Aliases for CCN2 Gene
External Ids for CCN2 Gene
Previous HGNC Symbols for CCN2 Gene
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
GeneCards Summary for CCN2 Gene
CCN2 (Cellular Communication Network Factor 2) is a Protein Coding gene. Diseases associated with CCN2 include Renal Fibrosis and Systemic Scleroderma. Among its related pathways are Apelin signaling pathway and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is CCN3.
UniProtKB/Swiss-Prot Summary for CCN2 Gene
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.