This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endo... See more...

Aliases for CCKAR Gene

Aliases for CCKAR Gene

  • Cholecystokinin A Receptor 2 3 5
  • Cholecystokinin Receptor Type A 3 4
  • Cholecystokinin-1 Receptor 3 4
  • CCK-A Receptor 3 4
  • CCK1-R 3 4
  • CCK-AR 3 4
  • CCKRA 3 4
  • Cholecystokinin Type-A Receptor 3
  • CCK-A 3
  • CCK1R 3
  • CCKAR 5

External Ids for CCKAR Gene

Previous GeneCards Identifiers for CCKAR Gene

  • GC04M026632
  • GC04M026171
  • GC04M026233
  • GC04M026159
  • GC04M025821

Summaries for CCKAR Gene

Entrez Gene Summary for CCKAR Gene

  • This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCKAR Gene

CCKAR (Cholecystokinin A Receptor) is a Protein Coding gene. Diseases associated with CCKAR include Panic Disorder and Functionless Pituitary Adenoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and cholecystokinin receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot Summary for CCKAR Gene

  • Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for CCKAR Gene

  • The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK2. CCK1 receptors play a role in food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility.

Gene Wiki entry for CCKAR Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCKAR Gene

Genomics for CCKAR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCKAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J026490 Promoter/Enhancer 0.8 EPDnew Ensembl CraniofacialAtlas 256.7 +0.4 394 1 EZH2 CCKAR piR-50437-500 RBPJ
GH04J026491 Enhancer 0.5 Ensembl 250.7 -0.3 -321 0.4 MAFF ZNF316 MAFK MAFG CHD2 CCKAR RF00017-3854 TBC1D19
GH04J026457 Enhancer 0.8 Ensembl ENCODE 25.8 +31.4 31430 2.9 ZNF654 YY1 REST TRIM22 CTCF RAD21 SMC3 RARA TBP ZNF2 piR-42491-165 CCKAR HSALNG0033481 RBPJ
GH04J026778 Enhancer 1 Ensembl ENCODE 9.8 -290.5 -290531 4.4 ZNF600 MYC NCOR1 IKZF1 JUND ATF2 NFIC NONO REST BHLHE40 STIM2 CCKAR TBC1D19 lnc-TBC1D19-2 HSALNG0033493
GH04J026318 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 +169.2 169183 6.2 EZH2 BCLAF1 SP1 ZNF207 NCOR1 ZNF600 MYC IKZF1 JUND ZNF580 lnc-CCKAR-10 RBPJ CCKAR HSALNG0033475
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCKAR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCKAR

Top Transcription factor binding sites by QIAGEN in the CCKAR gene promoter:
  • AML1a
  • AP-1
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for CCKAR Gene

Latest Assembly
chr4:26,481,396-26,490,484
(GRCh38/hg38)
Size:
9,089 bases
Orientation:
Minus strand

Previous Assembly
chr4:26,483,018-26,492,106
(GRCh37/hg19 by Entrez Gene)
Size:
9,089 bases
Orientation:
Minus strand

chr4:26,483,022-26,492,084
(GRCh37/hg19 by Ensembl)
Size:
9,063 bases
Orientation:
Minus strand

Genomic View for CCKAR Gene

Genes around CCKAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCKAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCKAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCKAR Gene

Proteins for CCKAR Gene

  • Protein details for CCKAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32238-CCKAR_HUMAN
    Recommended name:
    Cholecystokinin receptor type A
    Protein Accession:
    P32238
    Secondary Accessions:
    • B2R9Z5

    Protein attributes for CCKAR Gene

    Size:
    428 amino acids
    Molecular mass:
    47841 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCKAR Gene

neXtProt entry for CCKAR Gene

Post-translational modifications for CCKAR Gene

  • Glycosylation at Asn10, Asn24, and Asn190
  • Modification sites at PhosphoSitePlus

Other Protein References for CCKAR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for CCKAR
  • Santa Cruz Biotechnology (SCBT) Antibodies for CCKAR

No data available for DME Specific Peptides for CCKAR Gene

Domains & Families for CCKAR Gene

Gene Families for CCKAR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for CCKAR Gene

Suggested Antigen Peptide Sequences for CCKAR Gene

GenScript: Design optimal peptide antigens:
  • Cholecystokinin-1 receptor (CCKAR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32238

UniProtKB/Swiss-Prot:

CCKAR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCKAR: view

Function for CCKAR Gene

Molecular function for CCKAR Gene

UniProtKB/Swiss-Prot Function:
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GENATLAS Biochemistry:
cholecystokinin A,receptor,G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle

Phenotypes From GWAS Catalog for CCKAR Gene

Gene Ontology (GO) - Molecular Function for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004951 cholecystokinin receptor activity TAS,IDA 8503909
GO:0017046 peptide hormone binding IPI 8503909
genes like me logo Genes that share ontologies with CCKAR: view
genes like me logo Genes that share phenotypes with CCKAR: view

Animal Models for CCKAR Gene

MGI Knock Outs for CCKAR:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCKAR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCKAR Gene

Localization for CCKAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCKAR Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCKAR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IDA 8503909
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCKAR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCKAR Gene

Pathways & Interactions for CCKAR Gene

genes like me logo Genes that share pathways with CCKAR: view

SIGNOR curated interactions for CCKAR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway TAS 8343165
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with CCKAR: view

Drugs & Compounds for CCKAR Gene

(43) Drugs for CCKAR Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ceruletide Approved Pharma Target, inducer, agonist 0
Cholecystokinin Approved, Investigational Pharma Target, agonist 25
Rebamipide Approved, Investigational Pharma 43
Dexloxiglumide Investigational Pharma Antagonist, Target 0
Lintitript Investigational Pharma Antagonist, Target 0

(20) Additional Compounds for CCKAR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for CCKAR Gene

Compound Action Cas Number
A-71623 Potent and selective CCK1 agonist; suppresses feeding 130408-77-4
Devazepide Selective, orally active CCK1 receptor antagonist 103420-77-5
SR 27897 Potent and selective CCK1 antagonist 136381-85-6

(5) ApexBio Compounds for CCKAR Gene

Compound Action Cas Number
A-71623 CCK receptor agonist,potent and selective 130408-77-4
CCK Octapeptide, non-sulfated 25679-24-7
Proglumide sodium salt 99247-33-3
Rebamipide 90098-04-7
SR 27897 136381-85-6
genes like me logo Genes that share compounds with CCKAR: view

Drug products for research

Transcripts for CCKAR Gene

mRNA/cDNA for CCKAR Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCKAR

Alternative Splicing Database (ASD) splice patterns (SP) for CCKAR Gene

No ASD Table

Relevant External Links for CCKAR Gene

GeneLoc Exon Structure for
CCKAR

Expression for CCKAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCKAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCKAR Gene

This gene is overexpressed in Stomach (x35.1).

Protein differential expression in normal tissues from HIPED for CCKAR Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCKAR Gene



Protein tissue co-expression partners for CCKAR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCKAR

SOURCE GeneReport for Unigene cluster for CCKAR Gene:

Hs.129

Evidence on tissue expression from TISSUES for CCKAR Gene

  • Stomach(4.7)
  • Gall bladder(4.6)
  • Nervous system(4.6)
  • Blood(4.4)
  • Intestine(2.8)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with CCKAR: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCKAR Gene

Orthologs for CCKAR Gene

This gene was present in the common ancestor of animals.

Orthologs for CCKAR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCKAR 29 30
  • 99.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCKAR 29 30
  • 90.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCKAR 29 30
  • 89.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cckar 29
  • 86.89 (n)
Mouse
(Mus musculus)
Mammalia Cckar 29 16 30
  • 86.21 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCKAR 30
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCKAR 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCK1R 30
  • 76 (a)
OneToOne
CCKAR 29
  • 74.49 (n)
Lizard
(Anolis carolinensis)
Reptilia CCKAR 30
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cckar 29
  • 71.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia cckar-A 29
Zebrafish
(Danio rerio)
Actinopterygii LOC569038 29
  • 66.49 (n)
CR352260.1 30
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCCK1 29
  • 49.71 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CCKLR-17D3 30
  • 26 (a)
ManyToMany
CCKLR-17D1 30
  • 22 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ckr-1 29 30
  • 43.52 (n)
ManyToMany
Y39A3B.5 31
  • 33 (a)
npr-14 30
  • 25 (a)
ManyToMany
npr-21 30
  • 23 (a)
ManyToMany
npr-20 30
  • 22 (a)
ManyToMany
ckr-2 30
  • 21 (a)
ManyToMany
npr-34 30
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 41 (a)
ManyToMany
-- 30
  • 33 (a)
ManyToMany
Species where no ortholog for CCKAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCKAR Gene

ENSEMBL:
Gene Tree for CCKAR (if available)
TreeFam:
Gene Tree for CCKAR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCKAR: view image
Alliance of Genome Resources:
Additional Orthologs for CCKAR

Paralogs for CCKAR Gene

(1) SIMAP similar genes for CCKAR Gene using alignment to 1 proteins:

  • CCKAR_HUMAN
genes like me logo Genes that share paralogs with CCKAR: view

Variants for CCKAR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCKAR Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs104893833 Benign: CHOLECYSTOKININ A RECEPTOR POLYMORPHISM 26,490,207(-) C/G
NM_000730.3(CCKAR):c.61G>C (p.Gly21Arg)
MISSENSE
rs52795588 Benign: CHOLECYSTOKININ A RECEPTOR POLYMORPHISM 26,481,832(-) C/T
NM_000730.3(CCKAR):c.1093G>A (p.Val365Ile)
MISSENSE
rs773043148 Likely Benign: not provided 26,483,259(-) G/A
NM_000730.3(CCKAR):c.651C>T (p.Leu217=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCKAR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCKAR Gene

Variant ID Type Subtype PubMed ID
esv275100 CNV gain+loss 21479260
esv2762417 CNV gain 21179565

Variation tolerance for CCKAR Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCKAR Gene

Human Gene Mutation Database (HGMD)
CCKAR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCKAR
Leiden Open Variation Database (LOVD)
CCKAR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCKAR Gene

Disorders for CCKAR Gene

MalaCards: The human disease database

(18) MalaCards diseases for CCKAR Gene - From: COP and GCD

Disorder Aliases PubMed IDs
panic disorder
  • panic anxiety syndrome
functionless pituitary adenoma
  • non-functioning neoplasm of the pituitary
acute pancreatitis
  • acute necrotizing pancreatitis
cholelithiasis
gallbladder disease
  • gall bladder
- elite association - COSMIC cancer census association via MalaCards
Search CCKAR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCKAR

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCKAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCKAR Gene

Publications for CCKAR Gene

  1. Gene variations in the cholecystokinin system in patients with panic disorder. (PMID: 20023595) Koefoed P … Rehfeld JF (Psychiatric genetics 2010) 3 22 40
  2. An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males. (PMID: 19753663) Koefoed P … Rehfeld JF (Acta psychiatrica Scandinavica 2009) 3 22 40
  3. Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer. (PMID: 17944886) Srivastava A … Mittal B (Journal of gastroenterology and hepatology 2008) 3 22 40
  4. Association study between the cholecystokinin A receptor gene and schizophrenia in the Japanese population. (PMID: 17413452) Minato T … Sasaki T (Psychiatric genetics 2007) 3 22 40
  5. Association between CCK-AR gene and schizophrenia with auditory hallucinations. (PMID: 17413443) Toirac I … de Frutos R (Psychiatric genetics 2007) 3 22 40

Products for CCKAR Gene

  • Addgene plasmids for CCKAR

Sources for CCKAR Gene