Aliases for CCKBR Gene
External Ids for CCKBR Gene
Previous GeneCards Identifiers for CCKBR Gene
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
GeneCards Summary for CCKBR Gene
CCKBR (Cholecystokinin B Receptor) is a Protein Coding gene. Diseases associated with CCKBR include Panic Disorder and Anxiety. Among its related pathways are Secretion of Hydrochloric Acid in Parietal Cells and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is CCKAR.
UniProtKB/Swiss-Prot Summary for CCKBR Gene
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain, spinal cord and stomach and influence neurotransmission.