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Aliases for CCDC89 Gene

Aliases for CCDC89 Gene

  • Coiled-Coil Domain Containing 89 2 3 5
  • Coiled-Coil Domain-Containing Protein 89 3 4
  • Bc8 Orange-Interacting Protein 3 4
  • BOIP 4

External Ids for CCDC89 Gene

Previous GeneCards Identifiers for CCDC89 Gene

  • GC11M085073
  • GC11M085394
  • GC11M081692

Summaries for CCDC89 Gene

GeneCards Summary for CCDC89 Gene

CCDC89 (Coiled-Coil Domain Containing 89) is a Protein Coding gene.

Additional gene information for CCDC89 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC89 Gene

Genomics for CCDC89 Gene

GeneHancer (GH) Regulatory Elements for CCDC89 Gene

Promoters and enhancers for CCDC89 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J085684 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 615.1 +0.5 450 2.9 SP1 MZF1 GLIS2 ZNF600 ZNF341 SP2 RFX3 RFX1 ZBTB48 ZBTB17 CCDC89 CREBZF SYTL2
GH11J085659 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.7 +22.2 22249 6.5 CC2D1A ZFX ELF3 CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ZNF384 ZNF687 CREBZF CCDC89 TMEM126A EED SYTL2 GC11M085678
GH11J085646 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.8 +38.5 38453 3.2 SP1 ZFX ELF3 MNT NKRF POLR2A GTF2F1 ZNF384 ZNF687 MAFK TMEM126A CREBZF CCDC89 DLG2 SYTL2 TMEM126B
GH11J085717 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.9 -32.2 -32221 4.9 MAFK SP7 SP1 PRDM1 POLR2A ZNF600 PRDM10 NFE2L2 ZEB2 ZNF629 SYTL2 CCDC89 CREBZF CCDC83 TMEM126A
GH11J085854 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 -168.4 -168352 2.5 ZFX ELF3 CEBPG RERE GTF2F1 ZSCAN21 CTCF AHR ZNF24 MAFK CCDC83 ENSG00000279742 SYTL2 CCDC89 CREBZF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC89 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC89 gene promoter:
  • ATF-2
  • ATF6
  • C/EBPalpha
  • FOXI1
  • Gfi-1
  • HFH-3
  • S8
  • SRF (504 AA)

Genomic Locations for CCDC89 Gene

Genomic Locations for CCDC89 Gene
2,434 bases
Minus strand
2,428 bases
Minus strand

Genomic View for CCDC89 Gene

Genes around CCDC89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC89 Gene

Proteins for CCDC89 Gene

  • Protein details for CCDC89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 89
    Protein Accession:

    Protein attributes for CCDC89 Gene

    374 amino acids
    Molecular mass:
    43809 Da
    Quaternary structure:
    • Interacts with HEY1.

neXtProt entry for CCDC89 Gene

Post-translational modifications for CCDC89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC89 Gene

Domains & Families for CCDC89 Gene

Gene Families for CCDC89 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC89 Gene


Suggested Antigen Peptide Sequences for CCDC89 Gene

GenScript: Design optimal peptide antigens:
  • Bc8 orange-interacting protein (CCD89_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC89 family.
  • Belongs to the CCDC89 family.
genes like me logo Genes that share domains with CCDC89: view

Function for CCDC89 Gene

Phenotypes From GWAS Catalog for CCDC89 Gene

genes like me logo Genes that share phenotypes with CCDC89: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC89 - Now 50% OFF >
  • * CCDC89 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC89 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC89 Gene

Localization for CCDC89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC89 Gene

Cytoplasm. Nucleus. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC89 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCDC89: view

Pathways & Interactions for CCDC89 Gene

PathCards logo

SuperPathways for CCDC89 Gene

No Data Available

Interacting Proteins for CCDC89 Gene

Gene Ontology (GO) - Biological Process for CCDC89 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC89 Gene

Drugs & Compounds for CCDC89 Gene

No Compound Related Data Available

Transcripts for CCDC89 Gene

mRNA/cDNA for CCDC89 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CCDC89 Gene

Coiled-coil domain containing 89:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CCDC89 - Now 50% OFF >
  • * CCDC89 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CCDC89 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC89 Gene

No ASD Table

Relevant External Links for CCDC89 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC89 Gene

This gene is overexpressed in Testis (x21.9).

Protein differential expression in normal tissues from HIPED for CCDC89 Gene

This gene is overexpressed in Ovary (50.8) and Colon muscle (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC89 Gene

Protein tissue co-expression partners for CCDC89 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC89 Gene:


SOURCE GeneReport for Unigene cluster for CCDC89 Gene:


Evidence on tissue expression from TISSUES for CCDC89 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CCDC89: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC89 Gene

Orthologs for CCDC89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC89 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CCDC89 35 34
  • 87.03 (n)
(Bos Taurus)
Mammalia CCDC89 35 34
  • 82.36 (n)
(Rattus norvegicus)
Mammalia Ccdc89 34
  • 80.54 (n)
(Mus musculus)
Mammalia Ccdc89 17 35 34
  • 80.27 (n)
(Monodelphis domestica)
Mammalia CCDC89 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC89 35
  • 59 (a)
(Gallus gallus)
Aves CCDC89 35 34
  • 61.65 (n)
(Anolis carolinensis)
Reptilia CCDC89 35
  • 50 (a)
African clawed frog
(Xenopus laevis)
Amphibia boip 34
(Danio rerio)
Actinopterygii zgc:172182 34
  • 53.52 (n)
CCDC89 35
  • 40 (a)
Species where no ortholog for CCDC89 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC89 Gene

Gene Tree for CCDC89 (if available)
Gene Tree for CCDC89 (if available)
Evolutionary constrained regions (ECRs) for CCDC89: view image

Paralogs for CCDC89 Gene

No data available for Paralogs for CCDC89 Gene

Variants for CCDC89 Gene

Sequence variations from dbSNP and Humsavar for CCDC89 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000569497 -- 85,683,793(-) C/T downstream_transcript_variant
rs1000633341 -- 85,687,862(-) G/T upstream_transcript_variant
rs1001739940 -- 85,688,147(-) A/G upstream_transcript_variant
rs1001811403 -- 85,684,931(-) T/C 3_prime_UTR_variant
rs1001918183 -- 85,686,960(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC89 Gene

Variant ID Type Subtype PubMed ID
esv2759845 CNV gain+loss 17122850
nsv468768 CNV loss 19166990
nsv555632 CNV loss 21841781

Variation tolerance for CCDC89 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC89 Gene

Disorders for CCDC89 Gene

Additional Disease Information for CCDC89

No disorders were found for CCDC89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC89 Gene

Publications for CCDC89 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PMID: 15188402) Hassel S … Souchelnytskyi S (Proteomics 2004) 3 58

Products for CCDC89 Gene

Sources for CCDC89 Gene

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