This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, n... See more...

Aliases for CCL22 Gene

Aliases for CCL22 Gene

  • C-C Motif Chemokine Ligand 22 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22 2 3
  • Chemokine (C-C Motif) Ligand 22 2 3
  • Macrophage-Derived Chemokine 3 4
  • C-C Motif Chemokine 22 3 4
  • CC Chemokine STCP-1 3 4
  • MDC(1-69) 3 4
  • SCYA22 3 4
  • MDC 3 4
  • Stimulated T Cell Chemotactic Protein 1 3
  • Stimulated T-Cell Chemotactic Protein 1 4
  • Small Inducible Cytokine A22 3
  • Small-Inducible Cytokine A22 4
  • A-152E5.1 3
  • DC/B-CK 3
  • ABCD-1 3
  • STCP-1 3

External Ids for CCL22 Gene

Previous HGNC Symbols for CCL22 Gene

  • SCYA22

Previous GeneCards Identifiers for CCL22 Gene

  • GC16P047788
  • GC16P057452
  • GC16P057127
  • GC16P057168
  • GC16P055950
  • GC16P057392
  • GC16P043260

Summaries for CCL22 Gene

Entrez Gene Summary for CCL22 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL22 Gene

CCL22 (C-C Motif Chemokine Ligand 22) is a Protein Coding gene. Diseases associated with CCL22 include Eosinophilic Pneumonia and Dermatitis. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL4.

UniProtKB/Swiss-Prot Summary for CCL22 Gene

  • May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Gene Wiki entry for CCL22 Gene

Additional gene information for CCL22 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL22 Gene

Genomics for CCL22 Gene

GeneHancer (GH) Regulatory Elements for CCL22 Gene

Promoters and enhancers for CCL22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057359 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.7 +0.4 412 1.2 RELA POLR2A RBM25 MEF2B SPI1 SMARCA5 BCOR ELF1 EBF1 TBP CCL22 DOK4 COQ9 lnc-CCL22-1
GH16J057357 Promoter/Enhancer 1.1 Ensembl ENCODE 500.7 -0.7 -736 1 SP1 EP300 TCF7 RELA BCL11A TCF12 CBFB SRF ARNT MEF2B CCL22 CIAPIN1 POLR2C PLLP lnc-PLLP-2 ENSG00000271456
GH16J057482 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.1 +126.0 126038 5.3 ZBTB40 EP300 NRF1 POLR2G NCOR1 ZFX ZIC2 POLR2A KDM6A ZBTB10 DOK4 CIAPIN1 COQ9 LOC105371286 POLR2C CX3CL1 CCL22 USB1 lnc-CIAPIN1-2
GH16J057343 Enhancer 0.7 FANTOM5 ENCODE 33.8 -15.3 -15306 0.4 IKZF1 SPI1 BCL3 IKZF2 EED CCL22 CX3CL1 lnc-PLLP-2 ENSG00000271456
GH16J057298 Promoter/Enhancer 1.8 ENCODE CraniofacialAtlas dbSUPER 11.8 -58.7 -58704 2.8 FOXK2 ZBTB40 ZNF217 EP300 CTCF TCF12 NRF1 SP1 BCLAF1 NCOR1 TRL-CAG2-1 TRL-CAG2-2 POLR2C LOC101927556 PSME3IP1 NUP93 CCL22 CCDC102A CX3CL1 RSPRY1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL22 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL22

Top Transcription factor binding sites by QIAGEN in the CCL22 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-3
  • IRF-7A
  • NF-kappaB1

Genomic Locations for CCL22 Gene

Genomic Locations for CCL22 Gene
chr16:57,358,783-57,366,190
(GRCh38/hg38)
Size:
7,408 bases
Orientation:
Plus strand
chr16:57,392,684-57,400,102
(GRCh37/hg19)
Size:
7,419 bases
Orientation:
Plus strand

Genomic View for CCL22 Gene

Genes around CCL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL22 Gene

Proteins for CCL22 Gene

  • Protein details for CCL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00626-CCL22_HUMAN
    Recommended name:
    C-C motif chemokine 22
    Protein Accession:
    O00626
    Secondary Accessions:
    • A0N0Q6
    • B2R4W2

    Protein attributes for CCL22 Gene

    Size:
    93 amino acids
    Molecular mass:
    10625 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL22 Gene

Post-translational modifications for CCL22 Gene

  • The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL22 Gene

Domains & Families for CCL22 Gene

Gene Families for CCL22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCL22 Gene

Blocks:
  • Small chemokine, C-C subfamily
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL22 Gene

GenScript: Design optimal peptide antigens:
  • Stimulated T-cell chemotactic protein 1 (CCL22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00626

UniProtKB/Swiss-Prot:

CCL22_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL22: view

Function for CCL22 Gene

Molecular function for CCL22 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Phenotypes From GWAS Catalog for CCL22 Gene

Gene Ontology (GO) - Molecular Function for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity TAS,IBA 21873635
GO:0048020 CCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CCL22: view
genes like me logo Genes that share phenotypes with CCL22: view

Animal Models for CCL22 Gene

MGI Knock Outs for CCL22:
  • Ccl22 Ccl22<tm1a(EUCOMM)Wtsi>
  • Ccl22 Ccl22<tm1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL22

CRISPR Products

miRNA for CCL22 Gene

miRTarBase miRNAs that target CCL22

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL22 Gene

Localization for CCL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL22 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA 21873635
genes like me logo Genes that share ontologies with CCL22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL22 Gene

Pathways & Interactions for CCL22 Gene

PathCards logo

SuperPathways for CCL22 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 CCR5 Pathway in Macrophages
.33
genes like me logo Genes that share pathways with CCL22: view

Pathways by source for CCL22 Gene

Gene Ontology (GO) - Biological Process for CCL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006935 chemotaxis TAS 10861057
GO:0006954 inflammatory response IBA,TAS 21873635
GO:0006955 immune response TAS 10861057
GO:0007165 signal transduction TAS 9743322
genes like me logo Genes that share ontologies with CCL22: view

No data available for SIGNOR curated interactions for CCL22 Gene

Drugs & Compounds for CCL22 Gene

(13) Drugs for CCL22 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for CCL22 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL22: view

Transcripts for CCL22 Gene

mRNA/cDNA for CCL22 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL22 Gene

No ASD Table

Relevant External Links for CCL22 Gene

GeneLoc Exon Structure for
CCL22

Expression for CCL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL22

SOURCE GeneReport for Unigene cluster for CCL22 Gene:

Hs.534347

mRNA Expression by UniProt/SwissProt for CCL22 Gene:

O00626-CCL22_HUMAN
Tissue specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.

Evidence on tissue expression from TISSUES for CCL22 Gene

  • Blood(4.6)
  • Lymph node(4.5)
  • Spleen(4.5)
  • Pancreas(4)
  • Skin(2.5)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CCL22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL22 Gene

Orthologs for CCL22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL22 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCL22 31 30
  • 82.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCL22 31 30
  • 80.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl22 30
  • 75.12 (n)
mouse
(Mus musculus)
Mammalia Ccl22 17 31 30
  • 74.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCL22 31
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL22 31
  • 46 (a)
OneToOne
Species where no ortholog for CCL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL22 Gene

ENSEMBL:
Gene Tree for CCL22 (if available)
TreeFam:
Gene Tree for CCL22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL22: view image

Paralogs for CCL22 Gene

(22) SIMAP similar genes for CCL22 Gene using alignment to 1 proteins:

  • CCL22_HUMAN
genes like me logo Genes that share paralogs with CCL22: view

Variants for CCL22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL22 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
769900 Likely Benign: not provided 57,360,481(+) T/C MISSENSE_VARIANT
rs4359426 - p.Asp2Ala

Additional dbSNP identifiers (rs#s) for CCL22 Gene

Variation tolerance for CCL22 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL22 Gene

Human Gene Mutation Database (HGMD)
CCL22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL22 Gene

Disorders for CCL22 Gene

MalaCards: The human disease database

(21) MalaCards diseases for CCL22 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic pneumonia
  • pneumonia, eosinophilic
dermatitis
  • eczema
mycosis fungoides
  • mycosis fungoides lymphoma
stevens-johnson syndrome/toxic epidermal necrolysis
  • stevens-johnson syndrome
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CCL22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL22 Gene

Publications for CCL22 Gene

  1. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. (PMID: 9151897) Godiska R … Gray PW (The Journal of experimental medicine 1997) 2 3 4 23 54
  2. Genetic polymorphism in chemokine CCL22 and susceptibility to Helicobacter pylori infection-related gastric carcinoma. (PMID: 19298002) Wang G … Lin D (Cancer 2009) 3 23 41 54
  3. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. (PMID: 11241286) Vulcano M … Sozzani S (European journal of immunology 2001) 3 4 23 54
  4. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. (PMID: 9691168) Nomiyama H … Yoshie O (Cytogenetics and cell genetics 1998) 2 3 23 54
  5. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PMID: 9430724) Imai T … Gray PW (The Journal of biological chemistry 1998) 3 4 23 54

Products for CCL22 Gene

Sources for CCL22 Gene