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This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Se... See more...
Aliases for CCL3 Gene
Aliases for CCL3 Gene
External Ids for CCL3 Gene
- HGNC: 10627
- Entrez Gene: 6348
- Ensembl: ENSG00000277632
- OMIM: 182283
- UniProtKB: P10147
Previous HGNC Symbols for CCL3 Gene
- SCYA3
Previous GeneCards Identifiers for CCL3 Gene
- GC17M034185
- GC17M036451
- GC17M034264
- GC17M034561
- GC17M031439
- GC17M034415
- GC17M030600
Summaries for CCL3 Gene
-
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
GeneCards Summary for CCL3 Gene
CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Loiasis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L1.
UniProtKB/Swiss-Prot Summary for CCL3 Gene
-
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Additional gene information for CCL3 Gene
- HGNC(10627)
- Entrez Gene(6348)
- Ensembl(ENSG00000277632)
- OMIM(182283)
- UniProtKB(P10147)
- Open Targets Platform(ENSG00000277632)
- Monarch Initiative
- Search for CCL3 at DataMed
- Search for CCL3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL3 Gene
Genomics for CCL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL3
- Top Transcription factor binding sites by QIAGEN in the CCL3 gene promoter:
-
- AML1a
- CREB
- deltaCREB
- STAT3
Genomic Locations for CCL3 Gene
Genomic Locations for CCL3 Gene
- chr17:36,088,256-36,090,169
- (GRCh38/hg38)
- Size:
- 1,914 bases
- Orientation:
- Minus strand
- chr17:34,415,602-34,417,515
- (GRCh37/hg19)
- Size:
- 1,914 bases
- Orientation:
- Minus strand
Genomic View for CCL3 Gene
Genes around CCL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
CCL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL3 Gene
Proteins for CCL3 Gene
-
Protein details for CCL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10147-CCL3_HUMAN
- Recommended name:
- C-C motif chemokine 3
- Protein Accession:
- P10147
Protein attributes for CCL3 Gene
- Size:
- 92 amino acids
- Molecular mass:
- 10085 Da
- Quaternary structure:
-
- Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
Post-translational modifications for CCL3 Gene
- N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.
Other Protein References for CCL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MIP-1 alpha Antibody
- Creative Diagnostics Anti-CCL3 monoclonal antibody, clone A104
-
Creative Biolabs
- Recombinant Anti-Human CCL3 Antibody
- Mouse Anti-CCL3 Recombinant Antibody (CBFYM-0939)
- Mouse Anti-CCL3 Recombinant Antibody (14215)
- Mouse Anti-CCL3 Recombinant Antibody (CBYY-C0571)
- Mouse Anti-CCL3 Recombinant Antibody (RCK108)
- Recombinant Mouse Anti-CCL3/CCL4/CCL5 Antibody scFv Fragment (7D12A)
- Recombinant Mouse Anti-CCL3/CCL4/CCL5 Antibody (18V4F)
- Recombinant Mouse Anti-CCL3/CCL4/CCL5 Antibody Fab Fragment (18P7E)
- Novus Biologicals Antibodies for CCL3
-
Abcam antibodies for CCL3
- Invitrogen Antibodies for CCL3 (AFLGC-Ccl3)
- antibodies-online: Show 99 available CCL3 Antibodies ranked by validation data
- Compare Top CCL3 Antibodies
-
Recommended
-
Custom Antibody ServicesProSci Antibodies for CCL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL3
- Sino Biological Antibodies for CCL3
Protein Products
- Creative Biomart Recombinant Human Chemokine (C-C Motif) Ligand 3
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL3
- Origene Custom Protein Services for CCL3
- Sino Biological Recombinant Proteins for CCL3
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for CCL3
-
Abcam proteins for CCL3
Assay Products
- RayBiotech Human MIP-1 alpha ELISA
- Novus Biologicals ELISA Kits for CCL3
- antibodies-online: Show 119 available CCL3 Elisa Kits ranked by validation data
- Compare Top CCL3 Elisa Kits
-
Quality Products:
- ABIN625046
- ABIN1115846
- ABIN414812
- ABIN365406
- ABIN411325
- ABIN2472065
- ABIN4993169
- ABIN491804
- ABIN1571224
- ABIN924789
- ABIN1115848
- ABIN1889299
- ABIN625163
- ABIN415487
- ABIN411322
- ABIN365464
- ABIN5563514
- ABIN1571225
- ABIN924825
- ABIN3198410
- ABIN1115847
- ABIN1889383
- ABIN416353
- ABIN924841
- ABIN5523166
- ABIN2683683
- ABIN365616
- ABIN5563515
- ABIN1571226
- ABIN2748356
- ABIN826368
- ABIN1055882
- ABIN1563837
- ABIN6215050
-
Abcam assays for CCL3
No data available for DME Specific Peptides for CCL3 Gene
Domains & Families for CCL3 Gene
Gene Families for CCL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted secreted proteins
Protein Domains for CCL3 Gene
- InterPro:
- Blocks:
-
- Small chemokine, C-C subfamily
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL3 Gene
- GenScript: Design optimal peptide antigens:
-
- HCG1749202, isoform CRA_b (A0N0R1_HUMAN)
- Tonsillar lymphocyte LD78 alpha protein (CCL3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P10147- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL3 Gene
Molecular function for CCL3 Gene
- UniProtKB/Swiss-Prot Function:
- Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
- UniProtKB/Swiss-Prot Induction:
- By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).
