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The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
CCN1 (Cellular Communication Network Factor 1) is a Protein Coding gene. Diseases associated with CCN1 include Wilms Tumor 5 and Rhabdomyosarcoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and amb2 Integrin signaling. An important paralog of this gene is CCN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005178 | integrin binding | IEA,IBA | 21873635 |
GO:0005201 | extracellular matrix structural constituent | RCA | 28327460 |
GO:0005515 | protein binding | IEA | -- |
GO:0005520 | insulin-like growth factor binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0031012 | extracellular matrix | IBA | 21873635 |
GO:0062023 | collagen-containing extracellular matrix | HDA | 23658023 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001649 | osteoblast differentiation | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IDA | 20675382 |
GO:0002041 | intussusceptive angiogenesis | IEA | -- |
GO:0003181 | atrioventricular valve morphogenesis | IEA | -- |
GO:0003278 | apoptotic process involved in heart morphogenesis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CYR61 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CYR61 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CYR61 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cyr61 30 31 |
|
OneToOne | |
Ccn1 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Cyr61 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CYR61 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CYR61 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CYR61 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CYR61 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cyr61 30 |
|
||
Str.9694 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC64237 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:85866 30 |
|
||
cyr61 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ccn 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
wilms tumor 5 |
|
|
rhabdomyosarcoma |
|
|
endometriosis |
|
|
endometrial cancer |
|
|
melanoma, uveal |
|