This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a ro... See more...

Aliases for CCL27 Gene

Aliases for CCL27 Gene

  • C-C Motif Chemokine Ligand 27 2 3 5
  • CC Chemokine ILC 2 3 4
  • Skinkine 2 3 4
  • CTACK 2 3 4
  • ILC 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27 2 3
  • Cutaneous T-Cell Attracting Chemokine 2 3
  • Chemokine (C-C Motif) Ligand 27 2 3
  • IL-11 R-Alpha-Locus Chemokine 3 4
  • IL-11 Ralpha-Locus Chemokine 2 3
  • Small-Inducible Cytokine A27 3 4
  • C-C Motif Chemokine 27 3 4
  • SCYA27 3 4
  • ESkine 2 4
  • PESKY 2 3
  • CTAK 2 3
  • ALP 2 3
  • Cutaneous T-Cell-Attracting Chemokine 4
  • ESKINE 3
  • CCL27 5

External Ids for CCL27 Gene

Previous HGNC Symbols for CCL27 Gene

  • SCYA27

Previous GeneCards Identifiers for CCL27 Gene

  • GC09M034974
  • GC09M034831
  • GC09M034651
  • GC09M034616

Summaries for CCL27 Gene

Entrez Gene Summary for CCL27 Gene

  • This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL27 Gene

CCL27 (C-C Motif Chemokine Ligand 27) is a Protein Coding gene. Diseases associated with CCL27 include Melanoma and Allergic Contact Dermatitis. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL28.

UniProtKB/Swiss-Prot Summary for CCL27 Gene

  • Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL27 Gene

Genomics for CCL27 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034662 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -0.7 -714 5 SP1 CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 LEF1 IKZF1 ZNF692 ENSG00000230074 CCL27 ENSG00000261215 LOC730098 LOC107987063 lnc-CCL27-1 lnc-IL11RA-2 PHF24 GALT ENSG00000228352
GH09J034650 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +10.9 10854 4.8 HNRNPL CREB1 GATAD2A ZNF629 REST TFE3 IKZF1 TARDBP JUND DDX20 IL11RA GALT ENSG00000230074 ENSG00000258728 lnc-CCL27-2 CCL27
GH09J034659 Enhancer 0.4 ENCODE 0.7 +4.3 4289 0.2 CTCF GLIS1 FOS lnc-CCL27-2 CCL27 IL11RA
GH09J034661 Enhancer 0.2 Ensembl 0.7 +2.5 2547 0.6 lnc-CCL27-2 SIGMAR1 GALT ARID3C CCL19 DCTN3 RPP25L ENSG00000230729 CCL27 IL11RA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL27 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL27

Top Transcription factor binding sites by QIAGEN in the CCL27 gene promoter:
  • ATF-2
  • c-Jun
  • ITF-2
  • p53
  • Tal-1beta

Genomic Locations for CCL27 Gene

Genomic Locations for CCL27 Gene
chr9:34,661,880-34,664,048
(GRCh38/hg38)
Size:
2,169 bases
Orientation:
Minus strand
chr9:34,661,877-34,664,045
(GRCh37/hg19)
Size:
2,169 bases
Orientation:
Minus strand

Genomic View for CCL27 Gene

Genes around CCL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL27 Gene

Proteins for CCL27 Gene

  • Protein details for CCL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X3-CCL27_HUMAN
    Recommended name:
    C-C motif chemokine 27
    Protein Accession:
    Q9Y4X3

    Protein attributes for CCL27 Gene

    Size:
    112 amino acids
    Molecular mass:
    12618 Da
    Quaternary structure:
    • Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

    Three dimensional structures from OCA and Proteopedia for CCL27 Gene

neXtProt entry for CCL27 Gene

Post-translational modifications for CCL27 Gene

No Post-translational modifications

Other Protein References for CCL27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL27 Gene

Domains & Families for CCL27 Gene

Gene Families for CCL27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCL27 Gene

InterPro:
Blocks:
  • Small chemokine, C-C subfamily
ProtoNet:

Suggested Antigen Peptide Sequences for CCL27 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A27 (CCL27_HUMAN)
  • Chemokine (C-C motif) ligand 27 (Q5VZ77_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4X3

UniProtKB/Swiss-Prot:

CCL27_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL27: view

Function for CCL27 Gene

Molecular function for CCL27 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Phenotypes From GWAS Catalog for CCL27 Gene

