This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays... See more...

Aliases for CCL23 Gene

Aliases for CCL23 Gene

  • C-C Motif Chemokine Ligand 23 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23 2 3
  • Myeloid Progenitor Inhibitory Factor 1 3 4
  • Macrophage Inflammatory Protein 3 3 4
  • Chemokine (C-C Motif) Ligand 23 2 3
  • C-C Motif Chemokine 23 3 4
  • SCYA23 3 4
  • MPIF-1 3 4
  • MIP-3 3 4
  • MIP3 3 4
  • Small-Inducible Cytokine A23 4
  • C6 Beta-Chemokine 3
  • CK-BETA-8 3
  • CK-Beta-8 4
  • Ckb-8-1 3
  • Hmrp-2a 3
  • Ckb-8 3
  • CKB-8 4
  • MPIF1 4
  • CKb8 3

External Ids for CCL23 Gene

Previous HGNC Symbols for CCL23 Gene

  • SCYA23

Previous GeneCards Identifiers for CCL23 Gene

  • GC17U990092
  • GC17M036375
  • GC17M034188
  • GC17M034485
  • GC17M031364
  • GC17M034340
  • GC17M030524

Summaries for CCL23 Gene

Entrez Gene Summary for CCL23 Gene

  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL23 Gene

CCL23 (C-C Motif Chemokine Ligand 23) is a Protein Coding gene. Diseases associated with CCL23 include Keshan Disease and Sialadenitis. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL15-CCL14.

UniProtKB/Swiss-Prot Summary for CCL23 Gene

  • Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

Additional gene information for CCL23 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL23 Gene

Genomics for CCL23 Gene

GeneHancer (GH) Regulatory Elements for CCL23 Gene

Promoters and enhancers for CCL23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036017 Promoter/Enhancer 0.8 EPDnew Ensembl 515 -0.5 -526 2.6 NR2F2 NR2F1 MAX CEBPB RAD21 CCL23 CCL15 piR-37972-284
GH17J035986 Promoter 0.8 EPDnew Ensembl 24.7 +32.0 31974 1.6 NR2F2 CCL14 CCL23 CCL18 ENSG00000275431 CCL15-CCL14
GH17J035990 Enhancer 0.9 Ensembl ENCODE 12.2 +27.1 27083 3 SKI TEAD1 FOXA2 MAFF SAP130 MAFK JUND SMAD4 BCL6 RAD21 CCL23 CCL18 CCL15 CCL14 ENSG00000275431 ENSG00000275944 CCL15-CCL14
GH17J036055 Enhancer 0.8 FANTOM5 Ensembl 8 -40.2 -40226 6.8 CREB1 FOXA2 ZFP37 ATF2 ZBTB40 GATA1 CEBPB STAT3 CCL3L3 CCL4 CCL3 CCL16 CCL15 CCL23 CCL5 LOC105371746 lnc-CCL23-1
GH17J035486 Promoter/Enhancer 1.1 Ensembl ENCODE 4.7 +530.2 530160 2.4 ZBTB40 ZNF423 CTCF HES1 RCOR1 RUNX1 RAD21 POLR2A CBFB GABPA SLFN13 SLFN12L SLFN5 NLE1 CCL23 E2F3P1 ENSG00000267349 ENSG00000286065
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL23 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL23

Top Transcription factor binding sites by QIAGEN in the CCL23 gene promoter:
  • Evi-1
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • GATA-1
  • HFH-3
  • NF-kappaB2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CCL23 Gene

Genomic Locations for CCL23 Gene
chr17:36,013,056-36,017,975
(GRCh38/hg38)
Size:
4,920 bases
Orientation:
Minus strand
chr17:34,340,096-34,345,005
(GRCh37/hg19)
Size:
4,910 bases
Orientation:
Minus strand

Genomic View for CCL23 Gene

Genes around CCL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL23 Gene

Proteins for CCL23 Gene

  • Protein details for CCL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55773-CCL23_HUMAN
    Recommended name:
    C-C motif chemokine 23
    Protein Accession:
    P55773
    Secondary Accessions:
    • B7ZKQ3
    • O00174
    • O75950
    • Q52LD4

    Protein attributes for CCL23 Gene

    Size:
    120 amino acids
    Molecular mass:
    13411 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL23 Gene

    Alternative splice isoforms for CCL23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL23 Gene

Post-translational modifications for CCL23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL23 Gene

Protein Products

No data available for DME Specific Peptides for CCL23 Gene

Domains & Families for CCL23 Gene

Gene Families for CCL23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCL23 Gene

Blocks:
  • Small chemokine, C-C subfamily
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL23 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A23 (CCL23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55773

UniProtKB/Swiss-Prot:

CCL23_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL23: view

Function for CCL23 Gene

Molecular function for CCL23 Gene

UniProtKB/Swiss-Prot Function:
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

Phenotypes From GWAS Catalog for CCL23 Gene

Gene Ontology (GO) - Molecular Function for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IDA,TAS 10660125
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 10660125
GO:0048020 CCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CCL23: view
genes like me logo Genes that share phenotypes with CCL23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL23 Gene

Localization for CCL23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL23 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL23 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL23 Gene

Pathways & Interactions for CCL23 Gene

PathCards logo

SuperPathways for CCL23 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Peptide ligand-binding receptors
4 Akt Signaling
.60
.60
.55
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with CCL23: view

Pathways by source for CCL23 Gene

Gene Ontology (GO) - Biological Process for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 9886417
GO:0006935 chemotaxis TAS 9104803
GO:0006954 inflammatory response TAS,IBA 21873635
GO:0006955 immune response TAS 9104803
genes like me logo Genes that share ontologies with CCL23: view

No data available for SIGNOR curated interactions for CCL23 Gene

Drugs & Compounds for CCL23 Gene

(2) Drugs for CCL23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCL23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL23: view

Transcripts for CCL23 Gene

mRNA/cDNA for CCL23 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL23

Alternative Splicing Database (ASD) splice patterns (SP) for CCL23 Gene

No ASD Table

Relevant External Links for CCL23 Gene

GeneLoc Exon Structure for
CCL23

Expression for CCL23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL23 Gene

This gene is overexpressed in Cervix - Endocervix (x8.0), Cervix - Ectocervix (x4.3), and Spleen (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL23

SOURCE GeneReport for Unigene cluster for CCL23 Gene:

Hs.169191

mRNA Expression by UniProt/SwissProt for CCL23 Gene:

P55773-CCL23_HUMAN
Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.

Evidence on tissue expression from TISSUES for CCL23 Gene

  • Blood(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CCL23: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL23 Gene

Orthologs for CCL23 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL23 30
  • 99.44 (n)
Species where no ortholog for CCL23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL23 Gene

ENSEMBL:
Gene Tree for CCL23 (if available)
TreeFam:
Gene Tree for CCL23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL23: view image

Paralogs for CCL23 Gene

(17) SIMAP similar genes for CCL23 Gene using alignment to 2 proteins:

  • CCL23_HUMAN
  • K7EMG9_HUMAN
genes like me logo Genes that share paralogs with CCL23: view

Variants for CCL23 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL23 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs386352289 Uncertain Significance: not provided 36,013,814(-) G/A NONSENSE
rs1003645 - p.Val106Met

Additional dbSNP identifiers (rs#s) for CCL23 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL23 Gene

Variant ID Type Subtype PubMed ID
esv3640462 CNV gain 21293372
nsv1055760 CNV gain 25217958
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL23 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL23 Gene

Disorders for CCL23 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCL23 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
keshan disease
  • caused by deficiency of selenium in the diet
sialadenitis
  • sialoadenitis
trichuriasis
  • infection by trichuris trichura
- elite association - COSMIC cancer census association via MalaCards
Search CCL23 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL23

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL23 Gene

Publications for CCL23 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel VP … Garotta G (The Journal of experimental medicine 1997) 2 3 4 23 54
  2. Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. (PMID: 11060285) Rajarathnam K … Gentz R (The Journal of biological chemistry 2001) 3 4 23 54
  3. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 4 23 54
  4. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PMID: 9558365) Youn BS … Kwon BS (Blood 1998) 3 4 23 54
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 41 54

Products for CCL23 Gene

Sources for CCL23 Gene