Aliases for CCN1 Gene
External Ids for CCN1 Gene
Previous HGNC Symbols for CCN1 Gene
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
GeneCards Summary for CCN1 Gene
CCN1 (Cellular Communication Network Factor 1) is a Protein Coding gene. Diseases associated with CCN1 include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Wilms Tumor 5. Among its related pathways are amb2 Integrin signaling and Hypertrophy Model. An important paralog of this gene is CCN2.
UniProtKB/Swiss-Prot for CCN1 Gene
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.