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The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
CCN2 (Cellular Communication Network Factor 2) is a Protein Coding gene. Diseases associated with CCN2 include Renal Fibrosis and Systemic Scleroderma. Among its related pathways are NF-KappaB Family Pathway and amb2 Integrin signaling. An important paralog of this gene is CCN3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J131946 | Promoter/Enhancer | 2.5 | VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +0.3 | 304 | 10.9 | HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 REST TFE3 | ENSG00000227220 CCN2 MED23 SNORA33 LINC01013 lnc-ENPP1-5 ENPP1 | |
GH06J131976 | Enhancer | 1.1 | Ensembl ENCODE | 12 | -25.6 | -25563 | 0.7 | GATAD2A TFE3 SOX13 NFKBIZ RCOR2 RXRB IRF2 CEBPA KMT2B ETS1 | CCN2 ENSG00000227220 LINC01013 piR-30853-065 MOXD1 | |
GH06J132146 | Enhancer | 1 | FANTOM5 Ensembl ENCODE dbSUPER | 3.8 | -196.4 | -196408 | 2 | ATF7 JUND ATF2 | CCN2 TAAR2 lnc-MOXD1-1 LINC01013 lnc-ENPP1-7 MOXD1 | |
GH06J131987 | Enhancer | 0.2 | Ensembl | 12.4 | -36.3 | -36329 | 0.2 | ENSG00000227220 CCN2 piR-30853-065 MOXD1 | ||
GH06J131988 | Enhancer | 0.2 | Ensembl | 12.4 | -38.2 | -38229 | 1.6 | ENSG00000227220 CCN2 LINC01013 piR-30853-065 MOXD1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001968 | fibronectin binding | IEA | -- |
GO:0005178 | integrin binding | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16457822 |
GO:0005520 | insulin-like growth factor binding | TAS,IEA | -- |
GO:0008022 | protein C-terminus binding | IPI | 9927660 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0005801 | cis-Golgi network | IEA | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0005886 | plasma membrane | TAS | 10809757 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001502 | cartilage condensation | IEA | -- |
GO:0001503 | ossification | IEA | -- |
GO:0001525 | angiogenesis | IEA | -- |
GO:0001894 | tissue homeostasis | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CTGF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CTGF 31 |
|
OneToOne | |
LOC476202 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | CTGF 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ctgf 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ctgf 30 31 |
|
OneToOne | |
Ccn2 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | CTGF 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CTGF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CTGF 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CTGF 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ctgf 30 |
|
||
Str.15550 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398003 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ctgfa 30 31 |
|
OneToOne | |
hmzeh1559 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13898 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727929 | Likely Benign: not provided | 131,950,057(-) | C/T | MISSENSE_VARIANT | |
733256 | Likely Benign: not provided | 131,949,399(-) | G/A | SYNONYMOUS_VARIANT | |
741982 | Likely Benign: not provided | 131,950,529(-) | G/A | MISSENSE_VARIANT | |
756064 | Likely Benign: not provided | 131,950,012(-) | T/A | SYNONYMOUS_VARIANT | |
770730 | Benign: not provided | 131,950,549(-) | G/A | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
renal fibrosis |
|
|
systemic scleroderma |
|
|
limited scleroderma |
|
|
diffuse cutaneous systemic sclerosis |
|
|
gingival overgrowth |
|