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Aliases for CCL17 Gene

Aliases for CCL17 Gene

  • C-C Motif Chemokine Ligand 17 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17 2 3
  • Thymus And Activation-Regulated Chemokine 3 4
  • Chemokine (C-C Motif) Ligand 17 2 3
  • Small-Inducible Cytokine A17 3 4
  • CC Chemokine TARC 3 4
  • SCYA17 3 4
  • TARC 3 4
  • T Cell-Directed CC Chemokine 3
  • C-C Motif Chemokine 17 3
  • A-152E5.3 3
  • ABCD-2 3

External Ids for CCL17 Gene

Previous HGNC Symbols for CCL17 Gene

  • SCYA17

Previous GeneCards Identifiers for CCL17 Gene

  • GC16P047843
  • GC16P057498
  • GC16P057173
  • GC16P057214
  • GC16P055996
  • GC16P057438
  • GC16P043306

Summaries for CCL17 Gene

Entrez Gene Summary for CCL17 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL17 Gene

CCL17 (C-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CCL17 include Eosinophilic Pneumonia and Paragonimiasis. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and CCR4 chemokine receptor binding.

UniProtKB/Swiss-Prot for CCL17 Gene

  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Gene Wiki entry for CCL17 Gene

Additional gene information for CCL17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL17 Gene

Genomics for CCL17 Gene

GeneHancer (GH) Regulatory Elements for CCL17 Gene

Promoters and enhancers for CCL17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057413 Promoter/Enhancer 1.1 EPDnew ENCODE 650.4 +17.4 17409 1 DPF2 IRF4 BCL11A IKZF1 EED ETV6 BCLAF1 IKZF2 CREM SPI1 CCL17 PLLP CX3CL1 CCL22 COQ9 GC16P057430
GH16J057394 Enhancer 0.9 FANTOM5 ENCODE 656 -1.6 -1596 0.9 NFIB MAX ASH1L CEBPG ZNF776 RCOR1 PRDM10 TRIM24 CHD2 NFIA CCL17 NUDT21 CX3CL1 CCL22 PLLP CNGB1 ADGRG1 GC16M057389
GH16J058125 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +731.8 731777 4.6 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC LOC101927556 CFAP20 RSPRY1 CNOT1 POLR2C CSNK2A2 CCL17 ENSG00000260545 GC16M058096
GH16J057633 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.3 +240.6 240593 7 MLX ARID4B SIN3A BMI1 DMAP1 ZNF48 ZBTB40 YY1 ZNF614 FOS ADGRG1 ADGRG3 CCL17 PLLP CX3CL1 GC16M057629 GC16P057639
GH16J056631 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 4.5 -763.7 -763717 1.5 SP1 SUZ12 MXD3 ERF EZH2 YY1 MT1M MT1L MT1E CCL17 MT1JP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL17 gene promoter:
  • deltaCREB
  • CREB
  • CUTL1
  • C/EBPalpha
  • FOXJ2 (long isoform)
  • FOXJ2
  • c-Rel
  • STAT5B
  • PPAR-alpha
  • RelA

Genomic Locations for CCL17 Gene

Genomic Locations for CCL17 Gene
chr16:57,396,190-57,416,063
(GRCh38/hg38)
Size:
19,874 bases
Orientation:
Plus strand
chr16:57,438,679-57,449,974
(GRCh37/hg19)
Size:
11,296 bases
Orientation:
Plus strand

Genomic View for CCL17 Gene

Genes around CCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL17 Gene

Proteins for CCL17 Gene

  • Protein details for CCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92583-CCL17_HUMAN
    Recommended name:
    C-C motif chemokine 17
    Protein Accession:
    Q92583
    Secondary Accessions:
    • A0N0Q9
    • Q2M287

    Protein attributes for CCL17 Gene

    Size:
    94 amino acids
    Molecular mass:
    10507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL17 Gene

neXtProt entry for CCL17 Gene

Post-translational modifications for CCL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL17 Gene

Antibody Products

  • Abcam antibodies for CCL17
  • Boster Bio Antibodies for CCL17
  • Santa Cruz Biotechnology (SCBT) Antibodies for CCL17

Assay Products

  • Abcam assays for CCL17

No data available for DME Specific Peptides for CCL17 Gene

Domains & Families for CCL17 Gene

Gene Families for CCL17 Gene

Protein Domains for CCL17 Gene

Suggested Antigen Peptide Sequences for CCL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92583

UniProtKB/Swiss-Prot:

CCL17_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL17: view

Function for CCL17 Gene

Molecular function for CCL17 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.

Phenotypes From GWAS Catalog for CCL17 Gene

Gene Ontology (GO) - Molecular Function for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8702936
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA,TAS --
GO:0031729 CCR4 chemokine receptor binding IEA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL17: view
genes like me logo Genes that share phenotypes with CCL17: view

Animal Models for CCL17 Gene

MGI Knock Outs for CCL17:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL17

miRNA for CCL17 Gene

miRTarBase miRNAs that target CCL17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL17 Gene

Localization for CCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL17 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL17 Gene

Pathways & Interactions for CCL17 Gene

genes like me logo Genes that share pathways with CCL17: view

Gene Ontology (GO) - Biological Process for CCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 9743322
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8702936
genes like me logo Genes that share ontologies with CCL17: view

No data available for SIGNOR curated interactions for CCL17 Gene

Drugs & Compounds for CCL17 Gene

(9) Drugs for CCL17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for CCL17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL17: view

Transcripts for CCL17 Gene

mRNA/cDNA for CCL17 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL17 Gene

Chemokine (C-C motif) ligand 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL17 Gene

No ASD Table

Relevant External Links for CCL17 Gene

GeneLoc Exon Structure for
CCL17
ECgene alternative splicing isoforms for
CCL17

Expression for CCL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL17 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.1), Lung (x6.1), and Esophagus - Mucosa (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CCL17 Gene:

CCL17

SOURCE GeneReport for Unigene cluster for CCL17 Gene:

Hs.546294

mRNA Expression by UniProt/SwissProt for CCL17 Gene:

Q92583-CCL17_HUMAN
Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Evidence on tissue expression from TISSUES for CCL17 Gene

  • Blood(4.6)
  • Skin(2.8)
  • Lymph node(2.6)
  • Lung(2.5)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with CCL17: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL17 Gene

Orthologs for CCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL17 34 33
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCL17 34 33
  • 82.02 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl17 33
  • 75.93 (n)
mouse
(Mus musculus)
Mammalia Ccl17 16 34 33
  • 73.7 (n)
cow
(Bos Taurus)
Mammalia CCL17 34 33
  • 71.99 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCL17 34
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCL17 34
  • 35 (a)
OneToOne
Species where no ortholog for CCL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL17 Gene

ENSEMBL:
Gene Tree for CCL17 (if available)
TreeFam:
Gene Tree for CCL17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL17: view image

Paralogs for CCL17 Gene

(23) SIMAP similar genes for CCL17 Gene using alignment to 1 proteins:

  • CCL17_HUMAN

Pseudogenes.org Pseudogenes for CCL17 Gene

genes like me logo Genes that share paralogs with CCL17: view

No data available for Paralogs for CCL17 Gene

Variants for CCL17 Gene

Sequence variations from dbSNP and Humsavar for CCL17 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000174590 -- 57,412,720(+) A/G intron_variant
rs1000277812 -- 57,400,065(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000508239 -- 57,409,955(+) C/T intron_variant
rs1000614522 -- 57,404,466(+) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000668281 -- 57,404,694(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for CCL17 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL17 Gene

Human Gene Mutation Database (HGMD)
CCL17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCL17 Gene

Disorders for CCL17 Gene

MalaCards: The human disease database

(31) MalaCards diseases for CCL17 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic pneumonia
  • pneumonia, eosinophilic
paragonimiasis
  • infection by paragonimus
alveolar echinococcosis
  • alveolococcosis
dermatitis
  • eczema
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search CCL17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL17 Gene

Publications for CCL17 Gene

  1. The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients. (PMID: 15500644) Tsunemi Y … Tamaki K (Experimental dermatology 2004) 3 22 44 58
  2. Structures of thymus and activation-regulated chemokine (TARC). (PMID: 12832759) Asojo OA … Lubkowski J (Acta crystallographica. Section D, Biological crystallography 2003) 3 4 22 58
  3. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi CG … Umland SP (European journal of immunology 1999) 3 4 22 58
  4. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. (PMID: 8702936) Imai T … Yoshie O (The Journal of biological chemistry 1996) 2 3 4 58
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58

Products for CCL17 Gene

Sources for CCL17 Gene

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