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This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is char... See more...
Aliases for CCL2 Gene
Aliases for CCL2 Gene
- C-C Motif Chemokine Ligand 2 2 3 5
- Monocyte Chemotactic And Activating Factor 2 3 4
- Monocyte Secretory Protein JE 2 3 4
- MCP-1 2 3 4
- HC11 2 3 4
- MCAF 2 3 4
- MCP1 2 3 4
- Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je) 2 3
- Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2 2 3
- Monocyte Chemoattractant Protein-1 2 3
- Chemokine (C-C Motif) Ligand 2 2 3
External Ids for CCL2 Gene
- HGNC: 10618
- NCBI Entrez Gene: 6347
- Ensembl: ENSG00000108691
- OMIM®: 158105
- UniProtKB/Swiss-Prot: P13500
Previous HGNC Symbols for CCL2 Gene
- SCYA2
Previous GeneCards Identifiers for CCL2 Gene
- GC17P032352
- GC17P034621
- GC17P032727
- GC17P029606
- GC17P032582
- GC17P028767
Summaries for CCL2 Gene
-
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
GeneCards Summary for CCL2 Gene
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are Rheumatoid arthritis and A-beta Pathways: Uptake and Degradation. Gene Ontology (GO) annotations related to this gene include protein kinase activity and heparin binding. An important paralog of this gene is CCL7.
UniProtKB/Swiss-Prot Summary for CCL2 Gene
-
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).
Additional gene information for CCL2 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL2 Gene
Genomics for CCL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL2
- Top Transcription factor binding sites by QIAGEN in the CCL2 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- STAT1
Genomic Locations for CCL2 Gene
Latest Assembly
- chr17:34,255,218-34,257,203
- (GRCh38/hg38)
- Size:
- 1,986 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:32,582,304-32,584,222
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 1,919 bases
- Orientation:
- Plus strand
Genomic View for CCL2 Gene
Genes around CCL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
CCL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCL2 Gene
Proteins for CCL2 Gene
-
Protein details for CCL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13500-CCL2_HUMAN
- Recommended name:
- C-C motif chemokine 2
- Protein Accession:
- P13500
- B2R4V3
- Q9UDF3
Protein attributes for CCL2 Gene
- Size:
- 99 amino acids
- Molecular mass:
- 11025 Da
- Quaternary structure:
-
- Monomer or homodimer; in equilibrium (PubMed:8898111, PubMed:9837883, PubMed:15033992, PubMed:8989326). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674).
Protein Expression for CCL2 Gene
Post-translational modifications for CCL2 Gene
- Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).
- N-Glycosylated.
-
Glycosylation at Asn37
- NX_P13500 (NX_P13500-1)
Other Protein References for CCL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CCL2 / MCP1 Antibody (LS-B4690) and CCL2 / MCP1 Antibody (LS-B10540)
- G Biosciences Immunotag™ MCP-1 Antibody and Immunotag™ MCP1 Antibody
- NSJ Bioreagents CCL2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CCL2
- AM06084PU-N
- AM06749PU-N
- AM26297PU-N
- AM26342BT-N
- AM26342PU-N
- AM31289AF-N
- AM31290AF-N
- AM32133BT-N
- AM32133PU-N
- AM32136PU-N
- AP09164PU-N
- AP09164PU-S
- CF805016
- DM2030
- DM2031
- DM2032
- DM2033
- DM2034
- DM2034B
- DM2034HRP
- PM1006A
- PP020B1
- PP020B2
- PP020P1
- PP020P2
- PP037B1
- PP037B2
- PP037P1
- PP037P2
- PP1044B1
- PP1044B2
- PP1044P1
- PP1044P2
- SM2289P
- TA319048
- TA319166
- TA319701
- TA320225
- TA320226
- TA320227
- TA321546
- TA321547
- TA324861
- TA328374
- TA328375
- TA328524
- TA328525
- TA328588
- TA328589
- TA336723
- TA336724
- TA336914
- TA600025
- TA700025
- TA805016
- TA805016S
- Novus Biologicals Antibodies for CCL2
-
Abcam antibodies for CCL2
- Invitrogen Antibodies for CCL2 (AFLGC-Ccl2)
- antibodies-online: Show 172 available Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Antibodies ranked by validation data
- Compare Top Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Antibodies
-
Recommended
- 269 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IA Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 102 WB Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 92 WB Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for CCL2
- chemokine (C-C motif) ligand 2 [7201]
- chemokine (C-C motif) ligand 2 [32-230]
- chemokine (C-C motif) ligand 2 [77-028]
- chemokine (C-C motif) ligand 2 [77-029]
- chemokine (C-C motif) ligand 2 [XP-5206]
- chemokine (C-C motif) ligand 2 [XP-5206Bt]
- chemokine (C-C motif) ligand 2 [XP-5218]
- chemokine (C-C motif) ligand 2 [XP-5218Bt]
- chemokine (C-C motif) ligand 2 [XP-5219]
- chemokine (C-C motif) ligand 2 [XP-5219Bt]
- chemokine (C-C motif) ligand 2 [XP-5732-M]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCL2
- Sino Biological Antibodies for CCL2
Protein products for research
- G Biosciences Human CCL2/MCP-1/C-C motif chemokine 2, Lyophilized
- RayBiotech Recombinant Human MCP-1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL2
- Origene Custom Protein Services for CCL2
- Sino Biological Recombinant Proteins for CCL2
- Sino Biological Cell Lysates for CCL2
- ProSpec Recombinant Proteins for CCL2
-
ProSci Proteins for CCL2
- C-C motif chemokine ligand 2 [92-669]
- chemokine (C-C motif) ligand 2 [90-376]
- chemokine (C-C motif) ligand 2 [90-377]
- chemokine (C-C motif) ligand 2 [90-378]
- chemokine (C-C motif) ligand 2 [90-379]
- chemokine (C-C motif) ligand 2 [40-338]
- chemokine (C-C motif) ligand 2 [40-362]
- chemokine (C-C motif) ligand 2 [40-410]
- chemokine (C-C motif) ligand 2 [40-564]
-
Abcam proteins for CCL2
Assay products for research
- RayBiotech Human MCP-1 ELISA
-
BioLegend
- LEGEND MAX(TM) Human MCP-1/CCL2 ELISA Kit with Pre-coated Plates
- Human MCP-1/CCL2 ELISA MAX(TM) Deluxe
- LEGENDplex(TM) Human CCL2 (MCP-1) Capture Bead A8, 13X
- LEGENDplex(TM) Human CCL2 (MCP-1) Capture Bead A7, 13X
- LEGENDplex(TM) Human CCL2 (MCP-1) Capture Bead A5, 13X
- LEGENDplex(TM) Human MCP-1 Capture Bead A8, 13X
- Novus Biologicals ELISA Kits for CCL2
- antibodies-online: Show 226 available Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Elisa Kits ranked by validation data
- Compare Top Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Elisa Kits
-
Quality Products:
- ABIN365052
- ABIN411320
- ABIN625039
- ABIN1116015
- ABIN414903
- ABIN491799
- ABIN2690571
- ABIN2472081
- ABIN924787
- ABIN3032958
- ABIN1116014
- ABIN625159
- ABIN921079
- ABIN1980569
- ABIN812082
- ABIN625160
- ABIN3032827
- ABIN1029300
- ABIN924820
- ABIN4947864
- ABIN625210
- ABIN1672827
- ABIN1116013
- ABIN365558
- ABIN924840
- ABIN625211
- ABIN3032877
- ABIN4947865
- ABIN5524906
- ABIN415999
- ABIN365536
- ABIN491800
- ABIN1571167
- ABIN5524905
- ABIN628458
- ABIN1564253
- ABIN5656943
- ABIN5656944
- ABIN2536753
-
Abcam assays for CCL2
- Sino Biological Assays for CCL2
No data available for DME Specific Peptides for CCL2 Gene
Domains & Families for CCL2 Gene
Gene Families for CCL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- FDA approved drug targets
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CCL2 Gene
- InterPro:
- Blocks:
-
- Small chemokine, C-C subfamily
Suggested Antigen Peptide Sequences for CCL2 Gene
- GenScript: Design optimal peptide antigens:
-
- Small-inducible cytokine A2 (CCL2_HUMAN)
- Metaphase chromosome protein 30 (MCP1_HUMAN)
- Monocyte chemoattractant protein-1 (Q6UZ82_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13500- Family:
-
- Belongs to the intercrine beta (chemokine CC) family.
Function for CCL2 Gene
Molecular function for CCL2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712).
Phenotypes From GWAS Catalog for CCL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS | 9973507 |
| GO:0005102 | signaling receptor binding | TAS | 10542238 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 26095031 |
| GO:0008009 | chemokine activity | TAS,IBA | 21873635 |
Phenotypes for CCL2 Gene
- MGI mutant phenotypes for CCL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCL2:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Reduced mammosphere formation
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased homologous recombination repair frequency
Animal Models for research
-
Taconic Biosciences Mouse Models for CCL2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCL2 - Starting at $85 >
- * CCL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
miRNA for CCL2 Gene
- miRTarBase miRNAs that target CCL2
-
- hsa-miR-124-3p (MIRT004284)
- mmu-miR-122-5p (MIRT005978)
- hsa-miR-155-5p (MIRT021047)
- hsa-miR-1-3p (MIRT024058)
- hsa-miR-26b-5p (MIRT030277)
- hsa-miR-24-3p (MIRT030558)
- rno-miR-190a-5p (MIRT438469)
- rno-miR-27b-3p (MIRT438470)
- hsa-miR-495-3p (MIRT731131)
- mmu-miR-33-5p (MIRT731930)
- hsa-miR-518a-5p (MIRT732272)
- hsa-miR-98-5p (MIRT732865)
- hsa-let-7g-3p (MIRT732866)
- hsa-miR-206 (MIRT734598)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL2
Clone products for research
- Applied Biological Materials (abm): Clones for CCL2 - Starting at $45 >
- * CCL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCL2
- Addgene plasmids for CCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL2
Cell Lines for research
-
Horizon Cell Lines for CCL2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCL2 Gene
Localization for CCL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | TAS,IBA | 21873635 |
Pathways & Interactions for CCL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
| 3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
| 4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
| 5 | Folate Metabolism | ||
Pathways by source for CCL2 Gene
13 BioSystems pathways for CCL2 Gene
9 Reactome pathways for CCL2 Gene
17 KEGG pathways for CCL2 Gene
3 GeneGo (Thomson Reuters) pathways for CCL2 Gene
- Development VEGF signaling via VEGFR2 - generic cascades
- Immune response Oncostatin M signaling via MAPK in human cells
- Immune response_Oncostatin M signaling via JAK-Stat in human cells
3 R&D Systems pathways for CCL2 Gene
30 Qiagen pathways for CCL2 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Chemokine Signaling
- Endothelin-1 Signaling Pathway
2 Cell Signaling Technology pathways for CCL2 Gene
1 GeneTex pathway for CCL2 Gene
Interacting Proteins for CCL2 Gene
Selected Interacting proteins:
P13500-CCL2_HUMAN
ENSP00000225831
for CCL2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CCL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0001525 | angiogenesis | TAS | 18334747 |
| GO:0002548 | monocyte chemotaxis | IDA | 12207323 |
| GO:0006468 | protein phosphorylation | TAS | 9670957 |
| GO:0006935 | chemotaxis | TAS | 10623817 |
Drugs & Compounds for CCL2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Danazol | Approved | Pharma | Target, inhibitor | 32 | ||
| Atorvastatin | Approved | Pharma | 928 | |||
| Simvastatin | Approved | Pharma | HMG-CoA reductase inhibitor | 592 | ||
| Chondroitin sulfate | Approved, Investigational | Nutra | Target | 0 | ||
| Risperidone | Approved, Investigational | Pharma | SR-2A inhibitor | 545 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for CCL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bindarit | 130641-38-2 |
Drug products for research
- G Biosciences Human CCL2/MCP-1/C-C motif chemokine 2, Lyophilized
- RayBiotech Recombinant Human MCP-1
- ApexBio compounds for CCL2
Transcripts for CCL2 Gene
mRNA/cDNA for CCL2 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000225831 741 nts (view in UCSC)
- ENST00000580907 736 nts (view in UCSC)
- ENST00000582017 996 nts (view in UCSC)
- ENST00000624362 992 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCL2 - Starting at $85 >
- * CCL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL2
Clone products for research
- Applied Biological Materials (abm): Clones for CCL2 - Starting at $45 >
- * CCL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCL2
- Addgene plasmids for CCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: |
Relevant External Links for CCL2 Gene
- GeneLoc Exon Structure for
- CCL2
Expression for CCL2 Gene
mRNA differential expression in normal tissues according to GTEx for CCL2 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).
This gene is overexpressed in Amniocyte (39.5) and Islet of Langerhans (29.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL2
SOURCE GeneReport for Unigene cluster for CCL2 Gene:
Hs.303649mRNA Expression by UniProt/SwissProt for CCL2 Gene:
P13500-CCL2_HUMAN
Tissue specificity:
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477).
Evidence on tissue expression from TISSUES for CCL2 Gene
- Pancreas(4.7)
- Blood(3.9)
- Nervous system(3.9)
- Heart(3.7)
- Liver(3.7)
- Intestine(3.6)
- Lymph node(3.6)
- Kidney(3.6)
- Spleen(3.5)
- Lung(3.5)
- Bone marrow(3.5)
- Muscle(3.5)
- Skin(3.4)
- Adrenal gland(3.1)
- Gall bladder(2.9)
- Eye(2.8)
- Stomach(2.8)
- Thyroid gland(2.6)
- Bone(2.5)
- Urine(2.5)
Primer products for research
-
OriGene qPCR primer pairs for CCL2
-
OriGene qPCR primer pairs and template standards for CCL2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL2 Gene
Orthologs for CCL2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCL2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CCL2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CCL2 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ccl12 29 16 |
|
||
| Ccl2 30 |
|
OneToOne | |||
| Rat (Rattus norvegicus) |
Mammalia | Ccl12 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany |
- Species where no ortholog for CCL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CCL2 Gene
- ENSEMBL:
- Gene Tree for CCL2 (if available)
- TreeFam:
- Gene Tree for CCL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCL2: view image
- Alliance of Genome Resources:
- Additional Orthologs for CCL2
Paralogs for CCL2 Gene
Paralogs for CCL2 Gene
(26) SIMAP similar genes for CCL2 Gene using alignment to 2 proteins:
- CCL2_HUMAN
- J3KRT7_HUMAN
Variants for CCL2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCL2 Gene
- CCL2_HUMAN-P13500
- Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL2 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1024611 | Pathogenic, Risk Factor: Spina bifida, susceptibility to; Mycobacterium tuberculosis, susceptibility to; Coronary artery disease, modifier of; Coronary artery disease, development of, in hiv | 34,252,769(+) |
A/G NG_012123.1:g.2493A>G |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3141n100 | CNV | gain | 25217958 |
| esv3572553 | CNV | gain | 25503493 |
| nsv517423 | CNV | gain+loss | 19592680 |
| nsv519297 | CNV | gain | 19592680 |
| nsv574714 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCL2 Gene
SNP Genotyping and Copy Number Assays for research
Disorders for CCL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neural tube defects |
|
|
| human immunodeficiency virus type 1 |
|
|
| severe acute respiratory syndrome |
|
|
| arteriosclerosis |
|
|
| proliferative glomerulonephritis |
|
|
Search CCL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCL2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCL2 Gene
Publications for CCL2 Gene
- A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PMID: 16352737) Flores-Villanueva PO … Granados J (The Journal of experimental medicine 2005) 3 4 22 40 72
- MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. (PMID: 14571188) Modi WS … Winkler C (AIDS (London, England) 2003) 3 22 40 72
- Association of CCL2 and CCR2 gene variants with endometrial cancer in Turkish women. (PMID: 20364004) Attar R … Isbir T (In vivo (Athens, Greece) 2010) 3 22 40
- Association of the MCP-1 -2518 A/G polymorphism and no association of its receptor CCR2 -64 V/I polymorphism with lupus nephritis. (PMID: 20231199) Malafronte P … Woronik V (The Journal of rheumatology 2010) 3 22 40
- MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese men. (PMID: 20497022) Liu SF … Lin MC (Experimental lung research 2010) 3 22 40
ExternalLinks
Products for CCL2 Gene
- View all 48 R&D Systems CCL2 (CCL2/JE/MCP-1) Products
- View all 2 R&D Systems CCL2 (CCL2/JE/MCP-1) Proteins and Enzymes
- View all 27 R&D Systems CCL2 (CCL2/JE/MCP-1) Primary Antibodies
- View all 2 R&D Systems CCL2 (CCL2/JE/MCP-1) ELISAs
- View all R&D Systems CCL2 (CCL2/JE/MCP-1) Simple Plex Assays
- View all 9 R&D Systems CCL2 (CCL2/JE/MCP-1) Luminex Assays
- View all 7 R&D Systems CCL2 (CCL2/JE/MCP-1) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CCL2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CCL2
- AM06084PU-N
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- AM31289AF-N
- AM31290AF-N
- AM32133BT-N
- AM32133PU-N
- AM32136PU-N
- AP09164PU-N
- AP09164PU-S
- CF805016
- DM2030
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- DM2034
- DM2034B
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- PM1006A
- PP020B1
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- PP020P1
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- PP037B1
- PP037B2
- PP037P1
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- PP1044B1
- PP1044B2
- PP1044P1
- PP1044P2
- SM2289P
- TA319048
- TA319166
- TA319701
- TA320225
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- TA320227
- TA321546
- TA321547
- TA324861
- TA328374
- TA328375
- TA328524
- TA328525
- TA328588
- TA328589
- TA336723
- TA336724
- TA336914
- TA600025
- TA700025
- TA805016
- TA805016S
- Custom Assay ServicesOriGene ELISA Kits for CCL2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCL2
- Origene Custom Protein Services for CCL2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCL2
- Browse OriGene Inhibitory RNA Products For CCL2
- OriGene qPCR primer pairs for CCL2
- OriGene qPCR primer pairs and template standards for CCL2
- OriGene CRISPR knockouts for CCL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCL2
- Sino Biological Human cDNA Clone for CCL2
- Sino Biological Recombinant Proteins for CCL2
- Sino Biological Cell Lysates for CCL2
- Sino Biological Antibodies for CCL2
- Sino Biological Assays for CCL2
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCL2
- Novus Biologicals proteins and lysates for CCL2
- Novus Biologicals ELISA Kits for CCL2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCL2
- Abcam proteins for CCL2
- Abcam assays for CCL2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CCL2
- Taconic Biosciences Mouse Models for CCL2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CCL2 (AFLGC-Ccl2)
- ApexBio compounds for CCL2
- VectorBuilder Custom and pre-made DNA vectors for CCL2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCL2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCL2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCL2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCL2
- Addgene plasmids for CCL2
- antibodies-online: Show 172 available Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Antibodies ranked by validation data
- Compare Top Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Antibodies
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- 269 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IA Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 102 WB Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 92 WB Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 226 available Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Elisa Kits ranked by validation data
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- ABIN365052
- ABIN411320
- ABIN625039
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- antibodies-online: Show 136 available Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Proteins ranked by validation data
- Compare Top Monocyte Chemotactic Protein 1/Monocyte Chemotactic and Activating Factor (MCP-1) Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CCL2
- Search Santa Cruz Biotechnology (SCBT) for CCL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCL2
- Custom Antibody ServicesProSci Antibodies for CCL2
- chemokine (C-C motif) ligand 2 [7201]
- chemokine (C-C motif) ligand 2 [32-230]
- chemokine (C-C motif) ligand 2 [77-028]
- chemokine (C-C motif) ligand 2 [77-029]
- chemokine (C-C motif) ligand 2 [XP-5206]
- chemokine (C-C motif) ligand 2 [XP-5206Bt]
- chemokine (C-C motif) ligand 2 [XP-5218]
- chemokine (C-C motif) ligand 2 [XP-5218Bt]
- chemokine (C-C motif) ligand 2 [XP-5219]
- chemokine (C-C motif) ligand 2 [XP-5219Bt]
- chemokine (C-C motif) ligand 2 [XP-5732-M]
- ProSci Proteins for CCL2
- C-C motif chemokine ligand 2 [92-669]
- chemokine (C-C motif) ligand 2 [90-376]
- chemokine (C-C motif) ligand 2 [90-377]
- chemokine (C-C motif) ligand 2 [90-378]
- chemokine (C-C motif) ligand 2 [90-379]
- chemokine (C-C motif) ligand 2 [40-338]
- chemokine (C-C motif) ligand 2 [40-362]
- chemokine (C-C motif) ligand 2 [40-410]
- chemokine (C-C motif) ligand 2 [40-564]
- Horizon Cell Lines for CCL2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCL2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL2
Sources for CCL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources