Aliases for CCL3 Gene
External Ids for CCL3 Gene
Previous HGNC Symbols for CCL3 Gene
Previous GeneCards Identifiers for CCL3 Gene
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
GeneCards Summary for CCL3 Gene
CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Chagas Disease. Among its related pathways are CCR5 Pathway in Macrophages and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L1.
UniProtKB/Swiss-Prot Summary for CCL3 Gene
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).