This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This ... See more...

Aliases for CCL16 Gene

Aliases for CCL16 Gene

  • C-C Motif Chemokine Ligand 16 2 3 5
  • HCC-4 2 3 4
  • LCC-1 2 3 4
  • NCC-4 2 3 4
  • LMC 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 16 2 3
  • Lymphocyte And Monocyte Chemoattractant 3 4
  • Chemokine (C-C Motif) Ligand 16 2 3
  • Small-Inducible Cytokine A16 3 4
  • IL-10-Inducible Chemokine 3 4
  • Liver-Expressed Chemokine 3 4
  • C-C Motif Chemokine 16 3 4
  • Chemokine LEC 3 4
  • Monotactin-1 3 4
  • ILINCK 3 4
  • SCYA16 3 4
  • CKb12 2 3
  • Mtn-1 2 3
  • SCYL4 2 3
  • NCC4 3 4
  • LEC 2 3
  • Liver CC Chemokine-1 3
  • New CC Chemokine 4 3
  • Chemokine CC-4 4
  • CCL16 5
  • MTN-1 4

External Ids for CCL16 Gene

Previous HGNC Symbols for CCL16 Gene

  • SCYA16

Previous GeneCards Identifiers for CCL16 Gene

  • GC17M034073
  • GC17M036339
  • GC17M034152
  • GC17M034449
  • GC17M031327
  • GC17M034303
  • GC17M030488

Summaries for CCL16 Gene

Entrez Gene Summary for CCL16 Gene

  • This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL16 Gene

CCL16 (C-C Motif Chemokine Ligand 16) is a Protein Coding gene. Diseases associated with CCL16 include Visceral Leishmaniasis and Adiaspiromycosis. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and chemoattractant activity. An important paralog of this gene is CCL13.

UniProtKB/Swiss-Prot Summary for CCL16 Gene

  • Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL16 Gene

Genomics for CCL16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035981 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 250.7 +1.6 1602 1.4 SSRP1 CEBPA YY1 THAP11 FOXA2 KDM6A RXRA SMAD4 SAP130 SMC3 CCL16 ENSG00000275431 SLFN12 HSALNG0115993 LYZL6
GH17J035984 Promoter 0.4 EPDnew 250.7 -1.1 -1116 0.1 HNF4A CCL14 CCL16 ENSG00000275431 CCL18 CCL15-CCL14
GH17J036055 Enhancer 0.7 FANTOM5 Ensembl 14.8 -74.6 -74581 6.8 FOXA2 ZFP37 ATF2 ZBTB40 CREB1 HSALNG0116000 LOC105371746 CCL3L3 CCL4 CCL3 CCL16 CCL15 CCL23 CCL5 CCL18
GH17J036004 Enhancer 0.4 Ensembl 10.9 -21.1 -21080 1.4 FOXA2 RXRA RAD21 CCL16 CCL18 CCL15 CCL15-CCL14 ENSG00000275944 LOC107985068 ENSG00000278690 CCL23
GH17J034990 Enhancer 0.7 Ensembl ENCODE dbSUPER 5.1 +991.3 991319 4.2 MYC POLR2A RUNX3 HSALNG0115902 lnc-CCT6B-3 LIG3 ENSG00000253084 NLE1 ZNF830 CCL16 CCT6B RFFL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL16

Top Transcription factor binding sites by QIAGEN in the CCL16 gene promoter:
  • C/EBPalpha
  • E4BP4
  • GR
  • GR-alpha
  • GR-beta
  • HOXA5
  • Lhx3a
  • LHX3b
  • MyoD
  • YY1

Genomic Locations for CCL16 Gene

Latest Assembly
chr17:35,976,493-35,983,620
(GRCh38/hg38)
Size:
7,128 bases
Orientation:
Minus strand

Previous Assembly
chr17:34,303,535-34,308,533
(GRCh37/hg19 by Entrez Gene)
Size:
4,999 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):211,063-216,061 (-)

Genomic View for CCL16 Gene

Genes around CCL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL16 Gene

Proteins for CCL16 Gene

  • Protein details for CCL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15467-CCL16_HUMAN
    Recommended name:
    C-C motif chemokine 16
    Protein Accession:
    O15467
    Secondary Accessions:
    • Q4KKU0

    Protein attributes for CCL16 Gene

    Size:
    120 amino acids
    Molecular mass:
    13600 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL16 Gene

neXtProt entry for CCL16 Gene

Post-translational modifications for CCL16 Gene

No Post-translational modifications

Other Protein References for CCL16 Gene

No data available for DME Specific Peptides for CCL16 Gene

Domains & Families for CCL16 Gene

Gene Families for CCL16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCL16 Gene

InterPro:
Blocks:
  • Small chemokine, C-C subfamily

Suggested Antigen Peptide Sequences for CCL16 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A16 (CCL16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15467

UniProtKB/Swiss-Prot:

CCL16_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL16: view

Function for CCL16 Gene

Molecular function for CCL16 Gene

UniProtKB/Swiss-Prot Function:
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
UniProtKB/Swiss-Prot Induction:
By IL10/interleukin-10.

Phenotypes From GWAS Catalog for CCL16 Gene

Gene Ontology (GO) - Molecular Function for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity TAS,IBA 21873635
GO:0042056 chemoattractant activity IDA 15001559
GO:0048020 CCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CCL16: view
genes like me logo Genes that share phenotypes with CCL16: view

miRNA for CCL16 Gene

miRTarBase miRNAs that target CCL16

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL16 Gene

Localization for CCL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL16 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CCL16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL16 Gene

Pathways & Interactions for CCL16 Gene

PathCards logo

SuperPathways for CCL16 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Peptide ligand-binding receptors
4 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with CCL16: view

Pathways by source for CCL16 Gene

27 Qiagen pathways for CCL16 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006935 chemotaxis TAS 9642106
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
GO:0007154 cell communication TAS 9642106
genes like me logo Genes that share ontologies with CCL16: view

No data available for SIGNOR curated interactions for CCL16 Gene

Drugs & Compounds for CCL16 Gene

(2) Drugs for CCL16 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6959

(1) Additional Compounds for CCL16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL16: view

Transcripts for CCL16 Gene

mRNA/cDNA for CCL16 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL16

Alternative Splicing Database (ASD) splice patterns (SP) for CCL16 Gene

No ASD Table

Relevant External Links for CCL16 Gene

GeneLoc Exon Structure for
CCL16

Expression for CCL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for CCL16 Gene

This gene is overexpressed in Liver (x42.2).

Protein differential expression in normal tissues from HIPED for CCL16 Gene

This gene is overexpressed in Plasma (50.0) and Serum (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL16 Gene



Protein tissue co-expression partners for CCL16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL16

SOURCE GeneReport for Unigene cluster for CCL16 Gene:

Hs.10458

mRNA Expression by UniProt/SwissProt for CCL16 Gene:

O15467-CCL16_HUMAN
Tissue specificity: Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Evidence on tissue expression from TISSUES for CCL16 Gene

  • Liver(4.6)
genes like me logo Genes that share expression patterns with CCL16: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL16 Gene

Orthologs for CCL16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCL16 29
  • 99.17 (n)
Cow
(Bos Taurus)
Mammalia CCL16 29
  • 85 (n)
Dog
(Canis familiaris)
Mammalia CCL16 29
  • 81.16 (n)
Species where no ortholog for CCL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCL16 Gene

ENSEMBL:
Gene Tree for CCL16 (if available)
TreeFam:
Gene Tree for CCL16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL16: view image
Alliance of Genome Resources:
Additional Orthologs for CCL16

Paralogs for CCL16 Gene

(24) SIMAP similar genes for CCL16 Gene using alignment to 3 proteins:

  • CCL16_HUMAN
  • H0YCC1_HUMAN
  • K7ELY7_HUMAN
genes like me logo Genes that share paralogs with CCL16: view

Variants for CCL16 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCL16 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCL16 Gene

Variant ID Type Subtype PubMed ID
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL16 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL16
Leiden Open Variation Database (LOVD)
CCL16

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL16 Gene

Disorders for CCL16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCL16 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
visceral leishmaniasis
  • infection by visceral leishmaniasis
adiaspiromycosis
- elite association - COSMIC cancer census association via MalaCards
Search CCL16 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL16

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCL16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL16 Gene

Publications for CCL16 Gene

  1. Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver. (PMID: 10671294) Yang JY … Widmer U (Cytokine 2000) 3 4 22
  2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 4 22
  3. Genomic organization of the genes for human and mouse CC chemokine LEC. (PMID: 10235110) Fukuda S … Nomiyama H (DNA and cell biology 1999) 3 4 22
  4. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. (PMID: 9642106) Youn BS … Kwon BS (Biochemical and biophysical research communications 1998) 3 4 22
  5. Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. (PMID: 9596672) Hedrick JA … Zlotnik A (Blood 1998) 3 4 22

Products for CCL16 Gene

  • Boster Bio Antibodies for CCL16
  • Boster Bio ELISA Kits for CCL16

Sources for CCL16 Gene