Aliases for CCL14 Gene
External Ids for CCL14 Gene
Previous HGNC Symbols for CCL14 Gene
Previous GeneCards Identifiers for CCL14 Gene
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
GeneCards Summary for CCL14 Gene
CCL14 (C-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CCL14 include Thyroid Angiosarcoma and Lynch Syndrome I. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL3L1.
UniProtKB/Swiss-Prot Summary for CCL14 Gene
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.