Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCL7 Gene

Aliases for CCL7 Gene

  • C-C Motif Chemokine Ligand 7 2 3 5
  • Monocyte Chemoattractant Protein 3 2 3 4
  • Monocyte Chemotactic Protein 3 2 3 4
  • Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3) 2 3
  • Chemokine (C-C Motif) Ligand 7 2 3
  • Small-Inducible Cytokine A7 3 4
  • SCYA6 3 4
  • SCYA7 3 4
  • MCP-3 3 4
  • MCP3 3 4
  • NC28 3 4
  • C-C Motif Chemokine 7 3
  • MARC 3
  • FIC 3

External Ids for CCL7 Gene

Previous HGNC Symbols for CCL7 Gene

  • SCYA6
  • SCYA7

Previous GeneCards Identifiers for CCL7 Gene

  • GC17P032366
  • GC17P034636
  • GC17P032742
  • GC17P029621
  • GC17P032597
  • GC17P028782

Summaries for CCL7 Gene

Entrez Gene Summary for CCL7 Gene

  • This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL7 Gene

CCL7 (C-C Motif Chemokine Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include Diffuse Gastric Cancer and Status Asthmaticus. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL7 Gene

  • Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Gene Wiki entry for CCL7 Gene

Additional gene information for CCL7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL7 Gene

Genomics for CCL7 Gene

GeneHancer (GH) Regulatory Elements for CCL7 Gene

Promoters and enhancers for CCL7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J034270 Promoter 0.5 EPDnew 650.7 0.0 -14 0.1 CCL7 CCL2
GH17J034245 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.9 -17.3 -17305 14 PKNOX1 SIN3A ZNF335 GLIS2 EGR1 FOS RUNX3 CREM RXRA ELF1 CCL2 CCL7 CCL11 CCL1 CCL8 ASIC2 GC17M034278
GH17J034237 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 37.1 -29.3 -29331 7.2 SRF CBFA2T3 REST DPF2 NR2F2 JUND POLR2A ZNF512 IKZF1 ZFP36 CCL7 CCL8 CCL1 ASIC2 CCL2 GC17M034278 GC17P034213
GH17J034299 Enhancer 1 FANTOM5 Ensembl ENCODE 36.7 +30.4 30380 2.5 JUND POLR2A JUN EBF1 FOS BATF RUNX3 CCL7 CCL8 CCL1 CCL2 CCL11
GH17J034306 Enhancer 1.1 FANTOM5 Ensembl ENCODE 19.9 +36.9 36894 1.5 CTCF REST EBF1 RAD21 NR2F2 RELA NFIC IKZF1 FOS CCL7 CCL11 CCL1 ASIC2 CCL8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL7 gene promoter:
  • STAT1
  • AP-1
  • c-Fos
  • c-Jun

Genomic Locations for CCL7 Gene

Genomic Locations for CCL7 Gene
2,027 bases
Plus strand
2,022 bases
Plus strand

Genomic View for CCL7 Gene

Genes around CCL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL7 Gene

Proteins for CCL7 Gene

  • Protein details for CCL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C motif chemokine 7
    Protein Accession:
    Secondary Accessions:
    • Q569J6

    Protein attributes for CCL7 Gene

    99 amino acids
    Molecular mass:
    11200 Da
    Quaternary structure:
    • Monomer.
    • Sequence=CAA50405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA50406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51055.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCL7 Gene

neXtProt entry for CCL7 Gene

Post-translational modifications for CCL7 Gene

Other Protein References for CCL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL7 Gene

Domains & Families for CCL7 Gene

Gene Families for CCL7 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CCL7 Gene

Suggested Antigen Peptide Sequences for CCL7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine beta (chemokine CC) family.
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL7: view

Function for CCL7 Gene

Molecular function for CCL7 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Phenotypes From GWAS Catalog for CCL7 Gene

Gene Ontology (GO) - Molecular Function for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IDA,TAS 10072545
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 7545673
genes like me logo Genes that share ontologies with CCL7: view
genes like me logo Genes that share phenotypes with CCL7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL7

miRNA for CCL7 Gene

miRTarBase miRNAs that target CCL7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL7 Gene

Localization for CCL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL7 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,TAS --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL7 Gene

Pathways & Interactions for CCL7 Gene

genes like me logo Genes that share pathways with CCL7: view

Gene Ontology (GO) - Biological Process for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 10770925
GO:0006935 chemotaxis TAS 9780207
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL7: view

No data available for SIGNOR curated interactions for CCL7 Gene

Drugs & Compounds for CCL7 Gene

(15) Drugs for CCL7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bindarit Investigational Pharma 0

(15) Additional Compounds for CCL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL7: view

Transcripts for CCL7 Gene

mRNA/cDNA for CCL7 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL7 Gene

Chemokine (C-C motif) ligand 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP3: - -

Relevant External Links for CCL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL7 Gene

mRNA differential expression in normal tissues according to GTEx for CCL7 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.6) and Lung (x4.7).

Protein differential expression in normal tissues from HIPED for CCL7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL7 Gene

Protein tissue co-expression partners for CCL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL7 Gene:


SOURCE GeneReport for Unigene cluster for CCL7 Gene:


Evidence on tissue expression from TISSUES for CCL7 Gene

  • Blood(4.7)
  • Intestine(4.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CCL7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL7 Gene

Orthologs for CCL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCL7 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia CCL7 34 33
  • 82.83 (n)
(Mus musculus)
Mammalia Ccl7 34
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
-- 34
  • 41 (a)
-- 34
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
-- 34
  • 44 (a)
Species where no ortholog for CCL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL7 Gene

Gene Tree for CCL7 (if available)
Gene Tree for CCL7 (if available)
Evolutionary constrained regions (ECRs) for CCL7: view image

Paralogs for CCL7 Gene

Paralogs for CCL7 Gene

(28) SIMAP similar genes for CCL7 Gene using alignment to 3 proteins:

  • A8MX17_HUMAN
genes like me logo Genes that share paralogs with CCL7: view

Variants for CCL7 Gene

Sequence variations from dbSNP and Humsavar for CCL7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000045109 -- 34,269,532(+) T/C upstream_transcript_variant
rs1001040406 -- 34,272,004(+) G/A 3_prime_UTR_variant
rs1001717241 -- 34,268,347(+) T/C upstream_transcript_variant
rs1002017945 -- 34,270,718(+) G/C/T intron_variant
rs1002070512 -- 34,270,959(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL7 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL7 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL7 Gene

Disorders for CCL7 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CCL7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diffuse gastric cancer
  • signet ring cell carcinoma
status asthmaticus
  • asthma with status asthmaticus
stachybotrys chartarum
  • stachybotrys atra
acute contagious conjunctivitis
  • contagious opthalmia
nephrogenic systemic fibrosis
  • nephrogenic fibrosing dermopathy
- elite association - COSMIC cancer census association via MalaCards
Search CCL7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL7 Gene

Publications for CCL7 Gene

  1. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PMID: 8461011) Opdenakker G … Van Damme J (Biochemical and biophysical research communications 1993) 2 3 4 22 58
  2. Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. (PMID: 15715950) Park BL … Shin HD (Journal of biochemistry and molecular biology 2005) 3 22 44 58
  3. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PMID: 9109648) Meunier S … Darbon H (Biochemistry 1997) 3 4 22 58
  4. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PMID: 8898111) Kim KS … Sykes BD (FEBS letters 1996) 3 4 22 58
  5. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. (PMID: 7916328) Opdenakker G … Van Damme J (Genomics 1994) 3 4 22 58

Products for CCL7 Gene

Sources for CCL7 Gene

Loading form....