This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for... See more...

Aliases for CCL14 Gene

Aliases for CCL14 Gene

  • C-C Motif Chemokine Ligand 14 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14 2 3
  • Chemokine (C-C Motif) Ligand 14 2 3
  • Small-Inducible Cytokine A14 3 4
  • C-C Motif Chemokine 14 3 4
  • Chemokine CC-1/CC-3 3 4
  • HCC-1(1-74) 3 4
  • HCC-1/HCC-3 3 4
  • SCYA14 3 4
  • NCC-2 3 4
  • NCC2 3 4
  • Hemofiltrate CC Chemokine 1 3
  • New CC Chemokine 2 3
  • Chemokine CC-3 3
  • HCC-1 3
  • HCC-3 3
  • SCYL2 3
  • CC-1 3
  • CC-3 3
  • CKB1 3
  • MCIF 3
  • SY14 3

External Ids for CCL14 Gene

Previous HGNC Symbols for CCL14 Gene

  • SCYA14

Previous GeneCards Identifiers for CCL14 Gene

  • GC17M034081
  • GC17M036346
  • GC17M034161
  • GC17M034457
  • GC17M034459
  • GC17M031335
  • GC17M034311
  • GC17M030495
  • GC17M034314
  • GC17M034343
  • GC17M034389
  • GC17M035984
  • GC17M036152
  • GC17M036181
  • GC17M036190
  • GC17M035986
  • GC17M036005
  • GC17M036025
  • GC17M036052
  • GC17M036077
  • GC17M036097
  • GC17M036112
  • GC17M036133

Summaries for CCL14 Gene

Entrez Gene Summary for CCL14 Gene

  • This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]

GeneCards Summary for CCL14 Gene

CCL14 (C-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CCL14 include Thyroid Angiosarcoma and Lynch Syndrome I. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3L1.

UniProtKB/Swiss-Prot Summary for CCL14 Gene

  • Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Additional gene information for CCL14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL14 Gene

Genomics for CCL14 Gene

GeneHancer (GH) Regulatory Elements for CCL14 Gene

Promoters and enhancers for CCL14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035986 Promoter 0.8 EPDnew Ensembl 500.7 +1.0 1003 1.6 NR2F2 CCL14 CCL23 CCL18 ENSG00000275431 CCL15-CCL14
GH17J035984 Promoter 0.4 EPDnew 500.7 +2.3 2268 0.1 HNF4A CCL14 CCL16 ENSG00000275431 CCL18 CCL15-CCL14
GH17J035533 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +449.3 449306 9 ZBTB40 CTCF SIN3A ZBTB5 EP300 RBM34 REST RELA MYC RAD21 ENSG00000286065 HSALNG0115956 AP2B1 SLFN12L CCL5 PEX12 SLFN5 TAF5LP1 GAS2L2 SLFN11
GH17J036064 Promoter/Enhancer 1 EPDnew Ensembl ENCODE dbSUPER 5.9 -77.0 -76997 1.2 ATF2 ZNF354B CCL18 LOC105371746 CCL14
GH17J036848 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.8 -862.9 -862936 4.3 CTCF ZSCAN5C JUND FOS REST TOE1 EP300 CTBP1 ZNF341 RBM25 DDX52 CCL14 DUSP14 lnc-LHX1-4 HSALNG0116067
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCL14

Top Transcription factor binding sites by QIAGEN in the CCL14 gene promoter:
  • ER-alpha
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for CCL14 Gene

Genomic Locations for CCL14 Gene
chr17:35,983,288-35,987,004
(GRCh38/hg38)
Size:
3,717 bases
Orientation:
Minus strand
chr17:34,310,327-34,329,100
(GRCh37/hg19)
Size:
18,774 bases
Orientation:
Minus strand

Genomic View for CCL14 Gene

Genes around CCL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL14 Gene

Proteins for CCL14 Gene

  • Protein details for CCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16627-CCL14_HUMAN
    Recommended name:
    C-C motif chemokine 14
    Protein Accession:
    Q16627
    Secondary Accessions:
    • E1P649
    • E1P650
    • Q13954

    Protein attributes for CCL14 Gene

    Size:
    93 amino acids
    Molecular mass:
    10678 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL14 Gene

    Alternative splice isoforms for CCL14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCL14 Gene

