Aliases for CCL3 Gene
Aliases for CCL3 Gene
External Ids for CCL3 Gene
- HGNC: 10627
- Entrez Gene: 6348
- Ensembl: ENSG00000277632
- OMIM: 182283
- UniProtKB: P10147
Previous HGNC Symbols for CCL3 Gene
- SCYA3
Previous GeneCards Identifiers for CCL3 Gene
- GC17M034185
- GC17M036451
- GC17M034264
- GC17M034561
- GC17M031439
- GC17M034415
- GC17M030600
Summaries for CCL3 Gene
-
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
GeneCards Summary for CCL3 Gene
CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Chagas Disease. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L1.
UniProtKB/Swiss-Prot for CCL3 Gene
-
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Additional gene information for CCL3 Gene
- Monarch Initiative
- Search for CCL3 at DataMed
- Search for CCL3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL3 Gene
Genomics for CCL3 Gene
GeneHancer (GH) Regulatory Elements for CCL3 Gene
Promoters and enhancers for CCL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCL3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCL3 gene promoter:
Regulatory Element Products
Genomic Locations for CCL3 Gene
Genomic Locations for CCL3 Gene
- chr17:36,088,256-36,090,169
- (GRCh38/hg38)
- Size:
- 1,914 bases
- Orientation:
- Minus strand
- chr17:34,415,602-34,417,515
- (GRCh37/hg19)
Genomic View for CCL3 Gene
Genes around CCL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
CCL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL3 Gene
Proteins for CCL3 Gene
-
Protein details for CCL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10147-CCL3_HUMAN
- Recommended name:
- C-C motif chemokine 3
- Protein Accession:
- P10147
Protein attributes for CCL3 Gene
- Size:
- 92 amino acids
- Molecular mass:
- 10085 Da
- Quaternary structure:
-
- Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
Post-translational modifications for CCL3 Gene
- N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.
Other Protein References for CCL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CCL3 (CCL3/MIP-1 alpha)
-
Custom Antibody ServicesOriGene Antibodies for CCL3
- Novus Biologicals Antibodies for CCL3
- Invitrogen Antibodies for CCL3
- antibodies-online: Search results for 302 available CCL3 Antibodies ranked by validation data
- Compare Top CCL3 Antibodies
-
Recommended
- 114 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 4 EIA Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 51 WB Antibodies (anti-rat)
- 59 WB Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 114 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 4 EIA Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 51 WB Antibodies (anti-rat)
- 59 WB Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- GeneTex CCL3 Antibody for CCL3
-
Custom Antibody ServicesProSci Antibodies for CCL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL3
- Sino Biological Antibodies for CCL3
Protein Products
- R&D Systems Proteins and Enzymes for CCL3 (CCL3/MIP-1 alpha)
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL3
- Origene Custom Protein Services for CCL3
- Sino Biological Recombinant Proteins for CCL3
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for CCL3
- GeneTex Proteins for CCL3
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL3 (CCL3/MIP-1 alpha)
- Novus Biologicals ELISA Kits for CCL3
- antibodies-online: Search results for 103 available CCL3 Elisa Kits ranked by validation data
- Compare Top CCL3 Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 34 Human ELISA Kits
- 3 Monkey ELISA Kits
- 23 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 19 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 34 Human ELISA Kits
- 3 Monkey ELISA Kits
- 23 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 19 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
No data available for DME Specific Peptides for CCL3 Gene
Domains & Families for CCL3 Gene
Gene Families for CCL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted secreted proteins
Protein Domains for CCL3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10147- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL3 Gene
Molecular function for CCL3 Gene
- UniProtKB/Swiss-Prot Function:
- Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
- UniProtKB/Swiss-Prot Induction:
- By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IDA | 10734056 |
| GO:0004698 | calcium-dependent protein kinase C activity | IDA | 15764707 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 20959807 |
| GO:0008009 | chemokine activity | IDA | 10072545 |
Phenotypes for CCL3 Gene
- GenomeRNAi human phenotypes for CCL3:
-
- Decreased homologous recombination repair frequency
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL3
-
CRISPR Products
-
OriGene CRISPR knockouts for CCL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL3
- genomics-online: gRNA clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- Applied Biological Materials CRISPR for CCL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL3
- GenScript: Design CRISPR guide RNA sequences for CCL3
miRNA for CCL3 Gene
