Aliases for CCDC86 Gene

Aliases for CCDC86 Gene

  • Coiled-Coil Domain Containing 86 2 3 5
  • Cytokine-Induced Protein With Coiled-Coil Domain 3 4
  • Coiled-Coil Domain-Containing Protein 86 3 4
  • Cyclon 3
  • CYCLON 4

External Ids for CCDC86 Gene

Previous GeneCards Identifiers for CCDC86 Gene

  • GC11P060367
  • GC11P060609
  • GC11P056955

Summaries for CCDC86 Gene

GeneCards Summary for CCDC86 Gene

CCDC86 (Coiled-Coil Domain Containing 86) is a Protein Coding gene. Diseases associated with CCDC86 include Granulomatosis With Polyangiitis.

Additional gene information for CCDC86 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC86 Gene

Genomics for CCDC86 Gene

GeneHancer (GH) Regulatory Elements for CCDC86 Gene

Promoters and enhancers for CCDC86 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC86 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC86 gene promoter:
  • AP-1
  • ATF
  • c-Fos
  • c-Jun
  • FOXC1
  • GATA-1
  • GATA-2
  • GATA-3

Genomic Locations for CCDC86 Gene

Genomic Locations for CCDC86 Gene
chr11:60,841,956-60,851,088
(GRCh38/hg38)
Size:
9,133 bases
Orientation:
Plus strand
chr11:60,609,429-60,618,561
(GRCh37/hg19)
Size:
9,133 bases
Orientation:
Plus strand

Genomic View for CCDC86 Gene

Genes around CCDC86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC86 Gene

Proteins for CCDC86 Gene

  • Protein details for CCDC86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6F5-CCD86_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 86
    Protein Accession:
    Q9H6F5
    Secondary Accessions:
    • B4DY99

    Protein attributes for CCDC86 Gene

    Size:
    360 amino acids
    Molecular mass:
    40236 Da
    Quaternary structure:
    • (Microbial infection) Interacts with hepatitis C virus (HCV) protein NS5A.

    Alternative splice isoforms for CCDC86 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC86 Gene

Post-translational modifications for CCDC86 Gene

Other Protein References for CCDC86 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC86 Gene

Domains & Families for CCDC86 Gene

Gene Families for CCDC86 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC86 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC86 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51395 (B4DY99_HUMAN)
  • Cytokine-induced protein with coiled-coil domain (CCD86_HUMAN)
genes like me logo Genes that share domains with CCDC86: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC86 Gene

Function for CCDC86 Gene

Phenotypes From GWAS Catalog for CCDC86 Gene

Gene Ontology (GO) - Molecular Function for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 15607035
genes like me logo Genes that share ontologies with CCDC86: view
genes like me logo Genes that share phenotypes with CCDC86: view

Animal Models for CCDC86 Gene

MGI Knock Outs for CCDC86:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC86

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC86 Gene

Localization for CCDC86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC86 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC86 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CCDC86: view

Pathways & Interactions for CCDC86 Gene

PathCards logo

SuperPathways for CCDC86 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CCDC86: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC86 Gene

Drugs & Compounds for CCDC86 Gene

No Compound Related Data Available

Transcripts for CCDC86 Gene

mRNA/cDNA for CCDC86 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC86

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC86 Gene

No ASD Table

Relevant External Links for CCDC86 Gene

GeneLoc Exon Structure for
CCDC86
ECgene alternative splicing isoforms for
CCDC86

Expression for CCDC86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC86 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC86 Gene

This gene is overexpressed in Lung (28.2) and Peripheral blood mononuclear cells (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC86 Gene



Protein tissue co-expression partners for CCDC86 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC86 Gene:

CCDC86

SOURCE GeneReport for Unigene cluster for CCDC86 Gene:

Hs.4253

Evidence on tissue expression from TISSUES for CCDC86 Gene

  • Skin(4.3)
  • Blood(4.2)
  • Liver(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with CCDC86: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC86 Gene

Orthologs for CCDC86 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC86 33 32
  • 98.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC86 32
  • 83.62 (n)
-- 33
  • 76 (a)
OneToMany
-- 33
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc86 32
  • 77.97 (n)
mouse
(Mus musculus)
Mammalia Ccdc86 17 33 32
  • 77.4 (n)
dog
(Canis familiaris)
Mammalia CCDC86 33
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC86 33
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC86 33
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC86 33
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733466 32
  • 65.61 (n)
Str.10541 32
zebrafish
(Danio rerio)
Actinopterygii CCDC86 33
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14210 33
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y40B1B.7 33
  • 42 (a)
OneToOne
Species where no ortholog for CCDC86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC86 Gene

ENSEMBL:
Gene Tree for CCDC86 (if available)
TreeFam:
Gene Tree for CCDC86 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC86: view image

Paralogs for CCDC86 Gene

Pseudogenes.org Pseudogenes for CCDC86 Gene

genes like me logo Genes that share paralogs with CCDC86: view

No data available for Paralogs for CCDC86 Gene

Variants for CCDC86 Gene

Sequence variations from dbSNP and Humsavar for CCDC86 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000406199 -- 60,851,281(+) T/C downstream_transcript_variant
rs1000583688 -- 60,845,786(+) C/A/G intron_variant
rs1001491769 -- 60,847,788(+) C/T intron_variant
rs1001640324 -- 60,841,970(+) C/G upstream_transcript_variant
rs1001745720 -- 60,850,388(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC86 Gene

Variant ID Type Subtype PubMed ID
nsv952456 CNV deletion 24416366

Variation tolerance for CCDC86 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC86 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC86 Gene

Disorders for CCDC86 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC86 Gene - From: GeneCards

Disorder Aliases PubMed IDs
granulomatosis with polyangiitis
  • gpa
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC86

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCDC86: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC86 Gene

Publications for CCDC86 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 43 56
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 43 56
  4. Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. (PMID: 17300783) Hoshino A … Fujii H (FEBS letters 2007) 3 4 56
  5. Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. (PMID: 15607035) Ahn J … Hoe KL (Journal of biochemistry and molecular biology 2004) 3 4 56

Products for CCDC86 Gene

Sources for CCDC86 Gene