Aliases for CCL2 Gene
Subcategory (RNA class) for CCL2 Gene
lncRNA
Aliases for CCL2 Gene
- C-C Motif Chemokine Ligand 2 2 3 5
- Monocyte Chemotactic And Activating Factor 2 3 4
- Monocyte Secretory Protein JE 2 3 4
- Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je) 2 3
- Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2 2 3
- Monocyte Chemoattractant Protein-1 2 3
- Monocyte Chemotactic Protein 1 3 4
- Chemokine (C-C Motif) Ligand 2 2 3
- Small-Inducible Cytokine A2 3 4
- SCYA2 3 4
- MCP-1 3 4
External Ids for CCL2 Gene
- HGNC: 10618
- Entrez Gene: 6347
- Ensembl: ENSG00000108691
- OMIM: 158105
- UniProtKB: P13500
ORGUL Members for CCL2 Gene
Previous HGNC Symbols for CCL2 Gene
- SCYA2
Previous GeneCards Identifiers for CCL2 Gene
- GC17P032352
- GC17P034621
- GC17P032727
- GC17P029606
- GC17P032582
- GC17P028767
Summaries for CCL2 Gene
-
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
GeneCards Summary for CCL2 Gene
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include protein kinase activity and heparin binding. An important paralog of this gene is CCL7.
UniProtKB/Swiss-Prot for CCL2 Gene
-
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Additional gene information for CCL2 Gene
- Monarch Initiative
- Search for CCL2 at DataMed
- Search for CCL2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL2 Gene
Genomics for CCL2 Gene
GeneHancer (GH) Regulatory Elements for CCL2 Gene
Promoters and enhancers for CCL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCL2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCL2 gene promoter:
-
- STAT1
- AP-1
- c-Fos
- c-Jun
Regulatory Element Products
Genomic Locations for CCL2 Gene
Genomic Locations for CCL2 Gene
- chr17:34,255,218-34,257,203
- (GRCh38/hg38)
- Size:
- 1,986 bases
- Orientation:
- Plus strand
- chr17:32,582,296-32,584,222
- (GRCh37/hg19)
- Size:
- 1,927 bases
- Orientation:
- Plus strand
Genomic View for CCL2 Gene
Genes around CCL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
CCL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL2 Gene
Proteins for CCL2 Gene
-
Protein details for CCL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13500-CCL2_HUMAN
- Recommended name:
- C-C motif chemokine 2
- Protein Accession:
- P13500
- B2R4V3
- Q9UDF3
Protein attributes for CCL2 Gene
- Size:
- 99 amino acids
- Molecular mass:
- 11025 Da
- Quaternary structure:
-
- Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
Protein Expression for CCL2 Gene
Post-translational modifications for CCL2 Gene
- Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
- Glycosylation at Asn37
Other Protein References for CCL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CCL2 (CCL2/JE/MCP-1)
-
Custom Antibody ServicesOriGene Antibodies for CCL2
- AM06084PU-N
- AM06749PU-N
- AM26297PU-N
- AM26342BT-N
- AM26342PU-N
- AM31289AF-N
- AM31290AF-N
- AM32133BT-N
- AM32133PU-N
- AM32136PU-N
- AP09164PU-N
- AP09164PU-S
- AP26385PU-N
- DM2030
- DM2031
- DM2032
- DM2033
- DM2034
- DM2034B
- DM2034HRP
- PM1006A
- PP020B1
- PP020B2
- PP020P1
- PP020P2
- PP037B1
- PP037B2
- PP037P1
- PP037P2
- PP1044B1
- PP1044B2
- PP1044P1
- PP1044P2
- SM2289P
- TA319048
- TA319166
- TA319701
- TA320225
- TA320226
- TA320227
- TA321546
- TA321547
- TA324861
- TA328374
- TA328375
- TA328524
- TA328525
- TA328588
- TA328589
- TA336723
- TA336724
- TA336914
- TA805016
- CF805016
- TA600025
- TA700025
- Novus Biologicals Antibodies for CCL2
- Invitrogen Antibodies for CCL2
- antibodies-online: Search results for 566 available CCL2 Antibodies ranked by validation data
- Compare Top CCL2 Antibodies
-
Recommended
- 90 WB Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 279 WB Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 IA Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 99 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 90 WB Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 279 WB Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 IA Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 99 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- GeneTex CCL2 Antibody for CCL2
-
Custom Antibody ServicesProSci Antibodies for CCL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL2
- Sino Biological Antibodies for CCL2
Protein Products
- R&D Systems Proteins and Enzymes for CCL2 (CCL2/JE/MCP-1)
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL2
- Origene Custom Protein Services for CCL2
- Sino Biological Cell Lysates for CCL2
- Sino Biological Recombinant Proteins for CCL2
- ProSpec Recombinant Proteins for CCL2
- GeneTex Proteins for CCL2
-
ProSci Proteins for CCL2
- chemokine (C-C motif) ligand 2 [90-376]
- chemokine (C-C motif) ligand 2 [90-377]
- chemokine (C-C motif) ligand 2 [90-378]
- chemokine (C-C motif) ligand 2 [90-379]
- C-C motif chemokine ligand 2 [92-669]
- chemokine (C-C motif) ligand 2 [40-338]
- chemokine (C-C motif) ligand 2 [40-362]
- chemokine (C-C motif) ligand 2 [40-410]
- chemokine (C-C motif) ligand 2 [40-564]
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL2 (CCL2/JE/MCP-1)
- Novus Biologicals ELISA Kits for CCL2
- antibodies-online: Search results for 191 available CCL2 Elisa Kits ranked by validation data
- Compare Top CCL2 Elisa Kits
-
Recommended
- 2 Chicken ELISA Kits
- 8 Cow (Bovine) ELISA Kits
- 17 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 8 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 52 Human ELISA Kits
- 9 Monkey ELISA Kits
- 36 Mouse (Murine) ELISA Kits
- 15 Pig (Porcine) ELISA Kits
- 14 Rabbit ELISA Kits
- 29 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
- 2 Chicken ELISA Kits
- 8 Cow (Bovine) ELISA Kits
- 17 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 8 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 52 Human ELISA Kits
- 9 Monkey ELISA Kits
- 36 Mouse (Murine) ELISA Kits
- 15 Pig (Porcine) ELISA Kits
- 14 Rabbit ELISA Kits
- 29 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
- Sino Biological Assays for CCL2
No data available for DME Specific Peptides for CCL2 Gene
Domains & Families for CCL2 Gene
Gene Families for CCL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- FDA approved drug targets
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CCL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13500- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL2 Gene
Molecular function for CCL2 Gene
- UniProtKB/Swiss-Prot Function:
- Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712).
Phenotypes From GWAS Catalog for CCL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS | 9973507 |
| GO:0005102 | signaling receptor binding | TAS | 10542238 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 26095031 |
| GO:0008009 | chemokine activity | TAS,IBA | -- |
Phenotypes for CCL2 Gene
- MGI mutant phenotypes for CCL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCL2:
-
- Decreased OCT4 protein expression
- Decreased POU5F1-GFP protein expression
- Decreased NANOG protein expression
- Decreased homologous recombination repair frequency
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Increased viability
Animal Model Products
-
Taconic Biosciences Mouse Models for CCL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL2
-
CRISPR Products
-
OriGene CRISPR knockouts for CCL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL2
- genomics-online: gRNA clones - Search results for available CCL2 gene related products
- Applied Biological Materials CRISPR for CCL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- GenScript: Design CRISPR guide RNA sequences for CCL2
miRNA for CCL2 Gene
- miRTarBase miRNAs that target CCL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL2
- genomics-online: shRNA clones - Search results for available CCL2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CCL2
- VectorBuilder custom plasmid, inducible vectors for CCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL2
- genomics-online: cdna clones - Search results for available CCL2 gene related products
- orf clones - Search results for available CCL2 gene related products
- Applied Biological Materials Clones for CCL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL2 Gene
Localization for CCL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| endosome | 1 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | IBA,TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005623 | cell | IEA | -- |
Pathways & Interactions for CCL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Akt Signaling |
.60
.60
|
|
| 4 | ERK Signaling |
.61
|
|
| 5 | Folate Metabolism | ||
Pathways by source for CCL2 Gene
1 GeneTex pathway for CCL2 Gene
13 BioSystems pathways for CCL2 Gene
9 Reactome pathways for CCL2 Gene
3 GeneGo (Thomson Reuters) pathways for CCL2 Gene
4 R&D Systems pathways for CCL2 Gene
30 Qiagen pathways for CCL2 Gene
2 Cell Signaling Technology pathways for CCL2 Gene
Interacting Proteins for CCL2 Gene
Selected Interacting proteins:
P13500-CCL2_HUMAN
ENSP00000225831
for CCL2 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for CCL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0001525 | angiogenesis | TAS | 18334747 |
| GO:0002548 | monocyte chemotaxis | IDA | 12207323 |
| GO:0006468 | protein phosphorylation | TAS | 9670957 |
| GO:0006935 | chemotaxis | TAS | 10623817 |
No data available for SIGNOR curated interactions for CCL2 Gene
Drugs & Compounds for CCL2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Danazol | Approved | Pharma | Target, inhibitor | 19 | ||
| Mimosine | Approved | Pharma | Target, inhibitor | 0 | ||
| atorvastatin | Approved | Pharma | Competitive, Inhibitor | 0 | ||
| Simvastatin | Approved | Pharma | Competitive, Inhibitor | HMG-CoA reductase inhibitor | 537 | |
| Chondroitin sulfate | Approved, Investigational | Nutra | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for CCL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bindarit | 130641-38-2 |
Transcripts for CCL2 Gene
mRNA/cDNA for CCL2 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (231) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000225831 741 bps (uc002hhy.4)
- ENST00000580907 736 bps (uc060dyg.1)
- ENST00000582017 996 bps (uc060dyh.1)
- ENST00000624362 992 bps (uc060dyf.1)
Unigene Clusters for CCL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL2
- genomics-online: gRNA clones - Search results for available CCL2 gene related products
- Applied Biological Materials CRISPR for CCL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- GenScript: Design CRISPR guide RNA sequences for CCL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL2
- genomics-online: shRNA clones - Search results for available CCL2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CCL2
- VectorBuilder custom plasmid, inducible vectors for CCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL2
- genomics-online: cdna clones - Search results for available CCL2 gene related products
- orf clones - Search results for available CCL2 gene related products
- Applied Biological Materials Clones for CCL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: |
Expression for CCL2 Gene
mRNA differential expression in normal tissues according to GTEx for CCL2 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).
This gene is overexpressed in Amniocyte (39.5) and Islet of Langerhans (29.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCL2 Gene:
CCL2SOURCE GeneReport for Unigene cluster for CCL2 Gene:
Hs.303649mRNA Expression by UniProt/SwissProt for CCL2 Gene:
P13500-CCL2_HUMAN
Tissue specificity:
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level).
Evidence on tissue expression from TISSUES for CCL2 Gene
- Pancreas(4.6)
- Blood(4.1)
- Heart(3.7)
- Nervous system(3.7)
- Kidney(3.6)
- Lung(3.6)
- Liver(3.4)
- Intestine(3.3)
- Lymph node(3.3)
- Muscle(3.3)
- Skin(3.2)
- Spleen(3.2)
- Bone marrow(3.1)
- Eye(2.7)
- Gall bladder(2.2)
- Urine(2.2)
- Stomach(2.1)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CCL2
-
OriGene qPCR primer pairs for CCL2
- genomics-online: primer clones - Search results for available CCL2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL2 Gene
Orthologs for CCL2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCL2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCL2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCL2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ccl12 16 33 |
|
||
| Ccl2 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ccl12 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for CCL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CCL2 Gene
- ENSEMBL:
- Gene Tree for CCL2 (if available)
- TreeFam:
- Gene Tree for CCL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCL2: view image
Paralogs for CCL2 Gene
(26) SIMAP similar genes for CCL2 Gene using alignment to 2 proteins:
- CCL2_HUMAN
- J3KRT7_HUMAN
Variants for CCL2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCL2 Gene
- CCL2_HUMAN-P13500
- Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000097225 | -- | 34,254,063(+) | G/A/T | upstream_transcript_variant | |
| rs1003064174 | -- | 34,254,653(+) | G/A | upstream_transcript_variant | |
| rs1003236569 | -- | 34,257,364(+) | C/T | downstream_transcript_variant | |
| rs1003310038 | -- | 34,257,642(+) | G/A/C | downstream_transcript_variant | |
| rs1004292278 | -- | 34,254,684(+) | G/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3141n100 | CNV | gain | 25217958 |
| esv3572553 | CNV | gain | 25503493 |
| nsv517423 | CNV | gain+loss | 19592680 |
| nsv519297 | CNV | gain | 19592680 |
| nsv574714 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCL2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for CCL2 Gene
(119) MalaCards diseases for CCL2 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neural tube defects |
|
|
| human immunodeficiency virus type 1 |
|
|
| proliferative glomerulonephritis |
|
|
| arthritis |
|
|
| anthracosis |
|
Search CCL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL2 Gene
Publications for CCL2 Gene
- A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PMID: 16352737) Flores-Villanueva PO … Granados J (The Journal of experimental medicine 2005) 3 4 22 44 58
- Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. (PMID: 19844201) Cavestro GM … Di Mario F (The American journal of gastroenterology 2010) 3 22 44 58
- CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. (PMID: 20339010) Hubal MJ … Clarkson PM (Journal of applied physiology (Bethesda, Md. : 1985) 2010) 3 22 44 58
- MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese men. (PMID: 20497022) Liu SF … Lin MC (Experimental lung research 2010) 3 22 44 58
- Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness. (PMID: 19148342) Alioglu E … Ercan E (The Canadian journal of cardiology 2009) 3 22 44 58
Products for CCL2 Gene
- R&D Systems Antibodies for CCL2 (CCL2/JE/MCP-1)
