This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocy... See more...

Aliases for CCL17 Gene

Aliases for CCL17 Gene

  • C-C Motif Chemokine Ligand 17 2 3 5
  • TARC 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17 2 3
  • Thymus And Activation-Regulated Chemokine 3 4
  • Chemokine (C-C Motif) Ligand 17 2 3
  • Small-Inducible Cytokine A17 3 4
  • C-C Motif Chemokine 17 3 4
  • CC Chemokine TARC 3 4
  • ABCD-2 2 3
  • SCYA17 3 4
  • T Cell-Directed CC Chemokine 3
  • A-152E5.3 3
  • CCL17 5

External Ids for CCL17 Gene

Previous HGNC Symbols for CCL17 Gene

  • SCYA17

Previous GeneCards Identifiers for CCL17 Gene

  • GC16P047843
  • GC16P057498
  • GC16P057173
  • GC16P057214
  • GC16P055996
  • GC16P057438
  • GC16P043306
  • GC16P057404
  • GC16P057398
  • GC16P057399
  • GC16P057400
  • GC16P057401

Summaries for CCL17 Gene

Entrez Gene Summary for CCL17 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL17 Gene

CCL17 (C-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CCL17 include Eosinophilic Pneumonia and Paragonimiasis. Among its related pathways are IL4-mediated signaling events and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and CCR4 chemokine receptor binding. An important paralog of this gene is CCL22.

UniProtKB/Swiss-Prot Summary for CCL17 Gene

  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Gene Wiki entry for CCL17 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL17 Gene

Genomics for CCL17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL17

Top Transcription factor binding sites by QIAGEN in the CCL17 gene promoter:
  • c-Rel
  • C/EBPalpha
  • CREB
  • CUTL1
  • deltaCREB
  • FOXJ2
  • FOXJ2 (long isoform)
  • PPAR-alpha
  • RelA
  • STAT5B

Genomic Locations for CCL17 Gene

Latest Assembly
chr16:57,396,076-57,416,063
(GRCh38/hg38)
Size:
19,988 bases
Orientation:
Plus strand

Previous Assembly
chr16:57,438,679-57,449,975
(GRCh37/hg19 by Entrez Gene)
Size:
11,297 bases
Orientation:
Plus strand

chr16:57,438,679-57,449,974
(GRCh37/hg19 by Ensembl)
Size:
11,296 bases
Orientation:
Plus strand

Genomic View for CCL17 Gene

Genes around CCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL17 Gene

Proteins for CCL17 Gene

  • Protein details for CCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92583-CCL17_HUMAN
    Recommended name:
    C-C motif chemokine 17
    Protein Accession:
    Q92583
    Secondary Accessions:
    • A0N0Q9
    • Q2M287

    Protein attributes for CCL17 Gene

    Size:
    94 amino acids
    Molecular mass:
    10507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL17 Gene

neXtProt entry for CCL17 Gene

Post-translational modifications for CCL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL17 Gene

No data available for DME Specific Peptides for CCL17 Gene

Domains & Families for CCL17 Gene

Gene Families for CCL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCL17 Gene

InterPro:
Blocks:
  • Small chemokine, C-C subfamily

Suggested Antigen Peptide Sequences for CCL17 Gene

GenScript: Design optimal peptide antigens:
  • Thymus and activation-regulated chemokine (CCL17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92583

UniProtKB/Swiss-Prot:

CCL17_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL17: view

Function for CCL17 Gene

Molecular function for CCL17 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Phenotypes From GWAS Catalog for CCL17 Gene

Gene Ontology (GO) - Molecular Function for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8702936
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity TAS,IBA 21873635
GO:0031729 CCR4 chemokine receptor binding IEA --
genes like me logo Genes that share ontologies with CCL17: view
genes like me logo Genes that share phenotypes with CCL17: view

Animal Models for CCL17 Gene

MGI Knock Outs for CCL17:

Animal Models for research

  • Taconic Biosciences Mouse Models for CCL17

miRNA for CCL17 Gene

miRTarBase miRNAs that target CCL17

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL17 Gene

Localization for CCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL17 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CCL17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL17 Gene

Pathways & Interactions for CCL17 Gene

PathCards logo

SuperPathways for CCL17 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 CCR5 Pathway in Macrophages
.33
genes like me logo Genes that share pathways with CCL17: view

Pathways by source for CCL17 Gene

27 Qiagen pathways for CCL17 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006935 chemotaxis TAS --
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IBA 21873635
genes like me logo Genes that share ontologies with CCL17: view

No data available for SIGNOR curated interactions for CCL17 Gene

Drugs & Compounds for CCL17 Gene

(9) Drugs for CCL17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL17: view

Transcripts for CCL17 Gene

mRNA/cDNA for CCL17 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL17

Alternative Splicing Database (ASD) splice patterns (SP) for CCL17 Gene

No ASD Table

Relevant External Links for CCL17 Gene

GeneLoc Exon Structure for
CCL17

Expression for CCL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL17 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.1), Lung (x6.1), and Esophagus - Mucosa (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL17

SOURCE GeneReport for Unigene cluster for CCL17 Gene:

Hs.546294

mRNA Expression by UniProt/SwissProt for CCL17 Gene:

Q92583-CCL17_HUMAN
Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Evidence on tissue expression from TISSUES for CCL17 Gene

  • Blood(4.6)
  • Lymph node(2.8)
  • Skin(2.6)
  • Lung(2.6)
  • Spleen(2.5)
  • Intestine(2.4)
  • Bone marrow(2.4)
  • Nervous system(2.2)
  • Heart(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CCL17: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL17 Gene

Orthologs for CCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCL17 29 30
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCL17 29 30
  • 82.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccl17 29
  • 75.93 (n)
Mouse
(Mus musculus)
Mammalia Ccl17 29 16 30
  • 73.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCL17 29 30
  • 71.99 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCL17 30
  • 44 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCL17 30
  • 35 (a)
OneToOne
Species where no ortholog for CCL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCL17 Gene

ENSEMBL:
Gene Tree for CCL17 (if available)
TreeFam:
Gene Tree for CCL17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL17: view image
Alliance of Genome Resources:
Additional Orthologs for CCL17

Paralogs for CCL17 Gene

(23) SIMAP similar genes for CCL17 Gene using alignment to 1 proteins:

  • CCL17_HUMAN

Pseudogenes.org Pseudogenes for CCL17 Gene

genes like me logo Genes that share paralogs with CCL17: view

Variants for CCL17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL17 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs61737346 Benign: not provided 57,415,094(+) T/C
NM_002987.3(CCL17):c.84T>C (p.Asn28=)
SYNONYMOUS
rs34379253 -- p.Val67Met
rs34693308 -- p.Lys5Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCL17 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CCL17 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL17 Gene

Human Gene Mutation Database (HGMD)
CCL17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL17
Leiden Open Variation Database (LOVD)
CCL17

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL17 Gene

Disorders for CCL17 Gene

MalaCards: The human disease database

(45) MalaCards diseases for CCL17 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
eosinophilic pneumonia
  • pneumonia, eosinophilic
paragonimiasis
  • infection by paragonimus
dermatitis
  • eczema
mycosis fungoides
  • mycosis fungoides lymphoma
palladium allergic contact dermatitis
  • allergic contact dermatitis to pd
- elite association - COSMIC cancer census association via MalaCards
Search CCL17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL17

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL17 Gene

Publications for CCL17 Gene

  1. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PMID: 18691306) Chan IH … Lam CW (Allergy 2008) 3 22 40
  2. The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PMID: 15500644) Tsunemi Y … Tamaki K (Experimental dermatology 2004) 3 22 40
  3. Structures of thymus and activation-regulated chemokine (TARC). (PMID: 12832759) Asojo OA … Lubkowski J (Acta crystallographica. Section D, Biological crystallography 2003) 3 4 22
  4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi CG … Umland SP (European journal of immunology 1999) 3 4 22
  5. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PMID: 9521068) Bernardini G … Napolitano M (European journal of immunology 1998) 3 4 22

Products for CCL17 Gene

Sources for CCL17 Gene