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Aliases for CCDC90B Gene

Aliases for CCDC90B Gene

  • Coiled-Coil Domain Containing 90B 2 3 5
  • Coiled-Coil Domain-Containing Protein 90B, Mitochondrial 3
  • MDS011 3
  • MDS025 3

External Ids for CCDC90B Gene

Previous GeneCards Identifiers for CCDC90B Gene

  • GC11M082651
  • GC11M082972
  • GC11M079269

Summaries for CCDC90B Gene

GeneCards Summary for CCDC90B Gene

CCDC90B (Coiled-Coil Domain Containing 90B) is a Protein Coding gene. An important paralog of this gene is MCUR1.

Gene Wiki entry for CCDC90B Gene

Additional gene information for CCDC90B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC90B Gene

Genomics for CCDC90B Gene

GeneHancer (GH) Regulatory Elements for CCDC90B Gene

Promoters and enhancers for CCDC90B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J083284 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 700.1 +0.7 660 3.4 MLX ZFP64 YBX1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D CCDC90B ENSG00000255234 PCF11 ENSG00000254676 GC11M083251
GH11J083256 Enhancer 0.8 ENCODE 60.9 +28.7 28748 2.6 FOXA2 RARA ETS1 YY1 MIXL1 RXRA CEBPB PPARG KAT8 NR2F2 CCDC90B ENSG00000255234 RAB30-AS1 RAB30 GC11M083251 ANKRD42
GH11J083282 Enhancer 0.4 Ensembl 50.1 +3.8 3806 0.4 ZNF335 SP1 HNF4A CCDC90B ENSG00000255234 GC11M083251
GH11J083272 Enhancer 0.4 ENCODE 49.8 +13.4 13431 1.4 JUND FOS CCDC90B ENSG00000255234 GC11M083251
GH11J082867 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 +418.8 418847 0.9 CTCF ZNF654 ZNF362 RB1 HLF TRIM22 REST ZNF384 NR3C1 RAD21 DDIAS PRCP FAM181B CCDC90B ENSG00000255234 RAB30 ENSG00000254441
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC90B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC90B gene promoter:
  • Nkx6-1
  • HFH-1
  • MEF-2A
  • aMEF-2
  • AREB6
  • Cdc5
  • STAT5A
  • RSRFC4

Genomic Locations for CCDC90B Gene

Genomic Locations for CCDC90B Gene
chr11:83,259,093-83,286,407
(GRCh38/hg38)
Size:
27,315 bases
Orientation:
Minus strand
chr11:82,970,139-82,997,450
(GRCh37/hg19)
Size:
27,312 bases
Orientation:
Minus strand

Genomic View for CCDC90B Gene

Genes around CCDC90B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC90B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC90B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC90B Gene

Proteins for CCDC90B Gene

  • Protein details for CCDC90B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZT6-CC90B_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 90B, mitochondrial
    Protein Accession:
    Q9GZT6
    Secondary Accessions:
    • A8K8I4
    • B3KP87
    • B4E3L2
    • Q3B781
    • Q9GZU6

    Protein attributes for CCDC90B Gene

    Size:
    254 amino acids
    Molecular mass:
    29506 Da
    Quaternary structure:
    • Interacts with MCU (PubMed:27184846).

    Alternative splice isoforms for CCDC90B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC90B Gene

Post-translational modifications for CCDC90B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC90B Gene

Domains & Families for CCDC90B Gene

Gene Families for CCDC90B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CCDC90B Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZT6

UniProtKB/Swiss-Prot:

CC90B_HUMAN :
  • Belongs to the CCDC90 family.
Family:
  • Belongs to the CCDC90 family.
genes like me logo Genes that share domains with CCDC90B: view

Function for CCDC90B Gene

Gene Ontology (GO) - Molecular Function for CCDC90B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27184846
genes like me logo Genes that share ontologies with CCDC90B: view
genes like me logo Genes that share phenotypes with CCDC90B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC90B Gene

Localization for CCDC90B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC90B Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC90B gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC90B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with CCDC90B: view

Pathways & Interactions for CCDC90B Gene

SuperPathways for CCDC90B Gene

No Data Available

Interacting Proteins for CCDC90B Gene

Gene Ontology (GO) - Biological Process for CCDC90B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC90B Gene

Drugs & Compounds for CCDC90B Gene

No Compound Related Data Available

Transcripts for CCDC90B Gene

Unigene Clusters for CCDC90B Gene

Coiled-coil domain containing 90B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC90B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - -
SP10: - - - - -
SP11: - - -

Relevant External Links for CCDC90B Gene

GeneLoc Exon Structure for
CCDC90B
ECgene alternative splicing isoforms for
CCDC90B

Expression for CCDC90B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC90B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC90B Gene

This gene is overexpressed in Bone (8.0) and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC90B Gene



Protein tissue co-expression partners for CCDC90B Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC90B Gene:

CCDC90B

SOURCE GeneReport for Unigene cluster for CCDC90B Gene:

Hs.368866

Evidence on tissue expression from TISSUES for CCDC90B Gene

  • Liver(4.4)
  • Nervous system(3.7)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CCDC90B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC90B Gene

Orthologs for CCDC90B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC90B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC90B 34 33
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC90B 34 33
  • 90.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC90B 34 33
  • 88.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc90b 16 34 33
  • 85.96 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc90b 33
  • 85.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC90B 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC90B 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC90B 34 33
  • 78.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC90B 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc90b 33
  • 65.48 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc90b 34 33
  • 63.56 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.494 33
Species where no ortholog for CCDC90B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC90B Gene

ENSEMBL:
Gene Tree for CCDC90B (if available)
TreeFam:
Gene Tree for CCDC90B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC90B: view image

Paralogs for CCDC90B Gene

Paralogs for CCDC90B Gene

(1) SIMAP similar genes for CCDC90B Gene using alignment to 11 proteins:

  • CC90B_HUMAN
  • B3KP87_HUMAN
  • E9PKQ5_HUMAN
  • E9PMQ7_HUMAN
  • E9PNI8_HUMAN
  • E9PPJ7_HUMAN
  • E9PRC2_HUMAN
  • E9PSG6_HUMAN
  • H0YD95_HUMAN
  • H0YF06_HUMAN
  • J3KN19_HUMAN

Pseudogenes.org Pseudogenes for CCDC90B Gene

genes like me logo Genes that share paralogs with CCDC90B: view

Variants for CCDC90B Gene

Sequence variations from dbSNP and Humsavar for CCDC90B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000036127 -- 83,267,472(-) C/T intron_variant
rs1000118027 -- 83,272,858(-) T/C intron_variant
rs1000144707 -- 83,273,451(-) G/A intron_variant
rs1000229576 -- 83,273,361(-) G/C intron_variant
rs1000392429 -- 83,266,996(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC90B Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV loss 17666407
nsv1138058 CNV deletion 24896259
nsv468764 CNV loss 19166990
nsv555606 CNV loss 21841781

Variation tolerance for CCDC90B Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC90B Gene

Human Gene Mutation Database (HGMD)
CCDC90B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC90B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC90B Gene

Disorders for CCDC90B Gene

Additional Disease Information for CCDC90B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC90B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC90B Gene

Publications for CCDC90B Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. (PMID: 27184846) Tomar D … Madesh M (Cell reports 2016) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson JC … Wiemann S (EMBO reports 2000) 3 4 58

Products for CCDC90B Gene

Sources for CCDC90B Gene

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