Aliases for CCL25 Gene
External Ids for CCL25 Gene
Previous HGNC Symbols for CCL25 Gene
Previous GeneCards Identifiers for CCL25 Gene
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL25 Gene
CCL25 (C-C Motif Chemokine Ligand 25) is a Protein Coding gene. Diseases associated with CCL25 include Ileitis and Cholangitis, Primary Sclerosing. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include hormone activity and chemokine receptor binding. An important paralog of this gene is CCL21.
UniProtKB/Swiss-Prot Summary for CCL25 Gene
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.