Gene Ontology (GO) - Molecular Function for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity TAS,IBA 21873635
GO:0031728 CCR3 chemokine receptor binding IPI 12538707
genes like me logo Genes that share ontologies with CCL27: view

Phenotypes for CCL27 Gene

genes like me logo Genes that share phenotypes with CCL27: view

Animal Model Products

CRISPR Products

miRNA for CCL27 Gene

miRTarBase miRNAs that target CCL27

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL27

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL27 Gene

Localization for CCL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL27 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA,TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL27 Gene

Pathways & Interactions for CCL27 Gene

PathCards logo

SuperPathways for CCL27 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.41
3 Peptide ligand-binding receptors
4 Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with CCL27: view

Pathways by source for CCL27 Gene

27 Qiagen pathways for CCL27 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10588729
GO:0006955 immune response TAS,IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 10588729
GO:0010820 positive regulation of T cell chemotaxis IBA 21873635
genes like me logo Genes that share ontologies with CCL27: view

No data available for SIGNOR curated interactions for CCL27 Gene

Drugs & Compounds for CCL27 Gene

(7) Drugs for CCL27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL27: view

Transcripts for CCL27 Gene

mRNA/cDNA for CCL27 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL27

Alternative Splicing Database (ASD) splice patterns (SP) for CCL27 Gene

No ASD Table

Relevant External Links for CCL27 Gene

GeneLoc Exon Structure for
CCL27

Expression for CCL27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x22.2) and Skin - Sun Exposed (Lower leg) (x16.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL27

SOURCE GeneReport for Unigene cluster for CCL27 Gene:

Hs.648124

mRNA Expression by UniProt/SwissProt for CCL27 Gene:

Q9Y4X3-CCL27_HUMAN
Tissue specificity: Testis, thymus, placenta, ovary and skin.

Evidence on tissue expression from TISSUES for CCL27 Gene

  • Skin(4.7)
  • Blood(3.1)
  • Lymph node(2.7)
  • Intestine(2.6)
  • Spleen(2.6)
  • Bone marrow(2.4)
  • Liver(2.2)
  • Lung(2.1)
  • Heart(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCL27: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL27 Gene

Orthologs for CCL27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL27 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCL27 30 31
  • 99.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCL27 30 31
  • 84.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCL27 30
  • 83.18 (n)
CTACK 31
  • 69 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm13306 30 17 31
  • 77.42 (n)
OneToMany
Ccl27b 17 31
  • 57 (a)
OneToMany
CCL27 31 31
  • 42 (a)
OneToMany
Ccl27a 31
  • 35 (a)
OneToMany
Gm2506 17
Platypus
(Ornithorhynchus anatinus)
Mammalia CCL27 31
  • 41 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 18 (a)
OneToMany
Species where no ortholog for CCL27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCL27 Gene

ENSEMBL:
Gene Tree for CCL27 (if available)
TreeFam:
Gene Tree for CCL27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL27: view image

Paralogs for CCL27 Gene

Paralogs for CCL27 Gene

(1) SIMAP similar genes for CCL27 Gene using alignment to 2 proteins:

  • CCL27_HUMAN
  • Q5VZ77_HUMAN
genes like me logo Genes that share paralogs with CCL27: view

Variants for CCL27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL27 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
768290 Benign: not provided 34,662,051(-) T/C MISSENSE_VARIANT
rs11575584 - p.Leu96Phe
rs11575594 - p.Ile78Val

Additional dbSNP identifiers (rs#s) for CCL27 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL27 Gene

Variant ID Type Subtype PubMed ID
dgv12659n54 CNV loss 21841781
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv1161857 CNV deletion 26073780
nsv818699 CNV gain 17921354
nsv831544 CNV gain 17160897

Variation tolerance for CCL27 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL27 Gene

Disorders for CCL27 Gene

MalaCards: The human disease database

(24) MalaCards diseases for CCL27 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
allergic contact dermatitis
  • contact dermatitis, allergic
dermatitis, atopic
  • atod
dermatitis
  • eczema
contact dermatitis
  • contact dermatitis/eczema
- elite association - COSMIC cancer census association via MalaCards
Search CCL27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCL27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL27 Gene

Publications for CCL27 Gene

  1. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. (PMID: 10588729) Morales J … Zlotnik A (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 23
  2. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 23
  3. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. (PMID: 10556532) Ishikawa-Mochizuki I … Yoshie O (FEBS letters 1999) 2 3 4
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for CCL27 Gene

Sources for CCL27 Gene