Aliases for CCL11 Gene
External Ids for CCL11 Gene
Previous HGNC Symbols for CCL11 Gene
Previous GeneCards Identifiers for CCL11 Gene
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL11 Gene
CCL11 (C-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include Asthma and Human Immunodeficiency Virus Type 1. Among its related pathways are Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL2.
UniProtKB/Swiss-Prot Summary for CCL11 Gene
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.