Aliases for CCL5 Gene
Aliases for CCL5 Gene
- C-C Motif Chemokine Ligand 5 2 3 5
- SIS-Delta 2 3 4
- Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted 2 3
- Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5 2 3
- Eosinophil Chemotactic Cytokine 3 4
- Chemokine (C-C Motif) Ligand 5 2 3
- T-Cell Specific Protein P288 2 3
- Beta-Chemokine RANTES 2 3
- D17S136E 3 4
- TCP228 3 4
- SCYA5 3 4
External Ids for CCL5 Gene
- HGNC: 10632
- Entrez Gene: 6352
- Ensembl: ENSG00000271503
- OMIM: 187011
- UniProtKB: P13501
Previous HGNC Symbols for CCL5 Gene
- D17S136E
- SCYA5
Previous GeneCards Identifiers for CCL5 Gene
- GC17M033968
- GC17M036234
- GC17M034344
- GC17M031222
- GC17M034198
- GC17M030383
Summaries for CCL5 Gene
-
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for CCL5 Gene
CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Ulcer Of Lower Limbs and Periapical Granuloma. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL3L1.
UniProtKB/Swiss-Prot for CCL5 Gene
-
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
Additional gene information for CCL5 Gene
- Monarch Initiative
- Search for CCL5 at DataMed
- Search for CCL5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL5 Gene
Genomics for CCL5 Gene
GeneHancer (GH) Regulatory Elements for CCL5 Gene
Promoters and enhancers for CCL5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCL5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCL5 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- PPAR-gamma2
- PPAR-gamma1
Regulatory Element Products
Genomic Locations for CCL5 Gene
Genomic Locations for CCL5 Gene
- chr17:35,871,491-35,880,793
- (GRCh38/hg38)
- Size:
- 9,303 bases
- Orientation:
- Minus strand
- chr17:34,198,495-34,207,797
- (GRCh37/hg19)
- Size:
- 9,303 bases
- Orientation:
- Minus strand
Genomic View for CCL5 Gene
Genes around CCL5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
CCL5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL5 Gene
Proteins for CCL5 Gene
-
Protein details for CCL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13501-CCL5_HUMAN
- Recommended name:
- C-C motif chemokine 5
- Protein Accession:
- P13501
- O43646
- Q0QVW8
- Q4ZGJ1
- Q9NYA2
- Q9UBG2
- Q9UC99
Protein attributes for CCL5 Gene
- Size:
- 91 amino acids
- Molecular mass:
- 9990 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCL5 Gene
Post-translational modifications for CCL5 Gene
- N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
- The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
- Glycosylation at posLast=2828 and posLast=2727
- Modification sites at PhosphoSitePlus
Other Protein References for CCL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CCL5 (CCL5/RANTES)
- Novus Biologicals Antibodies for CCL5
-
Abcam antibodies for CCL5
- Invitrogen Antibodies for CCL5 (AFLGC-CCL5)
- antibodies-online: Search results for 317 available CCL5 Antibodies ranked by validation data
- Compare Top CCL5 Antibodies
-
Recommended
- 43 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 120 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 Inhibition Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 65 WB Antibodies (anti-mouse)
- 19 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- GeneTex Ccl5 Antibody for CCL5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL5
Protein Products
- R&D Systems Proteins and Enzymes for CCL5 (CCL5/RANTES)
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL5
- Origene Custom Protein Services for CCL5
- Sino Biological Recombinant Proteins for CCL5
- Sino Biological Cell Lysates for CCL5
- ProSpec Recombinant Proteins for CCL5
- GeneTex Proteins for CCL5
-
ProSci Proteins for CCL5
- chemokine (C-C motif) ligand 5 [90-382]
- chemokine (C-C motif) ligand 5 [90-383]
- C-C motif chemokine ligand 5 [91-049]
- C-C motif chemokine ligand 5 [92-430]
- chemokine (C-C motif) ligand 5 [40-335]
- chemokine (C-C motif) ligand 5 [40-363]
- chemokine (C-C motif) ligand 5 [40-411]
- chemokine (C-C motif) ligand 5 [40-567]
-
Abcam proteins for CCL5
Assay Products
- R&D Systems ELISAs, ELISpot and FluoroSpot Kits, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL5 (CCL5/RANTES)
- Novus Biologicals ELISA Kits for CCL5
- antibodies-online: Search results for 118 available CCL5 Elisa Kits ranked by validation data
- Compare Top CCL5 Elisa Kits
-
Recommended
- 1 Cat (Feline) ELISA Kit
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 9 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 30 Human ELISA Kits
- 4 Monkey ELISA Kits
- 27 Mouse (Murine) ELISA Kits
- 8 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 22 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
-
Abcam assays for CCL5
No data available for DME Specific Peptides for CCL5 Gene
Domains & Families for CCL5 Gene
Gene Families for CCL5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CCL5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13501- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL5 Gene
Molecular function for CCL5 Gene
- UniProtKB/Swiss-Prot Function:
- Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
- UniProtKB/Swiss-Prot Induction:
- By mitogens.
Phenotypes From GWAS Catalog for CCL5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004435 | phosphatidylinositol phospholipase C activity | IDA | 10734056 |
| GO:0004672 | protein kinase activity | IDA | 10734056 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8699119 |
| GO:0008009 | chemokine activity | NAS,IEA | 7524281 |
Phenotypes for CCL5 Gene
- MGI mutant phenotypes for CCL5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CCL5:
Animal Models for CCL5 Gene
- MGI Knock Outs for CCL5:
-
- Ccl5 Ccl5<tm1Hso>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL5
-
CRISPR Products
-
OriGene CRISPR knockouts for CCL5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL5
- genomics-online: gRNA clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- Applied Biological Materials CRISPR for CCL5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL5
- GenScript: Design CRISPR guide RNA sequences for CCL5
miRNA for CCL5 Gene
- miRTarBase miRNAs that target CCL5
-
- hsa-mir-98-5p (MIRT005677)
- hsa-mir-125a-5p (MIRT005678)
- hsa-mir-214-3p (MIRT053786)
- hsa-mir-146a-5p (MIRT437504)
- hsa-mir-5089-5p (MIRT518342)
- hsa-mir-7151-3p (MIRT518343)
- hsa-mir-5095 (MIRT518344)
- hsa-mir-4775 (MIRT518345)
- hsa-mir-6508-3p (MIRT518346)
- hsa-mir-4726-5p (MIRT518347)
- hsa-mir-4640-5p (MIRT518348)
- hsa-mir-6853-5p (MIRT518349)
- hsa-mir-6506-5p (MIRT518350)
- hsa-mir-619-5p (MIRT518351)
- hsa-mir-4735-5p (MIRT518352)
- hsa-mir-6504-3p (MIRT518353)
- hsa-mir-4438 (MIRT518354)
- hsa-mir-590-3p (MIRT518355)
- hsa-mir-6807-5p (MIRT685341)
- hsa-mir-6720-5p (MIRT685342)
- hsa-mir-6512-3p (MIRT685343)
- hsa-mir-5589-5p (MIRT685344)
- hsa-mir-4731-5p (MIRT685345)
- hsa-mir-186-3p (MIRT685346)
- hsa-mir-6849-3p (MIRT685347)
- hsa-mir-520h (MIRT685348)
- hsa-mir-520g-3p (MIRT685349)
- hsa-mir-512-3p (MIRT685350)
- hsa-mir-520e (MIRT685351)
- hsa-mir-520d-3p (MIRT685352)
- hsa-mir-520c-3p (MIRT685353)
- hsa-mir-520b (MIRT685354)
- hsa-mir-520a-3p (MIRT685355)
- hsa-mir-373-3p (MIRT685356)
- hsa-mir-372-3p (MIRT685357)
- hsa-mir-302e (MIRT685358)
- hsa-mir-302d-3p (MIRT685359)
- hsa-mir-302c-3p (MIRT685360)
- hsa-mir-302b-3p (MIRT685361)
- hsa-mir-302a-3p (MIRT685362)
- hsa-mir-93-5p (MIRT685363)
- hsa-mir-526b-3p (MIRT685364)
- hsa-mir-519d-3p (MIRT685365)
- hsa-mir-20b-5p (MIRT685366)
- hsa-mir-20a-5p (MIRT685367)
- hsa-mir-17-5p (MIRT685368)
- hsa-mir-106b-5p (MIRT685369)
- hsa-mir-106a-5p (MIRT685370)
- hsa-let-7g-3p (MIRT732867)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL5
- Browse OriGene Inhibitory RNA Products For CCL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL5
- genomics-online: shRNA clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CCL5
- Addgene plasmids for CCL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL5
- Applied Biological Materials Clones for CCL5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCL5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL5 Gene
Localization for CCL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL5 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| endosome | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IBA,IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL5 Gene
Pathways & Interactions for CCL5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Peptide ligand-binding receptors | ||
| 5 | CCR5 Pathway in Macrophages | ||
Pathways by source for CCL5 Gene
9 BioSystems pathways for CCL5 Gene
12 Reactome pathways for CCL5 Gene
12 KEGG pathways for CCL5 Gene
2 GeneGo (Thomson Reuters) pathways for CCL5 Gene
2 R&D Systems pathways for CCL5 Gene
28 Qiagen pathways for CCL5 Gene
1 Cell Signaling Technology pathway for CCL5 Gene
Interacting Proteins for CCL5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0002407 | dendritic cell chemotaxis | TAS | 18337562 |
| GO:0002548 | monocyte chemotaxis | IC | 10660125 |
| GO:0002676 | regulation of chronic inflammatory response | TAS | 10488085 |
| GO:0006816 | calcium ion transport | IDA | 10734056 |
No data available for SIGNOR curated interactions for CCL5 Gene
Transcripts for CCL5 Gene
mRNA/cDNA for CCL5 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (77) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000605509 719 bps (uc060eei.1)
- ENST00000605140 1244 bps (uc060eeh.1)
- ENST00000603197 1365 bps (uc002hkf.5)
Unigene Clusters for CCL5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCL5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL5
- genomics-online: gRNA clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- Applied Biological Materials CRISPR for CCL5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL5
- GenScript: Design CRISPR guide RNA sequences for CCL5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL5
- Browse OriGene Inhibitory RNA Products For CCL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL5
- genomics-online: shRNA clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CCL5
- Addgene plasmids for CCL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL5
- Applied Biological Materials Clones for CCL5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CCL5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T-Cytotoxic Cells Thymus
- Endothelium (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for CCL5 Gene
This gene is overexpressed in Whole Blood (x33.8).
This gene is overexpressed in Peripheral blood mononuclear cells (31.9), Platelet (15.1), Serum (14.1), and Monocytes (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCL5 Gene:
CCL5SOURCE GeneReport for Unigene cluster for CCL5 Gene:
Hs.514821mRNA Expression by UniProt/SwissProt for CCL5 Gene:
P13501-CCL5_HUMAN
Tissue specificity:
Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Evidence on tissue expression from TISSUES for CCL5 Gene
- Blood(4.8)
- Nervous system(4.5)
- Lung(3.4)
- Lymph node(3.4)
- Spleen(3.4)
- Bone marrow(2.9)
- Intestine(2.7)
- Heart(2.5)
- Kidney(2.5)
- Liver(2.4)
- Skin(2.4)
- Stomach(2.3)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for CCL5
-
OriGene qPCR primer pairs and template standards for CCL5
- genomics-online: primer clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL5 Gene
Orthologs for CCL5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCL5 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccl5 33 |
|
||
| dog (Canis familiaris) |
Mammalia | CCL5 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CCL5 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccl5 16 33 |
|
||
| chicken (Gallus gallus) |
Aves | CCL5 33 |
|
- Species where no ortholog for CCL5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CCL5 Gene
- ENSEMBL:
- Gene Tree for CCL5 (if available)
- TreeFam:
- Gene Tree for CCL5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCL5: view image
Paralogs for CCL5 Gene
(30) SIMAP similar genes for CCL5 Gene using alignment to 3 proteins:
- CCL5_HUMAN
- D0EI67_HUMAN
- K7EJM0_HUMAN
Variants for CCL5 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000156922 | -- | 35,881,789(-) | C/T | upstream_transcript_variant | |
| rs1000165965 | -- | 35,871,362(-) | G/A | downstream_transcript_variant | |
| rs1000599672 | -- | 35,873,370(-) | G/A | intron_variant | |
| rs1000709472 | -- | 35,877,736(-) | T/A | intron_variant | |
| rs1000762147 | -- | 35,880,441(-) | A/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3640458 | CNV | loss | 21293372 |
| esv3892999 | CNV | loss | 25118596 |
| nsv1059795 | CNV | gain | 25217958 |
| nsv1079030 | OTHER | inversion | 25765185 |
Residual Variation Intolerance Score:
72.4% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCL5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL5 Gene
Disorders for CCL5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ulcer of lower limbs |
|
|
| periapical granuloma |
|
|
| whiplash |
|
|
| viral meningitis |
|
|
| genital herpes |
|
|
Search CCL5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCL5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL5 Gene
Publications for CCL5 Gene
- RANTES promoter genotype and gastric cancer risk in a Japanese population. (PMID: 19846984) Tahara T … Arisawa T (Anticancer research 2009) 3 22 44 58
- Analysis of CCR5, CCR2, SDF1 and RANTES gene polymorphisms in subjects with HIV-related PML and not determined leukoencephalopathy. (PMID: 17560067) Guerini FR … Ferrante P (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2008) 3 22 44 58
- Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PMID: 16323127) Shrestha S … Smith MW (The Journal of infectious diseases 2006) 3 22 44 58
- RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. (PMID: 17001303) Ignatov A … Schaller HC (British journal of pharmacology 2006) 3 4 22 58
- The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. (PMID: 15863470) Goulding C … Kelleher D (Gut 2005) 3 22 44 58
Products for CCL5 Gene
- R&D Systems Antibodies for CCL5 (CCL5/RANTES)
- R&D Systems Proteins and Enzymes for CCL5 (CCL5/RANTES)
- R&D Systems ELISAs, ELISpot and FluoroSpot Kits, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL5 (CCL5/RANTES)
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- Custom Antibody ServicesOriGene Antibodies for CCL5
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL5
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL5
- Browse OriGene Inhibitory RNA Products For CCL5
- OriGene qPCR primer pairs for CCL5
- OriGene qPCR primer pairs and template standards for CCL5
- OriGene CRISPR knockouts for CCL5
- OriGene ORF clones in human for CCL5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL5
- GenScript: Next-day shipping of latest version cDNA ORF clones for CCL5 in any vector
- GenScript Purified and Recombinant Proteins for CCL5
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- GenScript Custom overexpressing Cell Line Services for CCL5
- GenScript: Design CRISPR guide RNA sequences for CCL5
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- GenScript Custom Peptide Services for CCL5
- Sino Biological Human cDNA Clone for CCL5
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- Addgene plasmids for CCL5
- antibodies-online: Search results for 317 available CCL5 Antibodies ranked by validation data
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- Recommended
- 43 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 120 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 Inhibition Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 65 WB Antibodies (anti-mouse)
- 19 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- antibodies-online: Search results for 118 available CCL5 Elisa Kits ranked by validation data
- Compare Top CCL5 Elisa Kits
- Recommended
- 1 Cat (Feline) ELISA Kit
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 9 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 30 Human ELISA Kits
- 4 Monkey ELISA Kits
- 27 Mouse (Murine) ELISA Kits
- 8 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 22 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 119 available CCL5 Proteins ranked by validation data
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- GeneTex Ccl5 Antibody for CCL5
- GeneTex Proteins for CCL5
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL5
- Search Santa Cruz Biotechnology (SCBT) for CCL5 siRNA/shRNA
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- Search for CCL5 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CCL5
- chemokine (C-C motif) ligand 5 [90-382]
- chemokine (C-C motif) ligand 5 [90-383]
- C-C motif chemokine ligand 5 [91-049]
- C-C motif chemokine ligand 5 [92-430]
- chemokine (C-C motif) ligand 5 [40-335]
- chemokine (C-C motif) ligand 5 [40-363]
- chemokine (C-C motif) ligand 5 [40-411]
- chemokine (C-C motif) ligand 5 [40-567]
- Horizon Cell Lines for CCL5
- genomics-online: cdna clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- orf clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- genomics-online: gRNA clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- genomics-online: primer clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- genomics-online: shRNA clones - Search results for 145 available CCL5 gene related products
- Overview of 145 available CCL5 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL5
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- GeneCopoeia miRNA 3'UTR Target clone products for CCL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL5
Sources for CCL5 Gene
- (1) GeneCards
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