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This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Periapical Granuloma and Ulcer Of Lower Limbs. Among its related pathways are Signaling by GPCR and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL3L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004435 | phosphatidylinositol phospholipase C activity | IDA | 10734056 |
GO:0004672 | protein kinase activity | IDA | 10734056 |
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 8699119 |
GO:0008009 | chemokine activity | IDA,NAS | 7524281 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
3 | Toll-like Receptor Signaling Pathway | ||
4 | Peptide ligand-binding receptors | ||
5 | CCR5 Pathway in Macrophages |
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IMP | 21147091 |
GO:0002407 | dendritic cell chemotaxis | TAS | 18337562 |
GO:0002548 | monocyte chemotaxis | IC | 10660125 |
GO:0002676 | regulation of chronic inflammatory response | TAS | 10488085 |
GO:0006816 | calcium ion transport | IDA | 10734056 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CCL5 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Ccl5 30 |
|
||
Dog (Canis familiaris) |
Mammalia | CCL5 30 |
|
||
Cow (Bos Taurus) |
Mammalia | CCL5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ccl5 30 17 |
|
||
Chicken (Gallus gallus) |
Aves | CCL5 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs377415776 | - | p.Ser24Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3640458 | CNV | loss | 21293372 |
esv3892999 | CNV | loss | 25118596 |
nsv1059795 | CNV | gain | 25217958 |
nsv1079030 | OTHER | inversion | 25765185 |
Disorder | Aliases | PubMed IDs |
---|---|---|
periapical granuloma |
|
|
ulcer of lower limbs |
|
|
mast-cell leukemia |
|
|
bronchiolitis |
|
|
viral meningitis |
|