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Aliases for CCL20 Gene

Aliases for CCL20 Gene

  • C-C Motif Chemokine Ligand 20 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20 2 3
  • Liver And Activation-Regulated Chemokine 3 4
  • Macrophage Inflammatory Protein 3 Alpha 3 4
  • Chemokine (C-C Motif) Ligand 20 2 3
  • Small-Inducible Cytokine A20 3 4
  • CC Chemokine LARC 3 4
  • MIP-3-Alpha 3 4
  • SCYA20 3 4
  • MIP3A 3 4
  • LARC 3 4
  • Beta Chemokine Exodus-1 3
  • Beta-Chemokine Exodus-1 4
  • C-C Motif Chemokine 20 3
  • Exodus 3
  • MIP-3a 3
  • CKb4 3
  • ST38 3

External Ids for CCL20 Gene

Previous HGNC Symbols for CCL20 Gene

  • SCYA20

Previous GeneCards Identifiers for CCL20 Gene

  • GC02P226699
  • GC02P227410
  • GC02P228642
  • GC02P228881
  • GC02P228504
  • GC02P228386
  • GC02P228678
  • GC02P220520

Summaries for CCL20 Gene

Entrez Gene Summary for CCL20 Gene

  • This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL20 Gene

CCL20 (C-C Motif Chemokine Ligand 20) is a Protein Coding gene. Diseases associated with CCL20 include Rheumatoid Arthritis and Psoriasis. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.

UniProtKB/Swiss-Prot for CCL20 Gene

  • Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).

Gene Wiki entry for CCL20 Gene

Additional gene information for CCL20 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL20 Gene

Genomics for CCL20 Gene

GeneHancer (GH) Regulatory Elements for CCL20 Gene

Promoters and enhancers for CCL20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227812 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.4 +7.9 7928 1.8 FOXA2 MLX ARID4B DMAP1 ETS1 SLC30A9 ATF7 NFKBIZ PAF1 SP5 CCL20 GC02P227817
GH02J227805 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.7 0.0 -7 1.1 ZNF687 MAX MEF2B ELF1 ZNF217 TARDBP IKZF1 ATF7 ZSCAN29 MLLT1 CCL20 GC02P227805 AGFG1
GH02J227782 Enhancer 1.2 FANTOM5 Ensembl ENCODE 30.9 -22.4 -22423 1.7 PKNOX1 BACH1 PAX8 EBF1 BMI1 IRF4 RELA EED ATF7 ETV6 CCL20 AGFG1 SNRPGP8 LOC100533842
GH02J227700 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -102.9 -102923 4 PKNOX1 FOXA2 ZFP64 NEUROD1 FEZF1 RAD21 RARA ETS1 RFX5 YY1 CCL20 SLC19A3 GC02M227708 SCYGR5
GH02J227847 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.3 +43.2 43162 2.2 STAT5A BATF IRF4 RELA NFATC1 EED ATF7 ETV6 IKZF2 RUNX3 DAW1 TDGF1P2 CCL20 GC02P227844 GC02M227848
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCL20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL20 gene promoter:

Genomic Locations for CCL20 Gene

Genomic Locations for CCL20 Gene
chr2:227,805,739-227,817,564
(GRCh38/hg38)
Size:
11,826 bases
Orientation:
Plus strand
chr2:228,678,558-228,682,280
(GRCh37/hg19)

Genomic View for CCL20 Gene

Genes around CCL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL20 Gene

Proteins for CCL20 Gene

  • Protein details for CCL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78556-CCL20_HUMAN
    Recommended name:
    C-C motif chemokine 20
    Protein Accession:
    P78556
    Secondary Accessions:
    • Q53S51
    • Q99664

    Protein attributes for CCL20 Gene

    Size:
    96 amino acids
    Molecular mass:
    10762 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL20 Gene

    Alternative splice isoforms for CCL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL20 Gene

Post-translational modifications for CCL20 Gene

  • C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CCL20 Gene

No data available for DME Specific Peptides for CCL20 Gene

Domains & Families for CCL20 Gene

Gene Families for CCL20 Gene

Suggested Antigen Peptide Sequences for CCL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78556

UniProtKB/Swiss-Prot:

CCL20_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL20: view

Function for CCL20 Gene

Molecular function for CCL20 Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.

Phenotypes From GWAS Catalog for CCL20 Gene

Gene Ontology (GO) - Molecular Function for CCL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 17703191
GO:0008009 chemokine activity TAS,IBA --
GO:0031731 CCR6 chemokine receptor binding IEA,IDA 12081481
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL20: view
genes like me logo Genes that share phenotypes with CCL20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL20

miRNA for CCL20 Gene

miRTarBase miRNAs that target CCL20

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL20 Gene

Localization for CCL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL20 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with CCL20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL20 Gene

Pathways & Interactions for CCL20 Gene

genes like me logo Genes that share pathways with CCL20: view

Gene Ontology (GO) - Biological Process for CCL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS,IDA 20068036
GO:0006954 inflammatory response IBA,TAS --
GO:0006955 immune response TAS 10521347
GO:0007165 signal transduction TAS 9038201
genes like me logo Genes that share ontologies with CCL20: view

No data available for SIGNOR curated interactions for CCL20 Gene

Drugs & Compounds for CCL20 Gene

(13) Drugs for CCL20 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 7224
Antibodies, Monoclonal Pharma 4660
Immunoglobulins Pharma 7224
Pharmaceutical Solutions Pharma 9000

(11) Additional Compounds for CCL20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL20: view

Transcripts for CCL20 Gene

mRNA/cDNA for CCL20 Gene

Unigene Clusters for CCL20 Gene

Chemokine (C-C motif) ligand 20:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL20 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for CCL20 Gene

GeneLoc Exon Structure for
CCL20
ECgene alternative splicing isoforms for
CCL20

Expression for CCL20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL20 Gene

This gene is overexpressed in Minor Salivary Gland (x12.4), Lung (x6.9), and Liver (x5.5).

Protein differential expression in normal tissues from HIPED for CCL20 Gene

This gene is overexpressed in Islet of Langerhans (30.9), Pancreas (23.1), and Plasma (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL20 Gene



Protein tissue co-expression partners for CCL20 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL20 Gene:

CCL20

SOURCE GeneReport for Unigene cluster for CCL20 Gene:

Hs.75498

mRNA Expression by UniProt/SwissProt for CCL20 Gene:

P78556-CCL20_HUMAN
Tissue specificity: Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.

Evidence on tissue expression from TISSUES for CCL20 Gene

  • Liver(4.4)
  • Pancreas(4.2)
  • Intestine(3.4)
  • Lymph node(2.9)
  • Blood(2.7)
  • Lung(2.6)
  • Spleen(2.5)
  • Skin(2.3)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with CCL20: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL20 Gene

Orthologs for CCL20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL20 34 33
  • 98.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCL20 34 33
  • 83.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCL20 34 33
  • 81.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl20 16 34 33
  • 72.7 (n)
rat
(Rattus norvegicus)
Mammalia Ccl20 33
  • 69.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCL20 34
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL20 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCL20 33
  • 61.96 (n)
MIP-3ALPHA 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCL20 34
  • 47 (a)
OneToOne
Species where no ortholog for CCL20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL20 Gene

ENSEMBL:
Gene Tree for CCL20 (if available)
TreeFam:
Gene Tree for CCL20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL20: view image

Paralogs for CCL20 Gene

(18) SIMAP similar genes for CCL20 Gene using alignment to 1 proteins:

  • CCL20_HUMAN
genes like me logo Genes that share paralogs with CCL20: view

No data available for Paralogs for CCL20 Gene

Variants for CCL20 Gene

Sequence variations from dbSNP and Humsavar for CCL20 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000637413 -- 227,817,189(+) C/G 3_prime_UTR_variant
rs1000749225 -- 227,812,991(+) T/C upstream_transcript_variant
rs1000877730 -- 227,815,286(+) G/A intron_variant
rs1001591137 -- 227,817,907(+) C/T downstream_transcript_variant
rs1001622432 -- 227,817,579(+) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL20 Gene

Variant ID Type Subtype PubMed ID
nsv10221 CNV loss 18304495
nsv834562 CNV gain 17160897

Variation tolerance for CCL20 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL20 Gene

Disorders for CCL20 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CCL20 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CCL20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL20 Gene

Publications for CCL20 Gene

  1. Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. (PMID: 11352563) Nelson RT … McColl SR (Genomics 2001) 2 3 4 22 58
  2. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. (PMID: 9038201) Hieshima K … Nomiyama H (The Journal of biological chemistry 1997) 2 3 4 22 58
  3. The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. (PMID: 12149255) Hoover DM … Lubkowski J (The Journal of biological chemistry 2002) 3 4 22 58
  4. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. (PMID: 11035086) Schutyser E … Van Damme J (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  5. Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. (PMID: 25122636) Diao R … Chan HC (Science translational medicine 2014) 3 4 58

Products for CCL20 Gene

Sources for CCL20 Gene

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