The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012] See more...

Aliases for CCL4 Gene

Aliases for CCL4 Gene

  • C-C Motif Chemokine Ligand 4 2 3 5
  • Small Inducible Cytokine A4 (Homologous To Mouse Mip-1b) 2 3
  • Macrophage Inflammatory Protein 1-Beta 3 4
  • Lymphocyte Activation Gene 1 Protein 3 4
  • G-26 T-Lymphocyte-Secreted Protein 3 4
  • Chemokine (C-C Motif) Ligand 4 2 3
  • T-Cell Activation Protein 2 3 4
  • C-C Motif Chemokine 4 3 4
  • MIP-1-Beta(1-69) 3 4
  • MIP-1-Beta 3 4
  • SIS-Gamma 3 4
  • PAT 744 3 4
  • SCYA4 3 4
  • LAG-1 3 4
  • MIP1B 3 4
  • LAG1 3 4
  • HC21 3 4
  • Small-Inducible Cytokine A4 4
  • Secreted Protein G-26 3
  • Protein H400 4
  • AT744.1 3
  • MIP1B1 3
  • SCYA2 3
  • ACT-2 4
  • ACT2 3
  • G-26 3

External Ids for CCL4 Gene

Previous HGNC Symbols for CCL4 Gene

  • LAG1
  • SCYA4

Previous GeneCards Identifiers for CCL4 Gene

  • GC17P034201
  • GC17P036466
  • GC17P034279
  • GC17P034576
  • GC17P031421
  • GC17P034431
  • GC17P030617

Summaries for CCL4 Gene

Entrez Gene Summary for CCL4 Gene

  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

GeneCards Summary for CCL4 Gene

CCL4 (C-C Motif Chemokine Ligand 4) is a Protein Coding gene. Diseases associated with CCL4 include Human Immunodeficiency Virus Infectious Disease and Pulmonary Tuberculosis. Among its related pathways are CCR5 Pathway in Macrophages and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include identical protein binding and chemokine activity. An important paralog of this gene is CCL4L2.

UniProtKB/Swiss-Prot Summary for CCL4 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Gene Wiki entry for CCL4 Gene

Additional gene information for CCL4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL4 Gene

Genomics for CCL4 Gene

GeneHancer (GH) Regulatory Elements for CCL4 Gene

Promoters and enhancers for CCL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036102 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 791.2 +2.2 2178 6.2 ZNF24 MLLT1 SP7 POLR2A PRDM1 CREM IKZF1 CREB1 PRDM10 BACH1 CCL4 CCL3 CCL3L3 CCL5 AP2B1 CCL18 SNHG30 CCL15 PIGW SLFN12L
GH17J036148 Enhancer 1.3 FANTOM5 Ensembl ENCODE 62.8 +45.4 45373 2 CTCF CTBP1 ZNF362 MYC MAX RAD21 ZNF473 ZNF384 MLLT1 SP7 LOC101927369 CCL4 CCL3 CCL3L3 TBC1D3G CCL5 CCL23 LYZL6 GGNBP2 ENSG00000282738
GH17J036092 Enhancer 0.9 FANTOM5 ENCODE 37.1 -11.5 -11475 0.5 ETV6 RELA CREM IKZF1 BACH1 IKZF2 NFE2 EED MAFG BATF piR-61945-203 CCL3 CCL3L3 CCL4 CCL18 CCL5 GGNBP2 lnc-CCL3-1
GH17J036055 Enhancer 0.7 FANTOM5 Ensembl 43.6 -45.6 -45626 6.8 ZBTB40 CREB1 FOXA2 ATF2 ZFP37 CCL3L3 CCL4 CCL3 CCL16 CCL15 CCL23 CCL5 LOC105371746 lnc-CCL23-1
GH17J036154 Enhancer 0.7 FANTOM5 Ensembl 39.8 +49.9 49867 2.2 CTCF IKZF1 IKZF2 NFE2 SCRT2 SCRT1 SMARCA5 CCL4 CCL3L3 CCL3 CCL4L2 CCL5 CCL23 GGNBP2 LOC101927369 ENSG00000282738 LOC100420851
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL4 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • STAT3

Genomic Locations for CCL4 Gene

Genomic Locations for CCL4 Gene
chr17:36,103,827-36,105,621
(GRCh38/hg38)
Size:
1,795 bases
Orientation:
Plus strand
chr17:34,430,983-34,433,014
(GRCh37/hg19)
Size:
2,032 bases
Orientation:
Plus strand

Genomic View for CCL4 Gene

Genes around CCL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL4 Gene

Proteins for CCL4 Gene

  • Protein details for CCL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13236-CCL4_HUMAN
    Recommended name:
    C-C motif chemokine 4
    Protein Accession:
    P13236
    Secondary Accessions:
    • P22617
    • Q13704
    • Q3SXL8
    • Q6FGI8

    Protein attributes for CCL4 Gene

    Size:
    92 amino acids
    Molecular mass:
    10212 Da
    Quaternary structure:
    • Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL4 Gene

neXtProt entry for CCL4 Gene

Post-translational modifications for CCL4 Gene

  • N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Other Protein References for CCL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCL4 Gene

Domains & Families for CCL4 Gene

Gene Families for CCL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CCL4 Gene

GenScript: Design optimal peptide antigens:
  • T-cell activation protein 2 (CCL4_HUMAN)
  • Chemokine C-C motif ligand 4 (Q6JSE0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13236

UniProtKB/Swiss-Prot:

CCL4_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL4: view

Function for CCL4 Gene

Molecular function for CCL4 Gene

UniProtKB/Swiss-Prot Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
UniProtKB/Swiss-Prot Induction:
By mitogens.

Phenotypes From GWAS Catalog for CCL4 Gene

Gene Ontology (GO) - Molecular Function for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2462251
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IBA,TAS 21873635
GO:0031726 CCR1 chemokine receptor binding IPI 7545673
GO:0031730 CCR5 chemokine receptor binding IPI 10383387
genes like me logo Genes that share ontologies with CCL4: view
genes like me logo Genes that share phenotypes with CCL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL4

CRISPR Products

miRNA for CCL4 Gene

miRTarBase miRNAs that target CCL4

Clone Products

  • Addgene plasmids for CCL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL4 Gene

Localization for CCL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL4 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA 21873635
genes like me logo Genes that share ontologies with CCL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL4 Gene

Pathways & Interactions for CCL4 Gene

PathCards logo

SuperPathways for CCL4 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 CCR5 Pathway in Macrophages
.52
.33
4 Toll-like Receptor Signaling Pathway
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with CCL4: view

Pathways by source for CCL4 Gene

SIGNOR curated interactions for CCL4 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA,TAS 21873635
GO:0006955 immune response TAS 10929056
GO:0007155 cell adhesion TAS 10929056
genes like me logo Genes that share ontologies with CCL4: view

Drugs & Compounds for CCL4 Gene

(37) Drugs for CCL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(30) Additional Compounds for CCL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL4: view

Transcripts for CCL4 Gene

mRNA/cDNA for CCL4 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(177) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CCL4

Alternative Splicing Database (ASD) splice patterns (SP) for CCL4 Gene

No ASD Table

Relevant External Links for CCL4 Gene

GeneLoc Exon Structure for
CCL4
ECgene alternative splicing isoforms for
CCL4

Expression for CCL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL4 Gene

This gene is overexpressed in Whole Blood (x19.1) and Spleen (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of CCL4 Gene:

CCL4

SOURCE GeneReport for Unigene cluster for CCL4 Gene:

Hs.75703

Evidence on tissue expression from TISSUES for CCL4 Gene

  • Blood(4.9)
  • Liver(3)
  • Lymph node(3)
  • Spleen(3)
  • Bone marrow(2.9)
  • Lung(2.6)
  • Nervous system(2.6)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with CCL4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL4 Gene

Orthologs for CCL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL4 32
  • 98.19 (n)
dog
(Canis familiaris)
Mammalia CCL4 32
  • 88.04 (n)
cow
(Bos Taurus)
Mammalia CCL4 32
  • 88.04 (n)
rat
(Rattus norvegicus)
Mammalia Ccl4 32
  • 82.97 (n)
mouse
(Mus musculus)
Mammalia Ccl4 17 32
  • 81.88 (n)
chicken
(Gallus gallus)
Aves CCL4 32
  • 59.93 (n)
Species where no ortholog for CCL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL4 Gene

ENSEMBL:
Gene Tree for CCL4 (if available)
TreeFam:
Gene Tree for CCL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL4: view image

Paralogs for CCL4 Gene

(28) SIMAP similar genes for CCL4 Gene using alignment to 3 proteins:

  • CCL4_HUMAN
  • Q6JSE0_HUMAN
  • Q7M4M2_HUMAN
genes like me logo Genes that share paralogs with CCL4: view

Variants for CCL4 Gene

Sequence variations from dbSNP and Humsavar for CCL4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001482599 -- 36,103,753(+) A/T upstream_transcript_variant
rs1002080845 -- 36,102,907(+) G/T upstream_transcript_variant
rs1002543266 -- 36,106,030(+) T/C downstream_transcript_variant
rs1004106531 -- 36,102,934(+) A/G upstream_transcript_variant
rs1006028669 -- 36,105,111(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL4 Gene

Variant ID Type Subtype PubMed ID
dgv3144n100 CNV gain 25217958
dgv3145n100 CNV gain 25217958
dgv3147n100 CNV gain 25217958
dgv545e199 CNV deletion 23128226
dgv5538n54 CNV gain 21841781
dgv5540n54 CNV loss 21841781
dgv5541n54 CNV loss 21841781
dgv5544n54 CNV loss 21841781
dgv5545n54 CNV gain 21841781
dgv5546n54 CNV loss 21841781
dgv5547n54 CNV loss 21841781
dgv5548n54 CNV loss 21841781
esv2760467 CNV gain 21179565
esv2762388 CNV gain+loss 21179565
esv33107 CNV loss 17666407
esv3345949 CNV duplication 20981092
esv3450833 CNV duplication 20981092
esv3893001 CNV gain 25118596
esv3893005 CNV loss 25118596
nsv1061066 CNV loss 25217958
nsv1061448 CNV gain+loss 25217958
nsv1072731 CNV deletion 25765185
nsv1133405 CNV deletion 24896259
nsv1143852 CNV deletion 24896259
nsv2040 CNV deletion 18451855
nsv433448 CNV gain 18776910
nsv514838 CNV gain 21397061
nsv574780 CNV gain+loss 21841781
nsv574781 CNV gain 21841781
nsv574783 CNV gain 21841781
nsv574788 CNV gain+loss 21841781
nsv820772 CNV deletion 20802225
nsv953882 CNV deletion 24416366
nsv960473 CNV duplication 23825009

Variation tolerance for CCL4 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL4 Gene

Disorders for CCL4 Gene

MalaCards: The human disease database

(22) MalaCards diseases for CCL4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus infectious disease
  • hiv infections
pulmonary tuberculosis
  • tuberculosis, pulmonary
meningitis
bone disease
  • skeletal disease
viral infectious disease
  • viral disease
- elite association - COSMIC cancer census association via MalaCards
Search CCL4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL4 Gene

Publications for CCL4 Gene

  1. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W … Kaslow RA (Genes and immunity 2007) 3 23 43 56
  2. Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients. (PMID: 15843566) Colobran R … Juan M (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 23 56
  3. Macrophage inflammatory protein-1. (PMID: 12401480) Menten P … Van Damme J (Cytokine & growth factor reviews 2002) 3 4 23 56
  4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi CG … Umland SP (European journal of immunology 1999) 3 4 23 56
  5. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PMID: 9521068) Bernardini G … Napolitano M (European journal of immunology 1998) 3 4 23 56

Products for CCL4 Gene

Sources for CCL4 Gene