This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfa... See more...

Aliases for CCL11 Gene

Aliases for CCL11 Gene

  • C-C Motif Chemokine Ligand 11 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin) 2 3
  • Chemokine (C-C Motif) Ligand 11 2 3
  • Eosinophil Chemotactic Protein 3 4
  • Eotaxin-1 2 3
  • Eotaxin 3 4
  • SCYA11 3 4
  • Small-Inducible Cytokine A11 4
  • C-C Motif Chemokine 11 4

External Ids for CCL11 Gene

Previous HGNC Symbols for CCL11 Gene

  • SCYA11

Previous GeneCards Identifiers for CCL11 Gene

  • GC17P032382
  • GC17P034652
  • GC17P032758
  • GC17P029636
  • GC17P032612
  • GC17P028797

Summaries for CCL11 Gene

Entrez Gene Summary for CCL11 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL11 Gene

CCL11 (C-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include Asthma and Human Immunodeficiency Virus Type 1. Among its related pathways are Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot Summary for CCL11 Gene

  • In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

Gene Wiki entry for CCL11 Gene

Additional gene information for CCL11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL11 Gene

Genomics for CCL11 Gene

GeneHancer (GH) Regulatory Elements for CCL11 Gene

Promoters and enhancers for CCL11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J034285 Promoter 0.3 EPDnew 750.6 +0.1 55 0.1 CCL11 NONHSAG021518.2
GH17J034245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12 -32.8 -32802 14.1 SIN3A SMARCE1 MYC ELF1 MAX SP1 ZBTB33 MAFK PRDM1 ZNF639 CCL2 lnc-ASIC2-2 CCL7 CCL11 CCL8 CCL1 ASIC2 HSALNG0115862
GH17J034199 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.6 -84.6 -84567 3 SP1 CTCF CC2D1A DACH1 RAD21 ELF3 SP7 RELA ARID2 REST lnc-CCL2-13 CCL7 CCL8 CCL2 CCL1 ASIC2 CCL11 LINC01989
GH17J034307 Enhancer 0.8 FANTOM5 ENCODE 11.4 +21.6 21641 1.1 CTCF RELA REST NR2F2 EBF1 IKZF1 lnc-CCL1-10 CCL7 CCL11 CCL1 ASIC2 CCL8 piR-46002-249
GH17J034346 Enhancer 0.7 Ensembl 10.9 +61.4 61433 1 ZNF148 SMARCA4 TRIM24 PRDM10 HDAC1 ATF7 LEF1 EP300 SOX6 ZNF766 LIG3 CCL11 TLK2P1 ASIC2 ZNF830 CCL13 lnc-CCL1-4 ENSG00000265614
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL11 gene promoter:
  • c-Rel
  • C/EBPbeta
  • Cdc5
  • E47
  • E4BP4
  • NF-kappaB1
  • Pax-6
  • RelA
  • STAT1
  • STAT3

Genomic Locations for CCL11 Gene

Genomic Locations for CCL11 Gene
chr17:34,285,668-34,288,334
(GRCh38/hg38)
Size:
2,667 bases
Orientation:
Plus strand
chr17:32,612,687-32,615,353
(GRCh37/hg19)
Size:
2,667 bases
Orientation:
Plus strand

Genomic View for CCL11 Gene

Genes around CCL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL11 Gene

Proteins for CCL11 Gene

  • Protein details for CCL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51671-CCL11_HUMAN
    Recommended name:
    Eotaxin
    Protein Accession:
    P51671
    Secondary Accessions:
    • P50877
    • Q92490
    • Q92491

    Protein attributes for CCL11 Gene

    Size:
    97 amino acids
    Molecular mass:
    10732 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL11 Gene

neXtProt entry for CCL11 Gene

Post-translational modifications for CCL11 Gene

  • O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.
  • Glycosylation at Thr94
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL11 Gene

Domains & Families for CCL11 Gene

Gene Families for CCL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CCL11 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine A11 (CCL11_HUMAN)
  • Chemokine (C-C motif) ligand 11 (Q6I9T4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51671

UniProtKB/Swiss-Prot:

CCL11_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL11: view

Function for CCL11 Gene

Molecular function for CCL11 Gene

UniProtKB/Swiss-Prot Function:
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
UniProtKB/Swiss-Prot Induction:
Induced by TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.

