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The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq,... See more...
Aliases for CCN2 Gene
Aliases for CCN2 Gene
External Ids for CCN2 Gene
- HGNC: 2500
- Entrez Gene: 1490
- Ensembl: ENSG00000118523
- OMIM: 121009
- UniProtKB: P29279
Previous HGNC Symbols for CCN2 Gene
- CTGF
Summaries for CCN2 Gene
-
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
GeneCards Summary for CCN2 Gene
CCN2 (Cellular Communication Network Factor 2) is a Protein Coding gene. Diseases associated with CCN2 include Renal Fibrosis and Systemic Scleroderma. Among its related pathways are ERK Signaling and TGF-Beta Pathway. An important paralog of this gene is CCN3.
UniProtKB/Swiss-Prot Summary for CCN2 Gene
-
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Additional gene information for CCN2 Gene
- Monarch Initiative
- Search for CCN2 at DataMed
- Search for CCN2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN2 Gene
Genomics for CCN2 Gene
GeneHancer (GH) Regulatory Elements for CCN2 Gene
Promoters and enhancers for CCN2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J131946 | Promoter/Enhancer | 2.5 | VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 500.7 | +0.3 | 310 | 10.9 | FOXK2 ZNF217 EP300 TCF12 POLR2G NCOR1 JUND PHF8 FOS TEAD4 | ENSG00000227220 CCN2 MED23 SNORA33 RPS12 LINC01013 lnc-ENPP1-5 | |
| GH06J131976 | Enhancer | 1.1 | Ensembl ENCODE | 12 | -25.6 | -25557 | 0.7 | NCOR1 KDM6A TCF7 ZBTB25 SKI TEAD1 ZBTB26 ZKSCAN8 FOXA2 ZSCAN9 | CCN2 ENSG00000227220 LINC01013 piR-30853-065 | |
| GH06J132146 | Enhancer | 0.9 | FANTOM5 Ensembl ENCODE dbSUPER | 3.8 | -196.4 | -196402 | 2 | JUND ATF2 ATF7 | CCN2 TAAR2 lnc-MOXD1-1 LINC01013 lnc-ENPP1-7 | |
| GH06J131988 | Enhancer | 0.2 | Ensembl | 12.4 | -38.2 | -38223 | 1.6 | CCN2 ENSG00000227220 LINC01013 piR-30853-065 | ||
| GH06J131987 | Enhancer | 0.2 | Ensembl | 12.4 | -36.3 | -36323 | 0.2 | CCN2 ENSG00000227220 piR-30853-065 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCN2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN2
Genomic Locations for CCN2 Gene
Genomic Locations for CCN2 Gene
- chr6:131,948,176-131,951,378
- (GRCh38/hg38)
- Size:
- 3,203 bases
- Orientation:
- Minus strand
- chr6:132,269,316-132,272,518
- (GRCh37/hg19)
- Size:
- 3,203 bases
- Orientation:
- Minus strand
Genomic View for CCN2 Gene
Genes around CCN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q23.2 by HGNC
- 6q23.2 by Entrez Gene
- 6q23.2 by Ensembl
CCN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCN2 Gene
Proteins for CCN2 Gene
-
Protein details for CCN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29279-CCN2_HUMAN
- Recommended name:
- CCN family member 2
- Protein Accession:
- P29279
- E1P578
- Q6LCY0
- Q96A79
- Q96QX2
- Q9UDL6
Protein attributes for CCN2 Gene
- Size:
- 349 amino acids
- Molecular mass:
- 38091 Da
- Quaternary structure:
-
- Monomer.
Post-translational modifications for CCN2 Gene
Other Protein References for CCN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CTGF Antibody
- NSJ Bioreagents CTGF Antibody
-
Creative Biolabs
- Recombinant Anti-Human CTGF Antibody
- Recombinant Anti-Human CTGF Antibody Fab Fragment
- Afuco™ Anti-Human CTGF ADCC Therapeutic Antibody (FG-3019), ADCC Enhanced
- Anti-Human CTGF Therapeutic Antibody (FG-3019)
- Anti-Human CTGF Therapeutic Antibody (h37-45)
- Anti-Human CTGF Therapeutic Antibody Fab Fragment (h37-45-MH1)
- Anti-Human CTGF Therapeutic Antibody (37-45)
- Anti-Human CTGF Therapeutic Antibody Fab Fragment (37-45)
- Anti-Human CTGF Therapeutic Antibody (h37-45-MH1)
- Anti-Human CTGF Therapeutic Antibody Fab Fragment (h37-45)
- Mouse Anti-CTGF Recombinant Antibody (CBYY-C2268)
- Mouse Anti-CTGF Recombinant Antibody (6B13)
- Mouse Anti-CTGF Recombinant Antibody (CBXC-2218)
- Mouse Anti-CTGF Recombinant Antibody (2C9)
- Mouse Anti-CTGF Recombinant Antibody (5C10)
- Mouse Anti-CTGF Recombinant Antibody (6D1)
- Recombinant Human Anti-CTGF Antibody Fab Fragment (37-45-MH1)
- Mouse Anti-CTGF Recombinant Antibody (CBFYC-2383)
- Mouse Anti-CTGF Recombinant Antibody (CBYY-C2250)
- Recombinant Human Anti-CTGF Antibody Fab Fragment (mAbl)
- Mouse Anti-CTGF Recombinant Antibody (558CT34.4.4)
- Mouse Anti-CTGF Recombinant Antibody (13j27)
- Mouse Anti-CTGF Recombinant Antibody (88430)
- Mouse Anti-CTGF (AA 17-73) Recombinant Antibody (CBFYC-2384)
- Mouse Anti-CTGF Recombinant Antibody (4B12)
- Mouse Anti-CTGF Recombinant Antibody (2C11)
- Mouse Anti-CTGF Recombinant Antibody (CBYY-C2269)
- Mouse Anti-CTGF Recombinant Antibody (CBXC-2965)
- Mouse Anti-CTGF (AA 27-349) Recombinant Antibody (CBYY-C2237)
- Recombinant Human Anti-CTGF Antibody (37-45-MH1)
- Mouse Anti-CTGF (AA 27-349) Recombinant Antibody (CBYY-C2251)
- Mouse Anti-CTGF (AA 27-349) Recombinant Antibody (CBYY-C2217)
- Mouse Anti-CTGF Recombinant Antibody (4D9)
- Anti-Human CTGF Therapeutic Antibody (Pamrevlumab)
- Mouse Anti-CTGF Recombinant Antibody (2G3)
- Recombinant Human Anti-CTGF Antibody (mAbl)
- Mouse Anti-CTGF Recombinant Antibody (17-73-F1)
- Mouse Anti-CTGF Recombinant Antibody (CBXC-1345)
- Recombinant Anti-Human CTGF Antibody (Fc glycosylation)
-
Custom Antibody ServicesOriGene Antibodies for CCN2
- Novus Biologicals Antibodies for CCN2
-
Abcam antibodies for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CTGF)
- antibodies-online: Show 77 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
-
Recommended
- 72 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 204 WB Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for CCN2
-
Custom Antibody ServicesProSci Antibodies for CCN2
Protein Products
- RayBiotech Recombinant Human CTGF
-
Creative Biomart
- Recombinant Human Connective Tissue Growth Factor, His-tagged
- Recombinant Human Connective Tissue Growth Factor
- Recombinant Human CTGF
- Recombinant Human CTGF, His-tagged (CTGF-16H)
- Recombinant Human CTGF, Fc-tagged
- Recombinant Human CTGF 293 Cell Lysate
- Recombinant Human CTGF, His-tagged (CTGF-2605H)
- Recombinant Human CTGF Protein, DDK-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- ProSpec Recombinant Proteins for CCN2
-
Abcam proteins for CCN2
Assay Products
- Novus Biologicals ELISA Kits for CCN2
- antibodies-online: Show 106 available CTGF Elisa Kits ranked by validation data
- Compare Top CTGF Elisa Kits
-
Quality Products:
- ABIN6730903
- ABIN6720478
- ABIN415039
- ABIN1114355
- ABIN365076
- ABIN2472068
- ABIN1081336
- ABIN1028444
- ABIN924759
- ABIN454827
- ABIN1114357
- ABIN415622
- ABIN367659
- ABIN1569230
- ABIN5520367
- ABIN454828
- ABIN5669765
- ABIN1081337
- ABIN627668
- ABIN5591947
- ABIN1114356
- ABIN416372
- ABIN368064
- ABIN1081338
- ABIN5520369
- ABIN5670431
- ABIN1569232
- ABIN626847
- ABIN5591948
- ABIN5653299
- ABIN2851082
- ABIN990454
- ABIN4968415
- ABIN1127701
No data available for DME Specific Peptides for CCN2 Gene
Domains & Families for CCN2 Gene
Gene Families for CCN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CCN2 Gene
- Blocks:
-
- Thrombospondin, type I
- von Willebrand factor, type C
- Insulin-like growth factor-binding protein, IGFBP
- Cystine knot, C-terminal
- Cystine knot domain
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCN2 Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like growth factor-binding protein 8 (CTGF_HUMAN)
- cDNA FLJ77666, highly similar to Homo sapiens connective tissue growth factor (CTGF), mRNA (Q5M8T4_HUMAN)
- CTGF protein (Q6FHL8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29279- Family:
-
- Belongs to the CCN family.
Function for CCN2 Gene
Molecular function for CCN2 Gene
- UniProtKB/Swiss-Prot Function:
- Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Phenotypes From GWAS Catalog for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA | -- |
| GO:0005178 | integrin binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI,IEA | 16457822 |
| GO:0005520 | insulin-like growth factor binding | IEA,TAS | -- |
| GO:0008022 | protein C-terminus binding | IPI | 9927660 |
Phenotypes for CCN2 Gene
- MGI mutant phenotypes for CCN2:
-
inferred from 7 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CCN2:
-
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for CCN2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Select products 50% OFF >
- * CCN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- genomics-online: gRNA clones - Search for available CTGF gRNA products
- Overview of 124 available CTGF gene related products
miRNA for CCN2 Gene
- miRTarBase miRNAs that target CCN2
-
- hsa-mir-124-3p (MIRT002604)
- hsa-mir-18a-5p (MIRT004174)
- hsa-mir-26a-5p (MIRT004338)
- hsa-mir-205-5p (MIRT006936)
- hsa-mir-145-5p (MIRT007247)
- hsa-mir-375 (MIRT019692)
- hsa-mir-18b-5p (MIRT053207)
- hsa-mir-133b (MIRT438303)
- hsa-mir-1277-5p (MIRT538277)
- hsa-mir-190a-3p (MIRT538278)
- hsa-mir-493-5p (MIRT538279)
- hsa-mir-4789-5p (MIRT538280)
- hsa-mir-3941 (MIRT538281)
- hsa-mir-5011-5p (MIRT538282)
- hsa-mir-577 (MIRT538283)
- hsa-mir-5580-3p (MIRT538284)
- hsa-mir-603 (MIRT538285)
- hsa-mir-362-3p (MIRT538286)
- hsa-mir-329-3p (MIRT538287)
- hsa-mir-8485 (MIRT538288)
- hsa-mir-195-3p (MIRT610644)
- hsa-mir-16-2-3p (MIRT610645)
- hsa-mir-4699-3p (MIRT610646)
- hsa-mir-338-5p (MIRT610647)
- hsa-mir-143-3p (MIRT731589)
- hsa-mir-26b-5p (MIRT731945)
- hsa-mir-133a-3p (MIRT732490)
- hsa-mir-199a-5p (MIRT732585)
- hsa-mir-483-3p (MIRT734856)
- hsa-mir-30c-5p (MIRT735520)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
- genomics-online: shRNA clones - Search for available CTGF shRNA products
- Overview of 124 available CTGF gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CCN2 - Select products 50% OFF >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
- genomics-online: cdna clones - Search for available CTGF CDNA products
- Overview of 124 available CTGF gene related products
- orf clones - Search for available CTGF ORF products
- Overview of 124 available CTGF gene related products
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
-
Horizon Cell Lines for CCN2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCN2 Gene
Localization for CCN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCN2 Gene
- Secreted, extracellular space, extracellular matrix. Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| endosome | 1 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005801 | cis-Golgi network | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005886 | plasma membrane | TAS | 10809757 |
Pathways & Interactions for CCN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
Pathways by source for CCN2 Gene
4 BioSystems pathways for CCN2 Gene
8 Reactome pathways for CCN2 Gene
2 KEGG pathways for CCN2 Gene
54 Qiagen pathways for CCN2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
2 Cell Signaling Technology pathways for CCN2 Gene
Interacting Proteins for CCN2 Gene
Selected Interacting proteins:
P29279-CCN2_HUMAN
ENSP00000356954
for CCN2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCN2
SIGNOR curated interactions for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001502 | cartilage condensation | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001894 | tissue homeostasis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Drugs & Compounds for CCN2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- RayBiotech Recombinant Human CTGF
-
Creative Biomart
- Recombinant Human Connective Tissue Growth Factor, His-tagged
- Recombinant Human Connective Tissue Growth Factor
- Recombinant Human CTGF
- Recombinant Human CTGF, His-tagged (CTGF-16H)
- Recombinant Human CTGF, Fc-tagged
- Recombinant Human CTGF 293 Cell Lysate
- Recombinant Human CTGF, His-tagged (CTGF-2605H)
- Recombinant Human CTGF Protein, DDK-tagged
Transcripts for CCN2 Gene
mRNA/cDNA for CCN2 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367976 2338 bps (ENST00000367976.4)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Select products 50% OFF >
- * CCN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- genomics-online: gRNA clones - Search for available CTGF gRNA products
- Overview of 124 available CTGF gene related products
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
- genomics-online: shRNA clones - Search for available CTGF shRNA products
- Overview of 124 available CTGF gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CCN2 - Select products 50% OFF >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
- genomics-online: cdna clones - Search for available CTGF CDNA products
- Overview of 124 available CTGF gene related products
- orf clones - Search for available CTGF ORF products
- Overview of 124 available CTGF gene related products
Relevant External Links for CCN2 Gene
- GeneLoc Exon Structure for
- CCN2
Expression for CCN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Endochondral Preosteoblasts Stylopod Perichondrium
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Lung (Respiratory System)
- Chondrocytes Tracheal Cartilage
- Tracheal Cartilage
- Trachea
-
Tooth (Integumentary System)
- Secondary Enamel Knot Cells Enamel Knot
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Heart (Cardiovascular System)
- Limb (Muscoskeletal System)
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Epiblast (Early Embryonic Tissues)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN2
SOURCE GeneReport for Unigene cluster for CCN2 Gene:
Hs.410037mRNA Expression by UniProt/SwissProt for CCN2 Gene:
P29279-CCN2_HUMAN
Tissue specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Evidence on tissue expression from TISSUES for CCN2 Gene
- Heart(4.7)
- Kidney(4.7)
- Liver(4.6)
- Bone(4.5)
- Nervous system(4.5)
- Skin(4.4)
- Lung(4.2)
- Eye(4)
- Pancreas(3.8)
- Intestine(3.7)
- Muscle(3.6)
- Stomach(3.5)
- Blood(2.7)
- Spleen(2.6)
- Gall bladder(2.4)
- Thyroid gland(2.2)
- Lymph node(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- salivary gland
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- esophagus
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CCN2
-
OriGene qPCR primer pairs and template standards for CCN2
- genomics-online: primer clones - Search for available CTGF Primer products
- Overview of 124 available CTGF gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCN2 Gene
Orthologs for CCN2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CTGF 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTGF 31 |
|
OneToOne | |
| LOC476202 30 |
|
||||
| cow (Bos Taurus) |
Mammalia | CTGF 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ctgf 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Ctgf 31 30 |
|
OneToOne | |
| Ccn2 17 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | CTGF 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CTGF 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CTGF 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CTGF 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ctgf 30 |
|
||
| Str.15550 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398003 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ctgfa 31 30 |
|
OneToOne | |
| hmzeh1559 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13898 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CCN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CCN2 Gene
- ENSEMBL:
- Gene Tree for CCN2 (if available)
- TreeFam:
- Gene Tree for CCN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCN2: view image
Paralogs for CCN2 Gene
Variants for CCN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs7451102 | - | p.His83Asp |
Residual Variation Intolerance Score:
45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCN2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN2 Gene
Disorders for CCN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal fibrosis |
|
|
| systemic scleroderma |
|
|
| limited scleroderma |
|
|
| diffuse cutaneous systemic sclerosis |
|
|
| gingival overgrowth |
|
Search CCN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCN2
No data available for UniProtKB/Swiss-Prot and Genatlas for CCN2 Gene
Publications for CCN2 Gene
- Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PMID: 17602195) Gauer S … Goppelt-Struebe M (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007) 3 23 26 54
- The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PMID: 12553878) Ball DK … Brigstock DR (The Journal of endocrinology 2003) 3 4 23 54
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PMID: 1654338) Bradham DM … Grotendorst GR (The Journal of cell biology 1991) 2 3 4 54
- Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. (PMID: 20032117) Kroening S … Goppelt-Struebe M (American journal of physiology. Renal physiology 2010) 3 23 54
- FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. (PMID: 20018872) Samarin J … Goppelt-Struebe M (The Journal of biological chemistry 2010) 3 23 54
ExternalLinks
Products for CCN2 Gene
- View all 7 R&D Systems CCN2 (CTGF/CCN2) Products
- View all R&D Systems CCN2 (CTGF/CCN2) Proteins and Enzymes
- View all 5 R&D Systems CCN2 (CTGF/CCN2) Primary Antibodies
- View all R&D Systems CCN2 (CTGF/CCN2) ELISAs
- Learn more about R&D Systems custom CCN2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCN2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- OriGene qPCR primer pairs for CCN2
- OriGene qPCR primer pairs and template standards for CCN2
- OriGene CRISPR knockouts for CCN2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCN2
- Sino Biological Human cDNA Clone for CCN2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCN2
- Novus Biologicals proteins and lysates for CCN2
- Novus Biologicals ELISA Kits for CCN2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCN2
- Abcam proteins for CCN2
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
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- ProSpec Recombinant Proteins for CCN2
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CTGF)
- Addgene plasmids for CCN2
- antibodies-online: Show 77 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
- Recommended
- 72 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 204 WB Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 106 available CTGF Elisa Kits ranked by validation data
- Compare Top CTGF Elisa Kits
- Quality Products:
- ABIN6730903
- ABIN6720478
- ABIN415039
- ABIN1114355
- ABIN365076
- ABIN2472068
- ABIN1081336
- ABIN1028444
- ABIN924759
- ABIN454827
- ABIN1114357
- ABIN415622
- ABIN367659
- ABIN1569230
- ABIN5520367
- ABIN454828
- ABIN5669765
- ABIN1081337
- ABIN627668
- ABIN5591947
- ABIN1114356
- ABIN416372
- ABIN368064
- ABIN1081338
- ABIN5520369
- ABIN5670431
- ABIN1569232
- ABIN626847
- ABIN5591948
- ABIN5653299
- ABIN2851082
- ABIN990454
- ABIN4968415
- ABIN1127701
- antibodies-online: Show 70 available CTGF Proteins ranked by validation data
- Compare Top CTGF Proteins
- Custom Antibody ServicesProSci Antibodies for CCN2
- Horizon Cell Lines for CCN2
- genomics-online: cdna clones - Search for available CTGF CDNA products
- Overview of 124 available CTGF gene related products
- orf clones - Search for available CTGF ORF products
- Overview of 124 available CTGF gene related products
- genomics-online: gRNA clones - Search for available CTGF gRNA products
- Overview of 124 available CTGF gene related products
- genomics-online: primer clones - Search for available CTGF Primer products
- Overview of 124 available CTGF gene related products
- genomics-online: shRNA clones - Search for available CTGF shRNA products
- Overview of 124 available CTGF gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
- Boster Bio Antibodies for CCN2
- Browse Boster Bio ELISA Kits
Sources for CCN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource