Aliases for CCN1 Gene
External Ids for CCN1 Gene
Previous HGNC Symbols for CCN1 Gene
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
GeneCards Summary for CCN1 Gene
CCN1 (Cellular Communication Network Factor 1) is a Protein Coding gene. Diseases associated with CCN1 include Wilms Tumor 1 and Endometriosis. Among its related pathways are RhoA signaling pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). An important paralog of this gene is CCN2.
UniProtKB/Swiss-Prot Summary for CCN1 Gene
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.