Phenotypes From GWAS Catalog for CCL11 Gene

Gene Ontology (GO) - Molecular Function for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 10072545
GO:0031728 CCR3 chemokine receptor binding IDA 11425309
GO:0046983 protein dimerization activity IDA 9712872
genes like me logo Genes that share ontologies with CCL11: view
genes like me logo Genes that share phenotypes with CCL11: view

Animal Models for CCL11 Gene

MGI Knock Outs for CCL11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL11 Gene

Localization for CCL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL11 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IBA 21873635
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL11 Gene

Pathways & Interactions for CCL11 Gene

PathCards logo

SuperPathways for CCL11 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 CCR5 Pathway in Macrophages
.33
genes like me logo Genes that share pathways with CCL11: view

SIGNOR curated interactions for CCL11 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002544 chronic inflammatory response IEA --
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0002551 mast cell chemotaxis IEA --
GO:0006468 protein phosphorylation TAS 10706854
genes like me logo Genes that share ontologies with CCL11: view

Drugs & Compounds for CCL11 Gene

(46) Drugs for CCL11 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methadone Approved, Illicit Pharma 383
CAT-213 Investigational Pharma Target 0

(35) Additional Compounds for CCL11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL11: view

Transcripts for CCL11 Gene

mRNA/cDNA for CCL11 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCL11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL11 Gene

No ASD Table

Relevant External Links for CCL11 Gene

GeneLoc Exon Structure for
CCL11
ECgene alternative splicing isoforms for
CCL11

Expression for CCL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL11 Gene

This gene is overexpressed in Colon - Sigmoid (x14.9), Stomach (x6.6), Colon - Transverse (x6.4), and Heart - Left Ventricle (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of CCL11 Gene:

CCL11

SOURCE GeneReport for Unigene cluster for CCL11 Gene:

Hs.54460

Evidence on tissue expression from TISSUES for CCL11 Gene

  • Blood(4.6)
  • Lung(4.6)
  • Intestine(4.5)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL11 Gene

Germ Layers:
  • endoderm
Systems:
  • immune
  • respiratory
Regions:
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CCL11: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCL11 Gene

Orthologs for CCL11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL11 33 32
  • 99.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCL11 33 32
  • 79.17 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl11 32
  • 75.6 (n)
mouse
(Mus musculus)
Mammalia Ccl11 17 33 32
  • 75.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 43 (a)
ManyToMany
-- 33
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 43 (a)
ManyToMany
-- 33
  • 39 (a)
ManyToMany
-- 33
  • 18 (a)
ManyToMany
Species where no ortholog for CCL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL11 Gene

ENSEMBL:
Gene Tree for CCL11 (if available)
TreeFam:
Gene Tree for CCL11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL11: view image

Paralogs for CCL11 Gene

(28) SIMAP similar genes for CCL11 Gene using alignment to 2 proteins:

  • CCL11_HUMAN
  • Q6I9T4_HUMAN
genes like me logo Genes that share paralogs with CCL11: view

Variants for CCL11 Gene

Sequence variations from dbSNP and Humsavar for CCL11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000218287 -- 34,286,524(+) C/T intron_variant
rs1000320152 -- 34,286,827(+) A/G intron_variant
rs1000554042 -- 34,287,931(+) C/A/G 3_prime_UTR_variant
rs1000806328 -- 34,284,845(+) T/C upstream_transcript_variant
rs1000875319 -- 34,286,190(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL11 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL11 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL11 Gene

Human Gene Mutation Database (HGMD)
CCL11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL11 Gene

Disorders for CCL11 Gene

MalaCards: The human disease database

(73) MalaCards diseases for CCL11 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
eosinophilic gastroenteritis
  • gastroenteritis, eosinophilic
giant papillary conjunctivitis
  • gpc
common cold
  • acute coryza
- elite association - COSMIC cancer census association via MalaCards
Search CCL11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL11 Gene

Publications for CCL11 Gene

  1. Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls. (PMID: 16510147) Sheikine Y … Ghaderi M (Atherosclerosis 2006) 3 23 43 56
  2. Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. (PMID: 15186951) Zee RY … Ridker PM (Atherosclerosis 2004) 3 23 43 56
  3. Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts. (PMID: 9578468) Noso N … Schröder JM (European journal of biochemistry 1998) 3 4 23 56
  4. Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. (PMID: 9712872) Crump MP … Sykes BD (The Journal of biological chemistry 1998) 3 4 23 56
  5. Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. (PMID: 9169149) Garcia-Zepeda EA … Luster AD (Genomics 1997) 2 3 4 56

Products for CCL11 Gene

Sources for CCL11 Gene