Aliases for CCN2 Gene
Aliases for CCN2 Gene
External Ids for CCN2 Gene
- HGNC: 2500
- Entrez Gene: 1490
- Ensembl: ENSG00000118523
- OMIM: 121009
- UniProtKB: P29279
Previous HGNC Symbols for CCN2 Gene
- CTGF
Summaries for CCN2 Gene
-
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
GeneCards Summary for CCN2 Gene
CCN2 (Cellular Communication Network Factor 2) is a Protein Coding gene. Diseases associated with CCN2 include Limited Scleroderma and Systemic Scleroderma. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is CCN3.
UniProtKB/Swiss-Prot for CCN2 Gene
-
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Additional gene information for CCN2 Gene
- Monarch Initiative
- Search for CCN2 at DataMed
- Search for CCN2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCN2 Gene
Genomics for CCN2 Gene
GeneHancer (GH) Regulatory Elements for CCN2 Gene
Promoters and enhancers for CCN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCN2 on UCSC Golden Path with GeneCards custom track
Genomic Locations for CCN2 Gene
Genomic Locations for CCN2 Gene
- chr6:131,948,176-131,951,378
- (GRCh38/hg38)
- Size:
- 3,203 bases
- Orientation:
- Minus strand
- chr6:132,269,316-132,272,518
- (GRCh37/hg19)
- Size:
- 3,203 bases
- Orientation:
- Minus strand
Genomic View for CCN2 Gene
Genes around CCN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q23.2 by HGNC
- 6q23.2 by Entrez Gene
- 6q23.2 by Ensembl
CCN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCN2 Gene
Proteins for CCN2 Gene
-
Protein details for CCN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29279-CTGF_HUMAN
- Recommended name:
- Connective tissue growth factor
- Protein Accession:
- P29279
- E1P578
- Q6LCY0
- Q96A79
- Q96QX2
- Q9UDL6
Protein attributes for CCN2 Gene
- Size:
- 349 amino acids
- Molecular mass:
- 38091 Da
- Quaternary structure:
-
- Monomer.
Post-translational modifications for CCN2 Gene
Other Protein References for CCN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents CTGF Antibody
- Atlas Antibodies Anti-CTGF Antibody (HPA031075) and Anti-CTGF Antibody (AMAb91366)
- Novus Biologicals Antibodies for CCN2
-
Abcam antibodies for CCN2
- Invitrogen Antibodies for CCN2 (AFLGC-CTGF)
- antibodies-online: Search results for 255 available CTGF Antibodies ranked by validation data
- Compare Top CTGF Antibodies
-
Recommended
- 56 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 164 WB Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for CCN2
-
Custom Antibody ServicesProSci Antibodies for CCN2
Protein Products
- RayBiotech Recombinant Human CTGF
- Atlas Antibodies PrEST Antigen CTGF
-
OriGene Purified Proteins for CCN2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN2
- Origene Custom Protein Services for CCN2
- ProSpec Recombinant Proteins for CCN2
-
Abcam proteins for CCN2
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CCN2
- Novus Biologicals ELISA Kits for CCN2
- antibodies-online: Search results for 87 available CTGF Elisa Kits ranked by validation data
- Compare Top CTGF Elisa Kits
-
Recommended
- 4 Chicken ELISA Kits
- 4 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 3 Goat ELISA Kits
- 2 Guinea Pig ELISA Kits
- 19 Human ELISA Kits
- 2 Monkey ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 9 Pig (Porcine) ELISA Kits
- 11 Rabbit ELISA Kits
- 15 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 3 Wild boar (Sus scrofa) ELISA Kits
No data available for DME Specific Peptides for CCN2 Gene
Domains & Families for CCN2 Gene
Gene Families for CCN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CCN2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCN2 Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like growth factor-binding protein 8 (CTGF_HUMAN)
- cDNA FLJ77666, highly similar to Homo sapiens connective tissue growth factor (CTGF), mRNA (Q5M8T4_HUMAN)
- CTGF protein (Q6FHL8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29279- Family:
-
- Belongs to the CCN family.
Function for CCN2 Gene
Molecular function for CCN2 Gene
- UniProtKB/Swiss-Prot Function:
- Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Phenotypes From GWAS Catalog for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA | -- |
| GO:0005178 | integrin binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 16457822 |
| GO:0005520 | insulin-like growth factor binding | IEA,TAS | -- |
| GO:0008022 | protein C-terminus binding | IPI | 9927660 |
Phenotypes for CCN2 Gene
- MGI mutant phenotypes for CCN2:
-
inferred from 7 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CCN2:
-
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for CCN2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCN2
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Now 50% OFF >
- * CCN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- genomics-online: gRNA clones - Search results for 112 available CTGF gene related products
- Overview of 112 available CTGF gene related products
miRNA for CCN2 Gene
- miRTarBase miRNAs that target CCN2
-
- hsa-mir-124-3p (MIRT002604)
- hsa-mir-18a-5p (MIRT004174)
- hsa-mir-26a-5p (MIRT004338)
- hsa-mir-205-5p (MIRT006936)
- hsa-mir-145-5p (MIRT007247)
- hsa-mir-375 (MIRT019692)
- hsa-mir-18b-5p (MIRT053207)
- hsa-mir-133b (MIRT438303)
- hsa-mir-1277-5p (MIRT538277)
- hsa-mir-190a-3p (MIRT538278)
- hsa-mir-493-5p (MIRT538279)
- hsa-mir-4789-5p (MIRT538280)
- hsa-mir-3941 (MIRT538281)
- hsa-mir-5011-5p (MIRT538282)
- hsa-mir-577 (MIRT538283)
- hsa-mir-5580-3p (MIRT538284)
- hsa-mir-603 (MIRT538285)
- hsa-mir-362-3p (MIRT538286)
- hsa-mir-329-3p (MIRT538287)
- hsa-mir-8485 (MIRT538288)
- hsa-mir-195-3p (MIRT610644)
- hsa-mir-16-2-3p (MIRT610645)
- hsa-mir-4699-3p (MIRT610646)
- hsa-mir-338-5p (MIRT610647)
- hsa-mir-143-3p (MIRT731589)
- hsa-mir-26b-5p (MIRT731945)
- hsa-mir-133a-3p (MIRT732490)
- hsa-mir-199a-5p (MIRT732585)
- hsa-mir-483-3p (MIRT734856)
- hsa-mir-30c-5p (MIRT735520)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
- genomics-online: shRNA clones - Search results for 112 available CTGF gene related products
- Overview of 112 available CTGF gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CCN2 - Now 50% OFF >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG226802
- MR226802
- MR226802L1
- MR226802L1V
- MR226802L2
- MR226802L2V
- MR226802L3
- MR226802L3V
- MR226802L4
- MR226802L4V
- RC210336
- RC210336L1
- RC210336L1V
- RC210336L2
- RC210336L2V
- RC210336L3
- RC210336L3V
- RC210336L4
- RC210336L4V
- RG210336
- RR204597
- RR204597L1
- RR204597L1V
- RR204597L2
- RR204597L2V
- RR204597L3
- RR204597L3V
- RR204597L4
- RR204597L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN2
-
Horizon Cell Lines for CCN2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCN2 Gene
Localization for CCN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCN2 Gene
- Secreted, extracellular space, extracellular matrix. Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| cytosol | 3 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005801 | cis-Golgi network | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005886 | plasma membrane | TAS | 10809757 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCN2 Gene
Pathways & Interactions for CCN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for CCN2 Gene
4 BioSystems pathways for CCN2 Gene
8 Reactome pathways for CCN2 Gene
2 KEGG pathways for CCN2 Gene
54 Qiagen pathways for CCN2 Gene
2 Cell Signaling Technology pathways for CCN2 Gene
Interacting Proteins for CCN2 Gene
Selected Interacting proteins:
P29279-CTGF_HUMAN
ENSP00000356954
for CCN2 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for CCN2
SIGNOR curated interactions for CCN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001502 | cartilage condensation | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001894 | tissue homeostasis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Drugs & Compounds for CCN2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CCN2 Gene
mRNA/cDNA for CCN2 Gene
- (1) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (962) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367976 2338 bps (ENST00000367976.3)
Unigene Clusters for CCN2 Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCN2 - Now 50% OFF >
- * CCN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CCN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN2
- genomics-online: gRNA clones - Search results for 112 available CTGF gene related products
- Overview of 112 available CTGF gene related products
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CCN2
- Browse OriGene Inhibitory RNA Products For CCN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN2
- genomics-online: shRNA clones - Search results for 112 available CTGF gene related products
- Overview of 112 available CTGF gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CCN2 - Now 50% OFF >
- * CCN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CCN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG226802
- MR226802
- MR226802L1
- MR226802L1V
- MR226802L2
- MR226802L2V
- MR226802L3
- MR226802L3V
- MR226802L4
- MR226802L4V
- RC210336
- RC210336L1
- RC210336L1V
- RC210336L2
- RC210336L2V
- RC210336L3
- RC210336L3V
- RC210336L4
- RC210336L4V
- RG210336
- RR204597
- RR204597L1
- RR204597L1V
- RR204597L2
- RR204597L2V
- RR204597L3
- RR204597L3V
- RR204597L4
- RR204597L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCN2
- Addgene plasmids for CCN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN2
Expression for CCN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Endochondral Preosteoblasts Stylopod Perichondrium
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Chondrocytes Vertebrae
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
-
Lung (Respiratory System)
- Chondrocytes Tracheal Cartilage
- Tracheal Cartilage
- Trachea
-
Tooth (Integumentary System)
- Secondary Enamel Knot Cells Enamel Knot
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Heart (Cardiovascular System)
- Limb (Muscoskeletal System)
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Brain (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Epiblast (Early Embryonic Tissues)
NURSA nuclear receptor signaling pathways regulating expression of CCN2 Gene:
CCN2SOURCE GeneReport for Unigene cluster for CCN2 Gene:
Hs.410037mRNA Expression by UniProt/SwissProt for CCN2 Gene:
P29279-CTGF_HUMAN
Tissue specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Evidence on tissue expression from TISSUES for CCN2 Gene
- Heart(4.7)
- Kidney(4.7)
- Liver(4.6)
- Bone(4.5)
- Nervous system(4.5)
- Skin(4.4)
- Lung(4.2)
- Eye(4)
- Pancreas(3.8)
- Intestine(3.7)
- Muscle(3.6)
- Stomach(3.5)
- Blood(2.7)
- Spleen(2.6)
- Gall bladder(2.4)
- Thyroid gland(2.2)
- Lymph node(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- salivary gland
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- esophagus
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CCN2
-
OriGene qPCR primer pairs and template standards for CCN2
- genomics-online: primer clones - Search results for 112 available CTGF gene related products
- Overview of 112 available CTGF gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCN2 Gene
Orthologs for CCN2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CTGF 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTGF 35 |
|
OneToOne | |
| LOC476202 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | CTGF 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ctgf 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ctgf 35 34 |
|
OneToOne | |
| Ccn2 17 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | CTGF 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CTGF 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CTGF 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CTGF 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ctgf 34 |
|
||
| Str.15550 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398003 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ctgfa 35 34 |
|
OneToOne | |
| hmzeh1559 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13898 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for CCN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CCN2 Gene
- ENSEMBL:
- Gene Tree for CCN2 (if available)
- TreeFam:
- Gene Tree for CCN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCN2: view image
Paralogs for CCN2 Gene
Variants for CCN2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000198671 | -- | 131,951,420(-) | C/T | upstream_transcript_variant | |
| rs1000248948 | -- | 131,950,303(-) | G/A | coding_sequence_variant, missense_variant | |
| rs1000250802 | -- | 131,951,821(-) | C/A/G | upstream_transcript_variant | |
| rs1000584692 | -- | 131,951,347(-) | C/T | 5_prime_UTR_variant | |
| rs1000734182 | -- | 131,950,891(-) | G/A | coding_sequence_variant, synonymous_variant |
Residual Variation Intolerance Score:
45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCN2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN2 Gene
Disorders for CCN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| limited scleroderma |
|
|
| systemic scleroderma |
|
|
| diffuse cutaneous systemic sclerosis |
|
|
| renal fibrosis |
|
|
| pulmonary fibrosis |
|
Search CCN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCN2
No data available for UniProtKB/Swiss-Prot and Genatlas for CCN2 Gene
Publications for CCN2 Gene
- Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PMID: 17602195) Gauer S … Goppelt-Struebe M (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007) 3 23 26 58
- The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PMID: 12553878) Ball DK … Brigstock DR (The Journal of endocrinology 2003) 3 4 23 58
- Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PMID: 1654338) Bradham DM … Grotendorst GR (The Journal of cell biology 1991) 2 3 4 58
- Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. (PMID: 20032117) Kroening S … Goppelt-Struebe M (American journal of physiology. Renal physiology 2010) 3 23 58
- FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. (PMID: 20018872) Samarin J … Goppelt-Struebe M (The Journal of biological chemistry 2010) 3 23 58
ExternalLinks
Products for CCN2 Gene
- View all 7 R&D Systems CCN2 (CTGF/CCN2) Products
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- View all 5 R&D Systems CCN2 (CTGF/CCN2) Primary Antibodies
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- antibodies-online: Search results for 255 available CTGF Antibodies ranked by validation data
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Sources for CCN2 Gene
- (1) GeneCards
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