Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009] See more...
Aliases for CCN3 Gene
Aliases for CCN3 Gene
External Ids for CCN3 Gene
- HGNC: 7885
- Entrez Gene: 4856
- Ensembl: ENSG00000136999
- OMIM: 164958
- UniProtKB: P48745
Previous HGNC Symbols for CCN3 Gene
- NOV
Summaries for CCN3 Gene
-
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
GeneCards Summary for CCN3 Gene
CCN3 (Cellular Communication Network Factor 3) is a Protein Coding gene. Diseases associated with CCN3 include Wilms Tumor 5 and Rhabdomyosarcoma. Among its related pathways are Notch Signaling Pathway (WikiPathways) and Adhesion. An important paralog of this gene is CCN2.
UniProtKB/Swiss-Prot Summary for CCN3 Gene
-
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
Additional gene information for CCN3 Gene
- HGNC(7885)
- Entrez Gene(4856)
- Ensembl(ENSG00000136999)
- OMIM(164958)
- UniProtKB(P48745)
- Open Targets Platform(ENSG00000136999)
- Search for CCN3 at DataMed
- Search for CCN3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN3 Gene
Genomics for CCN3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCN3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN3
Genomic Locations for CCN3 Gene
Genomic Locations for CCN3 Gene
- chr8:119,416,446-119,424,434
- (GRCh38/hg38)
- Size:
- 7,989 bases
- Orientation:
- Plus strand
- chr8:120,428,546-120,436,678
- (GRCh37/hg19)
- Size:
- 8,133 bases
- Orientation:
- Plus strand
Genomic View for CCN3 Gene
Genes around CCN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.12 by HGNC
- 8q24.12 by Entrez Gene
- 8q24.12 by Ensembl
CCN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCN3 Gene
Proteins for CCN3 Gene
-
Protein details for CCN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48745-CCN3_HUMAN
- Recommended name:
- CCN family member 3
- Protein Accession:
- P48745
- B2R5X7
- Q6I9S3
- Q96BY5
- Q9UDE4
Protein attributes for CCN3 Gene
- Size:
- 357 amino acids
- Molecular mass:
- 39162 Da
- Quaternary structure:
-
- Interacts with FBLN1. Interacts (via CTCK domain) with NOTCH1 (via the EGF-like repeat region) (PubMed:12050162). Interacts with GJA1/CX43 (PubMed:15181016, PubMed:15213231). Interacts with ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:12695522, PubMed:15611078). Interacts with ZDHHC22; the interaction may lead to CCN3 palmitoylation (By similarity).
Post-translational modifications for CCN3 Gene
- May be palmitoylated on Cys-244, which is important for extracellular secretion.
-
Glycosylation at Thr46, Thr49, Asn97, Asn280, Thr352, and Thr353
- NX_P48745 (NX_P48745-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CCN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CCN3 / NOV Antibody and CCN3 / NOV Monoclonal Antibody
- NSJ Bioreagents CCN3 Antibody / NOV / IGFBP9 (C-Terminal Region)
- GeneTex Anti-CCN3 antibody [7H11] and Anti-CCN3 antibody
-
Custom Antibody ServicesOriGene Antibodies for CCN3
- Novus Biologicals Antibodies for CCN3
-
Abcam antibodies for CCN3
- Invitrogen Antibodies for CCN3 (AFLGC-CCN3)
- Sino Biological Antibodies for CCN3
Protein Products
-
OriGene Purified Proteins for CCN3
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN3
- Origene Custom Protein Services for CCN3
- Sino Biological Cell Lysates for CCN3
- Sino Biological Recombinant Proteins for CCN3
- ProSpec Recombinant Proteins for CCN3
- antibodies-online: Show 25 available NOV Proteins ranked by validation data
- Compare Top NOV Proteins
-
ProSci Proteins for CCN3
-
Abcam proteins for CCN3
Assay Products
- RayBiotech Human NOV ELISA
- Novus Biologicals ELISA Kits for CCN3
-
Signalway ELISA kits for CCN3
-
Abcam assays for CCN3
- Sino Biological Assays for CCN3
No data available for DME Specific Peptides for CCN3 Gene
Domains & Families for CCN3 Gene
Gene Families for CCN3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
- Transporters
Protein Domains for CCN3 Gene
- InterPro:
- Blocks:
-
- Thrombospondin, type I
- von Willebrand factor, type C
- Insulin-like growth factor-binding protein, IGFBP
- Cystine knot, C-terminal
- Cystine knot domain
- ProtoNet:
Suggested Antigen Peptide Sequences for CCN3 Gene
- GenScript: Design optimal peptide antigens:
-
- CCN3 (B3FHX2_HUMAN)
- Nephroblastoma-overexpressed gene protein homolog (NOV_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48745- Family:
-
- Belongs to the CCN family.
Function for CCN3 Gene
Molecular function for CCN3 Gene
- UniProtKB/Swiss-Prot Function:
- Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
- UniProtKB/Swiss-Prot Induction:
- Expression is down-regulated by WT1. Expression is down-regulated by proinflammatory stimuli such as TNF or IL1B (PubMed:24722330, PubMed:21063504). Expression is induced by laminar shear stress and statins (PubMed:21063504).
Phenotypes From GWAS Catalog for CCN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005112 | Notch binding | IPI | 12050162 |
| GO:0005178 | integrin binding | IPI | 12695522 |
| GO:0005515 | protein binding | IPI | 9927660 |
| GO:0005520 | insulin-like growth factor binding | IEA | -- |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for CCN3 Gene
- MGI mutant phenotypes for CCN3:
-
inferred from 3 alleles
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for CCN3:
Animal Models for CCN3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CCN3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN3 - Select products 50% OFF >
- * CCN3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN3
miRNA for CCN3 Gene
- miRTarBase miRNAs that target CCN3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN3
- Browse OriGene Inhibitory RNA Products For CCN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN3
Clone Products
- Applied Biological Materials (abm): Clones for CCN3 - Select products 50% OFF >
- * CCN3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN3
Cell Line Products
-
Horizon Cell Lines for CCN3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCN3 Gene
Localization for CCN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCN3 Gene
- Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000250 UniProtKB:Q9QZQ5}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005921 | gap junction | ISS | -- |
| GO:0030054 | cell junction | IEA | -- |
| GO:0030424 | axon | IEA | -- |
Pathways & Interactions for CCN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adhesion |
-
|
|
| 2 | Notch Signaling Pathway (WikiPathways) | ||
| 3 | G-Beta Gamma Signaling |
Signaling in Gap Junctions
.30
|
|
Pathways by source for CCN3 Gene
1 R&D Systems pathway for CCN3 Gene
1 Qiagen pathway for CCN3 Gene
- Signaling in Gap Junctions
1 Cell Signaling Technology pathway for CCN3 Gene
Interacting Proteins for CCN3 Gene
Selected Interacting proteins:
P48745-CCN3_HUMAN
ENSP00000259526
for CCN3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CCN3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IDA | 12695522 |
| GO:0002062 | chondrocyte differentiation | IMP | 21871891 |
| GO:0007155 | cell adhesion | IBA | 21873635 |
| GO:0007165 | signal transduction | IBA | 21873635 |
| GO:0010468 | regulation of gene expression | IEA | -- |
Drugs & Compounds for CCN3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Insulin pork | Approved | Pharma | Target | 0 |
Transcripts for CCN3 Gene
mRNA/cDNA for CCN3 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000259526 2463 nts (view in UCSC)
- ENST00000520082 544 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN3 - Select products 50% OFF >
- * CCN3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN3
- Browse OriGene Inhibitory RNA Products For CCN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN3
Clone Products
- Applied Biological Materials (abm): Clones for CCN3 - Select products 50% OFF >
- * CCN3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN3
Relevant External Links for CCN3 Gene
- GeneLoc Exon Structure for
- CCN3
Expression for CCN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Early Floor Plate Cells Mesencephalic Floor Plate
- Adult Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Neural Tube (Nervous System)
- Early Floor Plate Cells Mesencephalic Floor Plate
- Late Floor Plate Cells Mesencephalic Floor Plate
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
- Bone (Muscoskeletal System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN3
SOURCE GeneReport for Unigene cluster for CCN3 Gene:
Hs.235935mRNA Expression by UniProt/SwissProt for CCN3 Gene:
P48745-CCN3_HUMAN
Tissue specificity:
Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
Evidence on tissue expression from TISSUES for CCN3 Gene
- Nervous system(4.8)
- Skin(4.4)
- Adrenal gland(3.3)
- Heart(2.7)
- Muscle(2.7)
- Kidney(2.3)
Primer Products
-
OriGene qPCR primer pairs for CCN3
-
OriGene qPCR primer pairs and template standards for CCN3
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN3 Gene
Orthologs for CCN3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NOV 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NOV 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NOV 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nov 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Nov 30 31 |
|
OneToOne | |
| Ccn3 17 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | NOV 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NOV 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NOV 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NOV 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nov 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | nov-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ctgfb 31 |
|
ManyToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CCN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CCN3 Gene
- ENSEMBL:
- Gene Tree for CCN3 (if available)
- TreeFam:
- Gene Tree for CCN3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCN3: view image
Paralogs for CCN3 Gene
Variants for CCN3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN3 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 721280 | Likely Benign: not provided | 119,416,950(+) | C/A | MISSENSE_VARIANT | |
| 775267 | Benign: not provided | 119,416,576(+) | G/T | MISSENSE_VARIANT | |
| rs796052179 | Likely Benign: Long QT syndrome | 119,419,173(+) | C/G | NONSENSE | |
| rs11538929 | - | p.Arg233His | |||
| rs2279112 | - | p.Arg42Gln |
Residual Variation Intolerance Score:
86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.45;
85.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCN3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN3 Gene
Disorders for CCN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wilms tumor 5 |
|
|
| rhabdomyosarcoma |
|
|
| obstructive nephropathy |
|
|
| wilms tumor 1 |
|
|
| renal cell carcinoma, nonpapillary |
|
|
Search CCN3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCN3
No data available for UniProtKB/Swiss-Prot and Genatlas for CCN3 Gene
Publications for CCN3 Gene
- NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. (PMID: 17463287) Gupta R … Enver T (Science (New York, N.Y.) 2007) 3 4 23
- CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. (PMID: 15213231) Fu CT … Naus CC (The Journal of biological chemistry 2004) 3 4 23
- Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. (PMID: 15181016) Gellhaus A … Winterhager E (The Journal of biological chemistry 2004) 3 4 23
- The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. (PMID: 12050162) Sakamoto K … Katsube K (The Journal of biological chemistry 2002) 3 4 23
- The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PMID: 9927660) Perbal B … Roizman B (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 23
Products for CCN3 Gene
- View all 10 R&D Systems CCN3 (NOV/CCN3) Products
- View all R&D Systems CCN3 (NOV/CCN3) Proteins and Enzymes
- View all 8 R&D Systems CCN3 (NOV/CCN3) Primary Antibodies
- View all R&D Systems CCN3 (NOV/CCN3) ELISAs
- Learn more about R&D Systems custom CCN3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCN3
- Custom Assay Services
- OriGene Purified Proteins for CCN3
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN3
- Origene Custom Protein Services for CCN3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN3
- Browse OriGene Inhibitory RNA Products For CCN3
- OriGene qPCR primer pairs for CCN3
- OriGene qPCR primer pairs and template standards for CCN3
- OriGene CRISPR knockouts for CCN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCN3
- Sino Biological Human cDNA Clone for CCN3
- Sino Biological Cell Lysates for CCN3
- Sino Biological Recombinant Proteins for CCN3
- Sino Biological Antibodies for CCN3
- Sino Biological Assays for CCN3
- Browse Recombinant Proteins
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCN3
- Novus Biologicals proteins and lysates for CCN3
- Novus Biologicals ELISA Kits for CCN3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCN3
- Abcam proteins for CCN3
- Abcam assays for CCN3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CCN3
- Taconic Biosciences Mouse Models for CCN3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CCN3 (AFLGC-CCN3)
- VectorBuilder Custom and pre-made DNA vectors for CCN3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCN3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCN3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCN3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCN3
- antibodies-online: Show 70 available NOV Antibodies ranked by validation data
- Compare Top NOV Antibodies
- antibodies-online: Show 21 available NOV Elisa Kits ranked by validation data
- Compare Top NOV Elisa Kits
- antibodies-online: Show 25 available NOV Proteins ranked by validation data
- Compare Top NOV Proteins
- Horizon Cell Lines for CCN3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN3
Sources for CCN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB