CCL24 Gene (Protein Coding)

C-C Motif Chemokine Ligand 24

GC07M075811
GIFtS:
38
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on m... See more...

Aliases for CCL24 Gene

Aliases for CCL24 Gene

  • C-C Motif Chemokine Ligand 24 2 3 5
  • Myeloid Progenitor Inhibitory Factor 2 2 3 4
  • Eotaxin-2 2 3 4
  • CK-Beta-6 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24 2 3
  • Eosinophil Chemotactic Protein 2 3 4
  • Chemokine (C-C Motif) Ligand 24 2 3
  • Small-Inducible Cytokine A24 3 4
  • C-C Motif Chemokine 24 3 4
  • SCYA24 3 4
  • MPIF-2 3 4
  • MPIF2 3 4
  • Ckb-6 3

External Ids for CCL24 Gene

Previous HGNC Symbols for CCL24 Gene

  • SCYA24

Previous GeneCards Identifiers for CCL24 Gene

  • GC07M073976
  • GC07M075039
  • GC07M075053
  • GC07M075085
  • GC07M075279
  • GC07M075440
  • GC07M070527

Summaries for CCL24 Gene

Entrez Gene Summary for CCL24 Gene

  • This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL24 Gene

CCL24 (C-C Motif Chemokine Ligand 24) is a Protein Coding gene. Diseases associated with CCL24 include Allergic Asthma and Allergic Hypersensitivity Disease. Among its related pathways are CCR5 Pathway in Macrophages and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CCL13.

UniProtKB/Swiss-Prot Summary for CCL24 Gene

  • Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

Additional gene information for CCL24 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL24 Gene

Genomics for CCL24 Gene

GeneHancer (GH) Regulatory Elements for CCL24 Gene

Promoters and enhancers for CCL24 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J075813 Promoter 1.3 EPDnew Ensembl 750.4 +9.5 9455 0.6 SMARCE1 TEAD4 ZNF148 SMARCA4 TRIM24 IKZF1 HDAC1 LEF1 ZNF24 ETV6 CCL24 SRRM3 RF00017-6382 RF00017-6374
GH07J075823 Promoter/Enhancer 0.6 EPDnew Ensembl 758.9 +0.0 46 0.2 SCRT2 CCL24 RF00017-6382 RF00017-6374
GH07J075877 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 -55.8 -55805 3.3 SIN3A SP1 ZBTB40 ZBTB6 RBPJ SMARCE1 POLR2A CREB1 HCFC1 RUNX1 RHBDD2 STAG3L1 PMS2P3 ENSG00000214243 MDH2 SPDYE5 ENSG00000205485 NSUN5P1 CCL24 STYXL1
GH07J075953 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -135.4 -135404 10.7 CTCF GATA3 SREBF1 LCORL MLX RBPJ TCF7L2 NR2F1 NR2F6 CREB1 POR ZP3 CCL26 RHBDD2 CCL24 STAG3L1 SPDYE5 SRRM3 POMZP3 ENSG00000205485
GH07J075850 Enhancer 0.7 FANTOM5 Ensembl 21.8 -26.1 -26145 4.6 MYC MAX GATAD2A FOS ZMYM3 POLR2A KDM1A SMARCE1 CCL24 CCL26 SRRM3 STAG3L1 RHBDD2 ENSG00000219039 ENSG00000205485 POMZP3 POR piR-57135-070
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL24 gene promoter:
  • AP-1
  • Hlf
  • IRF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • STAT5B
  • TBP

Genomic Locations for CCL24 Gene

Genomic Locations for CCL24 Gene
chr7:75,811,429-75,823,356
(GRCh38/hg38)
Size:
11,928 bases
Orientation:
Minus strand
chr7:75,440,983-75,452,674
(GRCh37/hg19)
Size:
11,692 bases
Orientation:
Minus strand

Genomic View for CCL24 Gene

Genes around CCL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL24 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCL24 Gene

Proteins for CCL24 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00175-CCL24_HUMAN
    Recommended name:
    C-C motif chemokine 24
    Protein Accession:
    O00175
    Secondary Accessions:
    • B2R5K2

    Protein attributes for CCL24 Gene

    Size:
    119 amino acids
    Molecular mass:
    13134 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL24 Gene

neXtProt entry for CCL24 Gene

Post-translational modifications for CCL24 Gene

Other Protein References for CCL24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CCL24 Gene

Domains & Families for CCL24 Gene

Gene Families for CCL24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCL24 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL24 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A24 (CCL24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00175

UniProtKB/Swiss-Prot:

CCL24_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL24: view

Function for CCL24 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CCL24 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

Phenotypes From GWAS Catalog for CCL24 Gene

Gene Ontology (GO) - Molecular Function for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity IDA,TAS 10072545
GO:0031728 CCR3 chemokine receptor binding IDA 11425309
GO:0048018 receptor ligand activity IDA 11425309
genes like me logo Genes that share ontologies with CCL24: view
genes like me logo Genes that share phenotypes with CCL24: view

Animal Models for CCL24 Gene

MGI Knock Outs for CCL24:

Animal Model Products

CRISPR Products

miRNA for CCL24 Gene

miRTarBase miRNAs that target CCL24

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL24 Gene

Localization for CCL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL24 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CCL24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL24 Gene

Pathways & Interactions for CCL24 Gene

PathCards logo

SuperPathways for CCL24 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
3 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
4 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
5 CCR5 Pathway in Macrophages
Chemokine Signaling
.33
Chemokine signaling pathway
.32
genes like me logo Genes that share pathways with CCL24: view

Pathways by source for CCL24 Gene

1 GeneGo (Thomson Reuters) pathway for CCL24 Gene
28 Qiagen pathways for CCL24 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • CCR3 Pathway in Eosinophils
  • Chemokine Signaling

Gene Ontology (GO) - Biological Process for CCL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006935 chemotaxis TAS 9104803
GO:0006954 inflammatory response TAS,IBA 21873635
GO:0006955 immune response TAS 10713092
genes like me logo Genes that share ontologies with CCL24: view

No data available for SIGNOR curated interactions for CCL24 Gene

Drugs & Compounds for CCL24 Gene

Products:

  1. Drug

(5) Drugs for CCL24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CCL24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL24: view

Transcripts for CCL24 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCL24 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL24 Gene

No ASD Table

Relevant External Links for CCL24 Gene

GeneLoc Exon Structure for
CCL24
ECgene alternative splicing isoforms for
CCL24

Expression for CCL24 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL24 Gene

mRNA expression in normal human tissues for CCL24 Gene
mRNA expression by BioGPS for CCL24 GenemRNA expression by GTEx for CCL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL24 Gene

This gene is overexpressed in Spleen (x30.9), Small Intestine - Terminal Ileum (x9.9), and Colon - Transverse (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL24 Gene:

CCL24

SOURCE GeneReport for Unigene cluster for CCL24 Gene:

Hs.247838

mRNA Expression by UniProt/SwissProt for CCL24 Gene:

O00175-CCL24_HUMAN
Tissue specificity: Activated monocytes and activated T lymphocytes.

Evidence on tissue expression from TISSUES for CCL24 Gene

  • Blood(4.5)
  • Intestine(4.4)
  • Lung(2.5)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CCL24: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL24 Gene

Orthologs for CCL24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCL24 33 32
  • 98.59 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CCL24 33 32
  • 75.15 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CCL24 33 32
  • 74.58 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ccl24 17 33 32
  • 71.51 (n)
rat
(Rattus norvegicus)
 Mammalia Ccl24 32
  • 68.66 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 37 (a)
 ManyToMany
-- 33
  • 30 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 33 (a)
 ManyToMany
-- 33
  • 31 (a)
 ManyToMany
-- 33
  • 14 (a)
 ManyToMany
Species where no ortholog for CCL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL24 Gene

ENSEMBL:
Gene Tree for CCL24 (if available)
TreeFam:
Gene Tree for CCL24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL24: view image

Paralogs for CCL24 Gene

Paralogs for CCL24 Gene

(23) SIMAP similar genes for CCL24 Gene using alignment to 1 proteins:

  • CCL24_HUMAN
genes like me logo Genes that share paralogs with CCL24: view

Variants for CCL24 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CCL24 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000476293 -- 75,817,012(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000925298 -- 75,811,723(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001847344 -- 75,813,110(-) A/G intron_variant
rs1001922285 -- 75,812,861(-) C/T intron_variant
rs1002204825 -- 75,823,915(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL24 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
esv2764051 CNV gain+loss 21179565
esv3571926 CNV loss 25503493
nsv1134897 CNV tandem duplication 24896259
nsv518028 CNV gain 19592680
nsv528969 CNV gain 19592680

Variation tolerance for CCL24 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.31; 70.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL24 Gene

Disorders for CCL24 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCL24 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic asthma
  • atopic asthma
allergic hypersensitivity disease
  • allergic disease
asthma
  • asthma, susceptibility to
mansonelliasis
  • mansonella perstans infections
eosinophilic gastritis
  • eosinophilic enteropathy
- elite association - COSMIC cancer census association via MalaCards
Search CCL24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL24 Gene

Publications for CCL24 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel VP … Garotta G (The Journal of experimental medicine 1997) 2 3 4 23 56
  2. Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration. (PMID: 15744457) Min JW … Shin HD (Journal of human genetics 2005) 3 23 43 56
  3. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. (PMID: 15580493) Chae SC … Chung HT (Immunogenetics 2005) 3 23 43 56
  4. The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis. (PMID: 16391516) Park YR … Chung HT (Experimental & molecular medicine 2005) 3 23 43 56
  5. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. (PMID: 15207712) Chae SC … Chung HT (Biochemical and biophysical research communications 2004) 3 23 43 56

ExternalLinks

View latest publications for CCL24 gene in Mastermind

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