Post-translational modifications for CCL14 Gene

  • The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
  • HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
  • Glycosylation at Ser26
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL14 Gene

No data available for DME Specific Peptides for CCL14 Gene

Domains & Families for CCL14 Gene

Gene Families for CCL14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCL14 Gene

Blocks:
  • Small chemokine, C-C subfamily
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCL14 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A14 (CCL14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16627

UniProtKB/Swiss-Prot:

CCL14_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL14: view

Function for CCL14 Gene

Molecular function for CCL14 Gene

UniProtKB/Swiss-Prot Function:
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Phenotypes From GWAS Catalog for CCL14 Gene

Gene Ontology (GO) - Molecular Function for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA,IEA 21873635
GO:0048020 CCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CCL14: view
genes like me logo Genes that share phenotypes with CCL14: view

Animal Model Products

CRISPR Products

miRNA for CCL14 Gene

miRTarBase miRNAs that target CCL14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL14 Gene

Localization for CCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL14 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL14 Gene

Pathways & Interactions for CCL14 Gene

PathCards logo

SuperPathways for CCL14 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 CCR5 Pathway in Macrophages
.33
genes like me logo Genes that share pathways with CCL14: view

Pathways by source for CCL14 Gene

27 Qiagen pathways for CCL14 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006874 cellular calcium ion homeostasis TAS 8551235
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL14: view

No data available for SIGNOR curated interactions for CCL14 Gene

Drugs & Compounds for CCL14 Gene

(1) Additional Compounds for CCL14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL14: view

Transcripts for CCL14 Gene

mRNA/cDNA for CCL14 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL14

Alternative Splicing Database (ASD) splice patterns (SP) for CCL14 Gene

No ASD Table

Relevant External Links for CCL14 Gene

GeneLoc Exon Structure for
CCL14

Expression for CCL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCL14 Gene

Protein differential expression in normal tissues from HIPED for CCL14 Gene

This gene is overexpressed in Plasma (56.5) and Serum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCL14 Gene



Protein tissue co-expression partners for CCL14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCL14

SOURCE GeneReport for Unigene cluster for CCL14 Gene:

Hs.740501

mRNA Expression by UniProt/SwissProt for CCL14 Gene:

Q16627-CCL14_HUMAN
Tissue specificity: Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.

Evidence on tissue expression from TISSUES for CCL14 Gene

  • Spleen(4.5)
  • Liver(4.4)
  • Bone marrow(4.2)
  • Pancreas(4.1)
  • Lymph node(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CCL14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL14 Gene

Orthologs for CCL14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL14 30
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia CCL14 30
  • 79.57 (n)
cow
(Bos Taurus)
Mammalia CCL14 30
  • 76.81 (n)
Species where no ortholog for CCL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL14 Gene

ENSEMBL:
Gene Tree for CCL14 (if available)
TreeFam:
Gene Tree for CCL14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL14: view image

Paralogs for CCL14 Gene

(27) SIMAP similar genes for CCL14 Gene using alignment to 2 proteins:

  • CCL14_HUMAN
  • K7END2_HUMAN
genes like me logo Genes that share paralogs with CCL14: view

Variants for CCL14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCL14 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs16971802 - p.Lys61Glu

Additional dbSNP identifiers (rs#s) for CCL14 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCL14 Gene

Variant ID Type Subtype PubMed ID
nsv1059795 CNV gain 25217958
nsv833424 CNV gain 17160897
nsv833427 CNV loss 17160897

Variation tolerance for CCL14 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL14 Gene

Disorders for CCL14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCL14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thyroid angiosarcoma
  • hemangiosarcoma of the thyroid
lynch syndrome i
  • colorectal cancer, hereditary nonpolyposis, type 1; hnpcc1
- elite association - COSMIC cancer census association via MalaCards
Search CCL14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL14 Gene

Publications for CCL14 Gene

  1. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. (PMID: 10213461) Nomiyama H … Yoshie O (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 4 23 54
  2. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. (PMID: 9600961) Pardigol A … Mägert HJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 23 54
  3. HCC-1, a novel chemokine from human plasma. (PMID: 8551235) Schulz-Knappe P … Forssmann WG (The Journal of experimental medicine 1996) 3 4 23 54
  4. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PMID: 8661057) Naruse K … Miura R (Genomics 1996) 2 3 23 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for CCL14 Gene

Sources for CCL14 Gene