Aliases for CCL7 Gene
External Ids for CCL7 Gene
Previous HGNC Symbols for CCL7 Gene
Previous GeneCards Identifiers for CCL7 Gene
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCL7 Gene
CCL7 (C-C Motif Chemokine Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include Nephrogenic Systemic Fibrosis and Diffuse Gastric Cancer. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.
UniProtKB/Swiss-Prot Summary for CCL7 Gene
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.