Aliases for CCKBR Gene
External Ids for CCKBR Gene
Previous GeneCards Identifiers for CCKBR Gene
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
GeneCards Summary for CCKBR Gene
CCKBR (Cholecystokinin B Receptor) is a Protein Coding gene. Diseases associated with CCKBR include Panic Disorder and Anxiety. Among its related pathways are Cell-type Dependent Selectivity of CCK2R Signaling and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is CCKAR.
UniProtKB/Swiss-Prot Summary for CCKBR Gene
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain, spinal cord and stomach and influence neurotransmission.