CCL3 Gene (Protein Coding)

C-C Motif Chemokine Ligand 3

GC17M036088
GIFtS:
41
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Se... See more...

Aliases for CCL3 Gene

Aliases for CCL3 Gene

  • C-C Motif Chemokine Ligand 3 2 3 5
  • Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a) 2 3
  • Macrophage Inflammatory Protein 1-Alpha 3 4
  • Tonsillar Lymphocyte LD78 Alpha Protein 3 4
  • G0/G1 Switch Regulatory Protein 19-1 3 4
  • Chemokine (C-C Motif) Ligand 3 2 3
  • C-C Motif Chemokine 3 3 4
  • MIP-1-Alpha 3 4
  • PAT 464.1 3 4
  • SIS-Beta 3 4
  • G0S19-1 3 4
  • SCYA3 3 4
  • MIP1A 3 4
  • Small-Inducible Cytokine A3 4
  • LD78ALPHA 3

External Ids for CCL3 Gene

Previous HGNC Symbols for CCL3 Gene

  • SCYA3

Previous GeneCards Identifiers for CCL3 Gene

  • GC17M034185
  • GC17M036451
  • GC17M034264
  • GC17M034561
  • GC17M031439
  • GC17M034415
  • GC17M030600

Summaries for CCL3 Gene

Entrez Gene Summary for CCL3 Gene

  • This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

GeneCards Summary for CCL3 Gene

CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Chagas Disease. Among its related pathways are CCR5 Pathway in Macrophages and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L1.

UniProtKB/Swiss-Prot Summary for CCL3 Gene

  • Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Gene Wiki entry for CCL3 Gene

Additional gene information for CCL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL3 Gene

Genomics for CCL3 Gene

GeneHancer (GH) Regulatory Elements for CCL3 Gene

Promoters and enhancers for CCL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J036088 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 750.6 +0.2 172 3.7 SP1 POLR2A JUND ETV6 RELA CEBPB BCL6B MLLT1 ZNF687 CREM CCL3 lnc-CCL3-1 CCL18 CCL4 ENSG00000277089
GH17J036148 Enhancer 1.3 FANTOM5 Ensembl ENCODE 61 -59.0 -59031 2 CTCF CTBP1 ZNF362 MYC MAX RAD21 ZNF473 ZNF384 MLLT1 SP7 LOC101927369 CCL4 CCL3 CCL3L3 TBC1D3G CCL5 CCL23 LYZL6 GGNBP2 ENSG00000282738
GH17J036102 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 41.1 -15.8 -15836 6.2 ZNF24 MLLT1 SP7 POLR2A PRDM1 CREM IKZF1 CREB1 PRDM10 BACH1 CCL4 CCL3 CCL3L3 CCL5 AP2B1 CCL18 SNHG30 CCL15 PIGW SLFN12L
GH17J036092 Enhancer 0.9 FANTOM5 ENCODE 41.8 -2.2 -2183 0.5 ETV6 RELA CREM IKZF1 BACH1 IKZF2 NFE2 EED MAFG BATF piR-61945-203 CCL3 CCL3L3 CCL4 CCL18 CCL5 GGNBP2 lnc-CCL3-1
GH17J036055 Enhancer 0.7 FANTOM5 Ensembl 42.2 +32.0 31968 6.8 ZBTB40 CREB1 FOXA2 ATF2 ZFP37 CCL3L3 CCL4 CCL3 CCL16 CCL15 CCL23 CCL5 LOC105371746 lnc-CCL23-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL3 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • STAT3

Genomic Locations for CCL3 Gene

Genomic Locations for CCL3 Gene
chr17:36,088,256-36,090,169
(GRCh38/hg38)
Size:
1,914 bases
Orientation:
Minus strand
chr17:34,415,602-34,417,515
(GRCh37/hg19)
Size:
1,914 bases
Orientation:
Minus strand

Genomic View for CCL3 Gene

Genes around CCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL3 Gene

Proteins for CCL3 Gene

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  3. Assay

  • Protein details for CCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10147-CCL3_HUMAN
    Recommended name:
    C-C motif chemokine 3
    Protein Accession:
    P10147

    Protein attributes for CCL3 Gene

    Size:
    92 amino acids
    Molecular mass:
    10085 Da
    Quaternary structure:
    • Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

    Three dimensional structures from OCA and Proteopedia for CCL3 Gene

neXtProt entry for CCL3 Gene

Post-translational modifications for CCL3 Gene

  • N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.

Other Protein References for CCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

Assay Products

No data available for DME Specific Peptides for CCL3 Gene

Domains & Families for CCL3 Gene

Gene Families for CCL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for CCL3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL3 Gene

GenScript: Design optimal peptide antigens:
  • HCG1749202, isoform CRA_b (A0N0R1_HUMAN)
  • Tonsillar lymphocyte LD78 alpha protein (CCL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10147

UniProtKB/Swiss-Prot:

CCL3_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL3: view

Function for CCL3 Gene

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  1. Animal Model
  2. CRISPR
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  6. Cell Line

Molecular function for CCL3 Gene

UniProtKB/Swiss-Prot Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
UniProtKB/Swiss-Prot Induction:
By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).

Phenotypes From GWAS Catalog for CCL3 Gene

Gene Ontology (GO) - Molecular Function for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10734056
GO:0004698 calcium-dependent protein kinase C activity IDA 15764707
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 20959807
GO:0008009 chemokine activity IDA 10072545
genes like me logo Genes that share ontologies with CCL3: view
genes like me logo Genes that share phenotypes with CCL3: view

Animal Model Products

CRISPR Products

miRNA for CCL3 Gene

miRTarBase miRNAs that target CCL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3 Gene

Localization for CCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL3 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IDA,IBA 20167378
GO:0005737 cytoplasm IDA 21784977
GO:0005829 cytosol IDA 19523456
genes like me logo Genes that share ontologies with CCL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL3 Gene

Pathways & Interactions for CCL3 Gene

PathCards logo

SuperPathways for CCL3 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
3 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Chagas disease (American trypanosomiasis)
.31
4 CCR5 Pathway in Macrophages
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
Chemokine signaling pathway
.32
5 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
genes like me logo Genes that share pathways with CCL3: view

SIGNOR curated interactions for CCL3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001649 osteoblast differentiation IEP 21403648
GO:0001775 cell activation IDA 10706735
GO:0002548 monocyte chemotaxis IDA 10706735
GO:0006816 calcium ion transport IDA 10734056
genes like me logo Genes that share ontologies with CCL3: view

Drugs & Compounds for CCL3 Gene

Products:

  1. Drug

(59) Drugs for CCL3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ROX-888 Investigational Pharma Target 0

(48) Additional Compounds for CCL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL3: view

Transcripts for CCL3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCL3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL3 Gene

No ASD Table

Relevant External Links for CCL3 Gene

GeneLoc Exon Structure for
CCL3
ECgene alternative splicing isoforms for
CCL3

Expression for CCL3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL3 Gene

mRNA expression in normal human tissues for CCL3 Gene
mRNA expression by GTEx for CCL3 GenemRNA expression by BioGPS for CCL3 Gene

mRNA differential expression in normal tissues according to GTEx for CCL3 Gene

This gene is overexpressed in Whole Blood (x14.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL3 Gene:

CCL3

SOURCE GeneReport for Unigene cluster for CCL3 Gene:

Hs.514107

Evidence on tissue expression from TISSUES for CCL3 Gene

  • Blood(4.7)
  • Bone marrow(3.3)
  • Spleen(3.2)
  • Lymph node(3.1)
  • Lung(2.9)
  • Nervous system(2.9)
  • Liver(2.8)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CCL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL3 Gene

Orthologs for CCL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCL3 32
  • 98.19 (n)
cow
(Bos Taurus)
 Mammalia LOC616364 32
  • 80.95 (n)
dog
(Canis familiaris)
 Mammalia LOC480600 32
  • 78.99 (n)
Species where no ortholog for CCL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL3 Gene

ENSEMBL:
Gene Tree for CCL3 (if available)
TreeFam:
Gene Tree for CCL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL3: view image

Paralogs for CCL3 Gene

Paralogs for CCL3 Gene

(28) SIMAP similar genes for CCL3 Gene using alignment to 2 proteins:

  • CCL3_HUMAN
  • A0N0R1_HUMAN

Pseudogenes.org Pseudogenes for CCL3 Gene

genes like me logo Genes that share paralogs with CCL3: view

Variants for CCL3 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CCL3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000276697 -- 36,089,061(-) G/A intron_variant
rs1001267821 -- 36,088,048(-) G/C downstream_transcript_variant
rs1002466957 -- 36,092,101(-) G/C/T upstream_transcript_variant
rs1002867209 -- 36,091,891(-) G/A upstream_transcript_variant
rs1004867390 -- 36,090,686(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL3 Gene

Variant ID Type Subtype PubMed ID
dgv120e55 CNV gain 17911159
dgv178n21 CNV loss 19592680
dgv3143n100 CNV gain 25217958
dgv3144n100 CNV gain 25217958
dgv522n67 CNV gain 20364138
dgv5534n54 CNV gain 21841781
esv2664544 CNV deletion 23128226
esv2670934 CNV deletion 23128226
esv2762388 CNV gain+loss 21179565
esv33166 CNV gain 17666407
esv3554365 CNV deletion 23714750
esv3640463 CNV gain 21293372
esv3893000 CNV gain+loss 25118596
nsv1059795 CNV gain 25217958
nsv1061066 CNV loss 25217958
nsv1062304 CNV loss 25217958
nsv457733 CNV gain 19166990
nsv471395 CNV gain 19718026
nsv514836 CNV gain 21397061
nsv523265 CNV gain 19592680
nsv574755 CNV gain 21841781
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897
nsv960470 CNV duplication 23825009

Variation tolerance for CCL3 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3 Gene

Disorders for CCL3 Gene

MalaCards: The human disease database

(39) MalaCards diseases for CCL3 Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
chagas disease
  • american trypanosomiasis
bone disease
  • skeletal disease
rheumatoid arthritis
  • ra
pneumonia
  • acute pneumonia
- elite association - COSMIC cancer census association via MalaCards
Search CCL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3 Gene

Publications for CCL3 Gene

  1. Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PMID: 19055602) Paximadis M … Tiemessen CT (International journal of immunogenetics 2009) 3 23 43 56
  2. Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. (PMID: 18242850) Li K … Wang B (Neuroscience letters 2008) 3 23 43 56
  3. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W … Kaslow RA (Genes and immunity 2007) 3 23 43 56
  4. Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. (PMID: 10347159) Czaplewski LG … Hunter MG (The Journal of biological chemistry 1999) 3 4 23 56
  5. Structures of human genes coding for cytokine LD78 and their expression. (PMID: 1694014) Nakao M … Shimada K (Molecular and cellular biology 1990) 3 4 23 56

ExternalLinks

View latest publications for CCL3 gene in Mastermind

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