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Aliases for CCDC89 Gene

Aliases for CCDC89 Gene

  • Coiled-Coil Domain Containing 89 2 3 5
  • Bc8 Orange-Interacting Protein 3 4
  • Coiled-Coil Domain-Containing Protein 89 3
  • BOIP 4

External Ids for CCDC89 Gene

Previous GeneCards Identifiers for CCDC89 Gene

  • GC11M085073
  • GC11M085394
  • GC11M081692

Summaries for CCDC89 Gene

GeneCards Summary for CCDC89 Gene

CCDC89 (Coiled-Coil Domain Containing 89) is a Protein Coding gene.

Additional gene information for CCDC89 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC89 Gene

Genomics for CCDC89 Gene

GeneHancer (GH) Regulatory Elements for CCDC89 Gene

Promoters and enhancers for CCDC89 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J085684 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 665.2 +0.5 450 2.9 ZBTB6 SAP130 MZF1 ZNF335 GLIS2 ZBTB48 ZNF600 RFX1 NFIA SP2 CCDC89 CREBZF SYTL2
GH11J085716 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.9 -32.2 -32200 5 INSM2 SIN3A ZEB1 ZNF335 ZNF366 SCRT2 RCOR1 FOS ZNF362 ZBTB11 SYTL2 CCDC89 CREBZF CCDC83 TMEM126A
GH11J085646 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +38.5 38455 3.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B ZNF766 TMEM126A CCDC89 CREBZF DLG2 SYTL2 TMEM126B
GH11J085661 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9 +21.7 21749 5.5 HDGF CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CREBZF TMEM126A EED CCDC89 SYTL2 GC11M085678
GH11J085854 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.8 -168.7 -168653 1.9 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 CCDC83 ENSG00000279742 SYTL2 CCDC89 CREBZF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC89 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC89 gene promoter:

Genomic Locations for CCDC89 Gene

Genomic Locations for CCDC89 Gene
chr11:85,683,844-85,686,277
(GRCh38/hg38)
Size:
2,434 bases
Orientation:
Minus strand
chr11:85,394,893-85,397,320
(GRCh37/hg19)

Genomic View for CCDC89 Gene

Genes around CCDC89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC89 Gene

Proteins for CCDC89 Gene

  • Protein details for CCDC89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N998-CCD89_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 89
    Protein Accession:
    Q8N998

    Protein attributes for CCDC89 Gene

    Size:
    374 amino acids
    Molecular mass:
    43809 Da
    Quaternary structure:
    • Interacts with HEY1.

neXtProt entry for CCDC89 Gene

Post-translational modifications for CCDC89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC89 Gene

Domains & Families for CCDC89 Gene

Gene Families for CCDC89 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC89 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N998

UniProtKB/Swiss-Prot:

CCD89_HUMAN :
  • Belongs to the CCDC89 family.
Family:
  • Belongs to the CCDC89 family.
genes like me logo Genes that share domains with CCDC89: view

Function for CCDC89 Gene

Phenotypes From GWAS Catalog for CCDC89 Gene

genes like me logo Genes that share phenotypes with CCDC89: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC89 Gene

Localization for CCDC89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC89 Gene

Cytoplasm. Nucleus. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC89 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCDC89: view

Pathways & Interactions for CCDC89 Gene

SuperPathways for CCDC89 Gene

No Data Available

Interacting Proteins for CCDC89 Gene

Selected Interacting proteins: Q8N998-CCD89_HUMAN for CCDC89 Gene via IID

Gene Ontology (GO) - Biological Process for CCDC89 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC89 Gene

Drugs & Compounds for CCDC89 Gene

No Compound Related Data Available

Transcripts for CCDC89 Gene

mRNA/cDNA for CCDC89 Gene

(12) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC89 Gene

Coiled-coil domain containing 89:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC89 Gene

No ASD Table

Relevant External Links for CCDC89 Gene

GeneLoc Exon Structure for
CCDC89
ECgene alternative splicing isoforms for
CCDC89

Expression for CCDC89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC89 Gene

This gene is overexpressed in Testis (x21.9).

Protein differential expression in normal tissues from HIPED for CCDC89 Gene

This gene is overexpressed in Ovary (50.8) and Colon muscle (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC89 Gene



Protein tissue co-expression partners for CCDC89 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC89 Gene:

CCDC89

SOURCE GeneReport for Unigene cluster for CCDC89 Gene:

Hs.376241

Evidence on tissue expression from TISSUES for CCDC89 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CCDC89: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC89 Gene

Orthologs for CCDC89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC89 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CCDC89 34 33
  • 87.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC89 34 33
  • 82.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911776 33
  • 80.54 (n)
mouse
(Mus musculus)
Mammalia Ccdc89 16 34 33
  • 80.27 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC89 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC89 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC89 34 33
  • 61.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC89 34
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia boip 33
zebrafish
(Danio rerio)
Actinopterygii zgc:172182 33
  • 53.52 (n)
CCDC89 34
  • 40 (a)
OneToOne
Species where no ortholog for CCDC89 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC89 Gene

ENSEMBL:
Gene Tree for CCDC89 (if available)
TreeFam:
Gene Tree for CCDC89 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC89: view image

Paralogs for CCDC89 Gene

No data available for Paralogs for CCDC89 Gene

Variants for CCDC89 Gene

Sequence variations from dbSNP and Humsavar for CCDC89 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000569497 -- 85,683,793(-) C/T downstream_transcript_variant
rs1000633341 -- 85,687,862(-) G/T upstream_transcript_variant
rs1001739940 -- 85,688,147(-) A/G upstream_transcript_variant
rs1001811403 -- 85,684,931(-) T/C 3_prime_UTR_variant
rs1001918183 -- 85,686,960(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC89 Gene

Variant ID Type Subtype PubMed ID
esv2759845 CNV gain+loss 17122850
nsv468768 CNV loss 19166990
nsv555632 CNV loss 21841781

Variation tolerance for CCDC89 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC89 Gene

Disorders for CCDC89 Gene

Additional Disease Information for CCDC89

No disorders were found for CCDC89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC89 Gene

Publications for CCDC89 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PMID: 15188402) Hassel S … Souchelnytskyi S (Proteomics 2004) 3 58

Products for CCDC89 Gene

Sources for CCDC89 Gene

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