Aliases for CCL1 Gene
External Ids for CCL1 Gene
Previous HGNC Symbols for CCL1 Gene
Previous GeneCards Identifiers for CCL1 Gene
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL1 Gene
CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Igg4-Related Sclerosing Cholangitis and Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CCL7.
UniProtKB/Swiss-Prot Summary for CCL1 Gene
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.