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Aliases for CCER2 Gene

Aliases for CCER2 Gene

  • Coiled-Coil Glutamate Rich Protein 2 2 3 5
  • Coiled-Coil Domain-Containing Glutamate-Rich Protein 2 3
  • Coiled-Coil Glutamate-Rich Protein 2 2

External Ids for CCER2 Gene

Previous GeneCards Identifiers for CCER2 Gene

  • GC19M039400

Summaries for CCER2 Gene

GeneCards Summary for CCER2 Gene

CCER2 (Coiled-Coil Glutamate Rich Protein 2) is a Protein Coding gene.

Additional gene information for CCER2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCER2 Gene

Genomics for CCER2 Gene

GeneHancer (GH) Regulatory Elements for CCER2 Gene

Promoters and enhancers for CCER2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038915 Promoter 0.8 EPDnew 650.7 -1.5 -1471 0.1 HIC1 ZFHX2 GLIS2 EGR2 CCER2 SARS2 MRPS12 ENSG00000269547
GH19J039397 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -492.7 -492705 20 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36 PAF1 HNRNPL FBL ZNF780B SUPT5H RN7SL566P ZNF780A ENSG00000269688 AKT2
GH19J038928 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.4 -15.6 -15633 4 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC ZC3H11A SARS2 MRPS12 HNRNPL SUPT5H FBL FBXO17 PAF1 RN7SL566P PAK4 ENSG00000269688
GH19J038918 Enhancer 0.7 ENCODE 0.7 -3.9 -3866 0.2 ELF3 ZNF263 CTCF FOXA2 ZNF189 FOXA3 RAD21 RARA ZNF148 XRCC5 HNRNPL RN7SL566P CCER2 SARS2 MRPS12 ENSG00000269547
GH19J038919 Enhancer 1.2 FANTOM5 ENCODE 0.4 -5.8 -5771 1.5 SIN3A ZNF48 YY2 ZNF662 GMEB1 ZNF184 ZSCAN16 NBN ZNF300 ZNF785 SUPT5H FBL HNRNPL SARS2 PAF1 RPS16 ERVK9-11 ENSG00000266963 ENSG00000269688 RN7SL566P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCER2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCER2 Gene

Genomic Locations for CCER2 Gene
chr19:38,908,980-38,914,370
(GRCh38/hg38)
Size:
5,391 bases
Orientation:
Minus strand
chr19:39,399,620-39,402,798
(GRCh37/hg19)

Genomic View for CCER2 Gene

Genes around CCER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCER2 Gene

Proteins for CCER2 Gene

  • Protein details for CCER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    I3L3R5-CCER2_HUMAN
    Recommended name:
    Coiled-coil domain-containing glutamate-rich protein 2
    Protein Accession:
    I3L3R5

    Protein attributes for CCER2 Gene

    Size:
    266 amino acids
    Molecular mass:
    30352 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCER2 Gene

Post-translational modifications for CCER2 Gene

No Post-translational modifications

Other Protein References for CCER2 Gene

No data available for DME Specific Peptides for CCER2 Gene

Domains & Families for CCER2 Gene

Gene Families for CCER2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CCER2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCER2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCER2 Gene

Function for CCER2 Gene

Phenotypes From GWAS Catalog for CCER2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCER2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCER2 Gene

Localization for CCER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCER2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for CCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CCER2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CCER2 Gene

Pathways & Interactions for CCER2 Gene

SuperPathways for CCER2 Gene

No Data Available

Interacting Proteins for CCER2 Gene

Gene Ontology (GO) - Biological Process for CCER2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCER2 Gene

Drugs & Compounds for CCER2 Gene

No Compound Related Data Available

Transcripts for CCER2 Gene

mRNA/cDNA for CCER2 Gene

(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCER2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCER2 Gene

No ASD Table

Relevant External Links for CCER2 Gene

GeneLoc Exon Structure for
CCER2
ECgene alternative splicing isoforms for
CCER2

Expression for CCER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCER2 Gene

Protein differential expression in normal tissues from HIPED for CCER2 Gene

This gene is overexpressed in Bone marrow stromal cell (39.0) and Esophagus (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCER2 Gene



Protein tissue co-expression partners for CCER2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCER2 Gene:

CCER2

mRNA Expression by UniProt/SwissProt for CCER2 Gene:

I3L3R5-CCER2_HUMAN
Tissue specificity: Expressed at higher levels in fetal brain and skeletal muscle. Lower expression is detected in fetal kidney, liver, spleen, thymus, heart and lung.
genes like me logo Genes that share expression patterns with CCER2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCER2 Gene

Orthologs for CCER2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC456015 33
  • 92.73 (n)
dog
(Canis familiaris)
Mammalia LOC100685415 33
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia LOC614600 33
  • 82.04 (n)
CCER2 34
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909701 33
  • 79.17 (n)
mouse
(Mus musculus)
Mammalia Gm6537 34 33
  • 75.21 (n)
OneToOne
Ccer2 16
Species where no ortholog for CCER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCER2 Gene

ENSEMBL:
Gene Tree for CCER2 (if available)
TreeFam:
Gene Tree for CCER2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCER2: view image

Paralogs for CCER2 Gene

(1) SIMAP similar genes for CCER2 Gene using alignment to 1 proteins:

  • CCER2_HUMAN
genes like me logo Genes that share paralogs with CCER2: view

No data available for Paralogs for CCER2 Gene

Variants for CCER2 Gene

Sequence variations from dbSNP and Humsavar for CCER2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs199819134 uncertain-significance, Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 38,915,584(-) G/A/T upstream_transcript_variant
rs374281807 uncertain-significance, Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 38,915,265(-) C/G upstream_transcript_variant
rs376335678 uncertain-significance, Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 38,916,027(-) C/G/T upstream_transcript_variant
rs565577459 uncertain-significance, Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 38,915,466(-) G/A/C upstream_transcript_variant
rs727502784 pathogenic, Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 38,916,306(-) T/C upstream_transcript_variant

Variation tolerance for CCER2 Gene

Gene Damage Index Score: 7.61; 82.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCER2 Gene

Human Gene Mutation Database (HGMD)
CCER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCER2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCER2 Gene

Disorders for CCER2 Gene

Additional Disease Information for CCER2

No disorders were found for CCER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCER2 Gene

Publications for CCER2 Gene

  1. Exome Sequencing Identified CCER2 as a Novel Candidate Gene for Moyamoya Disease. (PMID: 27717682) Mukawa M … Akagawa H (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  3. Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. (PMID: 12805274) Khambata-Ford S … Myers RM (Genome research 2003) 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for CCER2 Gene

Sources for CCER2 Gene

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