A cluster of CC chemokine genes exists on chromosome 17q11.2. The CC chemokines are secreted proteins characterized by two adjacent cysteines. The genes chemokine (C-C motif) ligand 14 and chemokine (C-C motif) ligand 15 are adjacent loci and express read-through transcripts spanning both loci. The read-through transcripts were originally interpreted as bicistronic transcripts,... See more...

Aliases for CCL15-CCL14 Gene

Subcategory (RNA class) for CCL15-CCL14 Gene

lncRNA

Number of RNA Genes sources:

1 / 17

Aliases for CCL15-CCL14 Gene

  • CCL15-CCL14 Readthrough (NMD Candidate) 2 3 5
  • CCL15-CCL14 Readthrough (Non-Protein Coding) 3
  • Macrophage Inflammatory Protein 5 3
  • Small-Inducible Cytokine A15 3
  • C-C Motif Chemokine 15 3
  • C-C Motif Chemokine 13
  • Lnc-CCL15-CCL14-72 165
  • Chemokine CC-2 3
  • Leukotactin-1 3
  • MIP-1 Delta 3
  • CCL15-CCL14 5
  • Mrp-2b 3
  • SCYA15 3
  • CCL15 3
  • HCC-2 3
  • LKN-1 3
  • MIP-5 3
  • NCC-3 3
  • MIP5 3
  • NCC3 3

External Ids for CCL15-CCL14 Gene

Previous GeneCards Identifiers for CCL15-CCL14 Gene

  • GC17M034316
  • GC17M034348
  • GC17M034392

Summaries for CCL15-CCL14 Gene

Entrez Gene Summary for CCL15-CCL14 Gene

  • A cluster of CC chemokine genes exists on chromosome 17q11.2. The CC chemokines are secreted proteins characterized by two adjacent cysteines. The genes chemokine (C-C motif) ligand 14 and chemokine (C-C motif) ligand 15 are adjacent loci and express read-through transcripts spanning both loci. The read-through transcripts were originally interpreted as bicistronic transcripts, but they are represented as non-coding because they are candidates for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Dec 2009]

GeneCards Summary for CCL15-CCL14 Gene

CCL15-CCL14 (CCL15-CCL14 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL15.

Additional gene information for CCL15-CCL14 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL15-CCL14 Gene

Genomics for CCL15-CCL14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL15-CCL14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036000 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 600.7 +0.5 458 2.8 GATAD2A TFE3 RCOR2 RBFOX2 RXRB TCF12 IKZF2 SP1 ZNF600 CEBPA CCL15 CCL15-CCL14 ENSG00000275944 LOC107985068 CCL23
GH17J035990 Enhancer 0.9 Ensembl ENCODE 0.4 +11.1 11146 3 GATAD2A RXRB SP1 SOX13 FOXA2 MAFF YY1 MAFK TEAD1 JUND CCL23 CCL18 CCL15 CCL14 ENSG00000275431 ENSG00000275944 CCL15-CCL14
GH17J035986 Promoter 0.8 EPDnew Ensembl 0.4 +16.0 16037 1.6 NR2F2 CCL14 CCL23 CCL18 CCL16 ENSG00000275431 CCL15-CCL14
GH17J036004 Enhancer 0.4 Ensembl 0.7 -2.5 -2463 1.4 FOXA2 RXRA RAD21 CCL16 CCL18 CCL15 CCL15-CCL14 ENSG00000275944 LOC107985068 ENSG00000278690 CCL23
GH17J035997 Promoter 0.3 EPDnew 0.7 +4.2 4179 0.1 CCL15 CCL18 CCL15-CCL14 ENSG00000275944 CCL14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL15-CCL14 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for CCL15-CCL14 Gene

Genomic Locations for CCL15-CCL14 Gene
chr17:35,983,656-36,002,038
(GRCh38/hg38)
Size:
18,383 bases
Orientation:
Minus strand
chr17:34,310,692-34,329,084
(GRCh37/hg19)
Size:
18,393 bases
Orientation:
Minus strand

Genomic View for CCL15-CCL14 Gene

Genes around CCL15-CCL14 on UCSC Golden Path with GeneCards custom track
CCL15-CCL14 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
CCL15-CCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL15-CCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL15-CCL14 Gene

Proteins for CCL15-CCL14 Gene

  • Protein details for CCL15-CCL14 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J2E2-A0A0B4J2E2_HUMAN
    Recommended name:
    C-C motif chemokine
    Protein Accession:
    A0A0B4J2E2

    Protein attributes for CCL15-CCL14 Gene

    Size:
    113 amino acids
    Molecular mass:
    12236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCL15-CCL14 Gene

Post-translational modifications for CCL15-CCL14 Gene

No Post-translational modifications

Other Protein References for CCL15-CCL14 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for CCL15-CCL14 Gene

Domains & Families for CCL15-CCL14 Gene

Gene Families for CCL15-CCL14 Gene

Unknown:
  • Belongs to the intercrine beta (chemokine CC) family.

Protein Domains for CCL15-CCL14 Gene

genes like me logo Genes that share domains with CCL15-CCL14: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCL15-CCL14 Gene

Function for CCL15-CCL14 Gene

Phenotypes From GWAS Catalog for CCL15-CCL14 Gene

Gene Ontology (GO) - Molecular Function for CCL15-CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA --
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL15-CCL14: view

miRNA for CCL15-CCL14 Gene

miRTarBase miRNAs that target CCL15-CCL14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL15-CCL14 Gene

Localization for CCL15-CCL14 Gene

Gene Ontology (GO) - Cellular Components for CCL15-CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CCL15-CCL14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CCL15-CCL14 Gene

Pathways & Interactions for CCL15-CCL14 Gene

PathCards logo

SuperPathways for CCL15-CCL14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCL15-CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CCL15-CCL14: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CCL15-CCL14 Gene

Drugs & Compounds for CCL15-CCL14 Gene

No Compound Related Data Available

Transcripts for CCL15-CCL14 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for CCL15-CCL14 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D7F9_9606 lncRNA 1464 2

RefSeq: NR_027921,

LNCipedia: lnc-CCL15-CCL14-72:1,

URS000075AA9F_9606 lncRNA 1416 2

RefSeq: NR_027922,

LNCipedia: lnc-CCL15-CCL14-72:2,

CCL15-CCL14 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for CCL15-CCL14 Gene

3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CCL15-CCL14 Gene

No ASD Table

Relevant External Links for CCL15-CCL14 Gene

GeneLoc Exon Structure for
CCL15-CCL14

Expression for CCL15-CCL14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL15-CCL14

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL15-CCL14 Gene

Orthologs for CCL15-CCL14 Gene

Evolution for CCL15-CCL14 Gene

ENSEMBL:
Gene Tree for CCL15-CCL14 (if available)
TreeFam:
Gene Tree for CCL15-CCL14 (if available)

No data available for Orthologs for CCL15-CCL14 Gene

Paralogs for CCL15-CCL14 Gene

genes like me logo Genes that share paralogs with CCL15-CCL14: view

Variants for CCL15-CCL14 Gene

Additional dbSNP identifiers (rs#s) for CCL15-CCL14 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL15-CCL14 Gene

Variant ID Type Subtype PubMed ID
esv3640462 CNV gain 21293372
nsv1055760 CNV gain 25217958
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Additional Variant Information for CCL15-CCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL15-CCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for CCL15-CCL14 Gene

Disorders for CCL15-CCL14 Gene

No disorders were found for CCL15-CCL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCL15-CCL14 Gene

Publications for CCL15-CCL14 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 13
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  4. Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15. (PMID: 11527984) Forssmann U … Forssmann WG (Journal of leukocyte biology 2001) 3
  5. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3

Products for CCL15-CCL14 Gene

Sources for CCL15-CCL14 Gene