Aliases for CCL26 Gene
External Ids for CCL26 Gene
Previous HGNC Symbols for CCL26 Gene
Previous GeneCards Identifiers for CCL26 Gene
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]
GeneCards Summary for CCL26 Gene
CCL26 (C-C Motif Chemokine Ligand 26) is a Protein Coding gene. Diseases associated with CCL26 include Esophagitis and Churg-Strauss Syndrome. Among its related pathways are IL4-mediated signaling events and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL13.
UniProtKB/Swiss-Prot Summary for CCL26 Gene
Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).