- miRTarBase miRNAs that target CCL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL3
- Browse OriGene Inhibitory RNA Products For CCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL3
- genomics-online: shRNA clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for CCL3
- Sino Biological Human cDNA Clone for CCL3
- VectorBuilder custom plasmid, inducible vectors for CCL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL3
- Applied Biological Materials Clones for CCL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCL3
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL3 Gene
Localization for CCL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IDA | -- |
| GO:0005615 | extracellular space | IEA,IDA | 20167378 |
| GO:0005622 | intracellular | IDA | 10072545 |
| GO:0005737 | cytoplasm | IDA | 21784977 |
| GO:0005829 | cytosol | IDA | 19523456 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL3 Gene
Pathways & Interactions for CCL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | CCR5 Pathway in Macrophages | ||
| 5 | Akt Signaling |
.60
.60
|
|
Pathways by source for CCL3 Gene
5 BioSystems pathways for CCL3 Gene
4 Reactome pathways for CCL3 Gene
3 R&D Systems pathways for CCL3 Gene
29 Qiagen pathways for CCL3 Gene
Interacting Proteins for CCL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0001649 | osteoblast differentiation | IEP | 21403648 |
| GO:0001775 | cell activation | IDA | 10706735 |
| GO:0002548 | monocyte chemotaxis | IDA | 10706735 |
| GO:0006816 | calcium ion transport | IDA | 10734056 |
No data available for SIGNOR curated interactions for CCL3 Gene
Drugs & Compounds for CCL3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ROX-888 | Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CCL3 Gene
mRNA/cDNA for CCL3 Gene
- (125) Selected AceView cDNA sequences:
- (9) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000614051 1494 bps (uc060efl.1)
- ENST00000613928 1117 bps (uc060efm.1)
- ENST00000613922 778 bps (uc002hkv.5)
Unigene Clusters for CCL3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL3
- genomics-online: gRNA clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- Applied Biological Materials CRISPR for CCL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL3
- GenScript: Design CRISPR guide RNA sequences for CCL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL3
- Browse OriGene Inhibitory RNA Products For CCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL3
- genomics-online: shRNA clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for CCL3
- Sino Biological Human cDNA Clone for CCL3
- VectorBuilder custom plasmid, inducible vectors for CCL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL3
- Applied Biological Materials Clones for CCL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CCL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
- Bone (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for CCL3 Gene
This gene is overexpressed in Whole Blood (x14.1).
NURSA nuclear receptor signaling pathways regulating expression of CCL3 Gene:
CCL3SOURCE GeneReport for Unigene cluster for CCL3 Gene:
Hs.514107Evidence on tissue expression from TISSUES for CCL3 Gene
- Blood(4.7)
- Bone marrow(3.3)
- Spleen(3.2)
- Lymph node(3.1)
- Lung(2.9)
- Nervous system(2.9)
- Liver(2.8)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CCL3
-
OriGene qPCR primer pairs for CCL3
- genomics-online: primer clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL3 Gene
Orthologs for CCL3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCL3 33 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC616364 33 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC480600 33 |
|
- Species where no ortholog for CCL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CCL3 Gene
- ENSEMBL:
- Gene Tree for CCL3 (if available)
- TreeFam:
- Gene Tree for CCL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCL3: view image
Paralogs for CCL3 Gene
(28) SIMAP similar genes for CCL3 Gene using alignment to 2 proteins:
- CCL3_HUMAN
- A0N0R1_HUMAN
Pseudogenes.org Pseudogenes for CCL3 Gene
Variants for CCL3 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000276697 | -- | 36,089,061(-) | G/A | intron_variant | |
| rs1001267821 | -- | 36,088,048(-) | G/C | downstream_transcript_variant | |
| rs1002466957 | -- | 36,092,101(-) | G/C | upstream_transcript_variant | |
| rs1002867209 | -- | 36,091,891(-) | G/A | upstream_transcript_variant | |
| rs1003856921 | -- | 36,092,149(-) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv120e55 | CNV | gain | 17911159 |
| dgv178n21 | CNV | loss | 19592680 |
| dgv3143n100 | CNV | gain | 25217958 |
| dgv3144n100 | CNV | gain | 25217958 |
| dgv522n67 | CNV | gain | 20364138 |
| dgv5534n54 | CNV | gain | 21841781 |
| esv2664544 | CNV | deletion | 23128226 |
| esv2670934 | CNV | deletion | 23128226 |
| esv2762388 | CNV | gain+loss | 21179565 |
| esv33166 | CNV | gain | 17666407 |
| esv3554365 | CNV | deletion | 23714750 |
| esv3640463 | CNV | gain | 21293372 |
| esv3893000 | CNV | gain+loss | 25118596 |
| nsv1059795 | CNV | gain | 25217958 |
| nsv1061066 | CNV | loss | 25217958 |