- R&D Systems Proteins and Enzymes for CCL2 (CCL2/JE/MCP-1)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CCL2 (CCL2/JE/MCP-1)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CCL2
- AM06084PU-N
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- TA319048
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- TA328374
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- TA336723
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- TA336914
- TA805016
- CF805016
- TA600025
- TA700025
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL2
- Origene Custom Protein Services for CCL2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
- OriGene qPCR primer pairs and template standards for CCL2
- OriGene qPCR primer pairs for CCL2
- OriGene CRISPR knockouts for CCL2
- OriGene ORF clones in human for CCL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL2
- GenScript: Next-day shipping of latest version cDNA ORF clones for CCL2 in any vector
- GenScript Purified and Recombinant Proteins for CCL2
- GenScript Custom Purified and Recombinant Proteins Services for CCL2
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- GenScript: Design CRISPR guide RNA sequences for CCL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCL2
- Sino Biological Human cDNA Clone for CCL2
- Sino Biological Cell Lysates for CCL2
- Sino Biological Recombinant Proteins for CCL2
- Sino Biological Antibodies for CCL2
- Sino Biological Assays for CCL2
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCL2
- Novus Biologicals proteins and lysates for CCL2
- Novus Biologicals ELISA Kits for CCL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for CCL2
- Taconic Biosciences Mouse Models for CCL2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CCL2
- ApexBio compounds for CCL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCL2
- VectorBuilder custom plasmid, inducible vectors for CCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CCL2
- antibodies-online: Search results for 566 available CCL2 Antibodies ranked by validation data
- Compare Top CCL2 Antibodies
- Recommended
- 90 WB Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 279 WB Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 IA Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 99 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 90 WB Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 279 WB Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 3 IA Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 99 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- antibodies-online: Search results for 191 available CCL2 Elisa Kits ranked by validation data
- Compare Top CCL2 Elisa Kits
- Recommended
- 2 Chicken ELISA Kits
- 8 Cow (Bovine) ELISA Kits
- 17 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 8 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 52 Human ELISA Kits
- 9 Monkey ELISA Kits
- 36 Mouse (Murine) ELISA Kits
- 15 Pig (Porcine) ELISA Kits
- 14 Rabbit ELISA Kits
- 29 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
- 2 Chicken ELISA Kits
- 8 Cow (Bovine) ELISA Kits
- 17 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 8 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 52 Human ELISA Kits
- 9 Monkey ELISA Kits
- 36 Mouse (Murine) ELISA Kits
- 15 Pig (Porcine) ELISA Kits
- 14 Rabbit ELISA Kits
- 29 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 130 available CCL2 Proteins ranked by validation data
- Compare Top CCL2 Proteins
- GeneTex CCL2 Antibody for CCL2
- GeneTex Proteins for CCL2
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL2
- Search Santa Cruz Biotechnology (SCBT) for CCL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- Custom Antibody ServicesProSci Antibodies for CCL2
- ProSci Proteins for CCL2
- chemokine (C-C motif) ligand 2 [90-376]
- chemokine (C-C motif) ligand 2 [90-377]
- chemokine (C-C motif) ligand 2 [90-378]
- chemokine (C-C motif) ligand 2 [90-379]
- C-C motif chemokine ligand 2 [92-669]
- chemokine (C-C motif) ligand 2 [40-338]
- chemokine (C-C motif) ligand 2 [40-362]
- chemokine (C-C motif) ligand 2 [40-410]
- chemokine (C-C motif) ligand 2 [40-564]
- Horizon Cell Lines for CCL2
- genomics-online: cdna clones - Search results for available CCL2 gene related products
- orf clones - Search results for available CCL2 gene related products
- genomics-online: gRNA clones - Search results for available CCL2 gene related products
- genomics-online: primer clones - Search results for available CCL2 gene related products
- genomics-online: shRNA clones - Search results for available CCL2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL2
- GeneCopoeia miRNA 3'UTR Target clone products for CCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL2
Sources for CCL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (19) MINT
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (125) NCBI Bookshelf
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt