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Aliases for CCL27 Gene

Aliases for CCL27 Gene

  • C-C Motif Chemokine Ligand 27 2 3 5
  • CC Chemokine ILC 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27 2 3
  • Cutaneous T-Cell Attracting Chemokine 2 3
  • Chemokine (C-C Motif) Ligand 27 2 3
  • IL-11 R-Alpha-Locus Chemokine 3 4
  • IL-11 Ralpha-Locus Chemokine 2 3
  • Small-Inducible Cytokine A27 3 4
  • Skinkine 3 4
  • ESKINE 3 4
  • SCYA27 3 4
  • CTACK 3 4
  • ILC 3 4
  • Cutaneous T-Cell-Attracting Chemokine 4
  • C-C Motif Chemokine 27 3
  • PESKY 3
  • CTAK 3
  • ALP 3

External Ids for CCL27 Gene

Previous HGNC Symbols for CCL27 Gene

  • SCYA27

Previous GeneCards Identifiers for CCL27 Gene

  • GC09M034974
  • GC09M034831
  • GC09M034651
  • GC09M034616

Summaries for CCL27 Gene

Entrez Gene Summary for CCL27 Gene

  • This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL27 Gene

CCL27 (C-C Motif Chemokine Ligand 27) is a Protein Coding gene. Diseases associated with CCL27 include Dermatitis and Dermatitis, Atopic. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL28.

UniProtKB/Swiss-Prot for CCL27 Gene

  • Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Additional gene information for CCL27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL27 Gene

Genomics for CCL27 Gene

GeneHancer (GH) Regulatory Elements for CCL27 Gene

Promoters and enhancers for CCL27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I034662 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.7 -714 5 HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B E2F8 ENSG00000230074 CCL27 ENSG00000261215 LOC730098 GALT ENSG00000228352 RPP25L ENSG00000231393 SIGMAR1
GH09I034650 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.4 +10.9 10854 4.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B IL11RA GALT ENSG00000230074 ENSG00000258728 CCL27
GH09I034659 Enhancer 0.4 ENCODE 0.8 +4.3 4289 0.2 CTCF GLIS1 FOS CCL27 IL11RA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCL27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL27 gene promoter:

Genomic Locations for CCL27 Gene

Genomic Locations for CCL27 Gene
chr9:34,661,880-34,664,048
(GRCh38/hg38)
Size:
2,169 bases
Orientation:
Minus strand
chr9:34,661,877-34,664,045
(GRCh37/hg19)

Genomic View for CCL27 Gene

Genes around CCL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL27 Gene

Proteins for CCL27 Gene

  • Protein details for CCL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X3-CCL27_HUMAN
    Recommended name:
    C-C motif chemokine 27
    Protein Accession:
    Q9Y4X3

    Protein attributes for CCL27 Gene

    Size:
    112 amino acids
    Molecular mass:
    12618 Da
    Quaternary structure:
    • Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

    Three dimensional structures from OCA and Proteopedia for CCL27 Gene

neXtProt entry for CCL27 Gene

Post-translational modifications for CCL27 Gene

No Post-translational modifications

Other Protein References for CCL27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL27 Gene

Domains & Families for CCL27 Gene

Gene Families for CCL27 Gene

Protein Domains for CCL27 Gene

Suggested Antigen Peptide Sequences for CCL27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4X3

UniProtKB/Swiss-Prot:

CCL27_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL27: view

Function for CCL27 Gene

Molecular function for CCL27 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Gene Ontology (GO) - Molecular Function for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity TAS,IEA --
GO:0031728 CCR3 chemokine receptor binding IPI 12538707
genes like me logo Genes that share ontologies with CCL27: view

Phenotypes for CCL27 Gene

GenomeRNAi human phenotypes for CCL27:
genes like me logo Genes that share phenotypes with CCL27: view

Animal Model Products

miRNA for CCL27 Gene

miRTarBase miRNAs that target CCL27

Clone Products

  • Addgene plasmids for CCL27

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL27 Gene

Localization for CCL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL27 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL27 Gene

Pathways & Interactions for CCL27 Gene

genes like me logo Genes that share pathways with CCL27: view

Gene Ontology (GO) - Biological Process for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10588729
GO:0006955 immune response IEA,TAS --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 10588729
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with CCL27: view

No data available for SIGNOR curated interactions for CCL27 Gene

Drugs & Compounds for CCL27 Gene

(7) Drugs for CCL27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL27: view

Transcripts for CCL27 Gene

mRNA/cDNA for CCL27 Gene

Unigene Clusters for CCL27 Gene

Chemokine (C-C motif) ligand 27:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCL27

Alternative Splicing Database (ASD) splice patterns (SP) for CCL27 Gene

No ASD Table

Relevant External Links for CCL27 Gene

GeneLoc Exon Structure for
CCL27
ECgene alternative splicing isoforms for
CCL27

Expression for CCL27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL27 Gene

mRNA differential expression in normal tissues according to GTEx for CCL27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x22.2) and Skin - Sun Exposed (Lower leg) (x16.2).

NURSA nuclear receptor signaling pathways regulating expression of CCL27 Gene:

CCL27

SOURCE GeneReport for Unigene cluster for CCL27 Gene:

Hs.648124

mRNA Expression by UniProt/SwissProt for CCL27 Gene:

Q9Y4X3-CCL27_HUMAN
Tissue specificity: Testis, thymus, placenta, ovary and skin.

Evidence on tissue expression from TISSUES for CCL27 Gene

  • Skin(4.7)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with CCL27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL27 Gene

Orthologs for CCL27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL27 33 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia CCL27 33 34
  • 84.44 (n)
dog
(Canis familiaris)
Mammalia CCL27 33
  • 83.18 (n)
CTACK 34
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm2506 16 33
  • 77.42 (n)
Ccl27b 34
  • 57 (a)
OneToMany
CCL27 34 34
  • 42 (a)
OneToMany
Gm13306 34
  • 42 (a)
OneToMany
Ccl27a 34
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCL27 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
OneToMany
Species where no ortholog for CCL27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL27 Gene

ENSEMBL:
Gene Tree for CCL27 (if available)
TreeFam:
Gene Tree for CCL27 (if available)

Paralogs for CCL27 Gene

Paralogs for CCL27 Gene

(1) SIMAP similar genes for CCL27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCL27: view

Variants for CCL27 Gene

Sequence variations from dbSNP and Humsavar for CCL27 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000276988 -- 34,664,290(-) C/T upstream_transcript_variant
rs1000645702 -- 34,661,564(-) G/C downstream_transcript_variant
rs1004945232 -- 34,662,725(-) G/A upstream_transcript_variant
rs1005179300 -- 34,663,174(-) C/A upstream_transcript_variant
rs1005474821 -- 34,661,668(-) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL27 Gene

Variant ID Type Subtype PubMed ID
dgv12659n54 CNV loss 21841781
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv1161857 CNV deletion 26073780
nsv818699 CNV gain 17921354
nsv831544 CNV gain 17160897

Variation tolerance for CCL27 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL27 Gene

Disorders for CCL27 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CCL27 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dermatitis
  • eczema
dermatitis, atopic
  • atod
contact dermatitis
  • contact dermatitis nos
psoriasis
malignant anus melanoma
  • anal melanoma
- elite association - COSMIC cancer census association via MalaCards
Search CCL27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL27 Gene

Publications for CCL27 Gene

  1. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. (PMID: 10588729) Morales J … Zlotnik A (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  3. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. (PMID: 10556532) Ishikawa-Mochizuki I … Yoshie O (FEBS letters 1999) 2 3 4 58
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for CCL27 Gene

  • Addgene plasmids for CCL27

Sources for CCL27 Gene

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