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Aliases for CCL28 Gene

Aliases for CCL28 Gene

  • C-C Motif Chemokine Ligand 28 2 3 5
  • Mucosae-Associated Epithelial Chemokine 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 28 2 3
  • Small Inducible Cytokine A28 2 3
  • CC Chemokine CCL28 2 3
  • SCYA28 3 4
  • MEC 3 4
  • Chemokine (C-C Motif) Ligand 28 Splice Variant Chi 3
  • Chemokine (C-C Motif) Ligand 28 2
  • Small-Inducible Cytokine A28 4
  • C-C Motif Chemokine 28 3
  • Protein CCK1 4
  • CCK1 3

External Ids for CCL28 Gene

Previous GeneCards Identifiers for CCL28 Gene

  • GC05M043684
  • GC05M044553
  • GC05M043376
  • GC05M043422
  • GC05M043229

Summaries for CCL28 Gene

Entrez Gene Summary for CCL28 Gene

  • This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL28 Gene

CCL28 (C-C Motif Chemokine Ligand 28) is a Protein Coding gene. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL27.

UniProtKB/Swiss-Prot for CCL28 Gene

  • Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Additional gene information for CCL28 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL28 Gene

Genomics for CCL28 Gene

GeneHancer (GH) Regulatory Elements for CCL28 Gene

Promoters and enhancers for CCL28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J043396 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.4 +15.4 15356 1.4 TAF1 RB1 SIN3A EBF1 BMI1 RAD21 E4F1 CHAMP1 YY1 E2F1 CCL28 ENSG00000249492 TMEM267 HMGCS1 ENSG00000188850
GH05J043411 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 650.7 0.0 -4 1.7 HLF OSR2 ARHGAP35 PRDM6 ZNF366 GLIS1 ZNF512 ZBTB33 PRDM1 ZBTB17 CCL28 NNT ENSG00000249492
GH05J043482 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.7 -72.6 -72616 5.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF585B GLIS1 NBN TMEM267 ENSG00000249492 ZNF131 EEF1A1P19 RPL29P12 C5orf34 NNT CCL28 HMGCS1 ENSG00000248240
GH05J043554 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.7 -144.0 -143983 3.2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 REST SMARCB1 PAIP1 NNT C5orf34 ENSG00000249492 ENSG00000248240 EEF1A1P19 NNT-AS1 RPL29P12 FGF10-AS1 LOC153684
GH05J043601 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.3 -190.6 -190637 3.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 NNT-AS1 NNT RPL29P12 TMEM267 ZNF131 EEF1A1P19 ANXA2R ENSG00000272382 CCL28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL28 gene promoter:
  • p53
  • STAT1beta
  • STAT1alpha
  • STAT1

Genomic Locations for CCL28 Gene

Genomic Locations for CCL28 Gene
chr5:43,356,972-43,412,391
(GRCh38/hg38)
Size:
55,420 bases
Orientation:
Minus strand
chr5:43,376,747-43,412,493
(GRCh37/hg19)
Size:
35,747 bases
Orientation:
Minus strand

Genomic View for CCL28 Gene

Genes around CCL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL28 Gene

Proteins for CCL28 Gene

  • Protein details for CCL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRJ3-CCL28_HUMAN
    Recommended name:
    C-C motif chemokine 28
    Protein Accession:
    Q9NRJ3
    Secondary Accessions:
    • D7RIE7

    Protein attributes for CCL28 Gene

    Size:
    127 amino acids
    Molecular mass:
    14280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCL28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL28 Gene

Post-translational modifications for CCL28 Gene

  • Glycosylation at Asn78
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL28 Gene

No data available for DME Specific Peptides for CCL28 Gene

Domains & Families for CCL28 Gene

Gene Families for CCL28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CCL28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRJ3

UniProtKB/Swiss-Prot:

CCL28_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL28: view

Function for CCL28 Gene

Molecular function for CCL28 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Phenotypes From GWAS Catalog for CCL28 Gene

Gene Ontology (GO) - Molecular Function for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008009 chemokine activity IEA,TAS 10781587
genes like me logo Genes that share ontologies with CCL28: view
genes like me logo Genes that share phenotypes with CCL28: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL28

miRNA for CCL28 Gene

miRTarBase miRNAs that target CCL28

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL28 Gene

Localization for CCL28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL28 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL28 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IEA --
GO:0005623 cell IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with CCL28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL28 Gene

Pathways & Interactions for CCL28 Gene

genes like me logo Genes that share pathways with CCL28: view

Gene Ontology (GO) - Biological Process for CCL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IDA 18308860
GO:0006935 chemotaxis TAS 10781587
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with CCL28: view

No data available for SIGNOR curated interactions for CCL28 Gene

Drugs & Compounds for CCL28 Gene

(2) Drugs for CCL28 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(2) Additional Compounds for CCL28 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL28: view

Transcripts for CCL28 Gene

Unigene Clusters for CCL28 Gene

Chemokine (C-C motif) ligand 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL28 Gene

No ASD Table

Relevant External Links for CCL28 Gene

GeneLoc Exon Structure for
CCL28
ECgene alternative splicing isoforms for
CCL28

Expression for CCL28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL28 Gene

mRNA differential expression in normal tissues according to GTEx for CCL28 Gene

This gene is overexpressed in Minor Salivary Gland (x23.7), Breast - Mammary Tissue (x5.6), and Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for CCL28 Gene

This gene is overexpressed in Milk (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL28 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCL28 Gene:

CCL28

SOURCE GeneReport for Unigene cluster for CCL28 Gene:

Hs.656904

mRNA Expression by UniProt/SwissProt for CCL28 Gene:

Q9NRJ3-CCL28_HUMAN
Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Evidence on tissue expression from TISSUES for CCL28 Gene

  • Bone(4)
  • Heart(4)
  • Gall bladder(3)
  • Stomach(2.5)
  • Intestine(2.4)
  • Pancreas(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCL28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL28 Gene

Orthologs for CCL28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL28 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCL28 34 33
  • 87.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCL28 34 33
  • 86.09 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl28 33
  • 77.69 (n)
mouse
(Mus musculus)
Mammalia Ccl28 16 34 33
  • 72.5 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
OneToMany
Species where no ortholog for CCL28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL28 Gene

ENSEMBL:
Gene Tree for CCL28 (if available)
TreeFam:
Gene Tree for CCL28 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL28: view image

Paralogs for CCL28 Gene

Paralogs for CCL28 Gene

(1) SIMAP similar genes for CCL28 Gene using alignment to 3 proteins:

  • CCL28_HUMAN
  • A0N0Q3_HUMAN
  • D6RC73_HUMAN
genes like me logo Genes that share paralogs with CCL28: view

Variants for CCL28 Gene

Sequence variations from dbSNP and Humsavar for CCL28 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000028138 -- 43,360,048(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000082254 -- 43,399,961(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000099907 -- 43,403,766(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000148948 -- 43,412,039(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000259522 -- 43,405,410(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL28 Gene

Variant ID Type Subtype PubMed ID
esv2677437 CNV deletion 23128226
esv3604897 CNV gain 21293372
esv3604900 CNV gain 21293372
esv3604901 CNV loss 21293372
nsv508352 CNV deletion 20534489

Variation tolerance for CCL28 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL28

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL28 Gene

Disorders for CCL28 Gene

Additional Disease Information for CCL28

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCL28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL28 Gene

Publications for CCL28 Gene

  1. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PMID: 10781587) Wang W … Zlotnik A (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J … Soler D (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 44 58

Products for CCL28 Gene

Sources for CCL28 Gene

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