| nsv1062304 | CNV | loss | 25217958 |
| nsv457733 | CNV | gain | 19166990 |
| nsv471395 | CNV | gain | 19718026 |
| nsv514836 | CNV | gain | 21397061 |
| nsv523265 | CNV | gain | 19592680 |
| nsv574755 | CNV | gain | 21841781 |
| nsv833424 | CNV | gain | 17160897 |
| nsv833427 | CNV | loss | 17160897 |
| nsv960470 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.67;
45.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCL3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL3 Gene
Disorders for CCL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human immunodeficiency virus type 1 |
|
|
| chagas disease |
|
|
| bone disease |
|
|
| pneumonia |
|
|
| rheumatoid arthritis |
|
Search CCL3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL3 Gene
Publications for CCL3 Gene
- Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection. (PMID: 19055602) Paximadis M … Tiemessen CT (International journal of immunogenetics 2009) 3 22 44 58
- Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. (PMID: 18242850) Li K … Wang B (Neuroscience letters 2008) 3 22 44 58
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. (PMID: 17330138) Shao W … Kaslow RA (Genes and immunity 2007) 3 22 44 58
- Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. (PMID: 10347159) Czaplewski LG … Hunter MG (The Journal of biological chemistry 1999) 3 4 22 58
- Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation. (PMID: 2271120) Blum S … Forsdyke DR (DNA and cell biology 1990) 3 4 22 58
Products for CCL3 Gene
- R&D Systems Antibodies for CCL3 (CCL3/MIP-1 alpha)
- R&D Systems Proteins and Enzymes for CCL3 (CCL3/MIP-1 alpha)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL3 (CCL3/MIP-1 alpha)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CCL3
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL3
- Origene Custom Protein Services for CCL3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL3
- Browse OriGene Inhibitory RNA Products For CCL3
- OriGene qPCR primer pairs and template standards for CCL3
- OriGene qPCR primer pairs for CCL3
- OriGene CRISPR knockouts for CCL3
- OriGene ORF clones in human for CCL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL3
- GenScript: Custom all cDNA clones Services for CCL3
- GenScript Purified and Recombinant Proteins for CCL3
- GenScript Custom Purified and Recombinant Proteins Services for CCL3
- GenScript Custom Assay Services for CCL3
- GenScript Custom overexpressing Cell Line Services for CCL3
- GenScript: Design CRISPR guide RNA sequences for CCL3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCL3
- Sino Biological Human cDNA Clone for CCL3
- Sino Biological Recombinant Proteins for CCL3
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CCL3
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CCL3
- Novus Biologicals proteins and lysates for CCL3
- Novus Biologicals ELISA Kits for CCL3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for CCL3
- VectorBuilder custom plasmid, inducible vectors for CCL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 302 available CCL3 Antibodies ranked by validation data
- Compare Top CCL3 Antibodies
- Recommended
- 114 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 4 EIA Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 51 WB Antibodies (anti-rat)
- 59 WB Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 114 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 4 EIA Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 51 WB Antibodies (anti-rat)
- 59 WB Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- antibodies-online: Search results for 103 available CCL3 Elisa Kits ranked by validation data
- Compare Top CCL3 Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 34 Human ELISA Kits
- 3 Monkey ELISA Kits
- 23 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 19 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 34 Human ELISA Kits
- 3 Monkey ELISA Kits
- 23 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 19 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- antibodies-online: Search results for 104 available CCL3 Proteins ranked by validation data
- Compare Top CCL3 Proteins
- GeneTex CCL3 Antibody for CCL3
- GeneTex Proteins for CCL3
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL3
- Search Santa Cruz Biotechnology (SCBT) for CCL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCL3
- Custom Antibody ServicesProSci Antibodies for CCL3
- Horizon Cell Lines for CCL3
- genomics-online: cdna clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- orf clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- genomics-online: gRNA clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- genomics-online: primer clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- genomics-online: shRNA clones - Search results for 120 available CCL3 gene related products
- Overview of 120 available CCL3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL3
- GeneCopoeia miRNA 3'UTR Target clone products for CCL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL3
Sources for CCL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio