Aliases for CCDC9 Gene

Aliases for CCDC9 Gene

  • Coiled-Coil Domain Containing 9 2 3 5
  • Coiled-Coil Domain-Containing Protein 9 3 4

External Ids for CCDC9 Gene

Previous GeneCards Identifiers for CCDC9 Gene

  • GC00U914334
  • GC19P052452
  • GC19P052453
  • GC19P047759
  • GC19P044183

Summaries for CCDC9 Gene

GeneCards Summary for CCDC9 Gene

CCDC9 (Coiled-Coil Domain Containing 9) is a Protein Coding gene. An important paralog of this gene is CCDC9B.

Additional gene information for CCDC9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC9 Gene

Genomics for CCDC9 Gene

GeneHancer (GH) Regulatory Elements for CCDC9 Gene

Promoters and enhancers for CCDC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC9

Top Transcription factor binding sites by QIAGEN in the CCDC9 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1
  • STAT5A

Genomic Locations for CCDC9 Gene

Genomic Locations for CCDC9 Gene
chr19:47,255,980-47,273,701
(GRCh38/hg38)
Size:
17,722 bases
Orientation:
Plus strand
chr19:47,759,237-47,775,210
(GRCh37/hg19)
Size:
15,974 bases
Orientation:
Plus strand

Genomic View for CCDC9 Gene

Genes around CCDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC9 Gene

Proteins for CCDC9 Gene

  • Protein details for CCDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3X0-CCDC9_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 9
    Protein Accession:
    Q9Y3X0

    Protein attributes for CCDC9 Gene

    Size:
    531 amino acids
    Molecular mass:
    59703 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC9 Gene

Post-translational modifications for CCDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC9 Gene

No data available for DME Specific Peptides for CCDC9 Gene

Domains & Families for CCDC9 Gene

Gene Families for CCDC9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CCDC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC9 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 9 (CCDC9_HUMAN)
genes like me logo Genes that share domains with CCDC9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC9 Gene

Function for CCDC9 Gene

Phenotypes From GWAS Catalog for CCDC9 Gene

Gene Ontology (GO) - Molecular Function for CCDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with CCDC9: view
genes like me logo Genes that share phenotypes with CCDC9: view

Animal Model Products

CRISPR Products

miRNA for CCDC9 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC9 Gene

Localization for CCDC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC9 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC9 Gene

Pathways & Interactions for CCDC9 Gene

PathCards logo

SuperPathways for CCDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC9 Gene

Drugs & Compounds for CCDC9 Gene

No Compound Related Data Available

Transcripts for CCDC9 Gene

mRNA/cDNA for CCDC9 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC9 Gene

No ASD Table

Relevant External Links for CCDC9 Gene

GeneLoc Exon Structure for
CCDC9

Expression for CCDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC9 Gene

Protein differential expression in normal tissues from HIPED for CCDC9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.6) and Pancreas (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC9 Gene



Protein tissue co-expression partners for CCDC9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC9

SOURCE GeneReport for Unigene cluster for CCDC9 Gene:

Hs.227782

Evidence on tissue expression from TISSUES for CCDC9 Gene

  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CCDC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC9 Gene

Orthologs for CCDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC9 31 30
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC9 30
  • 83.66 (n)
-- 31
  • 81 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CCDC9 31 30
  • 83.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc9 17 31 30
  • 80.23 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC9 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC9 31
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18808 30
zebrafish
(Danio rerio)
Actinopterygii ccdc9 31 30
  • 59.23 (n)
OneToOne
Species where no ortholog for CCDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC9 Gene

ENSEMBL:
Gene Tree for CCDC9 (if available)
TreeFam:
Gene Tree for CCDC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC9: view image

Paralogs for CCDC9 Gene

Paralogs for CCDC9 Gene

genes like me logo Genes that share paralogs with CCDC9: view

Variants for CCDC9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2032811 - p.Glu215Asp
rs35119724 - p.Ala456Val
rs888836 - p.Leu478Pro

Additional dbSNP identifiers (rs#s) for CCDC9 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC9 Gene

Variant ID Type Subtype PubMed ID
esv3893225 CNV loss 25118596
nsv1059583 CNV loss 25217958
nsv1067417 CNV gain 25217958
nsv833852 CNV loss 17160897

Variation tolerance for CCDC9 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.27; 81.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC9 Gene

Disorders for CCDC9 Gene

Additional Disease Information for CCDC9

No disorders were found for CCDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC9 Gene

Publications for CCDC9 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 54
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3 54
  5. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3 54

Products for CCDC9 Gene

Sources for CCDC9 Gene