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The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] See more...
Aliases for CCN1 Gene
Aliases for CCN1 Gene
External Ids for CCN1 Gene
- HGNC: 2654
- NCBI Entrez Gene: 3491
- Ensembl: ENSG00000142871
- OMIM®: 602369
- UniProtKB/Swiss-Prot: O00622
Previous HGNC Symbols for CCN1 Gene
- IGFBP10
- CYR61
Summaries for CCN1 Gene
-
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
GeneCards Summary for CCN1 Gene
CCN1 (Cellular Communication Network Factor 1) is a Protein Coding gene. Diseases associated with CCN1 include Wilms Tumor 1 and Endometriosis. Among its related pathways are RhoA signaling pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). An important paralog of this gene is CCN2.
UniProtKB/Swiss-Prot Summary for CCN1 Gene
-
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Additional gene information for CCN1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCN1 Gene
Genomics for CCN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCN1
Genomic Locations for CCN1 Gene
Latest Assembly
- chr1:85,580,761-85,584,589
- (GRCh38/hg38)
- Size:
- 3,829 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:86,046,444-86,049,633
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,190 bases
- Orientation:
- Plus strand
Genomic View for CCN1 Gene
Genes around CCN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by HGNC
- 1p22.3 by Entrez Gene
- 1p22.3 by Ensembl
CCN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCN1 Gene
Proteins for CCN1 Gene
-
Protein details for CCN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00622-CCN1_HUMAN
- Recommended name:
- CCN family member 1
- Protein Accession:
- O00622
- O14934
- O43775
- Q9BZL7
Protein attributes for CCN1 Gene
- Size:
- 381 amino acids
- Molecular mass:
- 42027 Da
- Quaternary structure:
-
- Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.
Post-translational modifications for CCN1 Gene
Other Protein References for CCN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CYR61 Antibody (LS-B8746) and CYR61 Antibody (LS-B13180)
- G Biosciences Immunotag™ CYR61 Antibody
- GeneTex Anti-CYR61 antibody [N1C3] and Anti-CYR61 antibody
-
Custom Antibody ServicesOriGene Antibodies for CCN1
- Novus Biologicals Antibodies for CCN1
- Invitrogen Antibodies for CCN1 (AFLGC-CCN1)
-
Custom Antibody ServicesProSci Antibodies for CCN1
Protein products for research
- G Biosciences Human Cyr61/CCN1, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN1
- Origene Custom Protein Services for CCN1
- ProSpec Recombinant Proteins for CCN1
-
ProSci Proteins for CCN1
-
Abcam proteins for CCN1
Assay products for research
- RayBiotech Human Cyr61/CCN1 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for CCN1
-
Boster Bio ELISA Kits for CCN1
-
Abcam assays for CCN1
No data available for DME Specific Peptides for CCN1 Gene
Domains & Families for CCN1 Gene
Gene Families for CCN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for CCN1 Gene
- InterPro:
- Blocks:
-
- Thrombospondin, type I
- von Willebrand factor, type C
- Insulin-like growth factor-binding protein, IGFBP
- Cystine knot, C-terminal
- Cystine knot domain
Suggested Antigen Peptide Sequences for CCN1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58182, highly similar to Protein CYR61 (B4DI61_HUMAN)
- Protein GIG1 (CYR61_HUMAN)
- cDNA, FLJ95400, highly similar to Homo sapiens cysteine-rich, angiogenic inducer, 61 (CYR61), mRNA (Q6FI18_HUMAN)
- CYR61 protein (Q9UID7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00622- Family:
-
- Belongs to the CCN family.
Function for CCN1 Gene
Molecular function for CCN1 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Phenotypes From GWAS Catalog for CCN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005178 | integrin binding | IEA,IBA | 21873635 |
| GO:0005201 | extracellular matrix structural constituent | RCA | 28327460 |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0005520 | insulin-like growth factor binding | IEA | -- |
Phenotypes for CCN1 Gene
- MGI mutant phenotypes for CCN1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CCN1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Decreased shRNA abundance
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased cell number and increased metaphase cell number
- Decreased viability with paclitaxel
Animal Models for CCN1 Gene
- MGI Knock Outs for CCN1:
-
- Ccn1 Ccn1<tm1Lfl>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCN1 - Starting at $85 >
- * CCN1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN1
miRNA for CCN1 Gene
- miRTarBase miRNAs that target CCN1
-
- hsa-miR-30a-3p (MIRT001764)
- hsa-miR-155-5p (MIRT005484)
- hsa-miR-205-5p (MIRT006935)
- hsa-miR-124-3p (MIRT023099)
- hsa-miR-26b-5p (MIRT030115)
- hsa-miR-22-3p (MIRT054848)
- hsa-miR-622 (MIRT080736)
- hsa-miR-634 (MIRT437968)
- hsa-miR-100-5p (MIRT438171)
- hsa-miR-4652-3p (MIRT538202)
- hsa-miR-6516-5p (MIRT538203)
- hsa-miR-4743-3p (MIRT538204)
- hsa-miR-1303 (MIRT538205)
- hsa-miR-455-3p (MIRT538206)
- hsa-miR-302a-5p (MIRT538207)
- hsa-miR-29a-5p (MIRT538208)
- hsa-miR-3622b-3p (MIRT538209)
- hsa-miR-3622a-3p (MIRT538210)
- hsa-miR-5586-3p (MIRT538211)
- hsa-miR-3591-5p (MIRT538212)
- hsa-miR-3912-5p (MIRT538213)
- hsa-miR-647 (MIRT538214)
- hsa-miR-519e-5p (MIRT538215)
- hsa-miR-515-5p (MIRT538216)
- hsa-miR-142-3p (MIRT538217)
- hsa-miR-630 (MIRT538218)
- hsa-miR-6762-3p (MIRT538219)
- hsa-miR-604 (MIRT538220)
- hsa-miR-20a-3p (MIRT538221)
- hsa-miR-5695 (MIRT538222)
- hsa-miR-1204 (MIRT538223)
- hsa-miR-3973 (MIRT538224)
- hsa-miR-548l (MIRT538225)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN1
- Browse OriGene Inhibitory RNA Products For CCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN1
Clone products for research
- Applied Biological Materials (abm): Clones for CCN1 - Starting at $45 >
- * CCN1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN1
Cell Lines for research
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN1
-
Horizon Cell Lines for CCN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCN1 Gene
Localization for CCN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCN1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0031012 | extracellular matrix | IBA | 21873635 |
| GO:0062023 | collagen-containing extracellular matrix | HDA | 23658023 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCN1 Gene
Pathways & Interactions for CCN1 Gene
Pathways by source for CCN1 Gene
1 Cell Signaling Technology pathway for CCN1 Gene
Interacting Proteins for CCN1 Gene
Selected Interacting proteins:
O00622-CCN1_HUMAN
ENSP00000398736
for CCN1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CCN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 20675382 |
| GO:0002041 | intussusceptive angiogenesis | IEA | -- |
| GO:0003181 | atrioventricular valve morphogenesis | IEA | -- |
| GO:0003278 | apoptotic process involved in heart morphogenesis | IEA | -- |
No data available for SIGNOR curated interactions for CCN1 Gene
Drugs & Compounds for CCN1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Cyr61/CCN1, Lyophilized
Transcripts for CCN1 Gene
mRNA/cDNA for CCN1 Gene
- 1 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000451137 2278 nts (view in UCSC)
- ENST00000480413 551 nts (view in UCSC)
- ENST00000674743 2446 nts (view in UCSC)
- ENST00000674818 3080 nts (view in UCSC)
- ENST00000675083 1868 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCN1 - Starting at $85 >
- * CCN1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN1
- Browse OriGene Inhibitory RNA Products For CCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN1
Clone products for research
- Applied Biological Materials (abm): Clones for CCN1 - Starting at $45 >
- * CCN1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN1
Relevant External Links for CCN1 Gene
- GeneLoc Exon Structure for
- CCN1
Expression for CCN1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCN1
SOURCE GeneReport for Unigene cluster for CCN1 Gene:
Hs.8867Evidence on tissue expression from TISSUES for CCN1 Gene
- Skin(4.8)
- Lung(4.7)
- Nervous system(4.5)
- Liver(3.8)
- Kidney(3.6)
- Heart(3.4)
- Bone(3.3)
- Muscle(3.2)
- Pancreas(3.2)
- Intestine(3.2)
- Spleen(2.9)
- Lymph node(2.9)
- Thyroid gland(2.8)
- Stomach(2.6)
- Adrenal gland(2.5)
- Eye(2.4)
- Gall bladder(2.4)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for CCN1
-
OriGene qPCR primer pairs and template standards for CCN1
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN1 Gene
Orthologs for CCN1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CYR61 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CYR61 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CYR61 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cyr61 29 30 |
|
OneToOne | |
| Ccn1 16 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Cyr61 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CYR61 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CYR61 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CYR61 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CYR61 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cyr61 29 |
|
||
| Str.9694 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64237 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:85866 29 |
|
||
| cyr61 30 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ccn 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany |
- Species where no ortholog for CCN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CCN1 Gene
- ENSEMBL:
- Gene Tree for CCN1 (if available)
- TreeFam:
- Gene Tree for CCN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCN1: view image
- Alliance of Genome Resources:
- Additional Orthologs for CCN1
Paralogs for CCN1 Gene
Variants for CCN1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCN1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140020167 | Benign: not provided | 85,582,796(+) |
C/T NM_001554.5(CCN1):c.900C>T (p.Tyr300=) |
SYNONYMOUS | |
| rs148330006 | Likely Benign: not provided | 85,582,843(+) |
C/G NM_001554.5(CCN1):c.947C>G (p.Ser316Cys) |
MISSENSE | |
| rs9658587 | -- |
p.Arg334Trp |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.21;
24.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCN1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN1 Gene
Disorders for CCN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wilms tumor 1 |
|
|
| endometriosis |
|
|
| progressive pseudorheumatoid dysplasia |
|
|
| endometrial cancer |
|
|
| rhabdomyosarcoma |
|
|
Search CCN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCN1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCN1 Gene
Publications for CCN1 Gene
- The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. (PMID: 9135077) Jay P … Berta P (Oncogene 1997) 2 3 4 22
- Organization and expression of the Cyr61 gene in normal human fibroblasts. (PMID: 11810026) Leng E … Sadowski I (Journal of biomedical science 2002) 3 4 22
- CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. (PMID: 11287419) Grzeszkiewicz TM … Lau LF (The Journal of biological chemistry 2001) 3 4 22
- The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. (PMID: 11584015) Chen CC … Lau LF (The Journal of biological chemistry 2001) 3 4 22
- Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. (PMID: 10852911) Albrecht C … Nitsch RM (The Journal of biological chemistry 2000) 3 4 22
ExternalLinks
Products for CCN1 Gene
- View all 11 R&D Systems CCN1 (Cyr61/CCN1) Products
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- Learn more about R&D Systems custom CCN1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCN1
- Custom Assay ServicesOriGene ELISA Kits for CCN1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCN1
- Origene Custom Protein Services for CCN1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCN1
- Browse OriGene Inhibitory RNA Products For CCN1
- OriGene qPCR primer pairs for CCN1
- OriGene qPCR primer pairs and template standards for CCN1
- OriGene CRISPR knockouts for CCN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCN1
- Sino Biological Human cDNA Clone for CCN1
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCN1
- Novus Biologicals proteins and lysates for CCN1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for CCN1
- Abcam assays for CCN1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CCN1
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for CCN1
- Invitrogen Antibodies for CCN1 (AFLGC-CCN1)
- VectorBuilder Custom and pre-made DNA vectors for CCN1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCN1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCN1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCN1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCN1
- antibodies-online: Show 34 available CYR61 Antibodies ranked by validation data
- Compare Top CYR61 Antibodies
- antibodies-online: Show 33 available CYR61 Elisa Kits ranked by validation data
- Compare Top CYR61 Elisa Kits
- antibodies-online: Show 21 available CYR61 Proteins ranked by validation data
- Compare Top CYR61 Proteins
- Custom Antibody ServicesProSci Antibodies for CCN1
- ProSci Proteins for CCN1
- Horizon Cell Lines for CCN1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCN1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCN1
Sources for CCN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
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