This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is i... See more...

Aliases for CCL25 Gene

Aliases for CCL25 Gene

  • C-C Motif Chemokine Ligand 25 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 25 2 3
  • Chemokine (C-C Motif) Ligand 25 2 3
  • Small-Inducible Cytokine A25 3 4
  • Thymus Expressed Chemokine 2 3
  • C-C Motif Chemokine 25 3 4
  • Chemokine TECK 3 4
  • Ck Beta-15 2 3
  • TECKvar 2 3
  • SCYA25 3 4
  • TECK 3 4
  • Thymus-Expressed Chemokine 4
  • Ckb15 3

External Ids for CCL25 Gene

Previous HGNC Symbols for CCL25 Gene

  • SCYA25

Previous GeneCards Identifiers for CCL25 Gene

  • GC19P008076
  • GC19P008222
  • GC19P008023
  • GC19P007788

Summaries for CCL25 Gene

Entrez Gene Summary for CCL25 Gene

  • This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL25 Gene

CCL25 (C-C Motif Chemokine Ligand 25) is a Protein Coding gene. Diseases associated with CCL25 include Ileitis and Cholangitis, Primary Sclerosing. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include hormone activity and chemokine receptor binding. An important paralog of this gene is CCL21.

UniProtKB/Swiss-Prot Summary for CCL25 Gene

  • Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Additional gene information for CCL25 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL25 Gene

Genomics for CCL25 Gene

GeneHancer (GH) Regulatory Elements for CCL25 Gene

Promoters and enhancers for CCL25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL25

Top Transcription factor binding sites by QIAGEN in the CCL25 gene promoter:
  • C/EBPalpha
  • Evi-1
  • HNF-4alpha2
  • HSF1 (long)
  • HSF1short
  • Lmo2
  • MIF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1

Genomic Locations for CCL25 Gene

Genomic Locations for CCL25 Gene
chr19:8,052,340-8,062,663
(GRCh38/hg38)
Size:
10,324 bases
Orientation:
Plus strand
chr19:8,117,646-8,127,547
(GRCh37/hg19)
Size:
9,902 bases
Orientation:
Plus strand

Genomic View for CCL25 Gene

Genes around CCL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL25 Gene

Proteins for CCL25 Gene

  • Protein details for CCL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15444-CCL25_HUMAN
    Recommended name:
    C-C motif chemokine 25
    Protein Accession:
    O15444
    Secondary Accessions:
    • A1L4J4
    • A6NI52
    • A8K9E7
    • B5MCA5
    • Q96KJ7

    Protein attributes for CCL25 Gene

    Size:
    150 amino acids
    Molecular mass:
    16609 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CCL25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL25 Gene

Post-translational modifications for CCL25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCL25 Gene

Domains & Families for CCL25 Gene

Gene Families for CCL25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCL25 Gene

Blocks:
  • Small chemokine, C-C subfamily
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL25 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77197, highly similar to Homo sapiens chemokine (C-C motif) ligand 25 (CCL25), transcript variant 1, mRNA (A6NI52_HUMAN)
  • Thymus-expressed chemokine (CCL25_HUMAN)
  • CCL25 protein (Q08AK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15444

UniProtKB/Swiss-Prot:

CCL25_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL25: view

Function for CCL25 Gene

Molecular function for CCL25 Gene

UniProtKB/Swiss-Prot Function:
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Phenotypes From GWAS Catalog for CCL25 Gene

Gene Ontology (GO) - Molecular Function for CCL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005179 hormone activity TAS 9285413
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity IDA,IEA 18308860
GO:0031735 CCR10 chemokine receptor binding IDA 10706668
genes like me logo Genes that share ontologies with CCL25: view
genes like me logo Genes that share phenotypes with CCL25: view

Animal Models for CCL25 Gene

MGI Knock Outs for CCL25:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL25

CRISPR Products

miRNA for CCL25 Gene

miRTarBase miRNAs that target CCL25

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL25 Gene

Localization for CCL25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL25 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL25 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CCL25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL25 Gene

Pathways & Interactions for CCL25 Gene

PathCards logo

SuperPathways for CCL25 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Peptide ligand-binding receptors
4 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with CCL25: view

Pathways by source for CCL25 Gene

27 Qiagen pathways for CCL25 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

SIGNOR curated interactions for CCL25 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IDA 18308860
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006935 chemotaxis TAS 10640743
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response TAS,IEA 10640743
genes like me logo Genes that share ontologies with CCL25: view

Drugs & Compounds for CCL25 Gene

(1) Drugs for CCL25 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CCL25 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL25: view

Transcripts for CCL25 Gene

mRNA/cDNA for CCL25 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for CCL25 Gene

GeneLoc Exon Structure for
CCL25

Expression for CCL25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL25 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x46.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL25

SOURCE GeneReport for Unigene cluster for CCL25 Gene:

Hs.310511

mRNA Expression by UniProt/SwissProt for CCL25 Gene:

O15444-CCL25_HUMAN
Tissue specificity: Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Evidence on tissue expression from TISSUES for CCL25 Gene

  • Lung(4.1)
  • Intestine(3.4)
genes like me logo Genes that share expression patterns with CCL25: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL25 Gene

Orthologs for CCL25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL25 31 30
  • 99.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCL25 31 30
  • 69.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCL25 31 30
  • 68.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl25 17 31 30
  • 63.82 (n)
rat
(Rattus norvegicus)
Mammalia Ccl25 30
  • 62.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CCL25 31
  • 36 (a)
OneToOne
Species where no ortholog for CCL25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL25 Gene

ENSEMBL:
Gene Tree for CCL25 (if available)
TreeFam:
Gene Tree for CCL25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL25: view image

Paralogs for CCL25 Gene

(2) SIMAP similar genes for CCL25 Gene using alignment to 3 proteins:

  • CCL25_HUMAN
  • C9JDZ7_HUMAN
  • Q08AK2_HUMAN
genes like me logo Genes that share paralogs with CCL25: view

Variants for CCL25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL25 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
782620 Benign: not provided 8,056,208(+) C/T MISSENSE_VARIANT
rs1129763 - p.Thr104Met
rs2032887 - p.His101Arg
rs960173 - p.Thr23Ala

Additional dbSNP identifiers (rs#s) for CCL25 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL25 Gene

Variant ID Type Subtype PubMed ID
esv1497112 CNV deletion 17803354
nsv1123216 CNV deletion 24896259
nsv833734 CNV loss 17160897

Variation tolerance for CCL25 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL25 Gene

Disorders for CCL25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCL25 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ileitis
  • crohn's ileitis
cholangitis, primary sclerosing
  • psc
- elite association - COSMIC cancer census association via MalaCards
Search CCL25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL25 Gene

Publications for CCL25 Gene

  1. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. (PMID: 9285413) Vicari AP … Zlotnik A (Immunity 1997) 2 3 4 23 54
  2. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. (PMID: 10229797) Zaballos A … Márquez G (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 23 54
  3. The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2. (PMID: 9722960) Nomiyama H … Matsuda Y (Genomics 1998) 2 3 23 54
  4. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. (PMID: 23341447) Watts AO … Vischer HF (The Journal of biological chemistry 2013) 3 4 54
  5. Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells. (PMID: 20081876) Wang Y … Li D (Cellular & molecular immunology 2010) 3 23 54

Products for CCL25 Gene

Sources for CCL25 Gene