Aliases for CCDC87 Gene

Aliases for CCDC87 Gene

  • Coiled-Coil Domain Containing 87 2 3 5
  • Coiled-Coil Domain-Containing Protein 87 3 4
  • FLJ10786 2
  • CCDC87 5

External Ids for CCDC87 Gene

Previous GeneCards Identifiers for CCDC87 Gene

  • GC11M066115
  • GC11M066357
  • GC11M062685

Summaries for CCDC87 Gene

GeneCards Summary for CCDC87 Gene

CCDC87 (Coiled-Coil Domain Containing 87) is a Protein Coding gene. Diseases associated with CCDC87 include Charcot-Marie-Tooth Disease, Axonal, Type 2B1 and Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot Summary for CCDC87 Gene

  • Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC87 Gene

Genomics for CCDC87 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC87 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J066591 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -1.0 -995 4.5 ZNF207 IKZF1 ZNF592 KLF9 POLR2A ZSCAN16 NFIC ZIC2 YY1 MXD4 CCS CCDC87 HSALNG0085041 ACTN3 BBS1 ENSG00000254461 RBM4B KAT5 SF3B2 ENSG00000250105
GH11J066567 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +23.5 23463 3.6 MYC ZNF592 POLR2A HES1 BHLHE40 MNT MAX SIN3B FOXA2 RXRA CTSF ACTN3 RBM14 ENSG00000254461 SF3B2 ENSG00000254855 DPP3 RBM4 KAT5 ENSG00000260233
GH11J066578 Enhancer 1 Ensembl ENCODE 0.4 +12.7 12692 2.9 ZNF654 ZNF600 IKZF1 CTCF REST TRIM22 ZBTB7B ZNF217 SIN3A SAP130 ACTN3 ZDHHC24 RNU4-39P RBM14 RBM14-RBM4 RBM4B DPP3 DPP3-DT MRPL11 PELI3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC87 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC87

Top Transcription factor binding sites by QIAGEN in the CCDC87 gene promoter:
  • ATF6
  • c-Myb
  • C/EBPbeta
  • CUTL1
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1
  • MZF-1
  • XBP-1

Genomic Locations for CCDC87 Gene

Latest Assembly
2,888 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,888 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,915 bases
Minus strand

Genomic View for CCDC87 Gene

Genes around CCDC87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC87 Gene

Proteins for CCDC87 Gene

  • Protein details for CCDC87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 87
    Protein Accession:
    Secondary Accessions:
    • Q8NE76

    Protein attributes for CCDC87 Gene

    849 amino acids
    Molecular mass:
    96402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC87 Gene

Post-translational modifications for CCDC87 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC87 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC87 Gene

Domains & Families for CCDC87 Gene

Gene Families for CCDC87 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC87 Gene


Suggested Antigen Peptide Sequences for CCDC87 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 87 (CCD87_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC87 family.
  • Belongs to the CCDC87 family.
genes like me logo Genes that share domains with CCDC87: view

Function for CCDC87 Gene

Molecular function for CCDC87 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.

Phenotypes From GWAS Catalog for CCDC87 Gene

Gene Ontology (GO) - Molecular Function for CCDC87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC87: view
genes like me logo Genes that share phenotypes with CCDC87: view

Animal Models for CCDC87 Gene

MGI Knock Outs for CCDC87:
  • Ccdc87 Ccdc87<tm1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC87

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC87 Gene

Localization for CCDC87 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC87 gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC87 Gene

Pathways & Interactions for CCDC87 Gene

PathCards logo

SuperPathways for CCDC87 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization IEA --
GO:0030154 cell differentiation IEA --
GO:1905516 positive regulation of fertilization IEA,ISS --
GO:2000344 positive regulation of acrosome reaction IEA,ISS --
genes like me logo Genes that share ontologies with CCDC87: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC87 Gene

Drugs & Compounds for CCDC87 Gene

No Compound Related Data Available

Transcripts for CCDC87 Gene

mRNA/cDNA for CCDC87 Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC87

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC87 Gene

No ASD Table

Relevant External Links for CCDC87 Gene

GeneLoc Exon Structure for

Expression for CCDC87 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for CCDC87 Gene

This gene is overexpressed in Spinal cord (38.3), NK cells (7.7), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC87 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC87

SOURCE GeneReport for Unigene cluster for CCDC87 Gene:

genes like me logo Genes that share expression patterns with CCDC87: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC87 Gene

Orthologs for CCDC87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC87 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC87 29 30
  • 99.25 (n)
(Canis familiaris)
Mammalia CCDC87 29 30
  • 80.66 (n)
(Bos Taurus)
Mammalia CCDC87 29 30
  • 78.65 (n)
(Rattus norvegicus)
Mammalia Ccdc87 29
  • 74.09 (n)
(Mus musculus)
Mammalia Ccdc87 29 16 30
  • 73.31 (n)
(Monodelphis domestica)
Mammalia CCDC87 30
  • 47 (a)
(Anolis carolinensis)
Reptilia CCDC87 30
  • 32 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486794 29
  • 43.18 (n)
(Danio rerio)
Actinopterygii ccdc87 30
  • 21 (a)
Species where no ortholog for CCDC87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC87 Gene

Gene Tree for CCDC87 (if available)
Gene Tree for CCDC87 (if available)
Evolutionary constrained regions (ECRs) for CCDC87: view image
Alliance of Genome Resources:
Additional Orthologs for CCDC87

Paralogs for CCDC87 Gene

No data available for Paralogs for CCDC87 Gene

Variants for CCDC87 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC87 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1110707 -- p.Ala156Thr
rs17853294 -- p.Phe217Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC87 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC87 Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV loss 19592680

Variation tolerance for CCDC87 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC87 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC87 Gene

Disorders for CCDC87 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCDC87 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC87

genes like me logo Genes that share disorders with CCDC87: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC87 Gene

Publications for CCDC87 Gene

  1. Ccdc87 is critical for sperm function and male fertility. (PMID: 29733332) Wang T … Zhou Y (Biology of reproduction 2018) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for CCDC87 Gene

  • Biorbyt antibodies for CCDC87

Sources for CCDC87 Gene