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This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
CCL7 (C-C Motif Chemokine Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include Nephrogenic Systemic Fibrosis and Stachybotrys Chartarum. Among its related pathways are p70S6K Signaling and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008009 | chemokine activity | IDA,TAS | 10072545 |
GO:0008201 | heparin binding | IEA | -- |
GO:0031726 | CCR1 chemokine receptor binding | IPI | 7545673 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | TAS,IBA | 21873635 |
GO:0005623 | cell | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
5 | CCR5 Pathway in Macrophages |
Chemokine Signaling
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002548 | monocyte chemotaxis | IC | 10660125 |
GO:0006874 | cellular calcium ion homeostasis | TAS | 10770925 |
GO:0006935 | chemotaxis | TAS | 9780207 |
GO:0006954 | inflammatory response | IBA | 21873635 |
GO:0006955 | immune response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bindarit | Investigational | Pharma | 2 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Bindarit | 130641-38-2 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | |||||||||||||
SP3: | - | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CCL7 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CCL7 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Ccl7 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000045109 | -- | 34,269,532(+) | T/C | upstream_transcript_variant | |
rs1001040406 | -- | 34,272,004(+) | G/A | 3_prime_UTR_variant | |
rs1001717241 | -- | 34,268,347(+) | T/C | upstream_transcript_variant | |
rs1002017945 | -- | 34,270,718(+) | G/C/T | intron_variant | |
rs1002070512 | -- | 34,270,959(+) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3141n100 | CNV | gain | 25217958 |
esv3572553 | CNV | gain | 25503493 |
nsv517423 | CNV | gain+loss | 19592680 |
nsv519297 | CNV | gain | 19592680 |
nsv574714 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
nephrogenic systemic fibrosis |
|
|
stachybotrys chartarum |
|
|
diffuse gastric cancer |
|
|
status asthmaticus |
|
|
acute contagious conjunctivitis |
|
|