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Aliases for CCL26 Gene

Aliases for CCL26 Gene

  • C-C Motif Chemokine Ligand 26 2 3 5
  • Macrophage Inflammatory Protein 4-Alpha 2 3 4
  • Thymic Stroma Chemokine-1 2 3 4
  • CC Chemokine IMAC 2 3 4
  • Eotaxin-3 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 26 2 3
  • Chemokine (C-C Motif) Ligand 26 2 3
  • Small Inducible Cytokine A26 2 3
  • Chemokine N1 2 3
  • MIP-4-Alpha 3 4
  • SCYA26 3 4
  • TSC-1 3 4
  • Small-Inducible Cytokine A26 4
  • C-C Motif Chemokine 26 3
  • MIP-4alpha 3
  • MIP-4a 3
  • IMAC 3

External Ids for CCL26 Gene

Previous HGNC Symbols for CCL26 Gene

  • SCYA26

Previous GeneCards Identifiers for CCL26 Gene

  • GC07M073934
  • GC07M074997
  • GC07M075010
  • GC07M075043
  • GC07M075236
  • GC07M075398
  • GC07M070484

Summaries for CCL26 Gene

Entrez Gene Summary for CCL26 Gene

  • This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL26 Gene

CCL26 (C-C Motif Chemokine Ligand 26) is a Protein Coding gene. Diseases associated with CCL26 include Esophagitis and Heart Tumor. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL18.

UniProtKB/Swiss-Prot for CCL26 Gene

  • Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).

Additional gene information for CCL26 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL26 Gene

Genomics for CCL26 Gene

GeneHancer (GH) Regulatory Elements for CCL26 Gene

Promoters and enhancers for CCL26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I075791 Enhancer 0.9 Ensembl ENCODE 556 -1.9 -1940 1.3 MEIS2 PKNOX1 ZBTB21 JUN FOSL1 ZNF335 ZNF121 POLR2A SCRT2 FOS CCL26 GC07P075817
GH07I075787 Enhancer 0.4 ENCODE 556.6 +1.1 1066 2.4 ZNF366 ZNF512 CCL26 CCL24 SRRM3 ZP3 SSC4D HIP1
GH07I075913 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -128.9 -128863 9.5 CLOCK MLX DMAP1 IRF4 YY1 ZNF143 SP3 SSRP1 GLIS1 RCOR2 POR RHBDD2 PMS2P3 STAG3L1 SNORA14A NSUN5P1 GTF2IRD2B LOC100133091 CCL26 ZP3
GH07I075950 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -161.1 -161137 1.9 PKNOX1 CLOCK NEUROD1 SIN3A RAD21 RFX5 YY1 FOS RCOR1 HCFC1 POR CCL26 SRRM3 MDH2 RHBDD2 GTF2IP1 TMEM120A SNORA14A GC07P075946 GC07P075817
GH07I075953 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.7 -168.9 -168864 10.7 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ATF7 FOS PAF1 RXRA POR ZP3 CCL26 RHBDD2 CCL24 SRRM3 ENSG00000230882 UPK3B MDH2 GTF2IP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCL26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL26 gene promoter:

Genomic Locations for CCL26 Gene

Genomic Locations for CCL26 Gene
chr7:75,769,524-75,789,896
(GRCh38/hg38)
Size:
20,373 bases
Orientation:
Minus strand
chr7:75,398,842-75,419,214
(GRCh37/hg19)

Genomic View for CCL26 Gene

Genes around CCL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL26 Gene

Proteins for CCL26 Gene

  • Protein details for CCL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y258-CCL26_HUMAN
    Recommended name:
    C-C motif chemokine 26
    Protein Accession:
    Q9Y258
    Secondary Accessions:
    • A0N0Q5
    • Q52LV8

    Protein attributes for CCL26 Gene

    Size:
    94 amino acids
    Molecular mass:
    10648 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CCL26 Gene

neXtProt entry for CCL26 Gene

Post-translational modifications for CCL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL26 Gene

No data available for DME Specific Peptides for CCL26 Gene

Domains & Families for CCL26 Gene

Gene Families for CCL26 Gene

Suggested Antigen Peptide Sequences for CCL26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y258

UniProtKB/Swiss-Prot:

CCL26_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL26: view

Function for CCL26 Gene

Molecular function for CCL26 Gene

UniProtKB/Swiss-Prot Function:
Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).

Phenotypes From GWAS Catalog for CCL26 Gene

Gene Ontology (GO) - Molecular Function for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IDA 10373330
GO:0031728 CCR3 chemokine receptor binding IDA 11425309
GO:0048018 receptor ligand activity IDA 11425309
genes like me logo Genes that share ontologies with CCL26: view
genes like me logo Genes that share phenotypes with CCL26: view

miRNA for CCL26 Gene

miRTarBase miRNAs that target CCL26

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL26 Gene

Localization for CCL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL26 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL26 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 10373330
genes like me logo Genes that share ontologies with CCL26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL26 Gene

Pathways & Interactions for CCL26 Gene

genes like me logo Genes that share pathways with CCL26: view

Pathways by source for CCL26 Gene

Gene Ontology (GO) - Biological Process for CCL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002548 monocyte chemotaxis IDA 10373330
GO:0006935 chemotaxis TAS 10373330
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL26: view

No data available for SIGNOR curated interactions for CCL26 Gene

Drugs & Compounds for CCL26 Gene

(7) Drugs for CCL26 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CCL26 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL26: view

Transcripts for CCL26 Gene

Unigene Clusters for CCL26 Gene

Chemokine (C-C motif) ligand 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL26 Gene

No ASD Table

Relevant External Links for CCL26 Gene

GeneLoc Exon Structure for
CCL26
ECgene alternative splicing isoforms for
CCL26

Expression for CCL26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL26 Gene

This gene is overexpressed in Ovary (x12.6), Nerve - Tibial (x5.7), and Pituitary (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL26 Gene:

CCL26

SOURCE GeneReport for Unigene cluster for CCL26 Gene:

Hs.131342

mRNA Expression by UniProt/SwissProt for CCL26 Gene:

Q9Y258-CCL26_HUMAN
Tissue specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary.

Evidence on tissue expression from TISSUES for CCL26 Gene

  • Lung(4.3)
  • Heart(4.2)
  • Intestine(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with CCL26: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL26 Gene

Orthologs for CCL26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL26 33 34
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia CCL26 33 34
  • 76.7 (n)
cow
(Bos Taurus)
Mammalia CCL26 33
  • 74.11 (n)
-- 34
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ccl26 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GGCL1 34
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZGC:193706 34
  • 32 (a)
OneToMany
Species where no ortholog for CCL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCL26 Gene

ENSEMBL:
Gene Tree for CCL26 (if available)
TreeFam:
Gene Tree for CCL26 (if available)

Paralogs for CCL26 Gene

Paralogs for CCL26 Gene

genes like me logo Genes that share paralogs with CCL26: view

Variants for CCL26 Gene

Sequence variations from dbSNP and Humsavar for CCL26 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000016318 -- 75,776,145(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000069524 -- 75,781,705(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000389392 -- 75,791,713(-) G/T upstream_transcript_variant
rs1000671810 -- 75,790,760(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000815763 -- 75,770,312(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL26 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv6468n100 CNV gain 25217958
esv23585 CNV loss 19812545
esv2764051 CNV gain+loss 21179565
esv3613726 CNV gain 21293372
esv3613737 CNV gain 21293372
esv3613738 CNV loss 21293372
esv3613739 CNV loss 21293372
nsv518028 CNV gain 19592680
nsv528969 CNV gain 19592680
nsv607516 CNV gain 21841781

Variation tolerance for CCL26 Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL26 Gene

Human Gene Mutation Database (HGMD)
CCL26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL26 Gene

Disorders for CCL26 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CCL26 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
esophagitis
  • acute esophagitis
heart tumor
  • intracavitary tumors
tuberous sclerosis
  • tuberous sclerosis 1
eosinophilic gastritis
  • eosinophilic enteropathy
tuberous sclerosis 1
  • ts
- elite association - COSMIC cancer census association via MalaCards
Search CCL26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL26 Gene

Publications for CCL26 Gene

  1. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PMID: 10373330) Guo RF … Shi MM (Genomics 1999) 2 3 4 22 58
  2. [The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma]. (PMID: 16604488) Gao GM … He ZQ (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2006) 3 22 44 58
  3. Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population. (PMID: 15784470) Chae SC … Chung HT (Human immunology 2005) 3 22 44 58
  4. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PMID: 16391516) Park YR … Chung HT (Experimental & molecular medicine 2005) 3 22 44 58
  5. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PMID: 15207712) Chae SC … Chung HT (Biochemical and biophysical research communications 2004) 3 22 44 58

Products for CCL26 Gene

Sources for CCL26 Gene

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