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Aliases for CCL23 Gene

Aliases for CCL23 Gene

  • C-C Motif Chemokine Ligand 23 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23 2 3
  • Myeloid Progenitor Inhibitory Factor 1 3 4
  • Macrophage Inflammatory Protein 3 3 4
  • Chemokine (C-C Motif) Ligand 23 2 3
  • SCYA23 3 4
  • MPIF-1 3 4
  • MIP-3 3 4
  • MIP3 3 4
  • Small-Inducible Cytokine A23 4
  • C-C Motif Chemokine 23 3
  • C6 Beta-Chemokine 3
  • CK-BETA-8 3
  • CK-Beta-8 4
  • Ckb-8-1 3
  • Hmrp-2a 3
  • Ckb-8 3
  • CKB-8 4
  • MPIF1 4
  • CKb8 3

External Ids for CCL23 Gene

Previous HGNC Symbols for CCL23 Gene

  • SCYA23

Previous GeneCards Identifiers for CCL23 Gene

  • GC17U990092
  • GC17M036375
  • GC17M034188
  • GC17M034485
  • GC17M031364
  • GC17M034340
  • GC17M030524

Summaries for CCL23 Gene

Entrez Gene Summary for CCL23 Gene

  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for CCL23 Gene

CCL23 (C-C Motif Chemokine Ligand 23) is a Protein Coding gene. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL15-CCL14.

UniProtKB/Swiss-Prot for CCL23 Gene

  • Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

Additional gene information for CCL23 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL23 Gene

Genomics for CCL23 Gene

GeneHancer (GH) Regulatory Elements for CCL23 Gene

Promoters and enhancers for CCL23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036017 Promoter/Enhancer 1 EPDnew Ensembl 665 -0.1 -126 0.6 NR2F1 MAX RAD21 THRB NR2F2 CCL23 CCL15 GC17M036124
GH17J035990 Enhancer 0.7 ENCODE 12.2 +26.7 26695 2.2 SOX13 FOXA2 SAP130 RAD21 RARA YY1 TEAD3 EGR1 HNF4G MAFK CCL23 CCL18 CCL15 GC17M036132 ENSG00000275431 CCL15-CCL14 ENSG00000275944
GH17J035486 Promoter/Enhancer 1.2 Ensembl ENCODE 4.7 +530.3 530261 2.2 CTCF SUZ12 MAX RAD21 HIC1 ZNF335 POLR2A EGR1 EED ATF7 SLFN13 SLFN12L SLFN5 NLE1 CCL23 E2F3P1 ENSG00000267349
GH17J036149 Enhancer 1.4 FANTOM5 Ensembl ENCODE 2.5 -131.4 -131391 0.9 PKNOX1 ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 DEK YY2 REST LOC101927369 CCL4 CCL3 CCL3L3 CCL3L1 CCL5 CCL23 GGNBP2 GC17P036146 LOC100420851
GH17J035533 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.3 +480.3 480302 9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZNF2 IRF4 YY1 ARID2 ZNF143 SLFN12L AP2B1 CCL5 ZNF830 PEX12 LIG3 SLFN5 TAF5LP1 GAS2L2 SLFN11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCL23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL23 gene promoter:

Genomic Locations for CCL23 Gene

Genomic Locations for CCL23 Gene
chr17:36,013,056-36,017,975
(GRCh38/hg38)
Size:
4,920 bases
Orientation:
Minus strand
chr17:34,340,096-34,345,005
(GRCh37/hg19)

Genomic View for CCL23 Gene

Genes around CCL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL23 Gene

Proteins for CCL23 Gene

  • Protein details for CCL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55773-CCL23_HUMAN
    Recommended name:
    C-C motif chemokine 23
    Protein Accession:
    P55773
    Secondary Accessions:
    • B7ZKQ3
    • O00174
    • O75950
    • Q52LD4

    Protein attributes for CCL23 Gene

    Size:
    120 amino acids
    Molecular mass:
    13411 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL23 Gene

    Alternative splice isoforms for CCL23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL23 Gene

Post-translational modifications for CCL23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL23 Gene

Antibody Products

  • R&D Systems Antibodies for CCL23 (CCL23/Ck beta 8-1)
  • R&D Systems Antibodies for CCL23 (CCL23/MPIF-1)
  • Boster Bio Antibodies for CCL23
  • Santa Cruz Biotechnology (SCBT) Antibodies for CCL23

No data available for DME Specific Peptides for CCL23 Gene

Domains & Families for CCL23 Gene

Gene Families for CCL23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCL23 Gene

Suggested Antigen Peptide Sequences for CCL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55773

UniProtKB/Swiss-Prot:

CCL23_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL23: view

Function for CCL23 Gene

Molecular function for CCL23 Gene

UniProtKB/Swiss-Prot Function:
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.

Phenotypes From GWAS Catalog for CCL23 Gene

Gene Ontology (GO) - Molecular Function for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IDA,TAS 10660125
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 10660125
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL23: view
genes like me logo Genes that share phenotypes with CCL23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL23

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCL23 Gene

Localization for CCL23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL23 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL23 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL23 Gene

Pathways & Interactions for CCL23 Gene

genes like me logo Genes that share pathways with CCL23: view

Interacting Proteins for CCL23 Gene

Gene Ontology (GO) - Biological Process for CCL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 9886417
GO:0006935 chemotaxis TAS 9104803
GO:0006954 inflammatory response TAS,IBA --
GO:0006955 immune response TAS 9104803
genes like me logo Genes that share ontologies with CCL23: view

No data available for SIGNOR curated interactions for CCL23 Gene

Drugs & Compounds for CCL23 Gene

(2) Drugs for CCL23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCL23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL23: view

Transcripts for CCL23 Gene

mRNA/cDNA for CCL23 Gene

(135) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL23 Gene

Chemokine (C-C motif) ligand 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL23

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL23 Gene

No ASD Table

Relevant External Links for CCL23 Gene

GeneLoc Exon Structure for
CCL23
ECgene alternative splicing isoforms for
CCL23

Expression for CCL23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL23 Gene

This gene is overexpressed in Cervix - Endocervix (x8.0), Cervix - Ectocervix (x4.3), and Spleen (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of CCL23 Gene:

CCL23

SOURCE GeneReport for Unigene cluster for CCL23 Gene:

Hs.169191

mRNA Expression by UniProt/SwissProt for CCL23 Gene:

P55773-CCL23_HUMAN
Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.

Evidence on tissue expression from TISSUES for CCL23 Gene

  • Blood(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CCL23: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL23 Gene

Orthologs for CCL23 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL23 33
  • 99.44 (n)
Species where no ortholog for CCL23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL23 Gene

ENSEMBL:
Gene Tree for CCL23 (if available)
TreeFam:
Gene Tree for CCL23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL23: view image

Paralogs for CCL23 Gene

Paralogs for CCL23 Gene

(17) SIMAP similar genes for CCL23 Gene using alignment to 2 proteins:

  • CCL23_HUMAN
  • K7EMG9_HUMAN
genes like me logo Genes that share paralogs with CCL23: view

Variants for CCL23 Gene

Sequence variations from dbSNP and Humsavar for CCL23 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs386352289 uncertain-significance, not provided 36,013,814(-) G/A/T coding_sequence_variant, non_coding_transcript_variant, stop_gained, synonymous_variant
rs1000239229 -- 36,012,627(-) C/G downstream_transcript_variant
rs1000249099 -- 36,016,359(-) T/C intron_variant
rs1001116162 -- 36,015,277(-) C/G intron_variant
rs1001253879 -- 36,015,020(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL23 Gene

Variant ID Type Subtype PubMed ID
esv3640462 CNV gain 21293372
nsv1055760 CNV gain 25217958
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL23 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL23 Gene

Disorders for CCL23 Gene

Additional Disease Information for CCL23

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL23 Gene

Publications for CCL23 Gene

  1. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PMID: 9104803) Patel VP … Garotta G (The Journal of experimental medicine 1997) 2 3 4 22 58
  2. Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. (PMID: 11060285) Rajarathnam K … Gentz R (The Journal of biological chemistry 2001) 3 4 22 58
  3. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 4 22 58
  4. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. (PMID: 9558365) Youn BS … Kwon BS (Blood 1998) 3 4 22 58
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58

Products for CCL23 Gene

  • Boster Bio Antibodies for CCL23
  • Boster Bio ELISA Kits for CCL23

Sources for CCL23 Gene

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