CCL7 Gene (Protein Coding)

C-C Motif Chemokine Ligand 7

GC17P034270
GIFtS:
43
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix... See more...

Aliases for CCL7 Gene

Aliases for CCL7 Gene

  • C-C Motif Chemokine Ligand 7 2 3 5
  • Monocyte Chemoattractant Protein 3 2 3 4
  • Monocyte Chemotactic Protein 3 2 3 4
  • Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3) 2 3
  • Chemokine (C-C Motif) Ligand 7 2 3
  • Small-Inducible Cytokine A7 3 4
  • C-C Motif Chemokine 7 3 4
  • SCYA6 3 4
  • SCYA7 3 4
  • MCP-3 3 4
  • MCP3 3 4
  • NC28 3 4
  • MARC 3
  • FIC 3

External Ids for CCL7 Gene

Previous HGNC Symbols for CCL7 Gene

  • SCYA6
  • SCYA7

Previous GeneCards Identifiers for CCL7 Gene

  • GC17P032366
  • GC17P034636
  • GC17P032742
  • GC17P029621
  • GC17P032597
  • GC17P028782

Summaries for CCL7 Gene

Entrez Gene Summary for CCL7 Gene

  • This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL7 Gene

CCL7 (C-C Motif Chemokine Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include Nephrogenic Systemic Fibrosis and Stachybotrys Chartarum. Among its related pathways are p70S6K Signaling and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot Summary for CCL7 Gene

  • Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Gene Wiki entry for CCL7 Gene

Additional gene information for CCL7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL7 Gene

Genomics for CCL7 Gene

GeneHancer (GH) Regulatory Elements for CCL7 Gene

Promoters and enhancers for CCL7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J034270 Promoter/Enhancer 0.6 EPDnew Ensembl 750.6 0.0 -15 1.2 JUN CCL7 NONHSAG021517.2 HSALNG0115862 CCL2
GH17J034245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.9 -17.4 -17350 14.1 SIN3A SMARCE1 MYC ELF1 MAX SP1 ZBTB33 MAFK PRDM1 ZNF639 CCL2 lnc-ASIC2-2 CCL7 CCL11 CCL8 CCL1 ASIC2 HSALNG0115862
GH17J034199 Enhancer 1.3 FANTOM5 Ensembl ENCODE 31.8 -69.1 -69115 3 SP1 CTCF CC2D1A DACH1 RAD21 ELF3 SP7 RELA ARID2 REST lnc-CCL2-13 CCL7 CCL8 CCL2 CCL1 ASIC2 CCL11 LINC01989
GH17J034220 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 36.5 -48.8 -48816 7.2 HLF MAFK CEBPB ZNF316 MAFG MAFF EMSY CCL7 CCL8 ASIC2 CCL2 piR-55948-040 lnc-ASIC2-2
GH17J034241 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 37.1 -27.0 -27027 2.6 IKZF1 IKZF2 DPF2 RUNX3 POLR2A SRF CCL7 CCL8 ASIC2 CCL2 lnc-ASIC2-2 piR-55948-040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL7 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • STAT1

Genomic Locations for CCL7 Gene

Genomic Locations for CCL7 Gene
chr17:34,270,216-34,272,242
(GRCh38/hg38)
Size:
2,027 bases
Orientation:
Plus strand
chr17:32,597,240-32,599,261
(GRCh37/hg19)
Size:
2,022 bases
Orientation:
Plus strand

Genomic View for CCL7 Gene

Genes around CCL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL7 Gene

Proteins for CCL7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80098-CCL7_HUMAN
    Recommended name:
    C-C motif chemokine 7
    Protein Accession:
    P80098
    Secondary Accessions:
    • Q569J6

    Protein attributes for CCL7 Gene

    Size:
    99 amino acids
    Molecular mass:
    11200 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=CAA50405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA50406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51055.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCL7 Gene

neXtProt entry for CCL7 Gene

Protein Expression for CCL7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCL7 Gene

Other Protein References for CCL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CCL7
  • Boster Bio Antibodies for CCL7

Protein Products

  • Abcam proteins for CCL7

No data available for DME Specific Peptides for CCL7 Gene

Domains & Families for CCL7 Gene

Gene Families for CCL7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CCL7 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL7 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A7 (CCL7_HUMAN)
  • Monocyte chemotactic protein-3 (Q7Z7Q8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P80098

UniProtKB/Swiss-Prot:

CCL7_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL7: view

Function for CCL7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CCL7 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Phenotypes From GWAS Catalog for CCL7 Gene

Gene Ontology (GO) - Molecular Function for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IDA,TAS 10072545
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 7545673
genes like me logo Genes that share ontologies with CCL7: view
genes like me logo Genes that share phenotypes with CCL7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL7

CRISPR Products

miRNA for CCL7 Gene

miRTarBase miRNAs that target CCL7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL7 Gene

Localization for CCL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL7 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL7 Gene

Pathways & Interactions for CCL7 Gene

PathCards logo

SuperPathways for CCL7 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
3 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
4 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
5 CCR5 Pathway in Macrophages
Chemokine Signaling
.33
Chemokine signaling pathway
.32
genes like me logo Genes that share pathways with CCL7: view

Pathways by source for CCL7 Gene

1 GeneGo (Thomson Reuters) pathway for CCL7 Gene
28 Qiagen pathways for CCL7 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

SIGNOR curated interactions for CCL7 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 10770925
GO:0006935 chemotaxis TAS 9780207
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL7: view

Drugs & Compounds for CCL7 Gene

Products:

  1. Drug

(15) Drugs for CCL7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bindarit Investigational Pharma 2

(15) Additional Compounds for CCL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CCL7 Gene

Compound Action Cas Number
Bindarit 130641-38-2
genes like me logo Genes that share compounds with CCL7: view

Transcripts for CCL7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCL7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -

Relevant External Links for CCL7 Gene

GeneLoc Exon Structure for
CCL7
ECgene alternative splicing isoforms for
CCL7

Expression for CCL7 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL7 Gene

mRNA expression in normal human tissues for CCL7 Gene
mRNA expression by BioGPS for CCL7 GenemRNA expression by GTEx for CCL7 Gene

mRNA differential expression in normal tissues according to GTEx for CCL7 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.6) and Lung (x4.7).

Protein differential expression in normal tissues from HIPED for CCL7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL7 Gene



Protein tissue co-expression partners for CCL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL7 Gene:

CCL7

SOURCE GeneReport for Unigene cluster for CCL7 Gene:

Hs.251526

Evidence on tissue expression from TISSUES for CCL7 Gene

  • Blood(4.7)
  • Intestine(4.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CCL7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL7 Gene

Orthologs for CCL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCL7 33 32
  • 99.33 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CCL7 33 32
  • 82.83 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ccl7 33
  • 60 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 45 (a)
 ManyToMany
-- 33
  • 41 (a)
 ManyToMany
-- 33
  • 19 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 44 (a)
 ManyToMany
-- 33
  • 44 (a)
 ManyToMany
Species where no ortholog for CCL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL7 Gene

ENSEMBL:
Gene Tree for CCL7 (if available)
TreeFam:
Gene Tree for CCL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL7: view image

Paralogs for CCL7 Gene

Paralogs for CCL7 Gene

(28) SIMAP similar genes for CCL7 Gene using alignment to 3 proteins:

  • CCL7_HUMAN
  • A8MVH1_HUMAN
  • A8MX17_HUMAN
genes like me logo Genes that share paralogs with CCL7: view

Variants for CCL7 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CCL7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000045109 -- 34,269,532(+) T/C upstream_transcript_variant
rs1001040406 -- 34,272,004(+) G/A 3_prime_UTR_variant
rs1001717241 -- 34,268,347(+) T/C upstream_transcript_variant
rs1002017945 -- 34,270,718(+) G/C/T intron_variant
rs1002070512 -- 34,270,959(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL7 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL7 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL7 Gene

Human Gene Mutation Database (HGMD)
CCL7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL7 Gene

Disorders for CCL7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CCL7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nephrogenic systemic fibrosis
  • nephrogenic fibrosing dermopathy
stachybotrys chartarum
  • stachybotrys atra
diffuse gastric cancer
  • signet ring cell carcinoma
status asthmaticus
  • asthma with status asthmaticus
acute contagious conjunctivitis
  • contagious opthalmia
- elite association - COSMIC cancer census association via MalaCards
Search CCL7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL7 Gene

Publications for CCL7 Gene

  1. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PMID: 8461011) Opdenakker G … Van Damme J (Biochemical and biophysical research communications 1993) 2 3 4 23 56
  2. Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. (PMID: 15715950) Park BL … Shin HD (Journal of biochemistry and molecular biology 2005) 3 23 43 56
  3. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PMID: 9109648) Meunier S … Darbon H (Biochemistry 1997) 3 4 23 56
  4. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PMID: 8898111) Kim KS … Sykes BD (FEBS letters 1996) 3 4 23 56
  5. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. (PMID: 7916328) Opdenakker G … Van Damme J (Genomics 1994) 3 4 23 56

ExternalLinks

View latest publications for CCL7 gene in Mastermind

Products for CCL7 Gene

Sources for CCL7 Gene