This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfa... See more...

Aliases for CCL1 Gene

Aliases for CCL1 Gene

  • C-C Motif Chemokine Ligand 1 2 3 5
  • T Lymphocyte-Secreted Protein I-309 2 3 4
  • Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3) 2 3
  • Chemokine (C-C Motif) Ligand 1 2 3
  • Inflammatory Cytokine I-309 2 3
  • C-C Motif Chemokine 1 3 4
  • SCYA1 3 4
  • Small-Inducible Cytokine A1 4
  • I-309 3
  • P500 3
  • SISe 3
  • TCA3 3

External Ids for CCL1 Gene

Previous HGNC Symbols for CCL1 Gene

  • SCYA1

Previous GeneCards Identifiers for CCL1 Gene

  • GC17M032457
  • GC17M034727
  • GC17M032536
  • GC17M032832
  • GC17M029711
  • GC17M032687
  • GC17M028873
  • GC17M034363

Summaries for CCL1 Gene

Entrez Gene Summary for CCL1 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL1 Gene

CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Igg4-Related Sclerosing Cholangitis and Peptic Ulcer Perforation. Among its related pathways are CCR5 Pathway in Macrophages and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CCL3L1.

UniProtKB/Swiss-Prot Summary for CCL1 Gene

  • Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.

Additional gene information for CCL1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCL1 Gene

Genomics for CCL1 Gene

GeneHancer (GH) Regulatory Elements for CCL1 Gene

Promoters and enhancers for CCL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J034360 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 750.6 -3.0 -2967 12.8 CTCF FOXA1 USF2 NR2F1 NR2F6 MYC CC2D1A MAX RAD21 ZNF148 CCL1 ASIC2 CCL7 ENSG00000267457 CCL8 CCL2 lnc-CCL13-1
GH17J034399 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 44.5 -37.6 -37568 6.4 L3MBTL2 MAX ZSCAN21 PRDM10 ATF1 ZBTB20 MGA OSR2 CREB1 NR2C2 CCL1 CCL2 CCL7 CCL8 ASIC2 lnc-CCL13-1
GH17J034387 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 47.9 -24.2 -24236 0.9 SMARCE1 ZKSCAN8 ZNF148 SMARCA4 ATF1 ZNF316 MTA2 SCRT2 ZBTB11 MAFG CCL1 CCL2 CCL7 CCL8 lnc-CCL13-1
GH17J034386 Enhancer 0.7 FANTOM5 dbSUPER 49.4 -23.5 -23501 0.2 ZKSCAN8 ZNF148 ZNF316 ZBTB11 CREB1 ZNF395 ATF7 CCL1 CCL2 lnc-CCL13-1
GH17J034245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +110.4 110367 14.1 SIN3A SMARCE1 MYC ELF1 MAX SP1 ZBTB33 MAFK PRDM1 ZNF639 CCL2 lnc-ASIC2-2 CCL7 CCL11 CCL8 CCL1 ASIC2 HSALNG0115862
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCL1 gene promoter:
  • AML1a
  • Elk-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NCX
  • NF-kappaB
  • NF-kappaB1
  • Nkx6-1

Genomic Locations for CCL1 Gene

Genomic Locations for CCL1 Gene
chr17:34,360,328-34,363,233
(GRCh38/hg38)
Size:
2,906 bases
Orientation:
Minus strand
chr17:32,687,347-32,690,252
(GRCh37/hg19)
Size:
2,906 bases
Orientation:
Minus strand

Genomic View for CCL1 Gene

Genes around CCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL1 Gene

Proteins for CCL1 Gene

  • Protein details for CCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22362-CCL1_HUMAN
    Recommended name:
    C-C motif chemokine 1
    Protein Accession:
    P22362
    Secondary Accessions:
    • B2R5G9
    • Q2M309

    Protein attributes for CCL1 Gene

    Size:
    96 amino acids
    Molecular mass:
    10992 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CCL1 Gene

neXtProt entry for CCL1 Gene

Post-translational modifications for CCL1 Gene

  • Glycosylation at Asn52

Other Protein References for CCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CCL1

No data available for DME Specific Peptides for CCL1 Gene

Domains & Families for CCL1 Gene

Gene Families for CCL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CCL1 Gene

GenScript: Design optimal peptide antigens:
  • T lymphocyte-secreted protein I-309 (CCL1_HUMAN)
  • I-309 (Q76BR7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22362

UniProtKB/Swiss-Prot:

CCL1_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL1: view

Function for CCL1 Gene

Molecular function for CCL1 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.
UniProtKB/Swiss-Prot Induction:
By phorbol myristate acetate (PMA).

Phenotypes From GWAS Catalog for CCL1 Gene

Gene Ontology (GO) - Molecular Function for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IDA 1557400
GO:0048020 CCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CCL1: view
genes like me logo Genes that share phenotypes with CCL1: view

Animal Models for CCL1 Gene

MGI Knock Outs for CCL1:
  • Ccl1 Ccl1<tm1Sman>

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL1 Gene

Localization for CCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 1557400
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL1 Gene

Pathways & Interactions for CCL1 Gene

PathCards logo

SuperPathways for CCL1 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
4 Akt Signaling
.60
.60
.55
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with CCL1: view

Pathways by source for CCL1 Gene

27 Qiagen pathways for CCL1 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

SIGNOR curated interactions for CCL1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA 21873635
GO:0006874 cellular calcium ion homeostasis TAS 9417093
GO:0006935 chemotaxis TAS 9417093
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL1: view

Drugs & Compounds for CCL1 Gene

(4) Drugs for CCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL1: view

Transcripts for CCL1 Gene

mRNA/cDNA for CCL1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL1 Gene

No ASD Table

Relevant External Links for CCL1 Gene

GeneLoc Exon Structure for
CCL1
ECgene alternative splicing isoforms for
CCL1

Expression for CCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL1 Gene

This gene is overexpressed in Testis (x10.6).

NURSA nuclear receptor signaling pathways regulating expression of CCL1 Gene:

CCL1

SOURCE GeneReport for Unigene cluster for CCL1 Gene:

Hs.72918

Evidence on tissue expression from TISSUES for CCL1 Gene

  • Nervous system(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CCL1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL1 Gene

Orthologs for CCL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL1 33 32
  • 98.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCL1 33 32
  • 69.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCL1 33 32
  • 69.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccl1 32
  • 64.1 (n)
mouse
(Mus musculus)
Mammalia Ccl1 17 33 32
  • 62.27 (n)
Species where no ortholog for CCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL1 Gene

ENSEMBL:
Gene Tree for CCL1 (if available)
TreeFam:
Gene Tree for CCL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCL1: view image

Paralogs for CCL1 Gene

(19) SIMAP similar genes for CCL1 Gene using alignment to 1 proteins:

  • CCL1_HUMAN
genes like me logo Genes that share paralogs with CCL1: view

Variants for CCL1 Gene

Sequence variations from dbSNP and Humsavar for CCL1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000144556 -- 34,361,237(-) A/G intron_variant
rs1000318014 -- 34,364,681(-) G/A upstream_transcript_variant
rs1000349152 -- 34,364,344(-) G/C upstream_transcript_variant
rs1000626190 -- 34,361,037(-) A/G intron_variant
rs1000680953 -- 34,363,076(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCL1 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL1 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL1 Gene

Disorders for CCL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
igg4-related sclerosing cholangitis
peptic ulcer perforation
  • acute peptic ulcer with perforation
dermatitis, atopic
  • atod
- elite association - COSMIC cancer census association via MalaCards
Search CCL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL1 Gene

Publications for CCL1 Gene

  1. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. (PMID: 2212659) Miller MD … Krangel MS (Journal of immunology (Baltimore, Md. : 1950) 1990) 2 3 4 23 56
  2. Human CC chemokine I-309, structural consequences of the additional disulfide bond. (PMID: 10821677) Keizer DW … Sykes BD (Biochemistry 2000) 3 4 23 56
  3. The human cytokine I-309 is a monocyte chemoattractant. (PMID: 1557400) Miller MD … Krangel MS (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 23 56
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 43 56
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 43 56

Products for CCL1 Gene

Sources for CCL1 Gene