Phenotypes From GWAS Catalog for CCL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IDA | 10734056 |
| GO:0004698 | calcium-dependent protein kinase C activity | IDA | 15764707 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 20959807 |
| GO:0008009 | chemokine activity | IDA | 10072545 |
Phenotypes for CCL3 Gene
- GenomeRNAi human phenotypes for CCL3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCL3 - Select products 50% OFF >
- * CCL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL3
miRNA for CCL3 Gene
- miRTarBase miRNAs that target CCL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL3
- Browse OriGene Inhibitory RNA Products For CCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL3
Clone Products
- Applied Biological Materials (abm): Clones for CCL3 - Select products 50% OFF >
- * CCL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL3
Cell Line Products
-
Horizon Cell Lines for CCL3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3 Gene
Localization for CCL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 20167378 |
| GO:0005623 | cell | IEA | -- |
| GO:0005737 | cytoplasm | IDA | 21784977 |
| GO:0005829 | cytosol | IDA | 19523456 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL3 Gene
Pathways & Interactions for CCL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | CCR5 Pathway in Macrophages |
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
|
|
| 5 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
Pathways by source for CCL3 Gene
5 BioSystems pathways for CCL3 Gene
4 Reactome pathways for CCL3 Gene
3 R&D Systems pathways for CCL3 Gene
29 Qiagen pathways for CCL3 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- CCR5 Pathway in Macrophages
- Chemokine Signaling
Interacting Proteins for CCL3 Gene
Selected Interacting proteins:
P10147-CCL3_HUMAN
ENSP00000477908
for CCL3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0001649 | osteoblast differentiation | IEP | 21403648 |
| GO:0001775 | cell activation | IDA | 10706735 |
| GO:0002548 | monocyte chemotaxis | IDA | 10706735 |
| GO:0006816 | calcium ion transport | IDA | 10734056 |
Drugs & Compounds for CCL3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ROX-888 | Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CCL3 Gene
mRNA/cDNA for CCL3 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000613922 780 nts (view in UCSC)
- ENST00000614051 1494 nts (view in UCSC)
- ENST00000613928 1117 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCL3 - Select products 50% OFF >
- * CCL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL3
- Browse OriGene Inhibitory RNA Products For CCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL3
Clone Products
- Applied Biological Materials (abm): Clones for CCL3 - Select products 50% OFF >
- * CCL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL3
Relevant External Links for CCL3 Gene
- GeneLoc Exon Structure for
- CCL3
Expression for CCL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Natural Killer Cells Peripheral Blood
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
mRNA differential expression in normal tissues according to GTEx for CCL3 Gene
This gene is overexpressed in Whole Blood (x14.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL3
SOURCE GeneReport for Unigene cluster for CCL3 Gene:
Hs.514107Evidence on tissue expression from TISSUES for CCL3 Gene
- Blood(4.8)
- Bone marrow(3.8)
- Spleen(3.7)
- Lymph node(3.7)
- Nervous system(3.5)
- Liver(3.4)
- Intestine(3.1)
- Lung(3.1)
- Heart(2.9)
- Kidney(2.9)
- Skin(2.8)
- Muscle(2.6)
- Bone(2.6)
- Adrenal gland(2.5)
- Pancreas(2.2)
- Stomach(2.2)
- Eye(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for CCL3
-
OriGene qPCR primer pairs and template standards for CCL3
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL3 Gene
Orthologs for CCL3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCL3 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | LOC616364 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LOC480600 30 |
|
- Species where no ortholog for CCL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CCL3 Gene
- ENSEMBL:
- Gene Tree for CCL3 (if available)
- TreeFam:
- Gene Tree for CCL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCL3: view image
Paralogs for CCL3 Gene
Paralogs for CCL3 Gene
(28) SIMAP similar genes for CCL3 Gene using alignment to 2 proteins:
- CCL3_HUMAN
- A0N0R1_HUMAN
Pseudogenes.org Pseudogenes for CCL3 Gene
