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This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
CCL26 (C-C Motif Chemokine Ligand 26) is a Protein Coding gene. Diseases associated with CCL26 include Esophagitis and Heart Tumor. Among its related pathways are CCR5 Pathway in Macrophages and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 28381538 |
GO:0008009 | chemokine activity | IDA | 10373330 |
GO:0031728 | CCR3 chemokine receptor binding | IDA | 11425309 |
GO:0048018 | receptor ligand activity | IDA | 11425309 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 10373330 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
5 | CCR5 Pathway in Macrophages |
Chemokine Signaling
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 19525930 |
GO:0002548 | monocyte chemotaxis | IDA | 10373330 |
GO:0006935 | chemotaxis | TAS | 10373330 |
GO:0006954 | inflammatory response | IBA | 21873635 |
GO:0006955 | immune response | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CCL26 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CCL26 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CCL26 32 |
|
||
-- 33 |
|
ManyToMany | |||
mouse (Mus musculus) |
Mammalia | Ccl26 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GGCL1 33 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | ZGC:193706 33 |
|
OneToMany |
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000016318 | -- | 75,776,145(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
rs1000069524 | -- | 75,781,705(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
rs1000389392 | -- | 75,791,713(-) | G/T | upstream_transcript_variant | |
rs1000671810 | -- | 75,790,760(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000815763 | -- | 75,770,312(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv120n16 | CNV | deletion | 17901297 |
dgv6468n100 | CNV | gain | 25217958 |
esv23585 | CNV | loss | 19812545 |
esv2764051 | CNV | gain+loss | 21179565 |
esv3613726 | CNV | gain | 21293372 |
esv3613737 | CNV | gain | 21293372 |
esv3613738 | CNV | loss | 21293372 |
esv3613739 | CNV | loss | 21293372 |
nsv518028 | CNV | gain | 19592680 |
nsv528969 | CNV | gain | 19592680 |
nsv607516 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
esophagitis |
|
|
heart tumor |
|
|
eosinophilic gastritis |
|
|
tuberous sclerosis |
|
|
churg-strauss syndrome |
|
|