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The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq,... See more...
Aliases for CCN2 Gene
Aliases for CCN2 Gene
External Ids for CCN2 Gene
- HGNC: 2500
- NCBI Entrez Gene: 1490
- Ensembl: ENSG00000118523
- OMIM®: 121009
- UniProtKB/Swiss-Prot: P29279
Previous HGNC Symbols for CCN2 Gene
- CTGF
Summaries for CCN2 Gene
-
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
GeneCards Summary for CCN2 Gene
CCN2 (Cellular Communication Network Factor 2) is a Protein Coding gene. Diseases associated with CCN2 include Renal Fibrosis and Systemic Scleroderma. Among its related pathways are Apelin signaling pathway and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is CCN3.
UniProtKB/Swiss-Prot Summary for CCN2 Gene
-
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Additional gene information for CCN2 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN2 Gene
Genomics for CCN2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCN2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J131946 | Promoter/Enhancer | 2.5 | VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +0.3 | 304 | 10.9 | ZNF654 ZNF600 SSRP1 JUND ATF2 CEBPA POLR2A CHD4 YY1 MXD4 | ENSG00000227220 CCN2 HSALNG0053516 MED23 SNORA33 LINC01013 lnc-ENPP1-5 HSALNG0053515 ENPP1 | |
| GH06J131976 | Enhancer | 1.1 | Ensembl ENCODE | 12 | -25.5 | -25540 | 1 | KLF9 CEBPA CHD4 YY1 MXD4 KLF11 ZFP64 HOMEZ KMT2B THAP11 | CCN2 ENSG00000227220 LINC01013 HSALNG0053518 piR-30853-065 MOXD1 | |
| GH06J132146 | Enhancer | 1 | FANTOM5 Ensembl ENCODE dbSUPER | 3.8 | -196.4 | -196409 | 2 | JUND ATF2 ATF7 | CCN2 TAAR2 HSALNG0053525 LINC01013 lnc-ENPP1-7 MOXD1 | |
| GH06J131988 | Enhancer | 0.2 | Ensembl | 12.4 | -38.2 | -38229 | 1.6 | CCN2 ENSG00000227220 LINC01013 HSALNG0053518 piR-30853-065 MOXD1 | ||
| GH06J131987 | Enhancer | 0.2 | Ensembl | 12.4 | -36.3 | -36329 | 0.2 | CCN2 ENSG00000227220 HSALNG0053518 piR-30853-065 MOXD1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCN2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN2
Genomic Locations for CCN2 Gene
Latest Assembly
- chr6:131,948,176-131,951,372
- (GRCh38/hg38)
- Size:
- 3,197 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:132,269,316-132,272,512
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,197 bases
- Orientation:
- Minus strand
Genomic View for CCN2 Gene
Genes around CCN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q23.2 by HGNC
- 6q23.2 by Entrez Gene
- 6q23.2 by Ensembl
CCN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCN2 Gene
Proteins for CCN2 Gene
-
Protein details for CCN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29279-CCN2_HUMAN
- Recommended name:
- CCN family member 2
- Protein Accession:
- P29279
- E1P578
- Q6LCY0
- Q96A79
- Q96QX2
- Q9UDL6
Protein attributes for CCN2 Gene
- Size:
- 349 amino acids
- Molecular mass:
- 38091 Da
- Quaternary structure:
-
- Monomer.
Post-translational modifications for CCN2 Gene
Other Protein References for CCN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CTGF Antibody
- G Biosciences Immunotag™ CTGF Antibody
- NSJ Bioreagents CTGF Antibody
- HUABIO CTGF Antibody (ER1802-69)
-
Custom Antibody ServicesOriGene Antibodies for CCN2
- Novus Biologicals Antibodies for CCN2
-
Abcam antibodies for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CCN2)
- antibodies-online: Show 77 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
-
Recommended
- 72 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 204 WB Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for CCN2
Protein products for research
- RayBiotech Recombinant Human CTGF
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- ProSpec Recombinant Proteins for CCN2
-
Abcam proteins for CCN2
Assay products for research
- Novus Biologicals ELISA Kits for CCN2
- antibodies-online: Show 106 available CTGF Elisa Kits ranked by validation data
- Compare Top CTGF Elisa Kits
-
Quality Products:
- ABIN6730903
- ABIN6720478
- ABIN415039
- ABIN1114355
- ABIN365076
- ABIN2472068
- ABIN1081336
- ABIN1028444
- ABIN924759
- ABIN454827
- ABIN1114357
- ABIN415622
- ABIN367659
- ABIN1569230
- ABIN5520367
- ABIN454828
- ABIN5669765
- ABIN1081337
- ABIN627668
- ABIN5591947
- ABIN1114356
- ABIN416372
- ABIN368064
- ABIN1081338
- ABIN5520369
- ABIN5670431
- ABIN1569232
- ABIN626847
- ABIN5591948
- ABIN5653299
- ABIN2851082
- ABIN990454
- ABIN4968415
- ABIN1127701
No data available for DME Specific Peptides for CCN2 Gene
Domains & Families for CCN2 Gene
Gene Families for CCN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CCN2 Gene
- InterPro:
- Blocks:
-
- Thrombospondin, type I
- von Willebrand factor, type C
- Insulin-like growth factor-binding protein, IGFBP
- Cystine knot, C-terminal
- Cystine knot domain
Suggested Antigen Peptide Sequences for CCN2 Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like growth factor-binding protein 8 (CTGF_HUMAN)
- cDNA FLJ77666, highly similar to Homo sapiens connective tissue growth factor (CTGF), mRNA (Q5M8T4_HUMAN)
- CTGF protein (Q6FHL8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29279- Family:
-
- Belongs to the CCN family.
Function for CCN2 Gene
Molecular function for CCN2 Gene
- UniProtKB/Swiss-Prot Function:
- Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Phenotypes From GWAS Catalog for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA | -- |
| GO:0005178 | integrin binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 16457822 |
| GO:0005520 | insulin-like growth factor binding | TAS,IEA | -- |
| GO:0008022 | protein C-terminus binding | IPI | 9927660 |
Phenotypes for CCN2 Gene
- MGI mutant phenotypes for CCN2:
-
inferred from 7 alleles
- normal phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- mortality/aging
- liver/biliary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CCN2:
-
- Strongly decreased CFP-tsO45G cell surface transport
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased viability in esophageal squamous lineage
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for CCN2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Starting at $85 >
- * CCN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
miRNA for CCN2 Gene
- miRTarBase miRNAs that target CCN2
-
- hsa-miR-124-3p (MIRT002604)
- rno-miR-30c-5p (MIRT003488)
- rno-miR-133b-3p (MIRT003489)
- hsa-miR-18a-5p (MIRT004174)
- hsa-miR-26a-5p (MIRT004338)
- rno-miR-133a-3p (MIRT005433)
- mmu-miR-122-5p (MIRT005980)
- hsa-miR-205-5p (MIRT006936)
- hsa-miR-145-5p (MIRT007247)
- mmu-miR-425-5p (MIRT008435)
- mmu-miR-297a-5p (MIRT013007)
- mmu-miR-9-5p (MIRT015134)
- hsa-miR-375 (MIRT019692)
- hsa-miR-18b-5p (MIRT053207)
- mmu-miR-26a-5p (MIRT054736)
- hsa-miR-133b (MIRT438303)
- hsa-miR-1277-5p (MIRT538277)
- hsa-miR-190a-3p (MIRT538278)
- hsa-miR-493-5p (MIRT538279)
- hsa-miR-4789-5p (MIRT538280)
- hsa-miR-3941 (MIRT538281)
- hsa-miR-5011-5p (MIRT538282)
- hsa-miR-577 (MIRT538283)
- hsa-miR-5580-3p (MIRT538284)
- hsa-miR-603 (MIRT538285)
- hsa-miR-362-3p (MIRT538286)
- hsa-miR-329-3p (MIRT538287)
- hsa-miR-8485 (MIRT538288)
- hsa-miR-195-3p (MIRT610644)
- hsa-miR-16-2-3p (MIRT610645)
- hsa-miR-4699-3p (MIRT610646)
- hsa-miR-338-5p (MIRT610647)
- hsa-miR-143-3p (MIRT731589)
- hsa-miR-26b-5p (MIRT731945)
- hsa-miR-133a-3p (MIRT732490)
- hsa-miR-199a-5p (MIRT732585)
- mmu-miR-26a-1-3p (MIRT733652)
- mmu-miR-199a-5p (MIRT734632)
- mmu-miR-214-3p (MIRT734668)
- hsa-miR-483-3p (MIRT734856)
- hsa-miR-30c-5p (MIRT735520)
- rno-miR-26b-5p (MIRT735551)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
Clone products for research
- Applied Biological Materials (abm): Clones for CCN2 - Starting at $45 >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
Cell Lines for research
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
-
Horizon Cell Lines for CCN2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCN2 Gene
Localization for CCN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCN2 Gene
- Secreted, extracellular space, extracellular matrix. Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005801 | cis-Golgi network | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005886 | plasma membrane | TAS | 10809757 |
Pathways & Interactions for CCN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
Pathways by source for CCN2 Gene
4 BioSystems pathways for CCN2 Gene
8 Reactome pathways for CCN2 Gene
2 KEGG pathways for CCN2 Gene
54 Qiagen pathways for CCN2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
2 Cell Signaling Technology pathways for CCN2 Gene
Interacting Proteins for CCN2 Gene
Selected Interacting proteins:
P29279-CCN2_HUMAN
ENSP00000356954
for CCN2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCN2
SIGNOR curated interactions for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001502 | cartilage condensation | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001894 | tissue homeostasis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Drugs & Compounds for CCN2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CCN2 Gene
mRNA/cDNA for CCN2 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367976 2338 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Starting at $85 >
- * CCN2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
Clone products for research
- Applied Biological Materials (abm): Clones for CCN2 - Starting at $45 >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
Relevant External Links for CCN2 Gene
- GeneLoc Exon Structure for
- CCN2
Expression for CCN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Endochondral Preosteoblasts Stylopod Perichondrium
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Lung (Respiratory System)
- Chondrocytes Tracheal Cartilage
- Tracheal Cartilage
- Trachea
-
Tooth (Integumentary System)
- Secondary Enamel Knot Cells Enamel Knot
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Heart (Cardiovascular System)
- Limb (Muscoskeletal System)
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Epiblast (Early Embryonic Tissues)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN2
SOURCE GeneReport for Unigene cluster for CCN2 Gene:
Hs.410037mRNA Expression by UniProt/SwissProt for CCN2 Gene:
P29279-CCN2_HUMAN
Tissue specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Evidence on tissue expression from TISSUES for CCN2 Gene
- Heart(4.7)
- Liver(4.7)
- Kidney(4.7)
- Nervous system(4.6)
- Bone(4.5)
- Skin(4.4)
- Lung(4.2)
- Eye(4.1)
- Pancreas(4.1)
- Intestine(4.1)
- Stomach(3.8)
- Muscle(3.6)
- Spleen(3.4)
- Thyroid gland(3.1)
- Blood(3)
- Lymph node(2.9)
- Gall bladder(2.9)
- Adrenal gland(2.7)
- Bone marrow(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- salivary gland
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- esophagus
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- skin
- spinal column
- vertebrae
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for CCN2
-
OriGene qPCR primer pairs and template standards for CCN2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCN2 Gene
Orthologs for CCN2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CTGF 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CTGF 30 |
|
OneToOne | |
| LOC476202 29 |
|
||||
| Cow (Bos Taurus) |
Mammalia | CTGF 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ctgf 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ctgf 29 30 |
|
OneToOne | |
| Ccn2 16 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | CTGF 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CTGF 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CTGF 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CTGF 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ctgf 29 |
|
||
| Str.15550 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398003 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ctgfa 29 30 |
|
OneToOne | |
| hmzeh1559 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13898 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany |
- Species where no ortholog for CCN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CCN2 Gene
- ENSEMBL:
- Gene Tree for CCN2 (if available)
- TreeFam:
- Gene Tree for CCN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCN2: view image
- Alliance of Genome Resources:
- Additional Orthologs for CCN2
Paralogs for CCN2 Gene
Variants for CCN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1181016968 | Likely Benign: not provided | 131,949,399(-) |
G/A NM_001901.3(CCN2):c.915C>T (p.Phe305=) |
SYNONYMOUS | |
| rs142873474 | Likely Benign: not provided | 131,950,057(-) |
C/T NM_001901.3(CCN2):c.645G>A (p.Met215Ile) |
MISSENSE | |
| rs45488997 | Benign: not provided | 131,950,549(-) |
G/A NM_001901.3(CCN2):c.290-6C>T |
INTRON | |
| rs560896250 | Likely Benign: not provided | 131,950,996(-) |
C/T NM_001901.3(CCN2):c.67-4G>A |
INTRON | |
| rs562990573 | Likely Benign: not provided | 131,950,529(-) |
G/A NM_001901.3(CCN2):c.304C>T (p.Pro102Ser) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCN2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN2 Gene
Disorders for CCN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal fibrosis |
|
|
| systemic scleroderma |
|
|
| limited scleroderma |
|
|
| diffuse cutaneous systemic sclerosis |
|
|
| gingival overgrowth |
|
|
Search CCN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCN2
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCN2 Gene
Publications for CCN2 Gene
- Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PMID: 17602195) Gauer S … Goppelt-Struebe M (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007) 3 22 25
- The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PMID: 12553878) Ball DK … Brigstock DR (The Journal of endocrinology 2003) 3 4 22
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PMID: 1654338) Bradham DM … Grotendorst GR (The Journal of cell biology 1991) 2 3 4
- Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. (PMID: 20056838) Xie JJ … Li EM (The American journal of pathology 2010) 3 22
- Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. (PMID: 20032117) Kroening S … Goppelt-Struebe M (American journal of physiology. Renal physiology 2010) 3 22
ExternalLinks
Products for CCN2 Gene
- View all 8 R&D Systems CCN2 (CTGF/CCN2) Products
- View all R&D Systems CCN2 (CTGF/CCN2) Proteins and Enzymes
- View all 5 R&D Systems CCN2 (CTGF/CCN2) Primary Antibodies
- View all R&D Systems CCN2 (CTGF/CCN2) ELISAs
- View all R&D Systems CCN2 (CTGF/CCN2) Simple Plex Assays
- Learn more about R&D Systems custom CCN2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCN2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- OriGene qPCR primer pairs for CCN2
- OriGene qPCR primer pairs and template standards for CCN2
- OriGene CRISPR knockouts for CCN2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCN2
- Sino Biological Human cDNA Clone for CCN2
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCN2
- Novus Biologicals proteins and lysates for CCN2
- Novus Biologicals ELISA Kits for CCN2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for CCN2
- Abcam proteins for CCN2
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for CCN2
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CCN2)
- VectorBuilder Custom and pre-made DNA vectors for CCN2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCN2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCN2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCN2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCN2
- Addgene plasmids for CCN2
- antibodies-online: Show 77 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
- Recommended
- 72 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 204 WB Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 106 available CTGF Elisa Kits ranked by validation data
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- Quality Products:
- ABIN6730903
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- ABIN415039
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- ABIN626847
- ABIN5591948
- ABIN5653299
- ABIN2851082
- ABIN990454
- ABIN4968415
- ABIN1127701
- antibodies-online: Show 70 available CTGF Proteins ranked by validation data
- Compare Top CTGF Proteins
- Custom Antibody ServicesProSci Antibodies for CCN2
- Horizon Cell Lines for CCN2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
Sources for CCN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources