This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy numbe... See more...

Aliases for CCL4L2 Gene

Aliases for CCL4L2 Gene

  • C-C Motif Chemokine Ligand 4 Like 2 2 3 5
  • Monocyte Adherence-Induced Protein 5-Alpha 3 4
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Chemokine (C-C Motif) Ligand 4-Like 2 2 3
  • C-C Motif Chemokine 4-Like 3 4
  • MIP-1-Beta 3 4
  • CCL4L 3 4
  • Lymphocyte Activation Gene 1 Protein 4
  • Macrophage Inflammatory Protein-1b2 3
  • Small-Inducible Cytokine A4-Like 4
  • AT744.2 3
  • SCYQ4L2 3
  • SCYA4L1 4
  • SCYA4L2 4
  • SCYA4L 3
  • CCL4L2 5
  • LAG-1 4
  • LAG1 4

External Ids for CCL4L2 Gene

Previous GeneCards Identifiers for CCL4L2 Gene

  • GC17P031665
  • GC17P034639
  • GC17Pj00266
  • GC17P036211
  • GC17P036213
  • GC17P036231

Summaries for CCL4L2 Gene

Entrez Gene Summary for CCL4L2 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL4L2 Gene

CCL4L2 (C-C Motif Chemokine Ligand 4 Like 2) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. An important paralog of this gene is CCL4.

UniProtKB/Swiss-Prot Summary for CCL4L2 Gene

  • Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Wiki entry for CCL4L2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL4L2 Gene

Genomics for CCL4L2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL4L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036210 Promoter 0.7 EPDnew Ensembl 250.7 +0.6 577 1.4 CCL4L2 NONHSAG021593.2 piR-39416-022 LOC100420851 TBC1D3I
GH17J036212 Promoter 0.3 Ensembl 250.7 +2.0 1977 0.2 CCL4L2 NONHSAG021593.2 piR-39416-022 TBC1D3I LOC100420851
GH17J036589 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5 +386.0 386022 14.5 BCLAF1 SP1 ZNF207 ZNF654 ZNF600 NCOR1 IKZF1 MYC ZNF580 ZNF592 DHRS11 LOC107985031 MRM1 piR-56497-065 ZNHIT3 MYO19 CCL4L2 HSALNG0116043 HSALNG0116045 GGNBP2
GH17J036463 Enhancer 1 Ensembl ENCODE 10.5 +253.2 253229 0.7 MYC REST BHLHE40 ZFP64 MNT MAX SIN3A KLF9 HCFC1 MAFF CCL4L2 piR-35666-009 lnc-MYO19-2 TBC1D3F ZNHIT3
GH17J036528 Enhancer 0.8 Ensembl ENCODE 7.6 +318.5 318470 1.6 IKZF1 JUND POLR2A SMARCA4 EHMT2 ZEB2 TCF12 DPF2 ARID1B JUNB HSALNG0116034 lnc-TBC1D3F-8 CCL4L2 PIGW MYO19 ZNHIT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL4L2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL4L2

Top Transcription factor binding sites by QIAGEN in the CCL4L2 gene promoter:
  • AML1a
  • AP-1
  • c-Myb
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Pbx1a

Genomic Locations for CCL4L2 Gene

Latest Assembly
chr17:36,210,924-36,212,878
(GRCh38/hg38)
Size:
1,955 bases
Orientation:
Plus strand

Previous Assembly
chr17:34,538,465-34,540,275
(GRCh37/hg19 by Entrez Gene)
Size:
1,811 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):445,967-447,777 (+)
  • chr17(ALT_REF_LOCI_2):165,200-167,010 (+)

Genomic View for CCL4L2 Gene

Genes around CCL4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4L2 Gene

Proteins for CCL4L2 Gene

  • Protein details for CCL4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHW4-CC4L_HUMAN
    Recommended name:
    C-C motif chemokine 4-like
    Protein Accession:
    Q8NHW4
    Secondary Accessions:
    • B2RUZ3
    • B7ZMA8
    • Q50EM1
    • Q50EM2
    • Q50EM3
    • Q50EM4
    • Q50EM5
    • Q50EM6
    • Q50EM7
    • Q50EM8
    • Q569J2
    • Q6NSB0

    Protein attributes for CCL4L2 Gene

    Size:
    92 amino acids
    Molecular mass:
    10166 Da
    Quaternary structure:
    • Interacts with CCR5.

    Alternative splice isoforms for CCL4L2 Gene

neXtProt entry for CCL4L2 Gene

Post-translational modifications for CCL4L2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCL4L2 Gene

Domains & Families for CCL4L2 Gene

Gene Families for CCL4L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCL4L2 Gene

InterPro:
Blocks:
  • Small chemokine, C-C subfamily

Suggested Antigen Peptide Sequences for CCL4L2 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A4-like (CC4L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHW4

UniProtKB/Swiss-Prot:

CC4L_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4L2: view

Function for CCL4L2 Gene

Molecular function for CCL4L2 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Phenotypes From GWAS Catalog for CCL4L2 Gene

Gene Ontology (GO) - Molecular Function for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI --
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

Phenotypes for CCL4L2 Gene

genes like me logo Genes that share phenotypes with CCL4L2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL4L2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL4L2 Gene

Localization for CCL4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4L2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CCL4L2 Gene

Pathways & Interactions for CCL4L2 Gene

PathCards logo

SuperPathways for CCL4L2 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 CCR5 Pathway in Macrophages
.33
4 Akt Signaling
.60
.60
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with CCL4L2: view

Pathways by source for CCL4L2 Gene

17 Qiagen pathways for CCL4L2 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

No data available for SIGNOR curated interactions for CCL4L2 Gene

Drugs & Compounds for CCL4L2 Gene

No Compound Related Data Available

Transcripts for CCL4L2 Gene

mRNA/cDNA for CCL4L2 Gene

9 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL4L2

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4L2 Gene

No ASD Table

Relevant External Links for CCL4L2 Gene

GeneLoc Exon Structure for
CCL4L2

Expression for CCL4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL4L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCL4L2 Gene

This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL4L2

mRNA Expression by UniProt/SwissProt for CCL4L2 Gene:

Q8NHW4-CC4L_HUMAN
Tissue specificity: Detected in B-cells.
genes like me logo Genes that share expression patterns with CCL4L2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL4L2 Gene

Orthologs for CCL4L2 Gene

Evolution for CCL4L2 Gene

ENSEMBL:
Gene Tree for CCL4L2 (if available)
TreeFam:
Gene Tree for CCL4L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL4L2: view image
Alliance of Genome Resources:
Additional Orthologs for CCL4L2

No data available for Orthologs for CCL4L2 Gene

Paralogs for CCL4L2 Gene

(28) SIMAP similar genes for CCL4L2 Gene using alignment to 2 proteins:

  • CC4L_HUMAN
  • F8W8W8_HUMAN
genes like me logo Genes that share paralogs with CCL4L2: view

Variants for CCL4L2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L2 Gene

CC4L_HUMAN-Q8NHW4
The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCL4L2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCL4L2 Gene

Variant ID Type Subtype PubMed ID
dgv120e55 CNV gain 17911159
dgv121e55 CNV gain 17911159
dgv178n21 CNV loss 19592680
dgv3143n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3146n100 CNV gain 25217958
dgv3147n100 CNV gain 25217958
dgv522n67 CNV gain 20364138
dgv523n67 CNV gain 20364138
dgv545e199 CNV deletion 23128226
dgv5534n54 CNV gain 21841781
dgv5535n54 CNV gain 21841781
dgv5538n54 CNV gain 21841781
dgv5540n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5544n54 CNV loss 21841781
dgv5545n54 CNV gain 21841781
dgv5546n54 CNV loss 21841781
dgv5547n54 CNV loss 21841781
dgv5548n54 CNV loss 21841781
dgv908e212 CNV gain 25503493
esv2664544 CNV deletion 23128226
esv2670934 CNV deletion 23128226
esv2715876 CNV deletion 23290073
esv2760467 CNV gain 21179565
esv2762388 CNV gain+loss 21179565
esv33107 CNV loss 17666407
esv3345949 CNV duplication 20981092
esv3441237 CNV duplication 20981092
esv3450833 CNV duplication 20981092
esv3554365 CNV deletion 23714750
esv3893000 CNV gain+loss 25118596
esv3893001 CNV gain 25118596
esv3893002 CNV loss 25118596
esv3893005 CNV loss 25118596
nsv1059497 CNV gain+loss 25217958
nsv1059795 CNV gain 25217958
nsv1061066 CNV loss 25217958
nsv1061448 CNV gain+loss 25217958
nsv1062304 CNV loss 25217958
nsv1072731 CNV deletion 25765185
nsv1133405 CNV deletion 24896259
nsv1143852 CNV deletion 24896259
nsv1160468 CNV duplication 26073780
nsv2040 CNV deletion 18451855
nsv433448 CNV gain 18776910
nsv457733 CNV gain 19166990
nsv471396 CNV gain 19718026
nsv514836 CNV gain 21397061
nsv514838 CNV gain 21397061
nsv517262 CNV gain+loss 19592680
nsv574755 CNV gain 21841781
nsv574780 CNV gain+loss 21841781
nsv574781 CNV gain 21841781
nsv574783 CNV gain 21841781
nsv574788 CNV gain+loss 21841781
nsv820772 CNV deletion 20802225
nsv833427 CNV loss 17160897
nsv953882 CNV deletion 24416366
nsv960470 CNV duplication 23825009
nsv960473 CNV duplication 23825009

Variation tolerance for CCL4L2 Gene

Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL4L2 Gene

Human Gene Mutation Database (HGMD)
CCL4L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL4L2
Leiden Open Variation Database (LOVD)
CCL4L2

SNP Genotyping and Copy Number Assays for research

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL4L2 Gene

Disorders for CCL4L2 Gene

Additional Disease Information for CCL4L2

No disorders were found for CCL4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL4L2 Gene

Publications for CCL4L2 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W … Kaslow RA (Genes and immunity 2007) 3 4 22
  2. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R … Juan M (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 22
  3. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi WS (Genomics 2004) 2 3 4
  4. Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. (PMID: 19148142) Colobran R … Palou E (Genes and immunity 2009) 3 22
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 40

Products for CCL4L2 Gene

Sources for CCL4L2 Gene