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The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq,... See more...
Aliases for CCN2 Gene
Aliases for CCN2 Gene
External Ids for CCN2 Gene
- HGNC: 2500
- Entrez Gene: 1490
- Ensembl: ENSG00000118523
- OMIM: 121009
- UniProtKB: P29279
Previous HGNC Symbols for CCN2 Gene
- CTGF
Summaries for CCN2 Gene
-
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
GeneCards Summary for CCN2 Gene
CCN2 (Cellular Communication Network Factor 2) is a Protein Coding gene. Diseases associated with CCN2 include Renal Fibrosis and Systemic Scleroderma. Among its related pathways are NF-KappaB Family Pathway and amb2 Integrin signaling. An important paralog of this gene is CCN3.
UniProtKB/Swiss-Prot Summary for CCN2 Gene
-
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Additional gene information for CCN2 Gene
- HGNC(2500)
- Entrez Gene(1490)
- Ensembl(ENSG00000118523)
- OMIM(121009)
- UniProtKB(P29279)
- Open Targets Platform(ENSG00000118523)
- Monarch Initiative
- Search for CCN2 at DataMed
- Search for CCN2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN2 Gene
Genomics for CCN2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCN2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J131946 | Promoter/Enhancer | 2.5 | VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +0.3 | 304 | 10.9 | HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 REST TFE3 | ENSG00000227220 CCN2 MED23 SNORA33 LINC01013 lnc-ENPP1-5 ENPP1 | |
| GH06J131976 | Enhancer | 1.1 | Ensembl ENCODE | 12 | -25.6 | -25563 | 0.7 | GATAD2A TFE3 SOX13 NFKBIZ RCOR2 RXRB IRF2 CEBPA KMT2B ETS1 | CCN2 ENSG00000227220 LINC01013 piR-30853-065 MOXD1 | |
| GH06J132146 | Enhancer | 1 | FANTOM5 Ensembl ENCODE dbSUPER | 3.8 | -196.4 | -196408 | 2 | ATF7 JUND ATF2 | CCN2 TAAR2 lnc-MOXD1-1 LINC01013 lnc-ENPP1-7 MOXD1 | |
| GH06J131987 | Enhancer | 0.2 | Ensembl | 12.4 | -36.3 | -36329 | 0.2 | ENSG00000227220 CCN2 piR-30853-065 MOXD1 | ||
| GH06J131988 | Enhancer | 0.2 | Ensembl | 12.4 | -38.2 | -38229 | 1.6 | ENSG00000227220 CCN2 LINC01013 piR-30853-065 MOXD1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCN2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN2
Genomic Locations for CCN2 Gene
Genomic Locations for CCN2 Gene
- chr6:131,948,176-131,951,372
- (GRCh38/hg38)
- Size:
- 3,197 bases
- Orientation:
- Minus strand
- chr6:132,269,316-132,272,518
- (GRCh37/hg19)
- Size:
- 3,203 bases
- Orientation:
- Minus strand
Genomic View for CCN2 Gene
Genes around CCN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q23.2 by HGNC
- 6q23.2 by Entrez Gene
- 6q23.2 by Ensembl
CCN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCN2 Gene
Proteins for CCN2 Gene
-
Protein details for CCN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29279-CCN2_HUMAN
- Recommended name:
- CCN family member 2
- Protein Accession:
- P29279
- E1P578
- Q6LCY0
- Q96A79
- Q96QX2
- Q9UDL6
Protein attributes for CCN2 Gene
- Size:
- 349 amino acids
- Molecular mass:
- 38091 Da
- Quaternary structure:
-
- Monomer.
Post-translational modifications for CCN2 Gene
Other Protein References for CCN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CTGF Antibody
- NSJ Bioreagents CTGF Antibody
- HUABIO CTGF Antibody (ER1802-69)
-
Custom Antibody ServicesOriGene Antibodies for CCN2
- Novus Biologicals Antibodies for CCN2
-
Abcam antibodies for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CCN2)
- antibodies-online: Show 77 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
-
Recommended
- 72 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 204 WB Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for CCN2
-
Custom Antibody ServicesProSci Antibodies for CCN2
Protein Products
- RayBiotech Recombinant Human CTGF
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- ProSpec Recombinant Proteins for CCN2
-
Abcam proteins for CCN2
Assay Products
- Novus Biologicals ELISA Kits for CCN2
- antibodies-online: Show 106 available CTGF Elisa Kits ranked by validation data
- Compare Top CTGF Elisa Kits
-
Quality Products:
- ABIN6730903
- ABIN6720478
- ABIN415039
- ABIN1114355
- ABIN365076
- ABIN2472068
- ABIN1081336
- ABIN1028444
- ABIN924759
- ABIN454827
- ABIN1114357
- ABIN415622
- ABIN367659
- ABIN1569230
- ABIN5520367
- ABIN454828
- ABIN5669765
- ABIN1081337
- ABIN627668
- ABIN5591947
- ABIN1114356
- ABIN416372
- ABIN368064
- ABIN1081338
- ABIN5520369
- ABIN5670431
- ABIN1569232
- ABIN626847
- ABIN5591948
- ABIN5653299
- ABIN2851082
- ABIN990454
- ABIN4968415
- ABIN1127701
-
Signalway ELISA kits for CCN2
No data available for DME Specific Peptides for CCN2 Gene
Domains & Families for CCN2 Gene
Gene Families for CCN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CCN2 Gene
- InterPro:
- Blocks:
-
- Thrombospondin, type I
- von Willebrand factor, type C
- Insulin-like growth factor-binding protein, IGFBP
- Cystine knot, C-terminal
- Cystine knot domain
- ProtoNet:
Suggested Antigen Peptide Sequences for CCN2 Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like growth factor-binding protein 8 (CTGF_HUMAN)
- cDNA FLJ77666, highly similar to Homo sapiens connective tissue growth factor (CTGF), mRNA (Q5M8T4_HUMAN)
- CTGF protein (Q6FHL8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29279- Family:
-
- Belongs to the CCN family.
Function for CCN2 Gene
Molecular function for CCN2 Gene
- UniProtKB/Swiss-Prot Function:
- Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Phenotypes From GWAS Catalog for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA | -- |
| GO:0005178 | integrin binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 16457822 |
| GO:0005520 | insulin-like growth factor binding | TAS,IEA | -- |
| GO:0008022 | protein C-terminus binding | IPI | 9927660 |
Phenotypes for CCN2 Gene
- MGI mutant phenotypes for CCN2:
-
inferred from 7 alleles
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CCN2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Strongly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
Animal Models for CCN2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Select products 50% OFF >
- * CCN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
miRNA for CCN2 Gene
- miRTarBase miRNAs that target CCN2
-
- hsa-miR-124-3p (MIRT002604)
- rno-miR-30c-5p (MIRT003488)
- rno-miR-133b-3p (MIRT003489)
- hsa-miR-18a-5p (MIRT004174)
- hsa-miR-26a-5p (MIRT004338)
- rno-miR-133a-3p (MIRT005433)
- mmu-miR-122-5p (MIRT005980)
- hsa-miR-205-5p (MIRT006936)
- hsa-miR-145-5p (MIRT007247)
- mmu-miR-425-5p (MIRT008435)
- mmu-miR-297a-5p (MIRT013007)
- mmu-miR-9-5p (MIRT015134)
- hsa-miR-375 (MIRT019692)
- hsa-miR-18b-5p (MIRT053207)
- mmu-miR-26a-5p (MIRT054736)
- hsa-miR-133b (MIRT438303)
- hsa-miR-1277-5p (MIRT538277)
- hsa-miR-190a-3p (MIRT538278)
- hsa-miR-493-5p (MIRT538279)
- hsa-miR-4789-5p (MIRT538280)
- hsa-miR-3941 (MIRT538281)
- hsa-miR-5011-5p (MIRT538282)
- hsa-miR-577 (MIRT538283)
- hsa-miR-5580-3p (MIRT538284)
- hsa-miR-603 (MIRT538285)
- hsa-miR-362-3p (MIRT538286)
- hsa-miR-329-3p (MIRT538287)
- hsa-miR-8485 (MIRT538288)
- hsa-miR-195-3p (MIRT610644)
- hsa-miR-16-2-3p (MIRT610645)
- hsa-miR-4699-3p (MIRT610646)
- hsa-miR-338-5p (MIRT610647)
- hsa-miR-143-3p (MIRT731589)
- hsa-miR-26b-5p (MIRT731945)
- hsa-miR-133a-3p (MIRT732490)
- hsa-miR-199a-5p (MIRT732585)
- mmu-miR-26a-1-3p (MIRT733652)
- mmu-miR-199a-5p (MIRT734632)
- mmu-miR-214-3p (MIRT734668)
- hsa-miR-483-3p (MIRT734856)
- hsa-miR-30c-5p (MIRT735520)
- rno-miR-26b-5p (MIRT735551)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
Clone Products
- Applied Biological Materials (abm): Clones for CCN2 - Select products 50% OFF >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
-
Horizon Cell Lines for CCN2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCN2 Gene
Localization for CCN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCN2 Gene
- Secreted, extracellular space, extracellular matrix. Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005801 | cis-Golgi network | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005886 | plasma membrane | TAS | 10809757 |
Pathways & Interactions for CCN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
Pathways by source for CCN2 Gene
4 BioSystems pathways for CCN2 Gene
8 Reactome pathways for CCN2 Gene
2 KEGG pathways for CCN2 Gene
54 Qiagen pathways for CCN2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
2 Cell Signaling Technology pathways for CCN2 Gene
Interacting Proteins for CCN2 Gene
Selected Interacting proteins:
P29279-CCN2_HUMAN
ENSP00000356954
for CCN2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCN2
SIGNOR curated interactions for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001502 | cartilage condensation | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001894 | tissue homeostasis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Transcripts for CCN2 Gene
mRNA/cDNA for CCN2 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367976 2338 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Select products 50% OFF >
- * CCN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
Clone Products
- Applied Biological Materials (abm): Clones for CCN2 - Select products 50% OFF >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
Relevant External Links for CCN2 Gene
- GeneLoc Exon Structure for
- CCN2
Expression for CCN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Endochondral Preosteoblasts Stylopod Perichondrium
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Lung (Respiratory System)
- Chondrocytes Tracheal Cartilage
- Tracheal Cartilage
- Trachea
-
Tooth (Integumentary System)
- Secondary Enamel Knot Cells Enamel Knot
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Heart (Cardiovascular System)
- Limb (Muscoskeletal System)
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Epiblast (Early Embryonic Tissues)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN2
SOURCE GeneReport for Unigene cluster for CCN2 Gene:
Hs.410037mRNA Expression by UniProt/SwissProt for CCN2 Gene:
P29279-CCN2_HUMAN
Tissue specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Evidence on tissue expression from TISSUES for CCN2 Gene
- Heart(4.8)
- Liver(4.7)
- Kidney(4.7)
- Nervous system(4.7)
- Bone(4.6)
- Skin(4.5)
- Lung(4.3)
- Eye(4.2)
- Pancreas(4.1)
- Intestine(4.1)
- Muscle(3.8)
- Stomach(3.8)
- Spleen(3.5)
- Blood(3.3)
- Thyroid gland(3.2)
- Lymph node(3)
- Gall bladder(2.9)
- Adrenal gland(2.8)
- Bone marrow(2.5)
- Urine(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- salivary gland
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- esophagus
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CCN2
-
OriGene qPCR primer pairs and template standards for CCN2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCN2 Gene
Orthologs for CCN2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CTGF 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CTGF 31 |
|
OneToOne | |
| LOC476202 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | CTGF 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ctgf 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ctgf 30 31 |
|
OneToOne | |
| Ccn2 17 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | CTGF 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CTGF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CTGF 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CTGF 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ctgf 30 |
|
||
| Str.15550 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398003 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ctgfa 30 31 |
|
OneToOne | |
| hmzeh1559 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13898 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CCN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CCN2 Gene
- ENSEMBL:
- Gene Tree for CCN2 (if available)
- TreeFam:
- Gene Tree for CCN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCN2: view image
Paralogs for CCN2 Gene
Variants for CCN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 727929 | Likely Benign: not provided | 131,950,057(-) | C/T | MISSENSE_VARIANT | |
| 733256 | Likely Benign: not provided | 131,949,399(-) | G/A | SYNONYMOUS_VARIANT | |
| 741982 | Likely Benign: not provided | 131,950,529(-) | G/A | MISSENSE_VARIANT | |
| 756064 | Likely Benign: not provided | 131,950,012(-) | T/A | SYNONYMOUS_VARIANT | |
| 770730 | Benign: not provided | 131,950,549(-) | G/A | INTRON_VARIANT |
Residual Variation Intolerance Score:
45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCN2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN2 Gene
Disorders for CCN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal fibrosis |
|
|
| systemic scleroderma |
|
|
| limited scleroderma |
|
|
| diffuse cutaneous systemic sclerosis |
|
|
| gingival overgrowth |
|
Search CCN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCN2
No data available for UniProtKB/Swiss-Prot and Genatlas for CCN2 Gene
Publications for CCN2 Gene
- Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PMID: 17602195) Gauer S … Goppelt-Struebe M (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007) 3 23 26
- The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PMID: 12553878) Ball DK … Brigstock DR (The Journal of endocrinology 2003) 3 4 23
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PMID: 1654338) Bradham DM … Grotendorst GR (The Journal of cell biology 1991) 2 3 4
- Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. (PMID: 20056838) Xie JJ … Li EM (The American journal of pathology 2010) 3 23
- Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion. (PMID: 20237235) Gerritsen KG … Goldschmeding R (American journal of physiology. Renal physiology 2010) 3 23
ExternalLinks
Products for CCN2 Gene
- View all 8 R&D Systems CCN2 (CTGF/CCN2) Products
- View all R&D Systems CCN2 (CTGF/CCN2) Proteins and Enzymes
- View all 5 R&D Systems CCN2 (CTGF/CCN2) Primary Antibodies
- View all R&D Systems CCN2 (CTGF/CCN2) ELISAs
- View all R&D Systems CCN2 (CTGF/CCN2) Simple Plex Assays
- Learn more about R&D Systems custom CCN2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCN2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- OriGene qPCR primer pairs for CCN2
- OriGene qPCR primer pairs and template standards for CCN2
- OriGene CRISPR knockouts for CCN2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCN2
- Sino Biological Human cDNA Clone for CCN2
- Browse Sino Biological Recombinant Proteins
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- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCN2
- Novus Biologicals proteins and lysates for CCN2
- Novus Biologicals ELISA Kits for CCN2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for CCN2
- Abcam proteins for CCN2
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for CCN2
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CCN2)
- VectorBuilder Custom and pre-made DNA vectors for CCN2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCN2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCN2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCN2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCN2
- Addgene plasmids for CCN2
- antibodies-online: Show 77 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
- Recommended
- 72 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 204 WB Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 106 available CTGF Elisa Kits ranked by validation data
- Compare Top CTGF Elisa Kits
- Quality Products:
- ABIN6730903
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- ABIN415039
- ABIN1114355
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- ABIN924759
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- ABIN367659
- ABIN1569230
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- ABIN5670431
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- ABIN626847
- ABIN5591948
- ABIN5653299
- ABIN2851082
- ABIN990454
- ABIN4968415
- ABIN1127701
- antibodies-online: Show 70 available CTGF Proteins ranked by validation data
- Compare Top CTGF Proteins
- Custom Antibody ServicesProSci Antibodies for CCN2
- Horizon Cell Lines for CCN2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
Sources for CCN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB