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Aliases for CCN1 Gene

Aliases for CCN1 Gene

  • Cellular Communication Network Factor 1 2 3 5
  • Insulin-Like Growth Factor-Binding Protein 10 3 4
  • Cysteine Rich Angiogenic Inducer 61 2 3
  • IGF-Binding Protein 10 3 4
  • CCN Family Member 1 3 4
  • Protein CYR61 3 4
  • IGFBP-10 3 4
  • IGFBP10 3 4
  • IBP-10 3 4
  • GIG1 3 4
  • Cysteine-Rich Heparin-Binding Protein 61 3
  • Cysteine-Rich, Anigogenic Inducer, 61 3
  • Cysteine-Rich Angiogenic Inducer 61 4
  • Protein GIG1 4
  • CYR61 3

External Ids for CCN1 Gene

Previous HGNC Symbols for CCN1 Gene

  • IGFBP10
  • CYR61

Summaries for CCN1 Gene

Entrez Gene Summary for CCN1 Gene

  • The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

GeneCards Summary for CCN1 Gene

CCN1 (Cellular Communication Network Factor 1) is a Protein Coding gene. Diseases associated with CCN1 include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Wilms Tumor 5. Among its related pathways are amb2 Integrin signaling and Hypertrophy Model. An important paralog of this gene is CCN2.

UniProtKB/Swiss-Prot for CCN1 Gene

  • Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Wiki entry for CCN1 Gene

Additional gene information for CCN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCN1 Gene

Genomics for CCN1 Gene

GeneHancer (GH) Regulatory Elements for CCN1 Gene

Promoters and enhancers for CCN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J085575 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 +0.0 40 11.4 ZNF473 HDGF SP1 ZFX MNT ZNF148 POLR2A ZNF121 CEBPG GTF2F1 CCN1 DDAH1 ZNHIT6 ODF2L C1orf52 BCL10 ENSG00000272691 GC01P085583 ENSG00000282057
GH01J085604 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 17.7 +28.8 28792 10 SP1 ELF3 CTCF TFE3 ELF1 SP7 HNF1A KLF14 PRDM1 GLIS2 CCN1 ZNHIT6 DDAH1 ODF2L ENSG00000230285 GC01P085628
GH01J085520 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -56.6 -56603 7.7 ZNF473 HDGF SP1 ZNF121 CEBPG NFIB ZSCAN21 SP7 ZNF174 PRDM1 ZNHIT6 CCN1 DDAH1 C1orf52 ENSG00000282057 ENSG00000273264
GH01J085459 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.2 -117.9 -117926 7.3 ZNF121 CEBPG ZSCAN21 ZNF24 YY1 SP7 SP1 HNF1A PPARG PRDM1 DDAH1 ODF2L CCN1 ENSG00000273264 GC01M085455
GH01J085706 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +127.1 127148 3.4 HDGF ZFX ELF3 MNT NKRF POLR2A MLLT1 GTF2F1 CSDE1 ZNF687 ZNHIT6 ODF2L DDAH1 CCN1 PIR53460
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCN1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCN1 Gene

Genomic Locations for CCN1 Gene
chr1:85,580,761-85,583,967
(GRCh38/hg38)
Size:
3,207 bases
Orientation:
Plus strand
chr1:86,046,444-86,049,650
(GRCh37/hg19)
Size:
3,207 bases
Orientation:
Plus strand

Genomic View for CCN1 Gene

Genes around CCN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCN1 Gene

Proteins for CCN1 Gene

  • Protein details for CCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00622-CYR61_HUMAN
    Recommended name:
    Protein CYR61
    Protein Accession:
    O00622
    Secondary Accessions:
    • O14934
    • O43775
    • Q9BZL7

    Protein attributes for CCN1 Gene

    Size:
    381 amino acids
    Molecular mass:
    42027 Da
    Quaternary structure:
    • Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

    Three dimensional structures from OCA and Proteopedia for CCN1 Gene

neXtProt entry for CCN1 Gene

Post-translational modifications for CCN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCN1 Gene

Domains & Families for CCN1 Gene

Gene Families for CCN1 Gene

Suggested Antigen Peptide Sequences for CCN1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58182, highly similar to Protein CYR61 (B4DI61_HUMAN)
  • Protein GIG1 (CYR61_HUMAN)
  • cDNA, FLJ95400, highly similar to Homo sapiens cysteine-rich, angiogenic inducer, 61 (CYR61), mRNA (Q6FI18_HUMAN)
  • CYR61 protein (Q9UID7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00622

UniProtKB/Swiss-Prot:

CYR61_HUMAN :
  • Belongs to the CCN family.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CCN1: view

Function for CCN1 Gene

Molecular function for CCN1 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Phenotypes From GWAS Catalog for CCN1 Gene

Gene Ontology (GO) - Molecular Function for CCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA,IBA 21873635
GO:0005201 extracellular matrix structural constituent RCA 28327460
GO:0005515 protein binding IEA --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA 21873635
genes like me logo Genes that share ontologies with CCN1: view
genes like me logo Genes that share phenotypes with CCN1: view

Animal Models for CCN1 Gene

MGI Knock Outs for CCN1:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCN1 - Now 50% OFF >
  • * CCN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCN1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCN1 Gene

Localization for CCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCN1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCN1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 extracellular matrix IBA 21873635
GO:0062023 collagen-containing extracellular matrix HDA 23658023
genes like me logo Genes that share ontologies with CCN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCN1 Gene

Pathways & Interactions for CCN1 Gene

genes like me logo Genes that share pathways with CCN1: view

Pathways by source for CCN1 Gene

Gene Ontology (GO) - Biological Process for CCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20675382
GO:0002041 intussusceptive angiogenesis IEA --
GO:0003181 atrioventricular valve morphogenesis IEA --
GO:0003278 apoptotic process involved in heart morphogenesis IEA --
genes like me logo Genes that share ontologies with CCN1: view

No data available for SIGNOR curated interactions for CCN1 Gene

Drugs & Compounds for CCN1 Gene

(9) Drugs for CCN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for CCN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCN1: view

Transcripts for CCN1 Gene

mRNA/cDNA for CCN1 Gene

(1) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(608) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CCN1 Gene

Cysteine-rich, angiogenic inducer, 61:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCN1 - Now 50% OFF >
  • * CCN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCN1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCN1 Gene

No ASD Table

Relevant External Links for CCN1 Gene

GeneLoc Exon Structure for
CCN1
ECgene alternative splicing isoforms for
CCN1

Expression for CCN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCN1 Gene:

CCN1

SOURCE GeneReport for Unigene cluster for CCN1 Gene:

Hs.8867

Evidence on tissue expression from TISSUES for CCN1 Gene

  • Lung(4.7)
  • Skin(4.7)
  • Nervous system(4.4)
  • Liver(3.5)
  • Kidney(3.3)
  • Bone(3.2)
  • Heart(3.2)
  • Muscle(3)
  • Intestine(2.5)
  • Lymph node(2.5)
  • Gall bladder(2.4)
  • Pancreas(2.4)
  • Spleen(2.3)
  • Stomach(2.3)
  • Thyroid gland(2.2)
  • Eye(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCN1 Gene

Orthologs for CCN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYR61 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia CYR61 34 35
  • 92.65 (n)
dog
(Canis familiaris)
Mammalia CYR61 34 35
  • 90.55 (n)
mouse
(Mus musculus)
Mammalia Cyr61 34 35
  • 88.95 (n)
Ccn1 17
rat
(Rattus norvegicus)
Mammalia Cyr61 34
  • 88.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYR61 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYR61 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYR61 34 35
  • 78.14 (n)
lizard
(Anolis carolinensis)
Reptilia CYR61 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyr61 34
  • 71.56 (n)
Str.9694 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64237 34
zebrafish
(Danio rerio)
Actinopterygii zgc:85866 34
  • 68.4 (n)
cyr61 35
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ccn 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
Species where no ortholog for CCN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCN1 Gene

ENSEMBL:
Gene Tree for CCN1 (if available)
TreeFam:
Gene Tree for CCN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCN1: view image

Paralogs for CCN1 Gene

Paralogs for CCN1 Gene

genes like me logo Genes that share paralogs with CCN1: view

Variants for CCN1 Gene

Sequence variations from dbSNP and Humsavar for CCN1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000706725 -- 85,579,245(+) G/C upstream_transcript_variant
rs1000846287 -- 85,580,855(+) C/G 5_prime_UTR_variant
rs1001078275 -- 85,579,665(+) G/A/T upstream_transcript_variant
rs1002071007 -- 85,580,184(+) G/C upstream_transcript_variant
rs1002730214 -- 85,582,258(+) A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CCN1 Gene

Variant ID Type Subtype PubMed ID
nsv950203 CNV deletion 24416366

Variation tolerance for CCN1 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCN1 Gene

Disorders for CCN1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthropathy, progressive pseudorheumatoid, of childhood
  • ppac
wilms tumor 5
  • nephroblastoma
rhabdomyosarcoma
melanoma, uveal
  • uveal melanoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CCN1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CCN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCN1 Gene

Publications for CCN1 Gene

  1. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. (PMID: 9135077) Jay P … Berta P (Oncogene 1997) 2 3 4 23 58
  2. Organization and expression of the Cyr61 gene in normal human fibroblasts. (PMID: 11810026) Leng E … Sadowski I (Journal of biomedical science 2002) 3 4 23 58
  3. CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. (PMID: 11287419) Grzeszkiewicz TM … Lau LF (The Journal of biological chemistry 2001) 3 4 23 58
  4. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. (PMID: 11584015) Chen CC … Lau LF (The Journal of biological chemistry 2001) 3 4 23 58
  5. Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. (PMID: 10852911) Albrecht C … Nitsch RM (The Journal of biological chemistry 2000) 3 4 23 58

Products for CCN1 Gene

  • Boster Bio Antibodies for CCN1
  • Boster Bio ELISA Kits for CCN1

Sources for CCN1 Gene

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