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This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Loiasis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IDA | 10734056 |
GO:0004698 | calcium-dependent protein kinase C activity | IDA | 15764707 |
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 20959807 |
GO:0008009 | chemokine activity | IDA | 10072545 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IDA,TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 20167378 |
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IDA | 21784977 |
GO:0005829 | cytosol | IDA | 19523456 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
3 | Toll-like Receptor Signaling Pathway | ||
4 | CCR5 Pathway in Macrophages |
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
|
|
5 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IMP | 21147091 |
GO:0001649 | osteoblast differentiation | IEP | 21403648 |
GO:0001775 | cell activation | IDA | 10706735 |
GO:0002548 | monocyte chemotaxis | IDA | 10706735 |
GO:0006816 | calcium ion transport | IDA | 10734056 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
ROX-888 | Investigational | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CCL3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC616364 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LOC480600 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34171309 | - | p.Glu78Asp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv120e55 | CNV | gain | 17911159 |
dgv178n21 | CNV | loss | 19592680 |
dgv3143n100 | CNV | gain | 25217958 |
dgv3144n100 | CNV | gain | 25217958 |
dgv522n67 | CNV | gain | 20364138 |
dgv5534n54 | CNV | gain | 21841781 |
esv2664544 | CNV | deletion | 23128226 |
esv2670934 | CNV | deletion | 23128226 |
esv2762388 | CNV | gain+loss | 21179565 |
esv33166 | CNV | gain | 17666407 |
esv3554365 | CNV | deletion | 23714750 |
esv3640463 | CNV | gain | 21293372 |
esv3893000 | CNV | gain+loss | 25118596 |
nsv1059795 | CNV | gain | 25217958 |
nsv1061066 | CNV | loss | 25217958 |
nsv1062304 | CNV | loss | 25217958 |
nsv457733 | CNV | gain | 19166990 |
nsv471395 | CNV | gain | 19718026 |
nsv514836 | CNV | gain | 21397061 |
nsv523265 | CNV | gain | 19592680 |
nsv574755 | CNV | gain | 21841781 |
nsv833424 | CNV | gain | 17160897 |
nsv833427 | CNV | loss | 17160897 |
nsv960470 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
human immunodeficiency virus type 1 |
|
|
loiasis |
|
|
aseptic meningitis |
|
|
african tick-bite fever |
|
|
pulmonary eosinophilia |
|