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Aliases for CCL4L2 Gene

Aliases for CCL4L2 Gene

  • C-C Motif Chemokine Ligand 4 Like 2 2 3 5
  • Monocyte Adherence-Induced Protein 5-Alpha 3 4
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Chemokine (C-C Motif) Ligand 4-Like 2 2 3
  • MIP-1-Beta 3 4
  • CCL4L 3 4
  • Lymphocyte Activation Gene 1 Protein 4
  • Macrophage Inflammatory Protein-1b2 3
  • Small Inducible Cytokine A4-Like 3
  • Small-Inducible Cytokine A4-Like 4
  • C-C Motif Chemokine 4-Like 3
  • CCL4L1 CCL4L2 4
  • AT744.2 3
  • SCYA4L1 4
  • SCYA4L2 4
  • SCYQ4L2 3
  • SCYA4L 3
  • LAG-1 4
  • LAG1 4

External Ids for CCL4L2 Gene

Previous GeneCards Identifiers for CCL4L2 Gene

  • GC17P031665
  • GC17P034639
  • GC17Pj00266

Summaries for CCL4L2 Gene

Entrez Gene Summary for CCL4L2 Gene

  • This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CCL4L2 Gene

CCL4L2 (C-C Motif Chemokine Ligand 4 Like 2) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. An important paralog of this gene is CCL4.

UniProtKB/Swiss-Prot for CCL4L2 Gene

  • Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Gene Wiki entry for CCL4L2 Gene

Additional gene information for CCL4L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL4L2 Gene

Genomics for CCL4L2 Gene

GeneHancer (GH) Regulatory Elements for CCL4L2 Gene

Promoters and enhancers for CCL4L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I036210 Promoter/Enhancer 0.7 EPDnew Ensembl 550.8 +1.0 1040 3 GC17P036212 CCL4L2 ENSG00000278097 LOC100420851
GH17I036589 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5 +385.6 385622 13.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 DHRS11 GC17P036618 MRM1 ZNHIT3 MYO19 CCL4L2 GGNBP2
GH17I036528 Enhancer 0.7 ENCODE 7.6 +318.1 318089 0.9 HDAC1 JUN FOSL1 TCF12 CTBP1 POLR2A FOS NFE2 SMARCE1 ZBTB2 GC17M036531 CCL4L2 MYO19 GC17M036499 PIR53886
GH17I036154 Enhancer 0.3 FANTOM5 7.4 -56.5 -56451 0.4 IKZF2 CCL4 CCL3 CCL3L3 CCL4L2 CCL5 CCL23 GGNBP2 ENSG00000282738 GC17P036146 LOC100420851
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCL4L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL4L2 gene promoter:

Genomic Locations for CCL4L2 Gene

Genomic Locations for CCL4L2 Gene
1,955 bases
Plus strand

Genomic View for CCL4L2 Gene

Genes around CCL4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4L2 Gene

Proteins for CCL4L2 Gene

  • Protein details for CCL4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C motif chemokine 4-like
    Protein Accession:
    Secondary Accessions:
    • B2RUZ3
    • B7ZMA8
    • Q50EM1
    • Q50EM2
    • Q50EM3
    • Q50EM4
    • Q50EM5
    • Q50EM6
    • Q50EM7
    • Q50EM8
    • Q569J2
    • Q6NSB0

    Protein attributes for CCL4L2 Gene

    92 amino acids
    Molecular mass:
    10166 Da
    Quaternary structure:
    • Interacts with CCR5.
    • Interacts with CCR5.

    Alternative splice isoforms for CCL4L2 Gene

neXtProt entry for CCL4L2 Gene

Post-translational modifications for CCL4L2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCL4L2 Gene

Domains & Families for CCL4L2 Gene

Gene Families for CCL4L2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CCL4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine beta (chemokine CC) family.
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4L2: view

Function for CCL4L2 Gene

Molecular function for CCL4L2 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Phenotypes From GWAS Catalog for CCL4L2 Gene

Gene Ontology (GO) - Molecular Function for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI --
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

Phenotypes for CCL4L2 Gene

GenomeRNAi human phenotypes for CCL4L2:
genes like me logo Genes that share phenotypes with CCL4L2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL4L2 Gene

Localization for CCL4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL4L2 gene
Compartment Confidence
extracellular 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL4L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL4L2 Gene

Pathways & Interactions for CCL4L2 Gene

genes like me logo Genes that share pathways with CCL4L2: view

Interacting Proteins for CCL4L2 Gene

Gene Ontology (GO) - Biological Process for CCL4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with CCL4L2: view

No data available for SIGNOR curated interactions for CCL4L2 Gene

Drugs & Compounds for CCL4L2 Gene

No Compound Related Data Available

Transcripts for CCL4L2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4L2 Gene

No ASD Table

Relevant External Links for CCL4L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCL4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL4L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCL4L2 Gene

This gene is overexpressed in Whole Blood (x12.6) and Spleen (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of CCL4L2 Gene:


mRNA Expression by UniProt/SwissProt for CCL4L2 Gene:

Tissue specificity: Detected in B-cells.

Evidence on tissue expression from TISSUES for CCL4L2 Gene

  • Blood(4.9)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CCL4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL4L2 Gene

Orthologs for CCL4L2 Gene

Evolution for CCL4L2 Gene

Gene Tree for CCL4L2 (if available)
Gene Tree for CCL4L2 (if available)

No data available for Orthologs for CCL4L2 Gene

Paralogs for CCL4L2 Gene

Paralogs for CCL4L2 Gene

genes like me logo Genes that share paralogs with CCL4L2: view

Variants for CCL4L2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4L2 Gene

The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.

Sequence variations from dbSNP and Humsavar for CCL4L2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1002141415 -- 36,209,179(+) C/T upstream_transcript_variant
rs1014227854 -- 36,209,992(+) TGTTTT/T upstream_transcript_variant
rs1024303240 -- 36,213,214(+) G/C downstream_transcript_variant
rs1027808767 -- 36,211,740(+) GGG/G intron_variant
rs1043549665 -- 36,209,119(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL4L2 Gene

Variant ID Type Subtype PubMed ID
dgv120e55 CNV gain 17911159
dgv121e55 CNV gain 17911159
dgv178n21 CNV loss 19592680
dgv3143n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3146n100 CNV gain 25217958
dgv3147n100 CNV gain 25217958
dgv522n67 CNV gain 20364138
dgv523n67 CNV gain 20364138
dgv545e199 CNV deletion 23128226
dgv5534n54 CNV gain 21841781
dgv5535n54 CNV gain 21841781
dgv5538n54 CNV gain 21841781
dgv5540n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5544n54 CNV loss 21841781
dgv5545n54 CNV gain 21841781
dgv5546n54 CNV loss 21841781
dgv5547n54 CNV loss 21841781
dgv5548n54 CNV loss 21841781
dgv908e212 CNV gain 25503493
esv2664544 CNV deletion 23128226
esv2670934 CNV deletion 23128226
esv2715876 CNV deletion 23290073
esv2760467 CNV gain 21179565
esv2762388 CNV gain+loss 21179565
esv33107 CNV loss 17666407
esv3345949 CNV duplication 20981092
esv3441237 CNV duplication 20981092
esv3450833 CNV duplication 20981092
esv3554365 CNV deletion 23714750
esv3893000 CNV gain+loss 25118596
esv3893001 CNV gain 25118596
esv3893002 CNV loss 25118596
esv3893005 CNV loss 25118596
nsv1059497 CNV gain+loss 25217958
nsv1059795 CNV gain 25217958
nsv1061066 CNV loss 25217958
nsv1061448 CNV gain+loss 25217958
nsv1062304 CNV loss 25217958
nsv1072731 CNV deletion 25765185
nsv1133405 CNV deletion 24896259
nsv1143852 CNV deletion 24896259
nsv1160468 CNV duplication 26073780
nsv2040 CNV deletion 18451855
nsv433448 CNV gain 18776910
nsv457733 CNV gain 19166990
nsv471396 CNV gain 19718026
nsv514836 CNV gain 21397061
nsv514838 CNV gain 21397061
nsv517262 CNV gain+loss 19592680
nsv574755 CNV gain 21841781
nsv574780 CNV gain+loss 21841781
nsv574781 CNV gain 21841781
nsv574783 CNV gain 21841781
nsv574788 CNV gain+loss 21841781
nsv820772 CNV deletion 20802225
nsv833427 CNV loss 17160897
nsv953882 CNV deletion 24416366
nsv960470 CNV duplication 23825009
nsv960473 CNV duplication 23825009

Variation tolerance for CCL4L2 Gene

Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL4L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for CCL4L2 Gene

Additional Disease Information for CCL4L2

No disorders were found for CCL4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL4L2 Gene

Publications for CCL4L2 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W … Kaslow RA (Genes and immunity 2007) 3 4 22 58
  2. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R … Juan M (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 22 58
  3. CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. (PMID: 15028295) Modi WS (Genomics 2004) 2 3 4 58
  4. Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation. (PMID: 19148142) Colobran R … Palou E (Genes and immunity 2009) 3 22 58
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 44 58

Products for CCL4L2 Gene

Sources for CCL4L2 Gene

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