CCN3 Gene (Protein Coding)

Cellular Communication Network Factor 3

GC08P119416
GIFtS:
33
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009] See more...

Aliases for CCN3 Gene

Aliases for CCN3 Gene

  • Cellular Communication Network Factor 3 2 3 4 5
  • IGFBP9 2 3 4
  • Nephro Blastoma-Overexpressed Gene Protein Homolog 3 4
  • Insulin-Like Growth Factor-Binding Protein 9 3 4
  • Nephroblastoma Overexpressed 2 3
  • IGF-Binding Protein 9 3 4
  • CCN Family Member 3 3 4
  • Protein NOV Homolog 3 4
  • IGFBP-9 3 4
  • IBP-9 3 4
  • NOV 3 4
  • Nephroblastoma-Overexpressed Gene Protein Homolog 3
  • Nephroblastoma Overexpressed Gene 2
  • NOVh 3
  • CCN3 5
  • NOVH 4
  • NovH 4

External Ids for CCN3 Gene

Previous HGNC Symbols for CCN3 Gene

  • NOV

Summaries for CCN3 Gene

Entrez Gene Summary for CCN3 Gene

  • The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

GeneCards Summary for CCN3 Gene

CCN3 (Cellular Communication Network Factor 3) is a Protein Coding gene. Diseases associated with CCN3 include Wilms Tumor 1 and Obstructive Nephropathy. Among its related pathways are G-Beta Gamma Signaling and Adhesion. An important paralog of this gene is CCN2.

UniProtKB/Swiss-Prot Summary for CCN3 Gene

  • Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).

Gene Wiki entry for CCN3 Gene

Additional gene information for CCN3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN3 Gene

Genomics for CCN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CCN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J119415 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 262.1 +0.5 467 3 ZIC2 ZBTB10 CTCF TRIM22 ZNF341 ZEB1 MAX SP2 RAD21 RFX5 CCN3 ENSG00000286282 ENSG00000253398 ENPP2
GH08J119203 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10 -209.4 -209438 8 SSRP1 CEBPA ATF3 POLR2A YY1 ZNF217 CEBPB DEK ZEB1 ZFP64 MAL2 NONHSAG051117.2 CCN3 DSCC1 piR-33313-018 LOC105375725
GH08J119436 Enhancer 0.7 ENCODE 24.3 +21.0 20990 2.5 ZNF654 YY1 CTCF FOXA2 RAD21 CUX1 SMC3 TEAD3 PKNOX1 FOXA1 CCN3 TAF2 MAL2 ENSG00000286282 ENSG00000253398 ENPP2
GH08J119585 Enhancer 0.9 Ensembl ENCODE dbSUPER 13.8 +171.1 171055 5 JUND CEBPB ZNF316 MAFK POLR2A EGR2 EP300 ZFHX2 CCN3 lnc-TAF2-3 RF00017-6706 ENPP2
GH08J119461 Promoter 0.6 Ensembl 14.9 +45.7 45654 0.6 ZNF217 SIN3A FOXA1 MNT ZNF444 ENSG00000253398 CCN3 MAL2 ENSG00000286282 ENPP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN3

Genomic Locations for CCN3 Gene

Latest Assembly
chr8:119,416,446-119,424,434
(GRCh38/hg38)
Size:
7,989 bases
Orientation:
Plus strand

Previous Assembly
chr8:120,428,686-120,436,674
(GRCh37/hg19 by Entrez Gene)
Size:
7,989 bases
Orientation:
Plus strand

chr8:120,428,546-120,436,593
(GRCh37/hg19 by Ensembl)
Size:
8,048 bases
Orientation:
Plus strand

Genomic View for CCN3 Gene

Genes around CCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCN3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCN3 Gene

Proteins for CCN3 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for CCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48745-CCN3_HUMAN
    Recommended name:
    CCN family member 3
    Protein Accession:
    P48745
    Secondary Accessions:
    • B2R5X7
    • Q6I9S3
    • Q96BY5
    • Q9UDE4

    Protein attributes for CCN3 Gene

    Size:
    357 amino acids
    Molecular mass:
    39162 Da
    Quaternary structure:
    • Interacts with FBLN1. Interacts (via CTCK domain) with NOTCH1 (via the EGF-like repeat region) (PubMed:12050162). Interacts with GJA1/CX43 (PubMed:15181016, PubMed:15213231). Interacts with ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:12695522, PubMed:15611078). Interacts with ZDHHC22; the interaction may lead to CCN3 palmitoylation (By similarity).

neXtProt entry for CCN3 Gene

Post-translational modifications for CCN3 Gene

  • May be palmitoylated on Cys-244, which is important for extracellular secretion.
  • Glycosylation at Thr46, Thr49, Asn97, Asn280, Thr352, and Thr353
  • Modification sites at PhosphoSitePlus

Other Protein References for CCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCN3 Gene

Domains & Families for CCN3 Gene

Gene Families for CCN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CCN3 Gene

InterPro:
Blocks:
  • Thrombospondin, type I
  • von Willebrand factor, type C
  • Insulin-like growth factor-binding protein, IGFBP
  • Cystine knot, C-terminal
  • Cystine knot domain

Suggested Antigen Peptide Sequences for CCN3 Gene

GenScript: Design optimal peptide antigens:
  • CCN3 (B3FHX2_HUMAN)
  • Nephroblastoma-overexpressed gene protein homolog (NOV_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48745

UniProtKB/Swiss-Prot:

CCN3_HUMAN :
  • Belongs to the CCN family.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CCN3: view

Function for CCN3 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for CCN3 Gene

UniProtKB/Swiss-Prot Function:
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated by WT1. Expression is down-regulated by proinflammatory stimuli such as TNF or IL1B (PubMed:24722330, PubMed:21063504). Expression is induced by laminar shear stress and statins (PubMed:21063504).

Phenotypes From GWAS Catalog for CCN3 Gene

Gene Ontology (GO) - Molecular Function for CCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 12050162
GO:0005178 integrin binding IPI 12695522
GO:0005515 protein binding IPI 9927660
GO:0005520 insulin-like growth factor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CCN3: view
genes like me logo Genes that share phenotypes with CCN3: view

Animal Models for CCN3 Gene

MGI Knock Outs for CCN3:

Animal Models for research

  • Taconic Biosciences Mouse Models for CCN3

miRNA for CCN3 Gene

miRTarBase miRNAs that target CCN3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCN3 Gene

Localization for CCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCN3 Gene

Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000250 UniProtKB:Q9QZQ5}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCN3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005737 cytoplasm ISS --
GO:0005921 gap junction ISS --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with CCN3: view

Pathways & Interactions for CCN3 Gene

PathCards logo

SuperPathways for CCN3 Gene

SuperPathway Contained pathways
1 Adhesion
Adhesion
-
2 Notch Signaling Pathway (WikiPathways)
Notch Signaling Pathways
.31
3 G-Beta Gamma Signaling
Signaling in Gap Junctions
.30
genes like me logo Genes that share pathways with CCN3: view

Pathways by source for CCN3 Gene

1 R&D Systems pathway for CCN3 Gene
1 Qiagen pathway for CCN3 Gene
  • Signaling in Gap Junctions
1 Cell Signaling Technology pathway for CCN3 Gene

SIGNOR curated interactions for CCN3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 12695522
GO:0002062 chondrocyte differentiation IMP 21871891
GO:0007155 cell adhesion IBA 21873635
GO:0007165 signal transduction IBA 21873635
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with CCN3: view

Drugs & Compounds for CCN3 Gene

Products:

  1. Drug products for research

(3) Drugs for CCN3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin human Approved, Investigational Pharma Target, downregulator 0
genes like me logo Genes that share compounds with CCN3: view

Transcripts for CCN3 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for CCN3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN3

Alternative Splicing Database (ASD) splice patterns (SP) for CCN3 Gene

No ASD Table

Relevant External Links for CCN3 Gene

GeneLoc Exon Structure for
CCN3

Expression for CCN3 Gene

Products:

  1. Primer products for research

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN3

SOURCE GeneReport for Unigene cluster for CCN3 Gene:

Hs.235935

mRNA Expression by UniProt/SwissProt for CCN3 Gene:

P48745-CCN3_HUMAN
Tissue specificity: Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.

Evidence on tissue expression from TISSUES for CCN3 Gene

  • Nervous system(4.8)
  • Skin(4.4)
  • Adrenal gland(3.3)
  • Heart(2.6)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with CCN3: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN3 Gene

Orthologs for CCN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NOV 29 30
  • 99.72 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NOV 29 30
  • 84.44 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NOV 29 30
  • 84.23 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nov 29
  • 83.62 (n)
Mouse
(Mus musculus)
 Mammalia Nov 29 30
  • 82.57 (n)
 OneToOne
Ccn3 16
Oppossum
(Monodelphis domestica)
 Mammalia NOV 30
  • 74 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NOV 30
  • 59 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NOV 29 30
  • 71.86 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NOV 30
  • 62 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nov 29
  • 68.92 (n)
African clawed frog
(Xenopus laevis)
 Amphibia nov-A 29
Zebrafish
(Danio rerio)
 Actinopterygii ctgfb 30
  • 47 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 36 (a)
 ManyToMany
-- 30
  • 36 (a)
 ManyToMany
Species where no ortholog for CCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCN3 Gene

ENSEMBL:
Gene Tree for CCN3 (if available)
TreeFam:
Gene Tree for CCN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCN3: view image
Alliance of Genome Resources:
Additional Orthologs for CCN3

Paralogs for CCN3 Gene

Paralogs for CCN3 Gene

genes like me logo Genes that share paralogs with CCN3: view

Variants for CCN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN3 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs17856478 Likely Benign: not provided 119,416,950(+) C/A
NM_002514.4(CCN3):c.291C>A (p.Asn97Lys) 		MISSENSE
rs35712802 Benign: not provided 119,416,576(+) G/T
NM_002514.4(CCN3):c.44G>T (p.Cys15Phe) 		MISSENSE
rs796052179 Likely Benign: Long QT syndrome 119,419,173(+) C/G
NM_002514.4(CCN3):c.605C>G (p.Ser202Ter) 		NONSENSE
rs11538929 -- p.Arg233His
rs2279112 -- p.Arg42Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCN3 Gene

Variant ID Type Subtype PubMed ID
nsv1026655 CNV gain 25217958
nsv521624 CNV loss 19592680
nsv527032 CNV loss 19592680

Variation tolerance for CCN3 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.45; 85.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCN3
Leiden Open Variation Database (LOVD)
CCN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN3 Gene

Disorders for CCN3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCN3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
wilms tumor 1
  • wt1
obstructive nephropathy
  • con
rhabdomyosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CCN3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCN3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCN3 Gene

Publications for CCN3 Gene

  1. NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. (PMID: 17463287) Gupta R … Enver T (Science (New York, N.Y.) 2007) 3 4 22
  2. Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. (PMID: 15181016) Gellhaus A … Winterhager E (The Journal of biological chemistry 2004) 3 4 22
  3. CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. (PMID: 15213231) Fu CT … Naus CC (The Journal of biological chemistry 2004) 3 4 22
  4. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. (PMID: 12050162) Sakamoto K … Katsube K (The Journal of biological chemistry 2002) 3 4 22
  5. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PMID: 9927660) Perbal B … Roizman B (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 22

ExternalLinks

View latest publications for CCN3 gene in Mastermind
View latest publications for CCN3 gene in Mastermind

Products for CCN3 Gene

Sources for CCN3 Gene