Aliases for CCL28 Gene
External Ids for CCL28 Gene
Previous GeneCards Identifiers for CCL28 Gene
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL28 Gene
CCL28 (C-C Motif Chemokine Ligand 28) is a Protein Coding gene. Diseases associated with CCL28 include Froelich Syndrome. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL27.
UniProtKB/Swiss-Prot Summary for CCL28 Gene
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.