Variants for CCL3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL3 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34171309 | - | p.Glu78Asp |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv120e55 | CNV | gain | 17911159 |
| dgv178n21 | CNV | loss | 19592680 |
| dgv3143n100 | CNV | gain | 25217958 |
| dgv3144n100 | CNV | gain | 25217958 |
| dgv522n67 | CNV | gain | 20364138 |
| dgv5534n54 | CNV | gain | 21841781 |
| esv2664544 | CNV | deletion | 23128226 |
| esv2670934 | CNV | deletion | 23128226 |
| esv2762388 | CNV | gain+loss | 21179565 |
| esv33166 | CNV | gain | 17666407 |
| esv3554365 | CNV | deletion | 23714750 |
| esv3640463 | CNV | gain | 21293372 |
| esv3893000 | CNV | gain+loss | 25118596 |
| nsv1059795 | CNV | gain | 25217958 |
| nsv1061066 | CNV | loss | 25217958 |
| nsv1062304 | CNV | loss | 25217958 |
| nsv457733 | CNV | gain | 19166990 |
| nsv471395 | CNV | gain | 19718026 |
| nsv514836 | CNV | gain | 21397061 |
| nsv523265 | CNV | gain | 19592680 |
| nsv574755 | CNV | gain | 21841781 |
| nsv833424 | CNV | gain | 17160897 |
| nsv833427 | CNV | loss | 17160897 |
| nsv960470 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.67;
45.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCL3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3 Gene
Disorders for CCL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human immunodeficiency virus type 1 |
|
|
| loiasis |
|
|
| aseptic meningitis |
|
|
| african tick-bite fever |
|
|
| pulmonary eosinophilia |
|
Search CCL3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3 Gene
Publications for CCL3 Gene
- Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PMID: 19055602) Paximadis M … Tiemessen CT (International journal of immunogenetics 2009) 3 23 41
- Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. (PMID: 18242850) Li K … Wang B (Neuroscience letters 2008) 3 23 41
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W … Kaslow RA (Genes and immunity 2007) 3 23 41
- Macrophage inflammatory protein-1. (PMID: 12401480) Menten P … Van Damme J (Cytokine & growth factor reviews 2002) 3 4 23
- Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in hemodialysis patients. (PMID: 12408680) Omori K … Gejyo F (Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002) 3 23 41
ExternalLinks
Products for CCL3 Gene
- View all 49 R&D Systems CCL3 (CCL3/MIP-1 alpha) Products
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- Learn more about R&D Systems custom CCL3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCL3
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL3
- Origene Custom Protein Services for CCL3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL3
- Browse OriGene Inhibitory RNA Products For CCL3
- OriGene qPCR primer pairs for CCL3
- OriGene qPCR primer pairs and template standards for CCL3
- OriGene CRISPR knockouts for CCL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL3
- Sino Biological Human cDNA Clone for CCL3
- Sino Biological Recombinant Proteins for CCL3
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CCL3
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCL3
- Novus Biologicals proteins and lysates for CCL3
- Novus Biologicals ELISA Kits for CCL3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCL3
- Abcam proteins for CCL3
- Abcam assays for CCL3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CCL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCL3
- antibodies-online: Show 99 available CCL3 Antibodies ranked by validation data
- Compare Top CCL3 Antibodies
- Recommended
- antibodies-online: Show 119 available CCL3 Elisa Kits ranked by validation data
- Compare Top CCL3 Elisa Kits
- Quality Products:
- ABIN625046
- ABIN1115846
- ABIN414812
- ABIN365406
- ABIN411325
- ABIN2472065
- ABIN4993169
- ABIN491804
- ABIN1571224
- ABIN924789
- ABIN1115848
- ABIN1889299
- ABIN625163
- ABIN415487
- ABIN411322
- ABIN365464
- ABIN5563514
- ABIN1571225
- ABIN924825
- ABIN3198410
- ABIN1115847
- ABIN1889383
- ABIN416353
- ABIN924841
- ABIN5523166
- ABIN2683683
- ABIN365616
- ABIN5563515
- ABIN1571226
- ABIN2748356
- ABIN826368
- ABIN1055882
- ABIN1563837
- ABIN6215050
- antibodies-online: Show 110 available CCL3 Proteins ranked by validation data
- Compare Top CCL3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL3
- Search Santa Cruz Biotechnology (SCBT) for CCL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCL3
- Custom Antibody ServicesProSci Antibodies for CCL3
- Horizon Cell Lines for CCL3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL3
Sources for CCL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB