaling Pathway (WikiPathways) and Adhesion. An important paralog of this gene is CCN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005112 | Notch binding | IPI | 12050162 |
GO:0005178 | integrin binding | IPI | 12695522 |
GO:0005515 | protein binding | IPI | 9927660 |
GO:0005520 | insulin-like growth factor binding | IEA | -- |
GO:0008083 | growth factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | ISS | -- |
GO:0005737 | cytoplasm | ISS | -- |
GO:0005921 | gap junction | ISS | -- |
GO:0030054 | cell junction | IEA | -- |
GO:0030424 | axon | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Adhesion |
-
|
|
2 | Notch Signaling Pathway (WikiPathways) | ||
3 | G-Beta Gamma Signaling |
Signaling in Gap Junctions
.30
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IDA | 12695522 |
GO:0002062 | chondrocyte differentiation | IMP | 21871891 |
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0010468 | regulation of gene expression | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Insulin pork | Approved | Pharma | Target | 0 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NOV 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NOV 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NOV 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nov 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nov 30 31 |
|
OneToOne | |
Ccn3 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | NOV 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NOV 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NOV 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NOV 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nov 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | nov-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ctgfb 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
721280 | Likely Benign: not provided | 119,416,950(+) | C/A | MISSENSE_VARIANT | |
775267 | Benign: not provided | 119,416,576(+) | G/T | MISSENSE_VARIANT | |
rs796052179 | Likely Benign: Long QT syndrome | 119,419,173(+) | C/G | NONSENSE | |
rs11538929 | - | p.Arg233His | |||
rs2279112 | - | p.Arg42Gln |
Disorder | Aliases | PubMed IDs |
---|---|---|
wilms tumor 5 |
|
|
rhabdomyosarcoma |
|
|
obstructive nephropathy |
|
|
wilms tumor 1 |
|
|
renal cell carcinoma, nonpapillary |
|
|