This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modula... See more...

Aliases for CCK Gene

Aliases for CCK Gene

  • Cholecystokinin 2 3 4 5
  • Cholecystokinin Triacontatriapeptide 2 3
  • Prepro-Cholecystokinin 2 3
  • CCK 5

External Ids for CCK Gene

Previous GeneCards Identifiers for CCK Gene

  • GC03P041561
  • GC03U900036
  • GC03M9D0028

Summaries for CCK Gene

Entrez Gene Summary for CCK Gene

  • This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for CCK Gene

CCK (Cholecystokinin) is a Protein Coding gene. Diseases associated with CCK include Cholecystitis and Biliary Dyskinesia. Among its related pathways are Gastric acid production and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot Summary for CCK Gene

  • This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Tocris Summary for CCK Gene

  • Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin. The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCK Gene

Genomics for CCK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J042264 Promoter 0.7 EPDnew 250.7 +1.4 1402 0.1 MNT REST EGR1 L3MBTL2 KLF1 SP3 KLF17 MGA CCK ENSG00000281160 lnc-TRAK1-2 TRAK1
GH03J042345 Enhancer 0.7 Ensembl ENCODE 38.6 -80.5 -80516 3.8 REST TAL1 NFE2 MAX TCF12 TEAD4 ARID1B CBFA2T2 CBFA2T3 CCK LYZL4 VIPR1 VIPR1-AS1 EIF4BP4 RF00994-650
GH03J042368 Enhancer 0.8 FANTOM5 Ensembl ENCODE 19.9 -103.1 -103116 1.8 BMI1 RFX1 SP1 MTA2 CCK LYZL4 HHATL TRAK1 HSALNG0025423 RF00994-650
GH03J042682 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.3 -419.0 -418954 5 CEBPA NFIC CEBPB FOXA2 KLF9 MAFF ZNF623 SAP130 ZNF316 FOSL2 ENSG00000287629 KLHL40 SEC22C HHATL LYZL4 NKTR CCDC13 CCK KRBOX1 ZBTB47
GH03J042231 Enhancer 0.6 Ensembl 10.6 +34.9 34884 0.2 YY1 JUND HNF4A NFYC RAD21 REST MAX HLF RXRA HNF4G HSALNG0025417 CCK VIPR1 VIPR1-AS1 piR-45012-338 TRAK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCK

Top Transcription factor binding sites by QIAGEN in the CCK gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • CREB
  • deltaCREB
  • STAT1
  • STAT3

Genomic Locations for CCK Gene

Latest Assembly
chr3:42,257,825-42,266,185
(GRCh38/hg38)
Size:
8,361 bases
Orientation:
Minus strand

Previous Assembly
chr3:42,299,318-42,307,677
(GRCh37/hg19 by Entrez Gene)
Size:
8,360 bases
Orientation:
Minus strand

chr3:42,299,317-42,307,699
(GRCh37/hg19 by Ensembl)
Size:
8,383 bases
Orientation:
Minus strand

Genomic View for CCK Gene

Genes around CCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCK Gene

Proteins for CCK Gene

  • Protein details for CCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06307-CCKN_HUMAN
    Recommended name:
    Cholecystokinin
    Protein Accession:
    P06307

    Protein attributes for CCK Gene

    Size:
    115 amino acids
    Molecular mass:
    12669 Da
    Quaternary structure:
    • Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.

neXtProt entry for CCK Gene

Post-translational modifications for CCK Gene

  • The precursor is cleaved by proteases to produce a number of active cholecystokinins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCK Gene

No data available for DME Specific Peptides for CCK Gene

Domains & Families for CCK Gene

Gene Families for CCK Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CCK Gene

InterPro:
Blocks:
  • Gastrin/cholecystokinin peptide hormone

Suggested Antigen Peptide Sequences for CCK Gene

GenScript: Design optimal peptide antigens:
  • Cholecystokinin (CCKN_HUMAN)
  • cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA (Q6FG82_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06307

UniProtKB/Swiss-Prot:

CCKN_HUMAN :
  • Belongs to the gastrin/cholecystokinin family.
Family:
  • Belongs to the gastrin/cholecystokinin family.
genes like me logo Genes that share domains with CCK: view

Function for CCK Gene

Molecular function for CCK Gene

UniProtKB/Swiss-Prot Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
GENATLAS Biochemistry:
cholecystokinin

Phenotypes From GWAS Catalog for CCK Gene

Gene Ontology (GO) - Molecular Function for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 10320330
GO:0005184 neuropeptide hormone activity IBA,ISS 15374756
GO:0005515 protein binding IPI 32296183
GO:0051428 peptide hormone receptor binding IPI 7681836
genes like me logo Genes that share ontologies with CCK: view
genes like me logo Genes that share phenotypes with CCK: view

Animal Models for CCK Gene

MGI Knock Outs for CCK:
  • Cck Cck<tm1Dgen>
  • Cck Cck<tm1Lcs>
  • Cck Cck<tm2b(EUCOMM)Hmgu>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCK Gene

Localization for CCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCK gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0030424 axon IBA,ISS 15152034
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CCK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCK Gene

Pathways & Interactions for CCK Gene

genes like me logo Genes that share pathways with CCK: view

Pathways by source for CCK Gene

SIGNOR curated interactions for CCK Gene

Activates:

Gene Ontology (GO) - Biological Process for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration ISS 15152034
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0007165 signal transduction TAS 10320330
genes like me logo Genes that share ontologies with CCK: view

Drugs & Compounds for CCK Gene

(122) Drugs for CCK Gene - From: DrugBank, ClinicalTrials, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxine Approved, Investigational, Vet_approved Nutra 243,243
Caffeine Approved Pharma 658
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 711
Cholecystokinin Approved, Investigational Pharma 25
Esomeprazole Approved, Investigational Pharma Proton pump inhibitor 430

(70) Additional Compounds for CCK Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CCK Octapeptide, sulfated
25126-32-3

(3) Tocris Compounds for CCK Gene

Compound Action Cas Number
CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide 25679-24-7
CCK Octapeptide, sulfated C-terminal octapeptide of CCK 25126-32-3
Proglumide sodium salt Non-selective CCK antagonist; orally active 99247-33-3
genes like me logo Genes that share compounds with CCK: view

Transcripts for CCK Gene

mRNA/cDNA for CCK Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCK

Alternative Splicing Database (ASD) splice patterns (SP) for CCK Gene

No ASD Table

Relevant External Links for CCK Gene

GeneLoc Exon Structure for
CCK

Expression for CCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCK Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.0), Brain - Cortex (x10.9), Brain - Anterior cingulate cortex (BA24) (x10.6), Brain - Amygdala (x7.3), and Brain - Hippocampus (x5.4).

Protein differential expression in normal tissues from HIPED for CCK Gene

This gene is overexpressed in Frontal cortex (49.9) and Brain (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCK Gene



Protein tissue co-expression partners for CCK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCK

SOURCE GeneReport for Unigene cluster for CCK Gene:

Hs.458426

Evidence on tissue expression from TISSUES for CCK Gene

  • Pancreas(4.7)
  • Nervous system(4.4)
  • Intestine(3.7)
  • Gall bladder(3.4)
  • Stomach(3.3)
  • Blood(2.9)
  • Muscle(2.6)
  • Liver(2.5)
  • Thyroid gland(2.4)
  • Adrenal gland(2.3)
  • Kidney(2.3)
  • Heart(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CCK: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCK Gene

Orthologs for CCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCK 29 30
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCK 29 30
  • 88.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCK 29 30
  • 85.51 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cck 29 16 30
  • 82.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cck 29
  • 81.45 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCK 30
  • 49 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCK 30
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCK 29 30
  • 66.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCK 30
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100497815 29
  • 55.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii CCK (1 of 2) 30
  • 38 (a)
OneToMany
cck 30
  • 35 (a)
OneToMany
Species where no ortholog for CCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCK Gene

ENSEMBL:
Gene Tree for CCK (if available)
TreeFam:
Gene Tree for CCK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCK: view image
Alliance of Genome Resources:
Additional Orthologs for CCK

Paralogs for CCK Gene

No data available for Paralogs for CCK Gene

Variants for CCK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCK Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs11571848 -- p.Gly32Glu
rs3774395 -- p.Arg95Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCK Gene

Variant ID Type Subtype PubMed ID
nsv1073220 CNV deletion 25765185
nsv1112823 CNV deletion 24896259
nsv590147 CNV loss 21841781
nsv834671 CNV gain 17160897
nsv954470 CNV deletion 24416366

Variation tolerance for CCK Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCK Gene

Human Gene Mutation Database (HGMD)
CCK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCK
Leiden Open Variation Database (LOVD)
CCK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCK Gene

Disorders for CCK Gene

MalaCards: The human disease database

(77) MalaCards diseases for CCK Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cholecystitis
  • acute and chronic cholecystitis
biliary dyskinesia
  • sphincter of oddi dysfunction
bulimia nervosa
  • bulimia nervosa, susceptibility to
acalculous cholecystitis
  • acute acalculous cholecystitis
bile reflux
- elite association - COSMIC cancer census association via MalaCards
Search CCK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCK

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCK Gene

Publications for CCK Gene

  1. Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (PMID: 15837012) Shindo S … Yoshioka N (Forensic science international 2005) 3 22 40
  2. Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (PMID: 15740988) Takimoto T … Iwahashi K (Psychiatry research 2005) 3 22 40
  3. Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PMID: 15313848) Goldman JG … Zhou L (Archives of neurology 2004) 3 22 40
  4. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. (PMID: 12777967) Wang J … Yu L (Pharmacogenetics 2003) 3 22 40
  5. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PMID: 12198366) Okubo T … Matsushita S (Alcoholism, clinical and experimental research 2002) 3 22 40

Products for CCK Gene

Sources for CCK Gene