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This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, function... See more...
Aliases for CCL5 Gene
Aliases for CCL5 Gene
- C-C Motif Chemokine Ligand 5 2 3 5
- SIS-Delta 2 3 4
- TCP228 2 3 4
- Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted 2 3
- Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5 2 3
- Eosinophil Chemotactic Cytokine 3 4
- Chemokine (C-C Motif) Ligand 5 2 3
- T-Cell Specific Protein P288 2 3
- Beta-Chemokine RANTES 2 3
- C-C Motif Chemokine 5 3 4
- D17S136E 3 4
External Ids for CCL5 Gene
- HGNC: 10632
- Entrez Gene: 6352
- Ensembl: ENSG00000271503
- OMIM: 187011
- UniProtKB: P13501
Previous HGNC Symbols for CCL5 Gene
- D17S136E
- SCYA5
Previous GeneCards Identifiers for CCL5 Gene
- GC17M033968
- GC17M036234
- GC17M034344
- GC17M031222
- GC17M034198
- GC17M030383
Summaries for CCL5 Gene
-
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for CCL5 Gene
CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Periapical Granuloma and Ulcer Of Lower Limbs. Among its related pathways are Signaling by GPCR and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL3L1.
UniProtKB/Swiss-Prot Summary for CCL5 Gene
-
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
Additional gene information for CCL5 Gene
- HGNC(10632)
- Entrez Gene(6352)
- Ensembl(ENSG00000271503)
- OMIM(187011)
- UniProtKB(P13501)
- Open Targets Platform(ENSG00000271503)
- Monarch Initiative
- Search for CCL5 at DataMed
- Search for CCL5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL5 Gene
Genomics for CCL5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCL5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCL5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL5
- Top Transcription factor binding sites by QIAGEN in the CCL5 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for CCL5 Gene
Genomic Locations for CCL5 Gene
- chr17:35,871,491-35,880,793
- (GRCh38/hg38)
- Size:
- 9,303 bases
- Orientation:
- Minus strand
- chr17:34,198,495-34,207,797
- (GRCh37/hg19)
- Size:
- 9,303 bases
- Orientation:
- Minus strand
Genomic View for CCL5 Gene
Genes around CCL5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
CCL5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL5 Gene
Proteins for CCL5 Gene
-
Protein details for CCL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13501-CCL5_HUMAN
- Recommended name:
- C-C motif chemokine 5
- Protein Accession:
- P13501
- O43646
- Q0QVW8
- Q4ZGJ1
- Q9NYA2
- Q9UBG2
- Q9UC99
Protein attributes for CCL5 Gene
- Size:
- 91 amino acids
- Molecular mass:
- 9990 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCL5 Gene
Post-translational modifications for CCL5 Gene
- N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
- The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
-
Glycosylation at Ser27 and Ser28
- NX_P13501 (NX_P13501-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CCL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CCL5 / RANTES Monoclonal Antibody (LS-B2472) and CCL5 / RANTES Monoclonal Antibody (LS-B6426)
- G Biosciences Immunotag™ RANTES Antibody and Immunotag™ CCL5 Antibody
- Creative Diagnostics Anti-CCL5 monoclonal antibody, clone 32529
-
Creative Biolabs
- Recombinant Anti-Human CCL5 Antibody
- Mouse Anti-CCL5 Recombinant Antibody (CBFYC-0995)
- Rat Anti-CCL5 Recombinant Antibody (CBYY-C1093)
- Mouse Anti-CCL5 Recombinant Antibody (50013-5)
- Recombinant Mouse Anti-CCL5 Antibody (CBL429)
- Mouse Anti-CCL5 Recombinant Antibody (16411)
- Chicken Anti-RANTES Polyclonal IgY
- Mouse Anti-CCL5 Recombinant Antibody (CBXC-2504)
- Mouse Anti-CCL5 Recombinant Antibody (CBCNR-187)
- Mouse Anti-CCL5 Recombinant Antibody (21418)
-
BioLegend
- RANTES (CCL5) Antibody (515502)
- RANTES (CCL5) Antibody (515505)
- RANTES (CCL5) Antibody (515506)
- PerCP/Cyanine5.5 RANTES (CCL5) Antibody (515507)
- PerCP/Cyanine5.5 RANTES (CCL5) Antibody (515508)
- RANTES (CCL5) Antibody (515503)
- RANTES (CCL5) Antibody (515504)
- CCL5 (RANTES) Antibody (526402)
- CCL5 (RANTES) Antibody (519703)
- Novus Biologicals Antibodies for CCL5
-
Abcam antibodies for CCL5
- Invitrogen Antibodies for CCL5 (AFLGC-CCL5)
- antibodies-online: Show 93 available CCL5 Antibodies ranked by validation data
- Compare Top CCL5 Antibodies
-
Recommended
- 48 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 125 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 Inhibition Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 20 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL5
- Sino Biological Antibodies for CCL5
Protein Products
- G Biosciences Human CCL5/RANTES, Lyophilized
- RayBiotech Recombinant Human CCL5 (RANTES)
- Creative Biomart Recombinant Human chemokine (C-C motif) ligand 5, His-tagged
-
BioLegend
- Recombinant Human CCL5 (RANTES) (carrier-free) (580202)
- Recombinant Human CCL5 (RANTES) (carrier-free) (580204)
- Recombinant Human CCL5 (RANTES) (carrier-free) (580208)
- Recombinant Human CCL5 (RANTES) (carrier-free) (580206)
- Recombinant Human CCL5 (RANTES) (Animal-Free)
- Recombinant Human CCL5 (RANTES) (ELISA Std.)
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL5
- Origene Custom Protein Services for CCL5
- Sino Biological Recombinant Proteins for CCL5
- Sino Biological Cell Lysates for CCL5
- ProSpec Recombinant Proteins for CCL5
-
ProSci Proteins for CCL5
- chemokine (C-C motif) ligand 5 [90-382]
- chemokine (C-C motif) ligand 5 [90-383]
- chemokine (C-C motif) ligand 5 [40-335]
- chemokine (C-C motif) ligand 5 [40-363]
- chemokine (C-C motif) ligand 5 [40-411]
- chemokine (C-C motif) ligand 5 [40-567]
- C-C motif chemokine ligand 5 [91-049]
- C-C motif chemokine ligand 5 [92-430]
-
Abcam proteins for CCL5
Assay Products
- G Biosciences Immunotag™ C-C motif chemokine 5 ELISA Kit
- RayBiotech Human RANTES ELISA
- Novus Biologicals ELISA Kits for CCL5
- antibodies-online: Show 129 available CCL5 Elisa Kits ranked by validation data
- Compare Top CCL5 Elisa Kits
-
Quality Products:
- ABIN625081
- ABIN414915
- ABIN411348
- ABIN832387
- ABIN491817
- ABIN924792
- ABIN3032985
- ABIN3198412
- ABIN5522262
- ABIN2708107
- ABIN625174
- ABIN921072
- ABIN415458
- ABIN366415
- ABIN491818
- ABIN924828
- ABIN3032837
- ABIN1029726
- ABIN3198413
- ABIN5522264
- ABIN1672748
- ABIN2683690
- ABIN367474
- ABIN5676221
- ABIN924842
- ABIN5522265
- ABIN2708626
- ABIN6719760
- ABIN416338
- ABIN2748590
- ABIN5696489
- ABIN6385204
- ABIN1051906
- ABIN5690800
- ABIN6210362
-
Abcam assays for CCL5
- Sino Biological Assays for CCL5
No data available for DME Specific Peptides for CCL5 Gene
Domains & Families for CCL5 Gene
Gene Families for CCL5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CCL5 Gene
- InterPro:
- Blocks:
-
- Small chemokine, C-C subfamily
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL5 Gene
- GenScript: Design optimal peptide antigens:
-
- T-cell-specific protein RANTES (CCL5_HUMAN)
- Chemokine ligand 5 (D0EI67_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13501- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL5 Gene
Molecular function for CCL5 Gene
- UniProtKB/Swiss-Prot Function:
- Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
- UniProtKB/Swiss-Prot Induction:
- By mitogens.
Phenotypes From GWAS Catalog for CCL5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004435 | phosphatidylinositol phospholipase C activity | IDA | 10734056 |
| GO:0004672 | protein kinase activity | IDA | 10734056 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8699119 |
| GO:0008009 | chemokine activity | IDA,NAS | 7524281 |
Phenotypes for CCL5 Gene
- MGI mutant phenotypes for CCL5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CCL5:
Animal Models for CCL5 Gene
- MGI Knock Outs for CCL5:
-
- Ccl5 Ccl5<tm1Hso>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCL5 - Select products 50% OFF >
- * CCL5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCL5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL5
miRNA for CCL5 Gene
- miRTarBase miRNAs that target CCL5
-
- hsa-miR-98-5p (MIRT005677)
- hsa-miR-125a-5p (MIRT005678)
- hsa-miR-214-3p (MIRT053786)
- hsa-miR-146a-5p (MIRT437504)
- hsa-miR-5089-5p (MIRT518342)
- hsa-miR-7151-3p (MIRT518343)
- hsa-miR-5095 (MIRT518344)
- hsa-miR-4775 (MIRT518345)
- hsa-miR-6508-3p (MIRT518346)
- hsa-miR-4726-5p (MIRT518347)
- hsa-miR-4640-5p (MIRT518348)
- hsa-miR-6853-5p (MIRT518349)
- hsa-miR-6506-5p (MIRT518350)
- hsa-miR-619-5p (MIRT518351)
- hsa-miR-4735-5p (MIRT518352)
- hsa-miR-6504-3p (MIRT518353)
- hsa-miR-4438 (MIRT518354)
- hsa-miR-590-3p (MIRT518355)
- hsa-miR-6807-5p (MIRT685341)
- hsa-miR-6720-5p (MIRT685342)
- hsa-miR-6512-3p (MIRT685343)
- hsa-miR-5589-5p (MIRT685344)
- hsa-miR-4731-5p (MIRT685345)
- hsa-miR-186-3p (MIRT685346)
- hsa-miR-6849-3p (MIRT685347)
- hsa-miR-520h (MIRT685348)
- hsa-miR-520g-3p (MIRT685349)
- hsa-miR-512-3p (MIRT685350)
- hsa-miR-520e (MIRT685351)
- hsa-miR-520d-3p (MIRT685352)
- hsa-miR-520c-3p (MIRT685353)
- hsa-miR-520b (MIRT685354)
- hsa-miR-520a-3p (MIRT685355)
- hsa-miR-373-3p (MIRT685356)
- hsa-miR-372-3p (MIRT685357)
- hsa-miR-302e (MIRT685358)
- hsa-miR-302d-3p (MIRT685359)
- hsa-miR-302c-3p (MIRT685360)
- hsa-miR-302b-3p (MIRT685361)
- hsa-miR-302a-3p (MIRT685362)
- hsa-miR-93-5p (MIRT685363)
- hsa-miR-526b-3p (MIRT685364)
- hsa-miR-519d-3p (MIRT685365)
- hsa-miR-20b-5p (MIRT685366)
- hsa-miR-20a-5p (MIRT685367)
- hsa-miR-17-5p (MIRT685368)
- hsa-miR-106b-5p (MIRT685369)
- hsa-miR-106a-5p (MIRT685370)
- hsa-let-7g-3p (MIRT732867)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL5
- Browse OriGene Inhibitory RNA Products For CCL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL5
Clone Products
- Applied Biological Materials (abm): Clones for CCL5 - Select products 50% OFF >
- * CCL5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCL5
- Addgene plasmids for CCL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL5
Cell Line Products
-
Horizon Cell Lines for CCL5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL5 Gene
Localization for CCL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL5 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005623 | cell | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL5 Gene
Pathways & Interactions for CCL5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Peptide ligand-binding receptors | ||
| 5 | CCR5 Pathway in Macrophages |
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
|
|
Pathways by source for CCL5 Gene
9 BioSystems pathways for CCL5 Gene
12 Reactome pathways for CCL5 Gene
15 KEGG pathways for CCL5 Gene
2 GeneGo (Thomson Reuters) pathways for CCL5 Gene
- Cell adhesion_Cell-matrix glycoconjugates
- Immune response CCR3 signaling in eosinophils
1 R&D Systems pathway for CCL5 Gene
28 Qiagen pathways for CCL5 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- CCR5 Pathway in Macrophages
- Chemokine Signaling
1 Cell Signaling Technology pathway for CCL5 Gene
Interacting Proteins for CCL5 Gene
Selected Interacting proteins:
P13501-CCL5_HUMAN
ENSP00000474412
for CCL5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCL5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0002407 | dendritic cell chemotaxis | TAS | 18337562 |
| GO:0002548 | monocyte chemotaxis | IC | 10660125 |
| GO:0002676 | regulation of chronic inflammatory response | TAS | 10488085 |
| GO:0006816 | calcium ion transport | IDA | 10734056 |
Drugs & Compounds for CCL5 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human CCL5/RANTES, Lyophilized
- RayBiotech Recombinant Human CCL5 (RANTES)
- Creative Biomart Recombinant Human chemokine (C-C motif) ligand 5, His-tagged
-
BioLegend
- Recombinant Human CCL5 (RANTES) (carrier-free) (580202)
- Recombinant Human CCL5 (RANTES) (carrier-free) (580204)
- Recombinant Human CCL5 (RANTES) (carrier-free) (580208)
- Recombinant Human CCL5 (RANTES) (carrier-free) (580206)
- Recombinant Human CCL5 (RANTES) (Animal-Free)
- Recombinant Human CCL5 (RANTES) (ELISA Std.)
Transcripts for CCL5 Gene
mRNA/cDNA for CCL5 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000605140 1217 nts (view in UCSC)
- ENST00000651122 1299 nts (view in UCSC)
- ENST00000603197 1352 nts (view in UCSC)
- ENST00000605509 659 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCL5 - Select products 50% OFF >
- * CCL5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCL5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL5
- Browse OriGene Inhibitory RNA Products For CCL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL5
Clone Products
- Applied Biological Materials (abm): Clones for CCL5 - Select products 50% OFF >
- * CCL5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCL5
- Addgene plasmids for CCL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL5
Relevant External Links for CCL5 Gene
- GeneLoc Exon Structure for
- CCL5
Expression for CCL5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T-Cytotoxic Cells Thymus
- Endothelium (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for CCL5 Gene
This gene is overexpressed in Whole Blood (x33.8).
This gene is overexpressed in Peripheral blood mononuclear cells (31.9), Platelet (15.1), Serum (14.1), and Monocytes (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL5
SOURCE GeneReport for Unigene cluster for CCL5 Gene:
Hs.514821mRNA Expression by UniProt/SwissProt for CCL5 Gene:
P13501-CCL5_HUMAN
Tissue specificity:
Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Evidence on tissue expression from TISSUES for CCL5 Gene
- Blood(4.8)
- Nervous system(4.6)
- Spleen(3.9)
- Lymph node(3.9)
- Lung(3.6)
- Bone marrow(3.6)
- Intestine(3.3)
- Heart(3.3)
- Liver(3.2)
- Kidney(3.1)
- Muscle(3)
- Skin(2.9)
- Stomach(2.9)
- Bone(2.5)
- Pancreas(2.4)
- Adrenal gland(2.3)
- Eye(2.3)
- Urine(2.2)
- Thyroid gland(2.1)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for CCL5
-
OriGene qPCR primer pairs and template standards for CCL5
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL5 Gene
Orthologs for CCL5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCL5 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Ccl5 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | CCL5 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | CCL5 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ccl5 30 17 |
|
||
| Chicken (Gallus gallus) |
Aves | CCL5 30 |
|
- Species where no ortholog for CCL5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CCL5 Gene
- ENSEMBL:
- Gene Tree for CCL5 (if available)
- TreeFam:
- Gene Tree for CCL5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCL5: view image
Paralogs for CCL5 Gene
Paralogs for CCL5 Gene
(30) SIMAP similar genes for CCL5 Gene using alignment to 3 proteins:
- CCL5_HUMAN
- D0EI67_HUMAN
- K7EJM0_HUMAN
Variants for CCL5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL5 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs377415776 | - | p.Ser24Phe |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3640458 | CNV | loss | 21293372 |
| esv3892999 | CNV | loss | 25118596 |
| nsv1059795 | CNV | gain | 25217958 |
| nsv1079030 | OTHER | inversion | 25765185 |
Residual Variation Intolerance Score:
72.4% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCL5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL5 Gene
Disorders for CCL5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| periapical granuloma |
|
|
| ulcer of lower limbs |
|
|
| mast-cell leukemia |
|
|
| bronchiolitis |
|
|
| viral meningitis |
|
Search CCL5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCL5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL5 Gene
Publications for CCL5 Gene
- Chemokine polymorphisms and lymphoma: a pooled analysis. (PMID: 20038229) Bracci PM … Wiencke JK (Leukemia & lymphoma 2010) 3 23 41
- Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy. (PMID: 20203694) Pettigrew KA … Maxwell AP (Journal of human genetics 2010) 3 23 41
- RANTES promoter genotype and gastric cancer risk in a Japanese population. (PMID: 19846984) Tahara T … Arisawa T (Anticancer research 2009) 3 23 41
- Analysis of CCR5, CCR2, SDF1 and RANTES gene polymorphisms in subjects with HIV-related PML and not determined leukoencephalopathy. (PMID: 17560067) Guerini FR … Ferrante P (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2008) 3 23 41
- Genetic control of chemokines in severe human internal carotid artery stenosis. (PMID: 18060801) Ghilardi G … Scorza R (Cytokine 2008) 3 23 41
ExternalLinks
Products for CCL5 Gene
- View all 39 R&D Systems CCL5 (CCL5/RANTES) Products
- View all 3 R&D Systems CCL5 (CCL5/RANTES) Proteins and Enzymes
- View all 24 R&D Systems CCL5 (CCL5/RANTES) Primary Antibodies
- View all 2 R&D Systems CCL5 (CCL5/RANTES) ELISAs
- View all R&D Systems CCL5 (CCL5/RANTES) Simple Plex Assays
- View all 4 R&D Systems CCL5 (CCL5/RANTES) Luminex Assays
- View all 4 R&D Systems CCL5 (CCL5/RANTES) Proteome Profiler Antibody Arrays
- View all R&D Systems CCL5 (CCL5/RANTES) ELISpot and FluoroSpot Kits
- Learn more about R&D Systems custom CCL5 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCL5
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL5
- Origene Custom Protein Services for CCL5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL5
- Browse OriGene Inhibitory RNA Products For CCL5
- OriGene qPCR primer pairs for CCL5
- OriGene qPCR primer pairs and template standards for CCL5
- OriGene CRISPR knockouts for CCL5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL5
- Sino Biological Human cDNA Clone for CCL5
- Sino Biological Recombinant Proteins for CCL5
- Sino Biological Cell Lysates for CCL5
- Sino Biological Antibodies for CCL5
- Sino Biological Assays for CCL5
- Browse Recombinant Proteins
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCL5
- Novus Biologicals proteins and lysates for CCL5
- Novus Biologicals ELISA Kits for CCL5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCL5
- Abcam proteins for CCL5
- Abcam assays for CCL5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CCL5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCL5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCL5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCL5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCL5
- Addgene plasmids for CCL5
- antibodies-online: Show 93 available CCL5 Antibodies ranked by validation data
- Compare Top CCL5 Antibodies
- Recommended
- 48 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 125 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 Inhibition Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 20 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- antibodies-online: Show 129 available CCL5 Elisa Kits ranked by validation data
- Compare Top CCL5 Elisa Kits
- Quality Products:
- ABIN625081
- ABIN414915
- ABIN411348
- ABIN832387
- ABIN491817
- ABIN924792
- ABIN3032985
- ABIN3198412
- ABIN5522262
- ABIN2708107
- ABIN625174
- ABIN921072
- ABIN415458
- ABIN366415
- ABIN491818
- ABIN924828
- ABIN3032837
- ABIN1029726
- ABIN3198413
- ABIN5522264
- ABIN1672748
- ABIN2683690
- ABIN367474
- ABIN5676221
- ABIN924842
- ABIN5522265
- ABIN2708626
- ABIN6719760
- ABIN416338
- ABIN2748590
- ABIN5696489
- ABIN6385204
- ABIN1051906
- ABIN5690800
- ABIN6210362
- antibodies-online: Show 109 available CCL5 Proteins ranked by validation data
- Compare Top CCL5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL5
- Search Santa Cruz Biotechnology (SCBT) for CCL5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCL5
- Search for CCL5 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CCL5
- chemokine (C-C motif) ligand 5 [90-382]
- chemokine (C-C motif) ligand 5 [90-383]
- chemokine (C-C motif) ligand 5 [40-335]
- chemokine (C-C motif) ligand 5 [40-363]
- chemokine (C-C motif) ligand 5 [40-411]
- chemokine (C-C motif) ligand 5 [40-567]
- C-C motif chemokine ligand 5 [91-049]
- C-C motif chemokine ligand 5 [92-430]
- Horizon Cell Lines for CCL5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL5
Sources for CCL5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB