This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also pla... See more...

Aliases for CCL19 Gene

Aliases for CCL19 Gene

  • C-C Motif Chemokine Ligand 19 2 3 5
  • CK Beta-11 2 3 4
  • ELC 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19 2 3
  • Epstein-Barr Virus-Induced Molecule 1 Ligand Chemokine 3 4
  • Macrophage Inflammatory Protein 3-Beta 2 3
  • Chemokine (C-C Motif) Ligand 19 2 3
  • Small-Inducible Cytokine A19 3 4
  • Beta Chemokine Exodus-3 2 3
  • CC Chemokine Ligand 19 2 3
  • C-C Motif Chemokine 19 3 4
  • EBI1-Ligand Chemokine 2 3
  • MIP-3-Beta 3 4
  • Exodus-3 2 3
  • MIP-3b 2 3
  • SCYA19 3 4
  • CKb11 2 3
  • MIP3B 3 4
  • Macrophage Inflammatory Protein 3 Beta 4
  • Beta-Chemokine Exodus-3 4
  • EBI1 Ligand Chemokine 4
  • CCL19 5

External Ids for CCL19 Gene

Previous HGNC Symbols for CCL19 Gene

  • SCYA19

Previous GeneCards Identifiers for CCL19 Gene

  • GC09M035001
  • GC09M034859
  • GC09M034680
  • GC09M034681
  • GC09M034682
  • GC09M034683
  • GC09M034685
  • GC09M034688
  • GC09M034643

Summaries for CCL19 Gene

Entrez Gene Summary for CCL19 Gene

  • This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL19 Gene

CCL19 (C-C Motif Chemokine Ligand 19) is a Protein Coding gene. Diseases associated with CCL19 include Polyradiculoneuropathy and Central Nervous System Lymphoma. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CCR10 chemokine receptor binding. An important paralog of this gene is CCL21.

UniProtKB/Swiss-Prot Summary for CCL19 Gene

  • May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Gene Wiki entry for CCL19 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL19 Gene

Genomics for CCL19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034691 Promoter/Enhancer 0.6 EPDnew Ensembl 250.7 -0.3 -325 2 ZNF652 CCL19 lnc-CCL21-1 ENSG00000230074 GALT RPP25L CCL21 ENSG00000288583
GH09J034690 Enhancer 0.2 Ensembl 250.7 +1.2 1175 0.2 CCL19 lnc-CCL21-1 piR-55107 LOC730098 ENSG00000288583
GH09J034123 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.1 +565.7 565676 4.8 MYC IKZF1 ZNF600 ZNF592 ATF2 POLR2A ZNF10 ZSCAN16 NFIC YY1 DCAF12 HSALNG0070824 ENSG00000228352 NOL6 PIGO NFX1 ENSG00000260947 KIF24 CCL19 TUBB4BP2
GH09J034575 Enhancer 0.9 FANTOM5 ENCODE CraniofacialAtlas 9.6 +113.0 112973 5.4 JUND ZNF341 REST GATA2 ZNF366 EGR2 EZH2 POLR2A ZFHX2 KDM1A GALT RPP25L ENSG00000230074 ENHO FAM219A CNTFR-AS1 ENSG00000232983 ARID3C CNTFR ENSG00000230729
GH09J034809 Promoter 0.7 Ensembl 10.5 -118.7 -118724 0.4 CTCF RAD21 EGR1 MAX EZH2 KDM1A MGA ENSG00000287368 PHF24 FAM205A CCL19 PIGO HSALNG0070876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL19

Top Transcription factor binding sites by QIAGEN in the CCL19 gene promoter:
  • AML1a
  • ARP-1
  • FOXD1
  • IRF-1
  • p53
  • Pax-4a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for CCL19 Gene

Latest Assembly
chr9:34,689,570-34,691,276
(GRCh38/hg38)
Size:
1,707 bases
Orientation:
Minus strand

Previous Assembly
chr9:34,689,567-34,691,273
(GRCh37/hg19 by Entrez Gene)
Size:
1,707 bases
Orientation:
Minus strand

chr9:34,689,564-34,691,274
(GRCh37/hg19 by Ensembl)
Size:
1,711 bases
Orientation:
Minus strand

Genomic View for CCL19 Gene

Genes around CCL19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL19 Gene

Proteins for CCL19 Gene

  • Protein details for CCL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99731-CCL19_HUMAN
    Recommended name:
    C-C motif chemokine 19
    Protein Accession:
    Q99731
    Secondary Accessions:
    • O00697
    • O00736

    Protein attributes for CCL19 Gene

    Size:
    98 amino acids
    Molecular mass:
    10993 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL19 Gene

neXtProt entry for CCL19 Gene

Post-translational modifications for CCL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL19 Gene

Domains & Families for CCL19 Gene

Gene Families for CCL19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for CCL19 Gene

Suggested Antigen Peptide Sequences for CCL19 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A19 (CCL19_HUMAN)
  • cDNA, FLJ92213, Homo sapiens chemokine (C-C motif) ligand 19 (CCL19), mRNA (Q6IBD6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99731

UniProtKB/Swiss-Prot:

CCL19_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL19: view

Function for CCL19 Gene

Molecular function for CCL19 Gene

UniProtKB/Swiss-Prot Function:
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Phenotypes From GWAS Catalog for CCL19 Gene

Gene Ontology (GO) - Molecular Function for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0008009 chemokine activity IEA,IDA 15778365
GO:0031732 CCR7 chemokine receptor binding ISS --
GO:0031735 CCR10 chemokine receptor binding IDA 10706668
genes like me logo Genes that share ontologies with CCL19: view
genes like me logo Genes that share phenotypes with CCL19: view

Animal Models for CCL19 Gene

MGI Knock Outs for CCL19:

miRNA for CCL19 Gene

miRTarBase miRNAs that target CCL19

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL19 Gene

Localization for CCL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL19 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
genes like me logo Genes that share ontologies with CCL19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL19 Gene

Pathways & Interactions for CCL19 Gene

PathCards logo

SuperPathways for CCL19 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Peptide ligand-binding receptors
4 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with CCL19: view

Pathways by source for CCL19 Gene

1 GeneGo (Thomson Reuters) pathway for CCL19 Gene
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
28 Qiagen pathways for CCL19 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IDA 12729902
GO:0001771 immunological synapse formation ISS --
GO:0002407 dendritic cell chemotaxis IDA 15778365
GO:0002408 myeloid dendritic cell chemotaxis IDA 14592837
GO:0002548 monocyte chemotaxis IBA 21873635
genes like me logo Genes that share ontologies with CCL19: view

No data available for SIGNOR curated interactions for CCL19 Gene

Drugs & Compounds for CCL19 Gene

(4) Drugs for CCL19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for CCL19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL19: view

Transcripts for CCL19 Gene

mRNA/cDNA for CCL19 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL19

Alternative Splicing Database (ASD) splice patterns (SP) for CCL19 Gene

No ASD Table

Relevant External Links for CCL19 Gene

GeneLoc Exon Structure for
CCL19

Expression for CCL19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL19 Gene

mRNA differential expression in normal tissues according to GTEx for CCL19 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x15.5) and Artery - Coronary (x5.5).

Protein differential expression in normal tissues from HIPED for CCL19 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL19 Gene



Protein tissue co-expression partners for CCL19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL19

SOURCE GeneReport for Unigene cluster for CCL19 Gene:

Hs.50002

mRNA Expression by UniProt/SwissProt for CCL19 Gene:

Q99731-CCL19_HUMAN
Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Evidence on tissue expression from TISSUES for CCL19 Gene

  • Spleen(4.7)
  • Lung(4.5)
  • Pancreas(4.3)
  • Lymph node(3.9)
  • Intestine(3.5)
  • Skin(2.9)
  • Heart(2.8)
  • Blood(2.7)
  • Liver(2.6)
  • Stomach(2.5)
  • Bone marrow(2.3)
  • Kidney(2.2)
  • Nervous system(2.1)
  • Muscle(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CCL19: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL19 Gene

Orthologs for CCL19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCL19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCL19 29 30
  • 98.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCL19 29 30
  • 85.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccl19 29
  • 82.56 (n)
Mouse
(Mus musculus)
Mammalia Ccl19 29 16 30
  • 82.56 (n)
OneToMany
Gm2564 16 30
  • 69 (a)
OneToMany
CR974586.2 30
  • 69 (a)
OneToMany
CCL19 30
  • 69 (a)
OneToMany
CR974586.5 30
  • 68 (a)
OneToMany
Ccl19-ps1 16
Gm12407 16
Gm13309 16
Gm21104 16
Gm2457 16
Cow
(Bos Taurus)
Mammalia CCL19 29 30
  • 80.9 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCL19 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCL19 30
  • 40 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CCL19 (1 of 2) 30
  • 29 (a)
OneToMany
ccl19 30
  • 28 (a)
OneToMany
Species where no ortholog for CCL19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCL19 Gene

ENSEMBL:
Gene Tree for CCL19 (if available)
TreeFam:
Gene Tree for CCL19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL19: view image
Alliance of Genome Resources:
Additional Orthologs for CCL19

Paralogs for CCL19 Gene

(12) SIMAP similar genes for CCL19 Gene using alignment to 3 proteins:

  • CCL19_HUMAN
  • Q5VZ75_HUMAN
  • Q6IBD6_HUMAN
genes like me logo Genes that share paralogs with CCL19: view

Variants for CCL19 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCL19 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCL19 Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv831544 CNV gain 17160897

Variation tolerance for CCL19 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL19
Leiden Open Variation Database (LOVD)
CCL19

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL19 Gene

Disorders for CCL19 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CCL19 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
polyradiculoneuropathy
central nervous system lymphoma
  • microglioma
b-lymphoblastic leukemia/lymphoma
  • b-all
sodoku disease
  • spirillary fever
common variable immunodeficiency
  • acquired agammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search CCL19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL19

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCL19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL19 Gene

Publications for CCL19 Gene

  1. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. (PMID: 9153236) Yoshida R … Yoshie O (The Journal of biological chemistry 1997) 2 3 4 22
  2. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. (PMID: 23341447) Watts AO … Vischer HF (The Journal of biological chemistry 2013) 3 4
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40
  4. HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. (PMID: 20015995) Nobile C … Sol-Foulon N (Journal of virology 2010) 3 22
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 40

Products for CCL19 Gene

  • Addgene plasmids for CCL19

Sources for CCL19 Gene