This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional... See more...

Aliases for CCL15 Gene

Aliases for CCL15 Gene

  • C-C Motif Chemokine Ligand 15 2 3 5
  • Macrophage Inflammatory Protein 5 2 3 4
  • Chemokine CC-2 2 3 4
  • MIP-1 Delta 2 3 4
  • HCC-2 2 3 4
  • MIP-5 2 3 4
  • NCC-3 2 3 4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 15 2 3
  • Chemokine (C-C Motif) Ligand 15 2 3
  • Small-Inducible Cytokine A15 3 4
  • C-C Motif Chemokine 15 3 4
  • Leukotactin 1 2 3
  • HMRP-2B 2 3
  • SCYA15 3 4
  • LKN-1 3 4
  • SCYL3 2 3
  • NCC3 3 4
  • New CC Chemokine 3 3
  • CC Chemokine 3 2
  • Leukotactin-1 4
  • MIP-1D 3
  • MRP-2B 3
  • MIP-1d 2
  • Mrp-2b 4
  • CCL15 5
  • Lkn-1 2
  • LKN1 3
  • SY15 3
  • MIP5 4

External Ids for CCL15 Gene

Previous HGNC Symbols for CCL15 Gene

  • SCYA15

Previous GeneCards Identifiers for CCL15 Gene

  • GC17U990091
  • GC17M036348
  • GC17M034160
  • GC17M034458
  • GC17M034460
  • GC17M031336
  • GC17M034312
  • GC17M030509
  • GC17M034315
  • GC17M034345
  • GC17M034391

Summaries for CCL15 Gene

Entrez Gene Summary for CCL15 Gene

  • This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

GeneCards Summary for CCL15 Gene

CCL15 (C-C Motif Chemokine Ligand 15) is a Protein Coding gene. Diseases associated with CCL15 include Asymptomatic Neurosyphilis and Postinfectious Encephalitis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CCL15-CCL14.

UniProtKB/Swiss-Prot Summary for CCL15 Gene

  • Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL15 Gene

Genomics for CCL15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J036000 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 261.6 +0.2 155 2.5 ZNF600 CEBPA NFIC YY1 HOMEZ FOXA2 SMAD4 RXRA SAP130 ETV4 CCL15 CCL15-CCL14 ENSG00000275944 LOC107985068 CCL14
GH17J035997 Promoter 0.3 EPDnew 250.7 +3.7 3694 0.1 CCL15 CCL18 CCL15-CCL14 ENSG00000275944 CCL14
GH17J036102 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 10.8 -104.5 -104452 6.2 ATF2 ZNF223 TRIM22 ZNF341 EBF1 BHLHE40 SPI1 ZNF189 POLR2A ELF1 CCL4 CCL3 CCL3L3 CCL5 CCL18 CCL15 PIGW SLFN12L MYO19 GGNBP2
GH17J036017 Promoter/Enhancer 0.8 EPDnew Ensembl 13.7 -16.9 -16948 2.6 NR2F1 MAX CEBPB RAD21 NR2F2 CCL23 CCL15 piR-37972-284 LOC107985068 CCL18
GH17J036034 Enhancer 0.7 Ensembl 10.9 -33.7 -33747 5.8 ZNF10 BCL11A TRIM22 IRF4 BHLHE40 SPI1 BATF ELF1 IKZF1 RB1 CCL18 CCL15 CCL5 CCL14 lnc-CCL23-1 piR-59297-272 CCL23 LOC105371746 LOC107985068
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL15

Genomic Locations for CCL15 Gene

Latest Assembly
chr17:35,996,440-36,001,553
(GRCh38/hg38)
Size:
5,114 bases
Orientation:
Minus strand

Previous Assembly
chr17:34,324,618-34,328,592
(GRCh37/hg19 by Entrez Gene)
Size:
3,975 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):232,146-236,120 (-)

Genomic View for CCL15 Gene

Genes around CCL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL15 Gene

Proteins for CCL15 Gene

  • Protein details for CCL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16663-CCL15_HUMAN
    Recommended name:
    C-C motif chemokine 15
    Protein Accession:
    Q16663
    Secondary Accessions:
    • B2RU34
    • E1P651
    • Q9UM74

    Protein attributes for CCL15 Gene

    Size:
    113 amino acids
    Molecular mass:
    12248 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CCL15 Gene

neXtProt entry for CCL15 Gene

Post-translational modifications for CCL15 Gene

No Post-translational modifications

Other Protein References for CCL15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL15 Gene

Domains & Families for CCL15 Gene

Gene Families for CCL15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CCL15 Gene

InterPro:
Blocks:
  • Small chemokine, C-C subfamily

Suggested Antigen Peptide Sequences for CCL15 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A15 (CCL15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16663

UniProtKB/Swiss-Prot:

CCL15_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL15: view

Function for CCL15 Gene

Molecular function for CCL15 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.

Phenotypes From GWAS Catalog for CCL15 Gene

Gene Ontology (GO) - Molecular Function for CCL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 9346309
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity TAS,IBA 21873635
GO:0008201 heparin binding IEA --
GO:0042056 chemoattractant activity IDA 15001559
genes like me logo Genes that share ontologies with CCL15: view
genes like me logo Genes that share phenotypes with CCL15: view

miRNA for CCL15 Gene

miRTarBase miRNAs that target CCL15

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL15 Gene

Localization for CCL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL15 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IBA 21873635
genes like me logo Genes that share ontologies with CCL15: view

Pathways & Interactions for CCL15 Gene

PathCards logo

SuperPathways for CCL15 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 CCR5 Pathway in Macrophages
.33
genes like me logo Genes that share pathways with CCL15: view

Pathways by source for CCL15 Gene

27 Qiagen pathways for CCL15 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006874 cellular calcium ion homeostasis TAS 9346309
GO:0006935 chemotaxis TAS 9600961
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL15: view

No data available for SIGNOR curated interactions for CCL15 Gene

Drugs & Compounds for CCL15 Gene

(5) Drugs for CCL15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCL15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL15: view

Transcripts for CCL15 Gene

mRNA/cDNA for CCL15 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL15

Alternative Splicing Database (ASD) splice patterns (SP) for CCL15 Gene

No ASD Table

Relevant External Links for CCL15 Gene

GeneLoc Exon Structure for
CCL15

Expression for CCL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL15 Gene

mRNA differential expression in normal tissues according to GTEx for CCL15 Gene

This gene is overexpressed in Colon - Transverse (x14.0), Liver (x12.2), Small Intestine - Terminal Ileum (x8.2), Kidney - Cortex (x6.2), and Bladder (x4.8).

Protein differential expression in normal tissues from HIPED for CCL15 Gene

This gene is overexpressed in Rectum (56.3) and Kidney (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL15 Gene



Protein tissue co-expression partners for CCL15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL15

SOURCE GeneReport for Unigene cluster for CCL15 Gene:

Hs.272493

mRNA Expression by UniProt/SwissProt for CCL15 Gene:

Q16663-CCL15_HUMAN
Tissue specificity: Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.

Evidence on tissue expression from TISSUES for CCL15 Gene

  • Spleen(4.3)
  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CCL15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL15 Gene

Orthologs for CCL15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCL15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCL15 29
  • 97.94 (n)
Species where no ortholog for CCL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCL15 Gene

ENSEMBL:
Gene Tree for CCL15 (if available)
TreeFam:
Gene Tree for CCL15 (if available)
Alliance of Genome Resources:
Additional Orthologs for CCL15

Paralogs for CCL15 Gene

(22) SIMAP similar genes for CCL15 Gene using alignment to 2 proteins:

  • CCL15_HUMAN
  • H7BYL4_HUMAN
genes like me logo Genes that share paralogs with CCL15: view

Variants for CCL15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL15 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs854625 -- p.Ile24Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCL15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCL15 Gene

Variant ID Type Subtype PubMed ID
esv3640462 CNV gain 21293372
nsv1055760 CNV gain 25217958
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL15 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL15
Leiden Open Variation Database (LOVD)
CCL15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL15 Gene

Disorders for CCL15 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CCL15 Gene - From: COP

Disorder Aliases PubMed IDs
asymptomatic neurosyphilis
  • neurosyphilis
postinfectious encephalitis
  • postinfective encephalitis
primary syphilis
  • early symptomatic syphilis
tertiary neurosyphilis
  • late neurosyphilis
- elite association - COSMIC cancer census association via MalaCards
Search CCL15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCL15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL15 Gene

Publications for CCL15 Gene

  1. Proteolytic activation of alternative CCR1 ligands in inflammation. (PMID: 15905581) Berahovich RD … Schall TJ (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 22
  2. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 4 22
  3. Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype. (PMID: 10320325) Sticht H … Adermann K (Biochemistry 1999) 3 4 22
  4. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PMID: 9600961) Pardigol A … Mägert HJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22
  5. Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10. (PMID: 9624581) Wang W … Schall TJ (Journal of clinical immunology 1998) 3 4 22

Products for CCL15 Gene

  • Boster Bio Antibodies for CCL15
  • Boster Bio ELISA Kits for CCL15

Sources for CCL15 Gene